Right-to-Left Displacement of an Airgun Lead Bullet after Transorbital Entry into the Skull Complicated by Posttraumatic Epilepsy : A Case Report

Chao-bin Wang,Hui Wang,Jun-shuang Zhao,Ze-jun Wu,Hao-dong Liu,Chao-jia Wang,An-rong Li,Dawei Wang,Juntao Hu 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.5

Penetrating head injury is a serious open cranial injury. In civilians, it is often caused by non-missile, low velocity flying objects that penetrate the skull through a weak cranial structure, forming intracranial foreign bodies. The intracranial foreign body can be displaced due to its special quality, shape, and location. In this paper, we report a rare case of right-to-left displacement of an airgun lead bullet after transorbital entry into the skull complicated by posttraumatic epilepsy, as a reminder to colleagues that intracranial metal foreign bodies maybe displaced intraoperatively. In addition, we have found that the presence of intracranial metallic foreign bodies may be a factor for the posttraumatic epilepsy, and their timely removal appears to be beneficial for epilepsy control.

The Interactive Relationship between Small and Medium-sized Enterprises' Clusters and Regional Economic Growth

Wang Rong,Xu Li 한국유통과학회 2015 유통과학연구 Vol.13 No.4

Purpose - This paper aims to explain the interactive relationship between small and medium-sized enterprises' clusters and regional economic growth, with Jiangsu Province as an illustrative example. It focuses on studying the promotional effects, if any, of small and medium-sized enterprises' cluster-development on regional economic growth, and vice-versa. Research design, data, and methodology - Data were collected from the Jiangsu Statistical Yearbook and the China Industrial Economic Statistical Yearbook, by selecting 26 industries as the research subjects. The sample interval selection is 1981–2012. The data were analyzed with the dynamic panel system using stata 12.0. Results - 1) The small and medium-sized enterprises' cluster degree and Jiangsu's economic growth have a long-term stable equilibrium relationship. 2) In the short term, they have a dynamic adjustment 3) The enterprises' cluster degree leads to regional economic growth in Jiangsu, but not vice-versa. Conclusions - Small and medium-sized enterprises' clusters have an important promotional effect on Jiangsu's economic growth, especially industries with high degree of agglomeration. Therefore, the formation of these clusters can significantly improve economic growth.

Effect of Bond Linkage on In vitro Drug Release and Anti-HIV Activity of Chitosan-Stavudine Conjugates

Rong Zeng,Renzhong Qiao,Zehu Wang,Hongran Wang,Liqiang Chen,Lin Yang,Liming Hu,Zelin Li 한국고분자학회 2012 Macromolecular Research Vol.20 No.4

Two kinds of chitosan-stavudine (d4T) conjugates, chitosan-O-isopropyl-5'-O-d4T monophosphate conjugate (Cs-P-d4T) with a phosphoramide linkage and chitosan-5'-O-succinyl-d4T conjugate (Cs-S-d4T) with a succinic spacer, were synthesized using an Atherton-Todd reaction and carbodiimide coupling reaction, respectively, and then structurally characterized. Their in vitro drug release behaviors and anti-human immunodeficiency virus (HIV) activity were investigated and compared. Both of the chitosan-d4T conjugates more strongly prefer to release corresponding d4T derivatives rather than free d4T in a prolonged manner but have different hydrolysis routes. The anti-HIV activity and cytotoxicity evaluated in the MT4 cell line revealed that the anti-HIV selectivity index was in the following order: Cs-P-d4T > d4T >> Cs-S-d4T since the released d4T-5'-(O-isopropyl) monophosphate from Cs-P-d4T can bypass the rate-limiting bottleneck of nucleoside phosphorylation, while the released 5'-O-succinyl-d4T from Cs-Sd4T has to be hydrolyzed to d4T and then successively phosphorylated to its active form to exert antiviral activity. The results suggested that constructing a chitosan-nucleoside reverse transcriptase inhibitor (NRTI) conjugate with a phosphoramide linkage may be an efficient approach for improving NRTI therapy efficacy in antiretroviral treatment.

Analysis of thermal conductivity in HI-LEDs lighting materials

Rong-Tsu Wang,Jung-Chang Wang 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.6

The present study devised a measurement system to estimate the thermal conductivity of electronic product materials, especially in HILEDslighting materials, exhibiting distinct thermal characteristics by conducting thermal performance experiments and theoreticalanalyses. First, steady-state conduction analysis with thermal resistance method was investigated on three composite material substratesof unknown heat conduction coefficients through a substrate material named Bakelite of low thermal conductivity revealing stable quality. Second, one-dimension semi-infinite transient conduction analysis was utilized to investigate metal materials with high thermal conductivities. Results showed that the Bakelite experimental module was verified for 62.5 % of the original wattages, which closest to thethermal conductivity 0.233 W/m-K of the Bakelite. And these composite materials M1, M2 and M3 composed of polymer and epoxywere 1.311, 0.844 and 2.403 W/m-K, respectively. The thermal performance experiments were investigated and the results have provedthe correctness of the theoretical model. According to the experimental results, calculating the temperature value of the metal materialscomprising cotton insulation and the transient analysis, this study determined the temperature error to be less 20 %. Consequently, a transientmeasurement system and method for metal materials with high heat conduction coefficients was established. Finally, the results ofthis work are the useful thermal conductivity method to facilitate rapid analysis in the future.

Evaluation of temperature stress tolerance in cultivated and wild tomatoes using photosynthesis and chlorophyll fuorescence

Rong Zhou,Zhen Wu,Xu Wang,Eva Rosenqvist,Yinlei Wang,Tongmin Zhao,Carl‑Otto Ottosen 한국원예학회 2018 Horticulture, Environment, and Biotechnology Vol.59 No.4

Tomato cultivation at lower or higher temperatures than the optimum negatively afects plant growth and development. Large diferences in abiotic stress tolerance have been found between Solanum lycopersicum and wild tomato species. Ouraim was to compare temperature stress tolerance in cultivated and wild tomato genotypes to identify cold- and heat-toleranttomatoes for further utilization in tomato breeding. The maintained net photosynthetic rate (PN) and chlorophyll fuorescencewas related to the tolerance of tomatoes at temperature stress. The PN and chlorophyll fuorescence of one cultivated tomato(Ly from S. lycopersicum) and six wild tomatoes genotypes (Ha from Solanum habrochaites, Pe from Solanum pennellii,Pi1 and Pi2 from Solanum pimpinellifolium, Pr1 and Pr2 from Solanum peruvianum) grown at low (12 °C) and high (33 °C)temperatures were compared. The PN of four tomato genotypes during temperature stress were lower than the control, butnot in Pe, Pr1, and Pr2. The maximum quantum efciency of photosystem II (Fv/Fm) of the cultivated tomatoes was lowerat both 12 and 33 °C than the control using Handy PEA, whereas Fv/Fm using MINI-PAM was lower only at 12 °C. Thechlorophyll fuorescence OJIP transient (OJIP curve) revealed diferences between temperature stress responses and tomatogenotype. With the exception of Pr2, the Fv/Fm in wild tomatoes was unafected by temperature stress; however, they stillmaintained clear genotype diferences for other physiological traits such as PN, quantum yield of PSII (Fq′/Fm′), electrontransport rate, non-photochemical quenching, and the fraction of open PSII centers (qL). These results indicated that the wildtomato varieties Pe and Pr1 had the highest temperature stress tolerance, while the cultivated species was the more sensitiveto temperature stress in comparison. In general, the wild tomato genotypes were more tolerant to both cold and heat stressthan the cultivated tomato, suggesting that these wild species could be used to uncover underlying mechanisms of temperaturestress tolerance and will be promising sources of genetic variability for temperature stress tolerance in breeding programs.

Vibration of T-type Timoshenko frames subjected to moving loads

Wang, Rong-Tyai,Lin, Jin-Sheng Techno-Press 1998 Structural Engineering and Mechanics, An Int'l Jou Vol.6 No.2

In this study, a theoretical method to analyze the vibration of a T-type Timoshenko frame is proposed. The effects of axial inertia, rotatory inertia and shear deformation of each branch are considered. The orthogonality of any two distinct sets of mode shape functions is also demonstrated. Vibration of the frame due to moving loads is studied by the method and the response characteristics of the frame are investigated. Furthermore, the effect of column length on the response of the frame is also studied.

Tight upper bound on the exponents of a class of two-colored digraphs

Rong Wang,Yanling Shao,Yubin Gao 한국전산응용수학회 2008 Journal of applied mathematics & informatics Vol.26 No.3-4

A two-colored digraph D is primitive if there exist nonnegative integers h and k with h + k > 0 such that for each pair (i, j) of vertices there exists an (h, k)-walk in D from i to j. The exponent of the primitive two-colored digraph D is the minimum value of h + k taken over all such h and k. In this paper, we give the tight upper bound on the exponents of a class of primitive two-colored digraphs with (s + 1) n−cycles and one (n − 1)−cycle, and the characterizations of the extremal two-colored digraphs.

A New Cell Counting Method to Evaluate Anti-tumor Compound Activity

Wang, Xue-Jian,Zhang, Xiu-Rong,Zhang, Lei,Li, Qing-Hua,Wang, Lin,Shi, Li-Hong,Fang, Chun-Yan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

Determining cell quantity is a common problem in cytology research and anti-tumor drug development. A simple and low-cost method was developed to determine monolayer and adherent-growth cell quantities. The cell nucleus is located in the cytoplasm, and is independent. Thus, the nucleus cannot make contact even if the cell density is heavy. This phenomenon is the foundation of accurate cell-nucleus recognition. The cell nucleus is easily recognizable in images after fluorescent staining because it is independent. A one-to-one relationship exists between the nucleus and the cell; therefore, this method can be used to determine the quantity of proliferating cells. Results indicated that the activity of the histone deacetylase inhibitor Z1 was effective after this method was used. The nude-mouse xenograft model also revealed the potent anti-tumor activity of Z1. This research presents a new anti-tumor-drug evaluation method.

Whole Cell-mediated Biocatalytic Synthesis of Helicid Cinnamylate and Its Biological Evaluation as a Novel Tyrosinase Inhibitor

Rong-ling Yang,Xi Chen,Yu-ye Song,Qian-lin Zhu,Muhammad Bilal,Yu Wang,Zheng Tong,Ting-ting Wu,Zhao-Yu Wang,Hong-zhen Luo,Xiang-jie Zhao,Ting-ting He 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.3

Tyrosinase inhibitors are clinically effective for treating some dermatological disorders related to melanin hyperpigmentation. Accordingly, the discovery and development of tyrosinase inhibitors have great value in the pharmaceutical and cosmetic industry. Here, a novel tyrosinase inhibitor, 6′-O-cinnamoyl-helicid (helicid cinnamylate) was successfully synthesized by a simple and effective biocatalytic approach with Aspergillus oryzae cells. Investigation of the effects of several key variables on helicid cinnamylate synthesis found that the reaction conversion, reaction rate and regioselectivity reached 99%, 9.40 mM/h and > 99%, respectively, at the optimal conditions with anhydrous acetone as the solvent, whole-cell concentration of 40 mg/mL, and the molar ratio of vinyl cinnamate to helicid of 10 at 45°C. The whole-cells retained 68.87% of its initial activity after reusing for seven batches, indicating a potent application potential in non-aqueous biocatalytic systems. It was worth noting that helicid cinnamylate demonstrated a more potent tyrosinase inhibitory activity with an IC50 value of 3.55 mM than helicid (IC50 = 4.48 mM) and arbutin (IC50 = 5.48 mM), which suggest that helicid cinnamylate could be developed as a more potential tyrosinase inhibitor. In conclusion, this study provides a novel whole-cell catalytic approach for the synthesis of helicid cinnamylate and insight into its application as a tyrosinase inhibitor.

Out-of-plane vibration of multi-span curved beam due to moving loads

Wang, Rong-Tyai,Sang, Yiu-Lo Techno-Press 1999 Structural Engineering and Mechanics, An Int'l Jou Vol.7 No.4

This paper presents an analytic method of examining the out-of-plane vibration of continuous curved beam on periodical supports. The orthogonality of two distinct sets of mode shape functions is derived. The forced vibration of beam due to moving loads is examined. Two types of moving loads, which are concentrated load and uniformly distributed load, are considered. The response characteristics of beam induced by these loads are investigated as well.