ZIF-67 modified MXene/sepiolite composite membrane for oil–water separation and heavy metal removal

Qiuxiang Wang,Zongxue Yu,Ximei Zhu,Qingcan Xiang,Haidong Chen,Yao Pang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-

In this study, polyvinylpyrrolidone (PVP) was used as a cross-linking agent leading to ZIF-67 in-situ growon the surface of sepiolite (Sep) to increase the specific surface area and space volume of Sep. Subsequently, a hydrothermal synthesis method was used to form a stable super-hydrophilic compositemembrane from the composite MXene by polydopamine. Compared to the MXene/PDA/Sep (MPS) compositemembrane, the composite membrane with ZIF-67 exhibited improved hydrophilicity and heavymetal separation. In addition, the introduction of negatively charged Sep@ZIF-67–24 (SZ-24) increasedthe number of adsorption active sites and negative potential for the surface of the membrane, and thiswas conducive to the demulsification and adsorption of oil–water emulsions. The MXene/PDA/Sep@ZIF-67–1 (MSZ-1) composite membrane had excellent separation effects on surfactant-stabilizedemulsions (SSEs) and surfactant-free emulsions (SFEs) oil–water emulsions which were above 99.4 %. Furthermore, the separation effect on oil–water, under extreme water conditions, was greater than99 %. The MSZ-1 composite membrane can achieve excellent separation of heavy metal ions, especiallyCu2+ that the rejection was 79.9 %, under high flux and extreme conditions. Therefore, the MSZ-1 compositemembrane has broad application prospects in oil–water treatment and heavy metal separation.

Application of Variable Projection Method based on Gram-Schmidt Orthogonalization in Spatial Cartesian Coordinate Transformation Model

Luyao Wang,Guolin Liu,Qiuxiang Tao,Ke Wang 대한토목학회 2019 KSCE Journal of Civil Engineering Vol.23 No.12

For the linear and nonlinear parameters that can be separated in the spatial Cartesian coordinate transformation model, we use the variable projection algorithm in this paper to represent the linear parameters with nonlinear parameters, which are transformed into least squares problems with only nonlinear parameters. We simplify the matrix of the nonlinear function by the Gram-Schmidt orthogonalization method, and combine the nonlinear least squares iterative method with the Levenberg-Marquardt (LM) algorithm to solve for the coordinate transformation parameters. Experiments are carried out by solving for the coordinate transformation parameters of the independent spatial Cartesian coordinate system and the CGCS2000 coordinate system. We compare the solution results of the four methods (parameter non-separation method, traditional variable projection method, variable projection method based on QR decomposition, and variable projection method based on Gram-Schmidt orthogonal decomposition) with respect to the calculated results, the number of iterations and the computation time. The experimental results show that the proposed method in this paper requires a lower computation time and achieves higher computational efficiency when obtaining the same solution results and with the same number of iterations.

Study on the Science and Engineering Course Contribution of Employment based on FNN

Qiuxiang Shi,Zhang Yuhong,Liying Wang 보안공학연구지원센터(IJUNESST) 2014 International Journal of u- and e- Service, Scienc Vol.7 No.3

Application of Data Mining in Network Instructional platform of "Modern Educational Technology" for Different Teaching

Qiuxiang Shi,Jianying Li,Liying Wang 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.3

2014 College Students’ Employment Expectation Prediction Based on ANP

Liying Wang,Yuhong Zhang,Qiuxiang Shi 보안공학연구지원센터(IJUNESST) 2014 International Journal of u- and e- Service, Scienc Vol.7 No.4

Optimum synthesis of esomeprazole catalyzed by Rhodococcus rhodochrous ATCC 4276 through response surface methodology

Yuanyuan Zhang,Qiuxiang Zhao,Hui Tang,Huiling Li,Depeng Li,Zhiyong Wang,Xin Gao,Fanye Wang 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.5

Enantiopure esomeprazole is an important drug in the treatment of gastric ulcer. The asymmetric sulfoxidation of omeprazole thioether was catalyzed by immobilized cells of a mutant of Rhodococcus rhodocrous ATCC 4276 to synthesize esomeprazole. The bioreaction was carried out in a biphasic system (chloroform-water), at a high substrate concentration (200mM), and optimized using response surface methodology (RSM). The optimal yield of esomeprazole obtained was 94.8% with e.e. (>99%) without the formation of the sulfone form as a byproduct, under the optimal conditions: the concentration of immobilized cells, 283.5 g/L, the incubation temperature, 37.05 oC, and pH of phosphate buffer, 7.35, respectively. A quadratic polynomial model was developed with R2 of 0.9998, which indicates that the model predicts the observed data with very high accuracy. The mutant exhibited a high enantioselective activity and substrate and product tolerance. The small size of immobilized cell beads (0.5-1 mm) creates a large reaction interface. The aerated flask provides enough oxygen for a high concentration of cells. The significant improvement of substrate tolerance may mainly be attributed to employing the chloroform-water biphasic system because organic substrates may be partitioned in the organic phase, eliminating potential damage and inhibition to cells. Based on the above, the asymmetric sulfoxidation catalyzed by immobilized bacterial cells is therefore more promising for efficient synthesis of chiral sulfoxides.

Lactobacillus rhamnosus CCFM1107 treatment ameliorates alcohol -induced liver injury in a mouse model of chronic alcohol feeding

Fengwei Tian,Feifei Chi,Gang Wang,Xiaoming Liu,Qiuxiang Zhang,Yongquan Chen,Hao Zhang,Wei Chen 한국미생물학회 2015 The journal of microbiology Vol.53 No.12

Lactobacillus rhamnosus CCFM1107 was screened for high antioxidative activity from 55 lactobacilli. The present study attempted to explore the protective properties of L. rhamnosus CCFM1107 in alcoholic liver injury. A mouse model was induced by orally feeding alcohol when simultaneously treated with L. rhamnosus CCFM1107, the drug Hu-Gan- Pian (HGP), L. rhamnosus GG (LGG), and L. plantarum CCFM1112 for 3 months. Biochemical analysis was performed for both serum and liver homogenate. Detailed intestinal flora and histological analyses were also carried out. Our results indicated that the administration of L. rhamnosus CCFM1107 significantly inhibited the increase in the levels of serum aminotransferase and endotoxin, as well as the levels of triglyceride (TG) and cholesterol (CHO) in the serum and in the liver. Glutathione (GSH), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were elevated while the levels of malondialdehyde (MDA) were decreased. The enteric dysbiosis caused by alcohol was restored by increasing the numbers of both lactobacilli and bifidobacteria and decreasing the numbers of both enterococci and enterobacter. Histological analysis confirmed the protective effect of L. rhamnosus CCFM1107. Compared with the other lactobacilli and to the drug Hu-Gan-Pian, there is a high chance that L. rhamnosus CCFM1107 provides protective effects on alcoholic liver injury by reducing oxidative stress and restoring the intestinal flora.

Relationships Among Character Strengths, Self-efficacy, Social Support, Depression, and Psychological Well-being of Hospital Nurses

Xie Jianfei,Liu Min,Zhong Zhuqing,Zhang Qiuxiang,Zhou Jianda,Wang Lu,Ma Keke,Ding Siqing,Zhang Xiaohong,Sun Qian,Cheng Andy S.K. 한국간호과학회 2020 Asian Nursing Research Vol.14 No.3

Purpose: From the perspective of positive psychology, our study aimed to explore depressive symptoms and psychological well-being among Chinese nurses, as well as analyze the impacts of character strengths, self-efficacy and social support on the mental health of nurses. Methods: A cross-sectional and descriptive design using five self-reported questionnaires was used to investigate a cohort of 4238 nurses during 2018. A structural equation modeling analysis was used to verify a hypothetical model linking character strengths, self-efficacy, social support, depressive symptoms, and psychological well-being. Results: The prevalence of depression among this cohort of Chinese nurses was 58.1%. The mean scores for caring, inquisitiveness, and self-control were 19.93 (SD ¼ 2.82), 15.94 (SD ¼ 3.00), and 16.34 (SD ¼ 2.95), respectively. The hypothesized model was a good fit of the data (c2/df ¼ 1.77, p ¼ .183, root mean square error of approximation ¼ 0.04, goodness of fit index ¼ 1.00, comparative fit index ¼ 1.00, TuckereLewis index ¼ 1.00). Except for the path from self-control to depression, the other hypothetical paths investigated were statistically significant. Conclusion: Character strengths were directly and positively associated with psychological well-being. Inquisitiveness was the strongest direct protective factor for depression. In addition, character strengths indirectly alleviated depression and increased psychological well-being through mediating variables of social support and self-efficacy. This study should alert nurse managers that more attention should be paid to the character strengths and mental health of nurses. This study provides evidence for interventions based on character strengths as a management strategy to support the mental health of nurses.

Current status, challenges, and future prospects of plant genome editing in China

Sulaiman Ahmed,Yandi Zhang,Muhammad Abdullah,Qiuxiang Ma,Hongxia Wang,Peng Zhang 한국식물생명공학회 2019 Plant biotechnology reports Vol.13 No.5

Genome editing (GE) is the most powerful tool for creating genetic variation in plants. This approach is valuable for studying the mechanism of gene function and regulation as well as to improve desirable traits using sequence-specific endonucleases. It is typically performed with diverse molecular scissors that cleave a particular gene at a defined position. The advent of sequence-specific nucleases such as ZFNs (zinc finger nucleases), TALENs (transcription activator-like effector nucleases), and CRISPR (clustered regularly interspaced short palindromic repeats), in particular, have allowed for the precise and efficient introduction of genetic variation into the genome. The newly developed CRISPR-associated protein 9 (Cas9) variants, base-editing systems, novel RNA-directed nucleases, and DNA-free CRISPR/Cas9 delivery methods offer great opportunities for plant genome engineering. China has made tremendous progress in the field of GE for crop improvement to meet the demand of growing population. Herein, we reviewed the recent progress in GE of different crops in China, highlighting advanced GE tools/methods, and also discussed the specific challenges and prospects of plant GE.

Genomic Correlates of Unfavorable Outcome in Locally Advanced Cervical Cancer Treated with Neoadjuvant Chemoradiation

Yuchun Wei,Chuqing Wei,Liang Chen,Ning Liu,Qiuxiang Ou,Jiani C. Yin,Jiaohui Pang,Zhenhao Fang,Xue Wu,Xiaonan Wang,Dianbin Mu,Yang Shao,Jinming Yu,Shuanghu Yuan 대한암학회 2022 Cancer Research and Treatment Vol.54 No.4

Purpose Neoadjuvant therapy modality can increase the operability rate and mitigate pathological risks in locally advanced cervical cancer, but treatment response varies widely. It remains unclear whether genetic alterations correlate with the response to neoadjuvant therapy and disease-free survival (DFS) in locally advanced cervical cancer. Materials and Methods A total of 62 locally advanced cervical cancer (stage IB-IIA) patients who received neoadjuvant chemoradiation plus radical hysterectomy were retrospectively analyzed. Patients’ tumor biopsy samples were comprehensively profiled using targeted next generation sequencing. Pathologic response to neoadjuvant treatment and DFS were evaluated against the association with genomic traits. Results Genetic alterations of PIK3CA were most frequent (37%), comparable to that of Caucasian populations from The Cancer Genome Atlas. The mutation frequency of genes including TERT, POLD1, NOS2, and FGFR3 was significantly higher in Chinese patients whereas RPTOR, EGFR, and TP53 were underrepresented in comparison to Caucasians. Germline mutations were identified in 21% (13/62) of the cohort and more than half (57%) had mutations in DNA damage repair genes, including BRCA1/2, TP53 and PALB2. Importantly, high tumor mutation burden, TP53 polymorphism (rs1042522), and KEAP1 mutations were found to be associated with poor pathologic response to neoadjuvant chemoradiation treatment. KEAP1 mutations, PIK3CA-SOX2 co-amplification, TERC copy number gain, and TYMS polymorphism correlated with an increased risk of disease relapse. Conclusion We report the genomic profile of locally advanced cervical cancer patients and the distinction between Asian and Caucasian cohorts. Our findings highlight genomic traits associated with unfavorable neoadjuvant chemoradiation response and a higher risk of early disease recurrence. PurposeNeoadjuvant therapy modality can increase the operability rate and mitigate pathological risks in locally advanced cervical cancer, but treatment response varies widely. It remains unclear whether genetic alterations correlate with the response to neoadjuvant therapy and disease-free survival (DFS) in locally advanced cervical cancer.Materials and MethodsA total of 62 locally advanced cervical cancer (stage IB-IIA) patients who received neoadjuvant chemoradiation plus radical hysterectomy were retrospectively analyzed. Patients’ tumor biopsy samples were comprehensively profiled using targeted next generation sequencing. Pathologic response to neoadjuvant treatment and DFS were evaluated against the association with genomic traits.ResultsGenetic alterations of <i>PIK3CA</i> were most frequent (37%), comparable to that of Caucasian populations from The Cancer Genome Atlas. The mutation frequency of genes including <i>TERT, POLD1, NOS2</i>, and <i>FGFR3</i> was significantly higher in Chinese patients whereas <i>RPTOR, EGFR</i>, and <i>TP53</i> were underrepresented in comparison to Caucasians. Germline mutations were identified in 21% (13/62) of the cohort and more than half (57%) had mutations in DNA damage repair genes, including <i>BRCA1/2, TP53</i> and <i>PALB2</i>. Importantly, high tumor mutation burden, <i>TP53</i> polymorphism (rs1042522), and <i>KEAP1</i> mutations were found to be associated with poor pathologic response to neoadjuvant chemoradiation treatment. <i>KEAP1</i> mutations, <i>PIK3CA-SOX2</i> co-amplification, <i>TERC</i> copy number gain, and <i>TYMS</i> polymorphism correlated with an increased risk of disease relapse.ConclusionWe report the genomic profile of locally advanced cervical cancer patients and the distinction between Asian and Caucasian cohorts. Our findings highlight genomic traits associated with unfavorable neoadjuvant chemoradiation response and a higher risk of early disease recurrence.