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Novel self nano emulsifying formulation of furosemide: a drug used in pulmonary edema
( Pankajkumar Yadav ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Purpose: Poor water solubility is one of the reasons for erratic absorption after oral administration of furosemide (FSM), an antihypertensive loop diuretic indicated for pulmonary edema. Aim of this study was to utilize Self nano emulsifying drug delivery system (SNEDDS), a novel drug delivery system, for improvement of water solubility, permeability and ultimately bioavailability of FSM. Methods: FSM solubility was determined in various vehicles oils, surfactants and co surfactants. Self emulsification region for the rational design of SNEDDS formulations was identified by pseudoternary diagrams. Developed formulations were characterized by zeta potential determination, droplet size analysis, dilution test, viscosity determination, in vitro dissolution studies and in vivo pharmacodynamic evaluation. Results:A remarkable increase in dissolution was observed for the optimized SNEDDS when compared with the plain FSM and marketed formulation by in vitro dissolution studies. The pharmacological effect of FSM was improved by SNEDDS formulation as compared to plain FSM. Conclusion: The study confirmed that SNEDDS formulation can be used as a possible alternative to traditional oral formulations of FSM to improve its bioavailability.
Pankajkumar Yadav,Ekta Yadav,Amita Verma,Saima Amin 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.6
Poor water solubility is one of the reasons forerratic absorption after oral administration of furosemide(FSM), an antihypertensive loop diuretic. Self nano emulsifyingdrug delivery system (SNEDDS) is a novel drugdelivery system utilized to improve the water solubility,permeability and ultimately bioavailability. FSM solubilitywas determined in various vehicles oils, surfactants and cosurfactants. Self emulsification region for the rationaldesign of SNEDDS formulations were identified bypseudoternary diagrams. Developed formulations werecharacterized by zeta potential determination, droplet sizeanalysis, dilution test, viscosity determination, in vitrodissolution studies and in vivo pharmacodynamic evaluation. A remarkable increase in dissolution was observed forthe optimized SNEDDS when compared with the plainFSM and marketed formulation by in vitro dissolutionstudies. The pharmacological effect of FSM was improvedby SNEDDS formulation as compared to plain FSM. Thestudy confirmed that the SNEDDS formulation can be usedas a possible alternative to traditional oral formulations ofFSM to improve its bioavailability.