Feet of Civilization

Qu Qian Qian 한국콘텐츠학회 2012 ICCC International Digital Design Invitation Exhib Vol.8 No.1

Affection, Love and Friendship

Qian Qian Qu 한국콘텐츠학회 2012 ICCC International Digital Design Invitation Exhib Vol.8 No.2

Hepatoprotective effects of loach (Misgurnus anguillicaudatus) lyophilized powder on dimethylnitrosamine-induced liver fibrosis in rats

Qian Zhang,Meng-Meng Shang,Qu-Fei Ling,Xiao-Ping Wu,Chun-Yu Liu 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.8

This study investigates the hepatoprotectiveeffects and the potential therapeutic mechanisms of loach(Misgurnus anguillicaudatus) lyophilized powder (MLP)on dimethylnitrosamine (DMN) induced liver fibrosis inrats. After treatment with MLP (50, 100, 200 mg/kg),alanine aminotransferase (ALT), aspartate aminotransferase(AST), albumin (Alb), total protein (TP) andhydroxyproline (Hyp) levels were detected, to assess thedestruction of hepatocytes and the extent of liver fibrosis. Matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), hyaluronic acid (HA), Laminin (LN),procollagen type-III (PC-III), collagen type-IV (C-IV), andtransforming growth factor-b1 (TGF-b1) contents in serumwere all tested using ELISA kits. Alpha-smooth muscleactin (a-SMA) and the tissue inhibitor of metalloproteinase-1 (TIMP-1) protein contents and distribution wereevaluated using western blot and immunohistochemicalanalysis. MLP significantly decreased the serum concentrationsof ALT, AST, Hyp, HA, LN, PC-III, C-IV, MMP-2,TIMP-1, a-SMA and TGF-b1, while increasing the contentsof Alb and MMP-9. No significant changes on TP serum concentrations were observed. These results suggest thatMLP has anti-hepatic fibrosis effects and its mechanism maybe associated with the attenuation of extracellular matrix(ECM) synthesis, the acceleration of ECM degradation,inhibition of hepatic stellate cells (HSCs) activation andTGF-b1 expression.

New Non-uniformity Correction Approach for Infrared Focal Plane Arrays Imaging

Qu Hui-Ming,Gong Jing-tan,Huang Yuan,Chen Qian 한국광학회 2013 Current Optics and Photonics Vol.17 No.2

Although infrared focal plane array (IRFPA) detectors have been commonly used, non-uniformity correction (NUC) remains an important problem in the infrared imaging realm. Non-uniformity severely degrades image quality and affects radiometric accuracy in infrared imaging applications. Residual non-uniformity (RNU) significantly affects the detection range of infrared surveillance and reconnaissance systems. More effort should be exerted to improve IRFPA uniformity. A novel NUC method that considers the surrounding temperature variation compensation is proposed based on the binary nonlinear non-uniformity theory model. The implementing procedure is described in detail. This approach simultaneously corrects response nonlinearity and compensates for the influence of surrounding temperature shift. Both qualitative evaluation and quantitative test comparison are performed among several correction technologies. The experimental result shows that the residual non-uniformity, which is corrected by the proposed method,is steady at approximately 0.02 percentage points within the target temperature range of 283 K to 373K. Real-time imaging shows that the proposed method improves image quality better than traditional techniques.

Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice

Qian Zhu,Qu Zhou,Xiao-li Luo,Xu-jie Zhang,San-yu Li 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.3

Diabetic kidney disease is one of the most serious complications of diabetes. Although diabetic kidney disease can be effectively controlled through strict blood glucose management and corresponding symptomatic treatment, these therapies cannot reduce its incidence in diabetic patients. The sodium-glucose cotransporter 2 (SGLT2) inhibitors and the traditional Chinese herb “Gegen” have been widely used in diabetes-related therapy. However, it remains unclear whether the combined use of these two kinds of medicines contributes to an increased curative effect on diabetic kidney disease. In this study, we examined this issue by evaluating the efficacy of the combination of puerarin, an active ingredient of Gegen, and canagliflozin, an SGLT2 inhibitor for a 12-week intervention using a mouse model of diabetes. The results indicated that the combination of puerarin and canagliflozin was superior to canagliflozin alone in improving the metabolic and renal function parameters of diabetic mice. Our findings suggested that the renoprotective effect of combined puerarin and canagliflozin in diabetic mice was achieved by reducing renal lipid accumulation. This study provides a new strategy for the clinical prevention and treatment of diabetic kidney disease. The puerarin and SGLT2 inhibitor combination therapy at the initial stage of diabetes may effectively delay the occurrence of diabetic kidney injury, and significantly alleviate the burden of renal lipotoxicity

Study on the Hydraulic Design of Mixed Flow Pump with Spiral Casing

H. Qian,L. Qu,N. Chen,Q. Guo,R. Lin,S. Bu 대한기계학회 1997 International Conference on Fluid Machinery Vol.1 No.1

Distinct mutations in MLH1 and MSH2 genes in Hereditary Non-polyposis Colorectal Cancer (HNPCC) families from China

( Wen Qian Wei ),( Fang Qi Liu ),( Lei Liu ),( Zuo Feng Li ),( Xiao Yan Zhang ),( Fan Jiang ),( Qu Shi ),( Xiao Yan Zhou ),( Wei Qi Sheng ),( San Jun Cai ),( Xuan Li ),( Ye Xu ),( Peng Nan ) 생화학분자생물학회 2011 BMB Reports Vol.44 No.5

Hereditary non-polyposis Colorectal Cancer (HNPCC) is an autosomal dominant inheritance syndrome. HNPCC is the most common hereditary variant of colorectal cancer (CRC), which accounts for 2-5% CRCs, mainly due to hMLH1 and hMSH2 mutations that impair DNA repair functions. Our study aimed to identify the patterns of hMSH2 and hMLH1 mutations in Chinese HNPCC patients. Ninety-eight unrelated families from China meeting Amsterdam or Bethesda criteria were included in our study. Germline mutations in MLH1 and MSH2 genes, located in the exons and the splice-site junctions, were screened in the 98 probands by direct sequencing. Eleven mutations were found in ten patients (11%), with six in MLH1 (54.5%) and five in MSH2 (45.5%) genes. One patient had mutations in both MLH1 and MSH2 genes. Three novel mutations in MLH1 gene (c.157_160delGAGG, c.2157dupT and c.-64G>T) were found for the first time, and one suspected hotspot in MSH2 (c.1168C>T) was revealed. [BMB reports 2011; 44(5): 317-322]

Bolt Loosening Localization at Flange Joints Using Wind-Induced Response for High-Rise Tower

Baifeng Ji,Qian Xiong,Panpan Xing,Penghui Qiu,Wei-lian Qu 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.5

Under long term wind load, the bolt looseness occurring at the joints of tower legs will reduce the wind-resistant capability, increasing the wind-induced displacement responses and aff ecting the serviceability of the high-rise steel tower. In order to detect the bolt looseness locations of the fl ange assembling joints of leg members in high-rise steel tubular tower structures, a new bolt loosening localization at fl ange joints method using wind-induced response for high-rise tower was presented in this paper. Wind-induced vertical strain response root variance of fl ange assembling joint on the tower vertical bar is defi ned as the identifi cation parameter of the bolt looseness damage. Then, the normalized wind-induced vertical strain response root variance is defi ned as the damage index of bolt loose-ness damage, thereby eliminating the impact of wind loads of diff erent magnitudes on damage identifi cation. When the damage index exceeds the threshold, it can be considered that the bolt looseness damage occurs in fl ange assembling joint, thereby to realize the damage identifi cation. The results both numerical analyses of a practical transmission tower and scaled model wind tunnel experiment of a steel tubular tower show that the proposed method is effi cient and noise immunity on the bolt looseness location detection for high-rise tower.

Cloning, Annotation and Expression Analysis of Mycoparasitism- Related Genes in Trichoderma harzianum 88

Lin Yao,Qian Yang,Jinzhu Song,Chong Tan,Changhong Guo,Li Wang,Lianhai Qu,Yun Wang 한국미생물학회 2013 The journal of microbiology Vol.51 No.2

Trichoderma harzianum 88, a filamentous soil fungus, is an effective biocontrol agent against several plant pathogens. High-throughput sequencing was used here to study the mycoparasitism mechanisms of T. harzianum 88. Plate confrontation tests of T. harzianum 88 against plant pathogens were conducted, and a cDNA library was constructed from T. harzianum 88 mycelia in the presence of plant pathogen cell walls. Randomly selected transcripts from the cDNA library were compared with eukaryotic plant and fungal genomes. Of the 1,386 transcripts sequenced, the most abundant Gene Ontology (GO) classification group was “physiological process”. Differential expression of 19 genes was confirmed by real-time RT-PCR at different mycoparasitism stages against plant pathogens. Gene expression analysis revealed the transcription of various genes involved in mycoparasitism of T. harzianum 88. Our study provides helpful insights into the mechanisms of T. harzianum 88-plant pathogen interactions.

Coefficient of Restitution and Kinetic Energy Loss of Rockfall Impacts

Li-Ping Li,Shang-qu Sun,Shucai Li,Qian-qing Zhang,Cong Hu,Shao-shuai Shi 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.6

This paper presents the results of the coefficient of restitution and the kinetic energy loss rate obtained by lab experiment, two parameters that are crucial for rockfall impact. However, various definitions of coefficient of restitution exist and the most appropriate one is still not formed and obtained. In addition, the energy variation during the rockfall impacts has important significance in practical design. In this research, two kind shapes of blocks including plate and strip were adopted in the laboratory testing and the block material was tested before, indicating that the material has sufficient strength to prevent shattering during the impact. Furthermore, an apparatus specifically built for this study was established including a base, a slope and a releasing device. The falling testing was performed using plate and strip block while the falling height as well as the slope angle and releasing height were altered during the tests in order to estimate the effect of each parameter on the coefficients of restitution and energy loss rate. It was observed that collision reflection angle is less than impact angle for all, suggesting energy loss in collision. Impact angle decreases with increasing slope angle while there was no obvious effect of releasing height and releasing angle on impact angle. The relevant coefficient of restitution was found to decrease with impact angle, and the kinetic energy loss rate increased. Finally, the kinetic energy before and after the impact was found to significantly affect the COR and energy loss rate and the results can provide basis for mitigation measures.