Causes and Predictive Factors Associated with “Diagnosis Changed” Outcomes in Patients Notified as Tuberculosis Cases in a Private Tertiary Hospital

( Byung Ju Kang ),( Kyung Wook Jo ),( Tai Sun Park ),( Jung Wan Yoo ),( Sei Won Lee ),( Chang Min Choi ),( Yeon Mok Oh ),( Sang Do Lee ),( Woo Sung Kim ),( Dong Soon Kim ),( Tae Sun Shim ) 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.75 No.6

Background: The aim of our study was to evaluate the “diagnosis changed” rate in patients notified as tuberculosis (TB) on the Korean TB surveillance system (KTBS). Methods: A total of 1,273 patients notified as TB cases on the KTBS in one private tertiary hospital in 2011 were enrolled in the present study. Patients were classified into three groups: “diagnosis maintained”, “diagnosis changed” (initially notified as TB, but ultimately diagnosed as non-TB), and “administrative error” (notified as TB due to administrative errors). Results: Excluding 17 patients in the “administrative error” group, the “diagnosis maintained” and “diagnosis changed” groups included 1,097 (87.3%) and 159 patients (12.7%), respectively. Common causes of “diagnosis changed” were nontuberculous mycobacterial (NTM) disease (51.7%, 61/118), and pneumonia (17.8%) in cases notified as pulmonary TB, and meningitis (19.5%, 8/41) and Crohn`s disease (12.2%) in cases notified as extrapulmonary TB. Being older than 35 years of age (odds ratio [OR], 2.18) and a positive acid-fast bacilli stain (OR, 1.58) were positive predictors and a TB-related radiological finding (OR, 0.42) was a negative predictor for a “diagnosis changed” result via multivariate logistic regression analysis in pulmonary TB cases. Conclusion: Because of a high “diagnosis changed” rate in TB notifications to the KTBS, the TB incidence rate measured by the KTBS may be overestimated. Considering the worldwide trend toward increased NTM disease, the “diagnosis changed” rate may increase over time. Thus, when reporting the annual TB notification rate in Korea, the exclusion of “diagnosis changed” cases is desirable.

Causes and Predictive Factors Associated with "Diagnosis Changed" Outcomes in Patients Notified as Tuberculosis Cases in a Private Tertiary Hospital

Kang, Byung Ju,Jo, Kyung-Wook,Park, Tai Sun,Yoo, Jung-Wan,Lee, Sei Won,Choi, Chang-Min,Oh, Yeon-Mok,Lee, Sang-Do,Kim, Woo Sung,Kim, Dong Soon,Shim, Tae Sun The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.6

Background: The aim of our study was to evaluate the "diagnosis changed" rate in patients notified as tuberculosis (TB) on the Korean TB surveillance system (KTBS). Methods: A total of 1,273 patients notified as TB cases on the KTBS in one private tertiary hospital in 2011 were enrolled in the present study. Patients were classified into three groups: "diagnosis maintained", "diagnosis changed" (initially notified as TB, but ultimately diagnosed as non-TB), and "administrative error" (notified as TB due to administrative errors). Results: Excluding 17 patients in the "administrative error" group, the "diagnosis maintained" and "diagnosis changed" groups included 1,097 (87.3%) and 159 patients (12.7%), respectively. Common causes of "diagnosis changed" were nontuberculous mycobacterial (NTM) disease (51.7%, 61/118), and pneumonia (17.8%) in cases notified as pulmonary TB, and meningitis (19.5%, 8/41) and Crohn's disease (12.2%) in cases notified as extrapulmonary TB. Being older than 35 years of age (odds ratio [OR], 2.18) and a positive acid-fast bacilli stain (OR, 1.58) were positive predictors and a TB-related radiological finding (OR, 0.42) was a negative predictor for a "diagnosis changed" result via multivariate logistic regression analysis in pulmonary TB cases. Conclusion: Because of a high "diagnosis changed" rate in TB notifications to the KTBS, the TB incidence rate measured by the KTBS may be overestimated. Considering the worldwide trend toward increased NTM disease, the "diagnosis changed" rate may increase over time. Thus, when reporting the annual TB notification rate in Korea, the exclusion of "diagnosis changed" cases is desirable.

아세틸 콜린 유발 검사시 허혈성 심전도 변화와 흉통의 발생이 내피세포 기능장애에 미치는 영향

최철웅(Cheol Ung Choi),나승운(Seung-Woon Rha),김선원(Sun Won Kim),나진오(Jin Oh Na),임홍의(Hong Euy Lim),김진원(Jin Won Kim),김응주(Eung Ju Kim),한성우(Seong Woo Han),박창규(Chang Gyu Park),서홍석(Hong Seog Seo),오동주(Dong Joo Oh) 대한임상노인의학회 2010 대한임상노인의학회지 Vol.11 No.4

연구배경: 아세틸 콜린 유발 검사시 발생하는 흉통과 허혈성 심전도 변화가 아세틸 콜린에 의해 발생하는 관상동맥의 내피세포 기능에 어떤 영향을 주는지 알아보고자 했다. 방법: 흉통으로 내원하여 관상동맥 조영술과 아세틸 콜린 유발검사를 시행받은 1,085명의 환자를 대상으로 하였다. 아세틸 콜린 유발 검사를 하는 동안 허혈성 심전도 변화 및 흉통의 발생 유무에 따른 관상동맥 내피세포 기능의 특징을 비교하였다. 결과: 539명의 환자에서 아세틸 콜린 검사시 내피세포 기능 장애가 발생 하였다. 허혈성 심전도 변화가 있었던 그룹이 심전도 변화가 없었던 그룹보다 흉통이 더 많았고(78.1% vs. 60.8%, P=0.007), 관상동맥 조영술상 다발성 관상동맥 경련이 빈번하였고(59.4% vs. 40.6%, P=0.004), 관상동맥의 경련 정도도 더 심하였다(64.1% vs. 46.5%, P=0.006). 흉통이 있었던 그룹이 흉통이 없었던 그룹보다 허혈성 심전도 변화의 빈도가 더 높았다(14.7% vs. 7.5%, P=0.007). 또한 흉통이 있었던 그룹이 관상동맥 경련이 다발성으로 발생하는 경우가 많았고 (50.7% vs. 29.5%, P<0.001), 미만성으로 발생하는 경우가 많았고(87.1% vs. 75%, P<0.001), 관상동맥의 경련의 정도도 더 심하였다(51.6% vs. 43.5%, P=0.041). 결론: 아세틸 콜린 유발검사시 발생하는 허혈성 심전도 변화와 흉통은 관상동맥 경련의 정도와 경련이 발생하는 관상동맥 개수와 연관이 있다. Background: ECG changes and chest pain during acetylcholine (Ach) provocation tests may constitute important clinical parameters for Ach-induced endothelial dysfunction. We investigated the association between ischemic ECG changes and chest pain during the Ach-provocation test and angiographic characteristics of Ach-induced endothelial dysfunction. Methods: A total of 1,085 patients with anginal symptoms underwent diagnostic coronary angiography (CAG) and Ach-provocation tests. We compared angiographic characteristics of Ach-induced endothelial dysfunction according to the presence of ECG change and chest pain. Results: A total of 539 patients experienced Ach-induced endothelial dysfunction. Patients who experienced ECG change group suffered more frequent chest pain (78.1% vs. 60.8%, P=0.007), angiographically more frequent multiple coronary artery spasm (59.4% vs. 40.6%, P=0.004), and more severe coronary artery spasm (64.1% vs. 46.5%, P=0.006) than patients without ECG change. However, there was no difference in the length of endothelial dysfunction between the groups. The incidence of ischemic ECG changes in patients with chest pain was higher than in patients without chest pain (14.7% vs. 7.5%, P=0.007). Patients who experienced chest pain more often experienced multiple (50.7% vs. 29.5%, P<0.001), diffuse (87.1% vs. 75%, P<0.001), and severe coronary artery spasm (51.6% vs. 43.5%, P=0.041) than patients without chest pain. Conclusion: Ischemic ECG changes and chest pain during the Ach-provocation test are associated with multi-vessel involvement and severe coronary artery spasm. Chest pain is associated with the length of endothelial dysfunction, but ischemic ECG change is not.

모악산도립공원 이용개발 및 보전관리 개선을 위한 기초 연구

金世泉,李昌憲,朴鍾旻,朴烽柱 全北大學校 1995 論文集 Vol.40 No.-

The purpose of this study is to analyze the conservation management and using development of the Moak-san provincial park with special regards to natural and cultural environment. Recently, with the rapid increase of use about national and provincial parks as a area of outdoor recreation, our natural park faces a serious environmental problems. So the quality of outdoor recreation has been decreased. Therefore, The conservation methods of natural park and resourse are very important for the maintenance of natural and cultural environment. Kumoh-san was appointed at first as a provincial park in 1970. And 20 provincial parks are present now in Korea. Moak-san provincial park extends over 2 Shis and 1 Gun including Kimjea-Shi(28.22㎢), Wanju-Gun(10.69㎢) and Chonju-Shi(3.31㎢). It's location is at 127˚ 02' E and 35˚42' N. In its climate, the annual mean precipitation is 1134.3mm, and temperature is 12.0∼12.5℃. In this park area, mostly Buddhist cultral asserts are collectively preserved, such as the Kumsansa, Kuksinsa. Soowangsa and Daewonsa. Vegetation of Moak-san was investigated 440 species. The Fegaceae is main species. As remarkable thing of park use, the trail which make an effect on the park resource conservation and effect promotion of park use established but if asked thorohgh management, because of intense gully erosion phenomenon. Recently, in the direction of Kumsansa and Kui project is developing or planning, but in the direction of Chunginri project is not established yet, so we request the valance Moak-san total development pslan. In the development plan, rational harmony of development and conservation was pointed out the essense factor.

서울숲 공원관리조직의 사회 연결망 분석

최선주,황원실,김선희,박창석,Choi, Sun-Ju,Hwang, Won-Sil,Kim, Sun-Hee,Park, Chang-Sug 한국조경학회 2011 韓國造景學會誌 Vol.39 No.3

본 연구는 공원관리 참여조직간의 사회적 연결망을 분석하고, 참여조직의 활동을 활성화하는 방향을 모색하기 위한 것이다. 이를 위해서 공원관리 참여조직 간의 신뢰, 참여, 정보교류의 실태를 사회 연결망 분석을 통해 살펴보았다. 구체적으로 서울숲을 대상으로 하였으며, 행정기관, 시민단체, 주민단체, 기업으로 구성된 15개 참여조직과 핵심인물 30명을 조사대상으로 선정하였다. 설문조사는 조직간 신뢰, 참여, 정보교류 및 연구 통계적 속성에 관한 내용으로 구성되었으며, 분석은 사회 연결망 분석 프로그램인 UCINET을 활용하였다. 분석결과, 1) 신뢰, 참여, 정보교류의 연결구조에서 다른 조직에 비해 많은 관계를 유지하고 있는 중추조직(HUB)는 서울숲 사랑모임과 서울숲 관리사무소로 나타났다. 2) 함께 일하고 싶은 조직과 향후 활발한 참여를 바라는 조직에 대한 연결망 분석에서는 환경 예술분야의 시민단체에 대한 요구가 높게 나타났다. 3) 부녀회, 통장단 등 지역 주민단체 연결망을 살펴보면 중심성이 매우 낮으며 서로간의 연결관계도 거의 없는 것으로 나타났다. 본 연구결과와 함께 다양한 도시공원과 지역을 대상으로 공원관리 참여조직간의 사회 연결망 실태를 파악함으로써 주민참여와 협력 이 활발한 공원관리 방안을 마련하는데 활용할 수 있다. This study was intended to devise means to encourage participation for organizations taking part in "resident participation parks.", "Resident participation" has become increasingly recognized as an effective means of park management in Korea. To this end, this study analyzed the current status of social networks for civic organizations participating in park management with respect to their degree of participation, credibility and trust, and exchange of information. Among resident participation parks, "Seoul Forest Park" has been widely recognized as a model example; accordingly this study designated Seoul Forest Park as its primary research focus. Thirty core members of resident participation organizations were selected as test subjects. Members of the resident participation organizations under review came from various backgrounds, including government administrative organizations, citizens' groups, residents' groups, and private businesses. Surveys were used to provide data on credibility and trust between organizations, levels of participation, and exchange of information, as well as statistics on demographic affiliation. Results were examined through UCINET, a program designed to analyze social networks. Survey results indicated that 1) The "Seoul Forest Park Conservancy" and the "Seoul Forest Park Management Office" constituted a hub within their social networks that maintained significantly more relationships than other organizations with regard to levels of credibility and trust, participation, and exchange of information; 2) Social networks for organizations wishing to work together, or desiring active participation in the future tended to center on citizens' organizations in the environmental and arts fields; and 3) Women's associations and meetings of neighborhood("tong") leaders had very little significance as a center in the social networks of local residents groups, and indeed very few connections amongst themselves. The results of this research can be applied in the devising of proposals for encouraging participation in resident participation parks in consideration of the social networks between organizations engaging in park management activities for a diverse array of urban parks and other areas.

치수절단술에 사용되는 약제가 백서 치배 및 치배주위조직세포에 미치는 영향에 관한 ^3H-thymidine을 이용한 자기방사법적인 연구

박경주,이종헌,임창윤 단국대학교 치의학연구소 1992 논문집 Vol.4 No.-

Formocresol(FC) had been widely used as medicament for pulpotomy, but because FC have strong toxicity, carcinogenic potential, and strong diffusible properties in tissues, Glutaraldehyde, another medicament for pulpotomy was greatly presented by many investigators and practitioners. Although many investigators had studied difference of two medicament's effects on periodontal tissues and tooth germ, there were no manuscripts of cellular activity about these medicaments applied to teeth, but there were almost clinical, histopathological studies. Especially in the investigative effects on tooth germ, the results were controversal. Thus to investigate about effects on cellular actiity of perigerminal tissue and tooth germ of rat, author presented the cellular activity and the pathologic change through calculating Thymidine labelling index(TLI) from autoradiographic technique using 3H-thymidine after these medicaments were applied to tooth. The obtained results were as follows. 1. Inflammation was initiated after one week of FC and two weeks of GA. It was thought that diffusible property of GA was lesser than that of FC. 2. In group treated with FC, inflammation, vasodilation and bone destruction continuously increased for all periods of experiment and the feature of 8 weeks was very severe. But in group treated with GA, inflammation, vasodilation and bone destruction slightly incresed for all period of experment. 3. TLI was increased after two weeks of FC, but decreased after four weeks because of different accumulative concentration between 2 and 4 weeks. 4. GA treated group which did not show the change of the cellular activity of perigerminal tissue and tooth germ presented the slight effects on these cells. 5. Changes of cellular activities in FC treated group did not result from inflammation, but formocresole's property itself. And bone destruction was derived from secondary effects of inflammation. 6. The fact that FC arose severe inflammation and change of cellular activity reflected that FC might affected

Kikuchi-Fujimoto Disease Coexistent with Papillary Thyroid Carcinoma in a Single Lymph Node

Jin Ju Park,Yu Bin Seo,Hyun Chang Choi,Jeong Won Kim,Mi Kyung Shin,Dong Jin Lee,Jacob Lee 순천향대학교 순천향의학연구소 2015 Journal of Soonchunhyang Medical Science Vol.21 No.1

Cervical lymphadenopathy can be developed from various causes such as viral infection, bacterial infection, Kikuchi-Fujimoto disease, tuberculosis, malignancy, and reactive changes. In patients who have malignancy, metastatic lymphadenopathy is possible but it is rare that other concomitant diseases are in the same lymph node. We experienced a case of coexistence of Kikuchi necrotizing lymphadenitis and papillary thyroid carcinoma in a single cervical lymph node. A 38-year-old man who was previously diagnosed with papillary thyroid cancer with cervical lymph nodes metastasis presented with cervical lymphadenopathy. The lymph node biopsy showed tuberculous lymphadenitis. After finishing anti-tuberculosis medication, recurrent lymphadenopathy had developed and a surgical biopsy was performed. At that time, the diagnosis was Kikuchi necrotizing lymphadenitis combined with metastatic papillary carcinoma in a single lymph node.

백자인(柏子仁)이 수컷 생쥐의 생식세포에 미치는 항산화 효과 연구

김주성 ( Ju Sung Kim ),홍민정 ( Min Jung Hong ),김도림 ( Do Rim Kim ),박은화 ( Eun Hwa Park ),장문석 ( Mun Seong Chang ),박성규 ( Seong Kyu Park ) 대한본초학회 2012 大韓本草學會誌 Vol.27 No.2

Objectives:The purpose of this study is to examine the antioxidant effects on male mouse reproductive cells of the extract of Platycladi Semen. Methods:The extract was studied for diphenyl-picryl-hydrazyl (DPPH) radical scavenging activity, cell viability by a modified MTT assay, the effects on H2O2-induced cytotoxicity by MTT assay, lipid peroxidation by malondialdehyde (MDA) formation and super oxide dismutase (SOD), respectively. Results:The results showed that the extract scavenged DPPH radical in a dose-dependent manner by up to 74.87%. The cell viability of the extract was within 72~96% on Leydig cells and GC-2 cells at concentrations of 1, 5, 10, 50 and 100 ug/ml. The hydrogen peroxide-induced cytotoxicity of Leydig cells was protected to 72.09% by the extract at concentration of 100 ug/ml, The hydrogen peroxide-induced lipid peroxidation of MDA formation was decreased to 1.80 and 1.65 nmoles/mg protein by the extract at concentrations of 50 and 100 ug/ml, The extract at all concentrations, SOD activity was not significantly changed. Conclusions:In conclusion, the extract of Platycladi Semen has antioxidant effects on Leydig cells and protect male reproductive system against oxidative stress.

인삼을 이용한 가공방법 개발과 효능검증

예은주,배만종,김수정,박창호 경산대학교 생명자원개발연구소 2003 생명자원과 산업 Vol.7 No.-

본 연구는 인삼의 가공방법을 개발하고 제품을 다양화하기 위한 기초 자료를 확립하고자, 우리나라의 전통주인 약주로 증자한 후 홍삼의 일반성분과 ginsenoside의 함량을 분석하고 갈색도 및 탁도의 변화를 알아보았다. 또한 항암효과를 검증하였던바 그 결과를 보고하고자 한다. 1. 백삼과 홍삼, 증자 횟수별 인삼의 갈색 변화를 보기 위해서 각 인삼의 60% 에탄올추출물의 갈변의 측정 결과 갈변의 전구물질과 중간생성물 및 fufural, 갈색계의 색소, 탁도 모두 증자횟수가 증가 할수록 값이 증가하였다. 그리고 백삼, 홍삼 A1는 3가지 항목에서 모두 비슷한 경향을 보였으며, 상대적으로 A3에서 높은 값을 보였다. 2. HPLC상으로 total ginsenoside의 함량을 측정한 결과 백삼 28.20mg/g, 홍삼 421.10mg/g이고 A1~A9에서는 46.10~76.80mg/g으로 홍삼과 백삼보다 증자 횟수가 증가 할 수록 total ginsenosied 함량이 증가하였다. 3. HPLC상에서 분석한 증자 횟수별 인삼의 ginsenosides(G-Rb₁, -Rb₂, -Rc, -Rd, -Re, -Rf, -Rg₁, -Rg₂, -Rg₃)의 함량변화는 G-Rc, -Rd, -Re는 1회 증자한 A1에서 함량이 증가 하다가 증자 횟수가 증가 할수록 다시 함량이 감소하였으며, G-Rg₂, -Rg₃는 증자 횟수와 비례하여 함량이 증가하는 경향을 보였다. 4. 인체유래 간암세포(Hep3B)에서의 항암효과 검증실험에서는 물, 60%에탄올 추출물을 각각 1000ppm, 2500ppm, 5000ppm으로 처리 한 후 세포 증식 억제율을 확인하였다. 백삼은 모든 처리군에서 미미한 증식억제 효과가 있었으나, 홍삼은 60%에탄올 추출물 5000ppm에서 54.52%, A9에서는 96.28%의 현저한 세포증식억제 효과가 있었다. A9가 Hep3B에 대해서 백삼과 홍삼보다 세포 증식 억제율이 더 높은 것을 확인 할 수 있었다. 이상의 결과로 볼 때 약주를 이용해서 증자한 홍삼이 백삼이나 일반홍삼보다 총 사포닌, 진세노사이드의 함량이 증가하였고, 기능과 효능이 증강된 것으로 확인되어 우수함이 입증되었다. 또한, 홍삼정과, 절편정과 등 제품의 다양화와 품질개선에 기여할 것으로 기대된다. 향후 증자 방법, 압력, 온도, 및 약주 등의 제조 조건에 따른 지속적인 연구가 요청된다. This study takes place to establish basic data to develop various ginseng-processing methods and products. It analyzed components and quantity of ginsenoside in red ginseng after brewing with the traditional medicinal wine as well as the brownness and impurity level changes, and verified anti-oxidization and anti-cancer effects. The following is the founding of these analyses. To examine the changes in the brownness of white and red ginseng, premonitory materials of 60% ethanol extracts were examined As the result of these examinations, all of the values of examined matters premonitory materials, mid products, Fufural, coloring matters and impurity level were increased as the brewing continued. And the brownness level for white and red ginseng was similar in Al and the values were relatively high in A3. The total Ginsenoside on HPLC was 28.20㎎/g for white ginseng and 42.10㎎/g for red ginseng. The quantity of total Ginsenoside was increased as the brewing continued as 46.10∼76.80㎎/g was shown in A1∼A9. To see the quantity changes of Ginsenosides(G-Rbi, -Rte, -Re, -Rd, -Re, -Rf, -Rg₁, -Rg₂, -Rg₃) contained in ginseng on HPLC, the quantity of G-Rc, -Rd, -Re were increased in Al the first brewing and decreased as the brewing continued. The quantity of G-Rg2, -Rg3 was increased proportionate to the number of times for brewing. In an anti-cancer test in liver cancer cells(Hep3B) extracted from human body, each of water and 60% ethanol extracts were processed with 1000ppm, 2500ppm, and 5000ppm and checked the multiplication restrain rate. All of the processing groups in white ginseng have minimum multiplication restrain rates, but red ginseng has 54.52% at 60% ethanol extract 5000ppm. At A9, 96.28%) of cell multiplication restrain effects were shown. Comparing Hep3B to A9, white ginseng has higher restrain effects than red ginseng. As seen in the above results, the reinforced red ginseng using the medicinal wine has higher total saponin and ginsenosides, as well as with increased functions and effects leading the superiority. And it is possible to use Red Ginseng Jung Kwa; Jung Kwas with flower pattern imprinted, and expect to increase the opportunities to use the extracts. Later, when brewing the pressure, temperature, and medicinal wine can be examined to continuous studies.

자동차 칵핏 모듈용 플라스틱 소재의 열화 동특성 평가

우창수(Chang Su Woo),박현성(Hyun Sung Park),조진호(Jin Ho Jo),김지훈(Ji Hoon Kim),최주호(Ju Ho Choi),김영국(Yeoung Kuk Kim) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.5-2

플라스틱 소재는 온도, 습도 및 자외선 등 다양한 환경의 영향으로 인해 기계적 물성변화가 심하기 때문에 체결부의 견고함이 느슨해지고 형태의 변형에 의해 부품간의 마찰 등을 유발하여 잡음이 발생하게 된다. 따라서, 본 논문에서는 자동차 칵핏 모듈에 사용되는 다양한 플라스틱 소재에 대해 온도변화에 따른 동 특성시험을 통해 유리전이온도, 저장탄성계수, 손실계수 등을 측정하여 상온 및 열화조건에 따른 물성변화를 파악하였다. 시험결과, 온도가 높을수록 저장탄성계수는 감소하고 손실계수는 증가하는 경향을 나타내었다. Engineering plastics are used in instrument panels, interior trim, and other vehicle applications, and the thermo-mechanical behaviors of plastic materials are strongly influenced by many environmental factors such as temperature, sun light, and rain. As the properties change, the mechanical parts creating unexpected noise. In this paper, the dynamic mechanical property changes of plastics for automobiles are measured to investigate the temperature effects. Visco-elastic properties such as the glass transition temperature and storage modulus and loss factor under temperature and frequency sweeps were measured. The data were compared with the original ones before the aging to analyze the behavior changes. As results, the temperature was increased, the storage modulus was decreased on the other hand, loss factor is slightly increases.