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설한국,이상구,Seol, Han-Guk,Lee, Sang-Gu 한국수학사학회 2009 Journal for history of mathematics Vol.22 No.3
Most who have heard of Sang-Seol Lee know him for his contribution to the Korean independence movement nearly a hundred years ago. This paper, however, will discuss Lee's other great contribution to his country; that of being "The father of modern mathematical education in Korea". Lee passed the rigorous government officer examination with the highest honor and became a teacher for the royal prince. Later he became the president of Sunkyunkwan, a national institute of higher learning since 1398, and eventually a well-known university bearing the same name. Lee was also a highly regarded Confucian scholar and well versed in foreign languages. He wanted Korea to become a modern country and felt that the areas of science and engineering were studies that needed improving in order to achieve modernization. While researching Western textbooks on the subjects he realized that Western mathematics would be especially important for Korea. With that, it became his mission to integrate Western mathematics into the Korean educational system. This paper will explain the importance of Sang-Seol Lee's contributions to mathematic education in Korea and how it helped Korea become the modern nation it is today.
A Study on Obstacle Factors of Global Start-up Promotion
Seol-Bin Lee(이설빈) 한국산학기술학회 2019 한국산학기술학회논문지 Vol.20 No.3
본 연구는 글로벌 스타트업 육성에 따른 국내 스타트기업의 해외진출을 위한 장애요인을 규명하기 위한 목적으로 실증조사 하였다. 조사방법은 스타트업으로 참여한 전국 각 지역별 광역시에 소재한 5년 이상 된 기업 300개 기업을 대상으로 조사 후 신뢰도 및 타당도 분석과 동시 구조모형에 의한 AMOS 구조방정식으로 통계 분석하였다. 그 연구결과를 보면 다음과 같다. 글로벌 스타트업으로 성장하기 위해서는 자금, 제품개발기간, 품질, 인적자원이 매우 밀접한 연관성이 있음을 실증해주었다. 그리고 스타트업 장애요인으로서의 자금요인은 유의하지 않았으며 개발기간과 품질, 인적자원은 산업경쟁력에 밀접한 연관성을 가지고 영향을 미침을 입증해주었다. 또한 스타트업에서의 장애요인이 산업경쟁력에 미치는 매개효과에 있어서도 자금요인은 기각된 반면, 품질과 개발기간 및 인적자원 요인은 채택되어 긍정적 매개효과를 있음을 실증해 주었다. 이는 스타트업 기업들의 특성상 자금 요인은 정부의 지속적인 지원으로 인해 경영에 큰 걸림돌이 되지 않으나 제품의 질을 일정 수준 유지하기 위한 독자적 제품 경쟁력과 이를 개발, 제품화 시켜주는 전문 인력의 뒷받침이 없는 한 성장이 요원함을 입증한 것으로 평가할 수 있다. This study was empirically intended to determine obstacle factors of the global start-up promotion for the international inroad of global start-up companies. The statistical analysis of reliability and validity was conducted through the AMOS structural equation model after surveying 300 companies over 5 years old into start-up in metropolitan cities across the country. The findings are as follows. The global start-up growth had a very close relationship with capital, product development period, quality and human resources. And capital as a start-up obstacle factor was insignificant, but development period, quality and human resources had a close relationship with industrial competitiveness. Even in the mediating effect of start-up obstacle factors on industrial competitiveness, capital was rejected, while quality, development period and human resources were adopted, having a positive mediating effect. These results demonstrate that capital is not a big obstacle to the management because of the continuous support of the government due to the nature of start-up companies, but growth is in a remote future as long as there is no independent product competitiveness to maintain the quality of products at a certain level and support of professional workforce to develop and commercialize them.
A CONSTRUCTION OF (0,1)-MATRICES WITH PRESCRIBED PERMANENT USING BINARY NUMBER SYSTEM OF INTEGERS
SEOL, HAN-GUK,LEE, SANG-GU 성균관대학교 기초과학연구소 1999 論文集 Vol.50 No.-
The permanent of the m-by-n matrix A is the sum of all possible products of m elements from A with the property that the elements in each of the products lie on different lines of A. This scalar valued function of the matrix A occurs throughout the combinatorial literature in connection with various enumeration and extremal problems. In this note, we show the construction of (0, 1)-matrices with a prescribed permanent, 1, 2, ... , 2^(n-1).
Seol-Hee Kim,Byung-Hoo Lee,Jong-Chul Kim,Sung-Seen Choi,Gwe-Won Kim,Mi-Hyun Joo,Sejong University 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.4
A major polyphenolic compound extracted from omija (Schisandra chinensis) fruit was structurally identified, and its composition of major nutrients was investigated as well in this study. A dominating high performance liquid chromatography (HPLC) peak of water-extracted anthocyanin represented 94.1% of total absorbable compounds at 520 nm, which was further identified with HPLC-mass spectrometry (MS). As a result, mass-to-charge ratio (m/z) of the predominant anthocyanin was determined to be 727, and it was identical to molecular mass of cyanidin-3-xylosylrutinoside (Cya-3-O-xylrut). This is the first report that colorant of omija is predominantly composed of Cya-3-O-xylrut. Omija fruit contained exclusively 3 types of monosaccharide such as glucose (0.68 g), galactose (0.01 g), and fructose (0.52 g) per 100 g of fruits. Several organic acids, citric (3.29 g), malic (1.4 g), acetic (0.4 g), and succinic acids (0.36 g) per 100 g of fruits, were detected by high performance anion exchange chromatography (HPAEC) analysis. During the compositional analysis of free amino acid by HPLC, it was noticed that omija fruit contained substantial amount (0.01 g/100 g of fruits) of γ-amino butyric acid (GABA).
Chitosan sponges as tissue engineering scaffolds for bone formation
Seol, Yang-Jo,Lee, Jue-Yeon,Park, Yoon-Jeong,Lee, Yong-Moo,Young-Ku,Rhyu, In-Chul,Lee, Seung-jin,Han, Soo-Boo,Chung, Chong-Pyoung 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14
Rat calvarial osteoblasts were grown in porous chitosan sponges fabricated by freeze drying. The prepared chitosan sponges had a porous structure with a 100-200 ㎛ pore diameter, which allowed cell proliferation. Cell density, alkaline phosphatase activity and calcium deposition were monitored for up to 56 d culture. Cell numbers were 4×10^(6)(day 1), 11×10^(6)(day 28) and 12×10^(6)(day 56) per g sponge. Calcium depositions were 9 (day 1), 40 (day 28) and 48 (day 56) ㎍ per sponge. Histological results corroborated that bone formation within the sponges had occurred. These results show that chitotsan sponges can be used as effective scaffolding materials for tissue engineered bone formation in vitro.
Characterization of the SCF ubiquitin ligase 'proteome'
Seol, Jae Hong 이화여자대학교 세포신호전달연구센터 2003 고사리 세포신호전달 심포지움 Vol. No.5
SCF ubiquitin ligases are comprised of Skp1, Cdc53(human Cull or Cullin), Hrt1(human Roc1 or Rbx1) and one member of a large family of substrate receptors(F-box proteins, or FBPs). To investigate how the subunits of SCF are integrate into protein networks in vivo, we employed sequential rounds of epitope-tagging, affinity purification, and mass spectrometry. Sixteen Skp1- and Cdc53-associated proteins were identified in budding yeast, including all components of SCF, nine FBPs, Yjr033(Rav1), and Ydr202(Rav2). Reiterative purification revealed that Rav1 and Rav2 form a novel protein complex with Skp1 named RAVE(Regulator of (H+)-ATPase of the Vacuolar and Endosomal membranes), which associates with the V1 domain of the vacuolar membrane (H+)-ATPase(V-ATPase). V-ATPase are conserved throughout eukaryotes, and have been implicated in tumor metastasis and multidrug resistance. Genetic and mechanistic dissection revealed that RAVE promotes the glucose-triggered assembly of V-ATPase holoenzyme. Systematic genome-wide two-hybrid screen yield 17 Skp1- and Cdc53-interactors, only 3 of which overlap with those that we found. Thus, reiterative rounds of purification/mass spectrometry provide a distinctive view of the web of interactions that link proteins into a comprehensive cellular network. To fully exploit the potential power of mass spectrometry for deciphering networks of interacting proteins, we have developed an epitope tag system('HTM' for His8-TEV2-Myc9) that enables a C-terminally tagged protein to be purified in consecutive affinity steps. The target protein is bound to anti-myc affinity resin, eluted with Tobacco Etch Virus protease(which cleaves at the TEV recognition sites in the tag), and recaptured on NTA resin. Using Skp1 as a test-bed, we have shown(in collaboration with John Yates at Scripps) that the MudPIT(multidimensional protein identification technology) approach developed in the Yates laboratory can be used to rapidly identify multiple interacting partners of Skp1 in a single LC/MS run. We tagged 25 proteins, which involved in cell cycle or transcription regulation, with the HTM epitope, and used MudPIT to identify the interacting partners. Iterative application of this approach on a large scale has the potential to reveal the web of protein interactions that underlie cell function and regulation.