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- 저자 : Pattipati S. Naidu (검색결과 2 건)
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Shrinivas K. Kulkarni,Pattipati S. Naidu,Amanpreet Singh 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.2
We investigated the role of oxidative stress in the pathophysiology of haloperidol (HP)-in-duced orofacial dyskinesia and evaluated the beneficial effect of Withania somnifera (Ws)root extract in the amelioration of HP-induced vacuous chewing movements (VCMs) andtongue protrusions in the rat model for TD. Rats were treated for 21 days with intraperitonealHP (1 mg/kg); on day 22, VCMs and tongue protrusions were counted during a 5-minute ob-servation period. HP-treated rats significantly developed these extrapyramidal symptoms, butcoadministration of Ws root extract (10 300 mg/kg) dose-dependent ly reduced them. Bio-chemical analysis revealed that chronic HP treatment significantly increased lipid peroxida-tion and decreased forebrain levels of glutathione and the antioxidant defense enzymes, su-peroxide dismutase (SOD) and catalase. Coadministration of Ws extract significantly reducedthe lipid peroxidation and significantly reversed the decrease in forebrain SOD and catalaselevels but had no significant effect on the HP-induced decrease in forebrain glutathione lev-els. These findings strongly suggest that oxidative stress plays a significant role in HP-in-duced orofacial dyskinesia and that Ws could be effective in preventing neuroleptic-induce dextrapyramidal side effects.107
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Effect of Natural and Synthetic Antioxidants in a Mouse Model of Chronic Fatigue Syndrome
Shrinivas K. Kulkarni,Amanpreet Singh,Pattipati S. Naidu,Saraswati Gupta 한국식품영양과학회 2002 Journal of medicinal food Vol.5 No.4
Chronic fatigue syndrome (CFS) is an illness characterized by persistent and relapsing fa-tigue, often accompanied by numerous symptoms involving various body systems. The eti-ology of CFS remains unclear; however, a number of studies have shown that oxidative stressmay be involved in its pathogenesis. In the present study, a mouse model of CFS was usedin which mice were forced to swim for one 6-minute session on each day for 15 days and theimmobility period was recorded. There was a significant increase in immobility period insaline-treated mice on successive days. Intraperitoneal treatment with the potent antioxidantscarvedilol (5 mg/kg) and melatonin (5 mg/kg) produced a significant reduction in immobil-ity period. Similar results were observed with herbal preparations administered orally: With-ania somnifera (10 mg/kg), quercetin (50 mg/kg), and St. John’ s wort (Hypericum perforatumL., 10 mg/kg). Biochemical analysis revealed that chronic swimming significantly inducedlipid peroxidation and decreased glutathione (GSH) levels in the brains of mice. The rats alsoshowed decreased levels of antioxidant defense enzymes, superoxide dismutase (SOD), andcatalase. Co-administration of antioxidants carvedilol, melatonin, W. somnifera , quercetin orSt. John’ s wort significantly reduced lipid peroxidation and restored the GSH levels decreasedby chronic swimming in mice. Further, the treatment increased levels of SOD in the forebrainand of catalase. The findings strongly suggest that oxidative stress plays a significant role inthe pathophysiology of CFS and that antioxidants could be useful in the treatment of CFS.21
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