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비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구
한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2
The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.
Sang Kun Park,Jin Hee Lim,Mi Seon Kim,Hyang Young Joung,Hak Ki Shin,Hae Ryong Cho,Hye Kyung Rhee 한국육종학회 2008 한국육종학회지 Vol.40 No.4
A new gerbera variety ‘Yellow Wing’ was released by the National Horticultural Research Institute (NHRI) in 2007. A cross was made between ‘Gold Finger’ with yellow and single and ‘Yellow Springs’ with yellow and spider in 2004. After investigation of the characteristics for 4 years (from 2004 to 2007), it was selected specially for the use of cut-flower. ‘Yellow Wing’ is a vigorous cultivar with yellow (RHS YO14B), green center and spider type. The flower diameter is 10.6cm. And inner ray floret and disc diameter is 2.83cm and 2.03cm, respectively. It produces a large yield with continuous supply of flowers and has adequate peduncle height and brilliant color. We believe that ‘Yellow Wing’ has a great potential for expanding cultivated area of domestic gerbera cultivar and increasing farmers-income.
조윤향 ( Yoon Hyang Cho ),김태흥 ( Tae Heung Kim ),박흥배 ( Heung Bae Park ),박철근 ( Chul Kun Park ),박기민 ( Kee Min Park ) 대한피부과학회 1995 大韓皮膚科學會誌 Vol.33 No.6
Background : The photsensitizing effect of quinolones has been recognized since their introdulation as an antibacterial agents. Recently several new second eneration antibacterial agents of this pharmacological class have become available for therapy, and are gaining increasing impotance, Objective : To reveal the phototoxic potentials of some new quinolones by photohemolysis test, estimation of fluorescenc spectra, and Candida albicans test. Methods : Nalidixic acid and four second-generation quinolones(ciprofloxacin, enoxacini, norfloxacin, and ofloxacitid were examined by fluorescence spertra which measured t.he phototoxc potentials by photochemial instability, photohemolsis test for the phototoxic properties against cell membranes and Candida tlbicans test for phototoxic properties against DNA. Results : All drugs showed a fluorescence spectra within 360 nm to 450 nm, and in the photohemolysis test, all studied drug except ofloxacin got above 5% hemolytic value, and all drugs showed clear zone. in Candida albicans test after 48hours. Conclusion : These results suggested that all tested drugs were photochemically unstable. According to the mechanisris of cellular phototoxicity, ciprofloxacin, enoxacin, and norfloxacin was phtototoxic to nucleus and cell membrane, whereas ofloxacin was phototoxic to nucleus only. (Kor J Dermatol 1995;33(6): 1021-1028)
박경호,민병철,김종향,전창재,이근선 한국공업화학회 1998 응용화학 Vol.2 No.1
Photolysis behaviors of pesticides over UV irradiation, UV irradiation with pH 3.0 and UV irradiation with 3.5% salt were studied. The reactions were conducted in annular reactor equipped with a low pressure mercury multilamp (8W x 6) and initial concentration was 10ppm.
( Kun-tae Kim ),( Hyun-jung Kim ),( Hyang-im Lee ),( Young-jin Park ),( Dong-geun Kang ),( Jun-ill Yoo ),( Dong-kyu Moon ),( Sung-hee Cho ),( Sun-chul Hwang ) 대한슬관절학회 2018 대한슬관절학회지 Vol.30 No.2
Purpose: Anterior cruciate ligament (ACL) injury is one of the most common injuries that occur in the knee, and ACL reconstruction (ACLR) is commonly performed for preventing aggravation of degenerative changes and restoring of knee stability in young, athletic patients. This metaanalysis has a purpose of evaluating the clinical and arthrometrical outcomes of ACLR in a group of middle age patients (40 years and older) and comparing with patients under 40 years of age. Methods: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, and SCOPUS electronic databases were searched for relevant articles comparing the outcomes of ACLR between younger and older than 40 years of age until December 2016. Data searching, extraction, analysis, and quality assessment were performed based on the Cochrane Collaboration guidelines. Clinical outcomes were evaluated and compared between groups. The results were presented as mean difference for continuous outcomes with 95% confidence intervals whereas risk ratio for binary outcomes. Results: Seven studies were included in the meta-analysis. Based on International Knee Documentation Committee classification, side-to-side difference, Tegner activity score, Lysholm knee score, there were no significant clinical and mechanical differences between the groups. Conclusions: This meta-analysis confirmed that after ACLR, middle age (>40 years) and young age (<40 years) patients did not present with significant difference in clinical and arthrometric results.
칼라의 무름병 저항성 품종 선발을 위한 검정 방법 개발
정향영(Hyang Young Joung),최목필(Mok Pil Choi),한경숙(Kyung Sook Han),김수(Su Kim),구대회(Dae Hoe Goo),강윤임(Yun Im Kang),최윤정(Youn Jung Choi),박상근(Sang Kun Park) 한국원예학회 2013 원예과학기술지 Vol.31 No.3
본 연구는 P. carotovorum subsp. carotovorum에 의해 발생하는 칼라의 무름병 저항성 품종 선발을 위한 효율적인 검정 방법을 구명하기 위해 수행되었다. Z. aethiopica 4품종에 대하여 1 × 10<SUP>7</SUP>cfu/mL, 1 × 10<SUP>8</SUP>cfu/mL, 1 × 10<SUP>9</SUP>cfu/mL 농도의 EccNHRI-21 균주 현탁액을 잎과 엽병에 상처접종하고, 접종 후 4, 18, 26시간 후에 무름병 발생 정도를 조사하였다. 그 결과, 1 × 10<SUP>9</SUP>cfu/mL 농도의 균주 현탁액을 잎에 접종한 후 18시간 이후에 저항성 정도를 평가하는 것이 칼라 무름병 저항성 검정 및 품종 선발을 위해 가장 적합한 것으로 나타났다. 상처접종법을 이용하여 Z. aethiopica 재배품종 10종과 야생종 4종 등 총 14종에 대하여 무름병 저항성 정도를 평가한 결과, 재배품종의 경우 ‘Crowbrough’와 ‘White Cutie’가 가장 강한 저항성을 보였으며, ‘Mont Blanc’과 ‘Silky White’도 저항성 품종으로 선발되었다. 또한 ‘Wedding March’와 ‘Kiwi blush’는 중도저항성 품종으로 평가되었고, ‘Childsiana’ 등 4품종은 감수성 품종으로 평가되었다. 야생종의 경우 ‘Z. aethiopica wildtype 11’이 저항성을 보이는 등 4종 모두 중도저항성 이상의 무름병 저항성을 가지는 것으로 평가되었다. 지금까지 경종적 방제 및 생물학적 방제, 화학적 방제 등 여러 가지 방제 방법이 시도되었으나, 무름병 발생 피해를 최소화하기 위해서는 내병성 품종을 재배하는 것이 가장 효율적이다. 따라서 상처접종법을 이용한 무름병 저항성 검정 기술이 칼라의 무름병 저항성 품종 개발에 유용하게 쓰일 것으로 기대된다. This experiment was carried out to establish the screening methods for the selection of Zantedeschia aethiopica cultivars resistant to calla lily soft rot caused by Pectobacterium carotovorum subsp. carotovorum. A center of leaf and petiole tissues of four Z. aethiopica cultivars were wounded and inoculated with three different inoculum concentrations, 1 × 10<SUP>7</SUP> cfu/mL, 1 × 10<SUP>8</SUP> cfu/mL, and 1 × 10<SUP>9</SUP> cfu/mL, of EccNHRI-21 isolate. And they were evaluated at 4, 18, and 26 hours after inoculation. The lesion of maceration was developed well in the leaf tissues inoculated with 1 × 10<SUP>9</SUP> cfu/mL concentration. And evaluation of resistance in 18 hours after inoculation was correlated with field resistance positively. Using this method, ten Z. aethiopica commercial cultivars and four wild types were screened. ‘Crowbrough’ and ‘White Cutie’ were selected as highly resistant genotypes and ‘Mont Blanc’ and ‘Silky White’ as resistant genotypes. ‘Wedding March’ and ‘Kiwi Blush’ were evaluated as moderate resistant and the others including ‘Childsiana’ were susceptible. And all of four wild types were evaluated as more than moderate resistant. In spite of control through cultural, biological and chemical methods, the use of resistant cultivars is most efficient to overcome calla lily soft rot. This newly developed screening method was helpful for breeding new varieties resistant to calla lily soft rot.