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Biomaterials Regulate Mechanosensors YAP/TAZ in Stem Cell Growth and Differentiation
Virdi Jasmeet Kaur,Pethe Prasad 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.2
Tissue-resident stem cells are surrounded by a microenvironment known as ‘stem cell niche’ which is specific for each stem cell type. This niche comprises of cell-intrinsic and -extrinsic factors like biochemical and biophysical signals, which regulate stem cell characteristics and differentiation. Biochemical signals have been thoroughly studied however, the effect of biophysical signals on stem cell regulation is yet to be completely understood. Biomaterials have aided in addressing this issue since they can provide a defined and tuneable microenvironment resembling in vivo conditions. We review various biomaterials used in many studies which have shown a connection between biomaterialgenerated mechanical signals and alteration in stem cell behaviour. Researchers probed to understand the mechanism of mechanotransduction and reported that the signals from the extracellular matrix regulate a transcription factor yesassociated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ), which is a downstream-regulator of the Hippo pathway and it transduces the mechanical signals inside the nucleus. We highlight the role of the YAP/TAZ as mechanotransducers in stem cell self-renewal and differentiation in response to substrate stiffness, also the possibility of mechanobiology as the emerging field of regenerative medicines and three-dimensional tissue printing.
Maldhure, A. K.,Pethe, G. B.,Yaul, A. R.,Aswar, A. S. Korean Chemical Society 2015 대한화학회지 Vol.59 No.3
Unsymmetrical tetradentate Schiff base N-(2-hydroxy-5-methylacetophenone)-N'-(2-hydroxy acetophenone) ethylene diamine (H<sub>2</sub>L) and its complexes with Cr(III), Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) have been synthesized and characterized by elemental analyses, magnetic susceptibility measurements, IR, electronic spectra and thermogravimetric analyses. <sup>1</sup>H, <sup>13</sup>C-NMR and FAB Mass spectra of ligand clearly indicate the presence of OH and azomethine groups. Elemental analyses of the complexes indicate that the metal to ligand ratio is 1:1 in all complexes. Infrared spectra of complexes indicate a dibasic quadridentate nature of the ligand and its coordination to metal ions through phenolic oxygen and azomethine nitrogen atoms. The thermal behavior of these complexes showed the loss of lattice water in the first step followed by decomposition of the ligand in subsequent steps. The thermal data have also been analyzed for the kinetic parameters by using Horowitz-Metzger method. The dependence of the electrical conductivity on the temperature has been studied over the temperature range 313-403 K and the complexes are found to show semiconducting behavior. XRD and SEM images of some representative complexes have been recorded. The antimicrobial activity of the ligand and its complexes has been screened against various microorganisms and all of them were found to be active against the test organisms. The Fe(III) and Ni(II) complex have been tested for the catalytic oxidation of styrene.
Next-generation antimicrobials: from chemical biology to first-in-class drugs
Michelle Lay Teng Ang,Paul Murima,Kevin Pethe 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.9
The global emergence of multi-drug resistantbacteria invokes an urgent and imperative necessity for theidentification of novel antimicrobials. The general lack ofsuccess in progressing novel chemical entities from targetbaseddrug screens have prompted calls for radical andinnovative approaches for drug discovery. Recent developmentsin chemical biology and target deconvolutionstrategies have revived interests in the utilization of wholecellphenotypic screens and resulted in several successstories for the discovery and development novel drugcandidates and target pathways. In this review, we presentand discuss recent chemical biology approaches focusingon the discovery of novel targets and new lead moleculesfor the treatment of human bacterial and protozoaninfections.
The invariant design of planar magnetron sputtering TFT-LCD
Yoo, W.J.,Demaray, E.,Hosokawa,Pethe, R. The Korean Vacuum Society 1999 Journal of Korean Vacuum Science & Technology Vol.3 No.2
The main consideration factor to design a magnetron of the sputtering system for TFT-LCD metallization is high sheet resistance (Rs) uniformity which is provided by the high target erosion and high current efficiency. The present study has developed a rectangular magnetron for TFT-LCD to bve considered full target erosion and high film uniformity. After an aluminum-2 at.% and alloy target was installed in a magnetron source and the film was deposited on the glass of 600${\times}$720 mm, the Rs uniformity of the deposited film was measured as functions of the magnet tilt and magnet scanning configuration. And the target erosion profile was observed with the target voltage. When sputtered at 4mtorr and 10kW, the magnet tilt for the high Rs uniformity of 8.38% was 7mm. The plasma voltage at the dwell home and end for full-face target erosion, when scanned the magnetron was 120% compared to the mean voltage of the other area.
Metallo-collagenase production by Arthrobacter creatinolyticus KP015744
Savita A. Kate,Madhuri Sahasrabudhe,Archana Pethe Techno-Press 2022 Advances in environmental research Vol.11 No.1
Amongst 27 isolates from deteriorated leather samples, Arthrobacter creatinolyticus KP015744 zzx28 was found to be an efficient collagenase producer. Collagenase production of 13.33 µmoles/min was shown at an optimum temperature at 37℃ after 72h and at pH 7.5 by using 2 ml/dL inoculum in 10 mg/ml collagen peptide type I as a substrate. In presence of Hg<sup>2+</sup>, EDTA and 𝛽-mercaptoethanol the collagenase production by the isolate was strongly inhibited however Fe<sup>2+</sup>, Ca<sup>2+</sup>and DMSO enhanced production of the enzyme. Specific activity was found to be 19.46×10<sup>3</sup> U/mg and molecular weight 66 kD by SDS PAGE. Isolate also has potential to hydrolyze keratin which is another important protein found in leather. Experimental results propose that collagenase can be effectively used as a tool for collagen and keratin rich solid waste treatment.