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Acremonium chrysogenum에 의한 Cephalosporin C 생산 및 모델링
이종일,류화원,박돈희 전남대학교 촉매연구소 2000 觸媒硏究 論文集 Vol.21 No.-
The production of cephalosporin C and its biosynthetic modeling were studied. Cultivation experiments were carried out in an agitated and aerated fermentor using Acremonium chrysogenum. Corn steep liquor was used as a major carbon source. Intracellular and extracellular concentrations of metabolites and enzymes were measured. Based on enzymatic kinetics the biosynthetic modeling of cephalosporin C was developed and used to compare the experimental data with simulation results. In the simulation the effect of dissolved oxygen concentraction on cephalosporin C production was investigated. For the high production yield of cephalosporin C the dissolved oxygen concentration should be kept over 40 % during the cultivation. The biosynthetic modeling can help further to understand the biosynthetic machinery of the microorganism to produce cephalosporin C.
장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4
Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.
High Frequency of Microsatellite Instability in Intestinal-type Gastric Cancer in Korean Patients
( Won Hyuk Choe ),( Sun Young Lee ),( Jun Haeng Lee ),( Sang Goon Shim ),( Young Ho Kim ),( Poong Lyul Rhee ),( Jong Chul Rhee ),( Chang Seok Ki ),( Jong Won Kim ),( Sang Yong Song ),( Jae J. Kim ) 대한내과학회 2005 The Korean Journal of Internal Medicine Vol.20 No.2
Won Jong RHEE 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Extracellular vesicles (EVs), nano-sized particles, are promising biomaterials for the delivery of therapeutic molecules and contain various biomarkers for disease diagnosis. Accordingly, an efficient concentration method is necessary for large-scale production or high-throughput isolation of EVs from bulk liquid samples, including culture medium and body fluids, to achieve their biomedical applications. However, current EV concentration methods are severely limited with respect to efficiency, cost, and centrifugation time. This study presents the single-step EV concentration method using super absorbent polymer (SAP) beads. SAP beads absorb small molecules, including water, via nano-sized channels but expel and thereby concentrate EVs. Consequently, the beads drastically enriched EVs by reducing the solution volume in a single step, without affecting EV characteristics. Moreover, the concentrated EV solution purity was high due to the absorption of protein impurities by SAP beads. The versatility of the method was demonstrated by investigating that SAP beads successfully enrich EVs in human urine samples and culture medium, enabling better isolation performance than conventional ultrafiltration. I believe the developed approach and insight gained in this study will facilitate the use of EVs as prominent biomaterials for disease diagnosis and therapy.