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노영태,서국웅,김명철,박승범 부산대학교 체육과학연구소 2000 體育科學硏究所 論文集 Vol.16 No.-
This study analyzed subjects of this study are one high school player, one business team player, and one national team player. M. deltoideus, M. trapezius, M pectoralis major, M. latissimus in upper part of the body muscles, M. flexor carpi radialis, M. brachioradialis, M. bireps brachii, M. triceps brachii upper arms muscles to analyzed work load, muscle activity of change in time they play with inverted cross of rings. The conclusions of this study are as follows. 1. The order of high work load in upper body muscle is as follows: M. deltoideus 41.00%, M. trapezius 36.67%, M. pectoralis 12.33%, M. latissimus 10.00%. 2. The order of high work load in upper arms muscles is as follows: M. biceps brachii 56.67%, M. brachioradialis 21.00%. M flexor carpi radialis 17.67%, M. triceps brachii 5.33%. 3. In the analysis of muscle activity by time phase when they stopped inverted cross of rings, M. deltoindeus, M. biceps brachii showed high muscle activity, so I found that they are the main muscular system.
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3, 4, 6번 뇌신경이 동시에 마비된 당뇨병성 다발성 뇌 신경병증 1예
반태현 ( Tae Hyun Ban ),장상아 ( Sang Ah Chang ),이정민 ( Jung Min Lee ),김지현 ( Ji Hyun Kim ),김지혜 ( Ji Hye Kim ),노지웅 ( Ji Woong Roh ),김경훈 ( Kyung Hoon Kim ) 대한내과학회 2014 대한내과학회지 Vol.87 No.1
Multiple simultaneous cranial neuropathies occur rarely in diabetes patients. In general, diabetic cranial neuropathy presents in an isolated form and frequently involves oculomotor or facial nerves. We report a 73-year-old man with known type 2 diabetes mellitus who presented with severe dizziness, diplopia and third, fourth and sixth nerve ophthalmoplegia of both eyes. Radiological, laboratory and ophthalmic work-up including magnetic resonance imaging and angiography (MRI and MRA) revealed no specific tumor, aneurysm, or inflammation findings, except for a previous cerebral infarction and atherosclerotic changes in the internal carotid and vertebral arteries. After strict blood glucose control, the multiple cranial nerve palsies spontaneously resolved in 12 weeks. We report the case with a review of the literature. (Korean J Med 2014;87:92-95)
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( Sang Woong Youn ),( Tae Yoon Kim ),( Byung Soo Kim ),( Seung Chul Lee ),( Jeung Hoon Lee ),( Yong-beom Choe ),( Joo-heung Lee ),( Jee-ho Choi ),( Joo Young Roh ),( Seong Jin Jo ),( Eun-so Lee ),( Mi 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: The Phase Ⅲ studies, VOYAGE 1 and 2, were conducted to assess guselkumab for the treatment of patients with moderate to severe psoriasis. However, these studies included a worldwide study population. Objectives: To determine the efficacy and safety of guselkumab in Korean patients. Methods: This analysis included 28 patients from VOYAGE 1 and 98 patients from VOYAGE 2. In total, 126 patients were analyzed. Outcomes through week 28 were analyzed due to differences in design after week28. Results: Of 126 Korean patients randomized, 30 received placebo, 63 were assigned to guselkumab, and 33 received adalimumab. Guselkumab was superior to adalimumab in achieving an IGA 0 score (clear skin) at week 12 (31.7% vs 0.0%, p<0.001) and at week 24 (52.4% vs 21.2%, p=0.004), respectively. Among patients treated with guselkumab, 40 of 63 (63.5%) achieved a PASI75 response at week 8; at week 24, a significantly higher proportion of guselkumab patients achieved a PASI 75 compared to adalimumab patients (93.7% vs 66.7%, respectively, p<0.001). In addition, higher proportions of guselkumab patients achieved PASI 90 and PASI 100 than adalimumab patients at week 24 (PASI90; 73.0% vs 57.6%, p=0.168 / PASI100; 20.6% vs 15.2%, p=0.591, respectively). Through week 28, guselkumab and adalimumab showed comparable safety profiles. Conclusion: The efficacy and safety of guselkumab in Korean psoriasis patients through 28 weeks was consistent with findings reported for the VOYAGE1 and 2 trials.
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제 2, 3 요추간을 이용한 척추마취시 감각차단범위에 영향을 미치는 소인자
박진웅,이태현,김봉일,노운석 대한마취과학회 1996 Korean Journal of Anesthesiology Vol.30 No.3
Background: Many factors affecting the spread of spinal anesthesia have been investigated. But L3-4 or L4-5 interspace was choosen which was known as the site of buffering, in their study. We investigated the effect of some of these factors on sensory blockade level by using L2-3 interspace. Methods: Eightyfive patients, ASA physical status I - Il, were involved in our study. Sensory blockade level was checked with pinprick test at 10 minutes and 30 minutes. The effect of age, sex, height, weight, CSF pressure and pressure difference generated when full flexed and non-full flexed lateral position on sensory blockade level was studied whereas other factors such as puncture technique, dosage and concentration of drug and patients position after injection, were kept constant under the same condition. And also studied the effect of degree of flexion at injection on the sensory blockade level. Results: Height and CSF pressure were correlated with sensory blockade level at 10 minutes after injection( R=0.14, P$lt;0.01). Only height was correlated with sensory blockade level at 30 minutes after injection( R =0.09, P$lt;0.0l). Conclusion: Only height was correlated with sensory blokade level at 30 minutes. So, height might be considered as the most impressive minor factor affecting the extent of sensory blockade level.
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Drug resistance of bladder cancer cells through activation of ABCG2 by FOXM1
( Yun-gil Roh ),( Mi-hye Mun ),( Mi-so Jeong ),( Won-tae Kim ),( Se-ra Lee ),( Jin-woong Chung ),( Seung Il Kim ),( Tae Nam Kim ),( Jong Kil Nam ),( Sun-hee Leem ) 생화학분자생물학회 2018 BMB Reports Vol.51 No.2
Recurrence is a serious problem in patients with bladder cancer. The hypothesis for recurrence was that the proliferation of drug-resistant cells was reported, and this study focused on drug resistance due to drug efflux. Previous studies have identified FOXM1 as the key gene for recurrence. We found that FOXM1 inhibition decreased drug efflux activity and increased sensitivity to Doxorubicin. Therefore, we examined whether the expression of ABC transporter gene related to drug efflux is regulated by FOXM1. As a result, ABCG2, one of the genes involved in drug efflux, has been identified as a new target for FOXM1. We also demonstrated direct transcriptional regulation of ABCG2 by FOXM1 using ChIP assay. Consequently, in the presence of the drug, FOXM1 is proposed to directly activate ABCG2 to increase the drug efflux activation and drug resistance, thereby involving chemoresistance of bladder cancer cells. Therefore, we suggest that FOXM1 and ABCG2 may be useful targets and important parameters in the treatment of bladder cancer. [BMB Reports 2018; 51(2): 98-103]
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