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Alcelaphine herpesvirus 1 진단을 위한 PCR-dot blot hybridization의 개발
김옥진,Kim, Okjin,Li, Hong 대한수의학회 2004 大韓獸醫學會誌 Vol.44 No.1
The aim of the present study was to develop a sensitive and specific assay for the diagnosis of alcelaphine herpesvirus 1 (AlHV-1) which is a cause agent of malignant catarrhal fever in ruminants. A1HV-1 is a gamma herpesvirus, which is frequent latent, and it is often difficult to detect its antigens or specific nucleic acids because of its low genomic copies in the infected tissues. In this study, polymerase chain reaction (PCR)-dot blot hybridization (DBH) assay for detecting AlHV-1 DNA was developed and evaluated for its sensitivity and specificity as comparison with PCR and DBH alone. The developed PCR-DBH was more sensitive than PCR or DBH alone and also very specific. The results showed that the sensitivity of PCR-DBH were higher and stronger than those of PCR and DBH alone. This PCR-DBH assay can be applied efficiently to confirm the presence of AlHV-1 virus on clinical samples and to differentiate specifically between AlHV-1 infection and other viral infections.
대기오염 장기 노출의 건강 영향 평가를 위한 표본코호트 자료의 탐색과 처리 방법 제안: 사망을 중심으로
김옥진 ( Okjin Kim ),김선영 ( Sun-young Kim ),권혜영 ( Hye-young Kwon ),김호 ( Ho Kim ) 한국보건정보통계학회 2017 보건정보통계학회지 Vol.42 No.1
Objectives: National-scale cohort studies provided evidence of the association between long-term exposure to air pollution and mortality. Recently, South Korean government created the National Health Insurance Service-National Sample Cohort (NHIS-NSC) which included about one million subjects in 2002 and followed up every year through 2013. We aimed to explore major data issues of NHIS-NSC and to provide plausible suggestions in data processing for cohort studies of long-term air pollution and mortality. Methods: We specified four data issues: tracking failure, address inconsistency, limited address information, and absence of risk factors. Our exploratory analyses clarified data characteristics related to four issues and led us to provide the best options out of several suggestions in data processing to aovid inaccurate risk estimates in subsequent health analyses. Results: Twelve percent of the cohort was lost to follow up for at least one year. We proposed to restrict the study population to cohort members with more than 50% of follow-ups. Although the NHIS-NSC report mentioned some address changes from workplaces to residences in 2005, our exploratory analysis provided little evidence of the change. We concluded that it is not suggestive to consider the change in data processing. The incomplete address information limited to the district level prevents us from estimating individual exposures to air pollution. However, we could compute population-represenative district-level averages by using exposure prediction models. Important individual-level risk factors such as smoking were not available in NHIS-NSC. Our suggestion was to use area-level information from external data or to restrict the study population to a subset who carried out national health examinations. Conclusions: Our extensive investigation of the NHIS-NSC data and constructive suggestions of data handling focusing on cohort studies of air pollution and mortality will help assess the association between long-term exposures to air pollution and health in South Korea.
Helicobacter pylori에 대한 항균활성을 가진 천연물의 검색과 항균력 비교 연구
이현아,김옥진,Lee, Hyun-A,Kim, Okjin 대한수의학회 2013 大韓獸醫學會誌 Vol.53 No.2
Infection with Helicobacter (H.) pylori is strongly associated with duodenal and gastric ulcers. Substantial epidemiological data has revealed that high rates of H. pylori infection might be related to high rates of gastric cancer. In this study, a medicinal herbal extracts were examined and screened for anti-H. pylori activity. Seventy percent ethanol was used for herbal extraction. For anti-H. pylori activity study, the inhibitory zone tests with 74 herbal compounds were conducted. As the results, thirteen compounds including Cinnamomi Cortex, Magnoliae Cortex and Meliae Fructus were revealed strong anti-H. pylori activities.
Helicobacter pylori에 대한 천련자 추출물의 in vitro와 in vivo 실험에서의 항균활성
이현아,김옥진,Lee, Hyun-A,Kim, Okjin 대한수의학회 2012 大韓獸醫學會誌 Vol.52 No.2
In this study, a medicinal herbal plant, Meliae fructus, was examined and screened for anti-Helicobacter (H.) pylori activity. Seventy percent ethanol was used for herbal extraction. For anti-H. pylori activity screening, inhibitory zone tests as an in vitro assay and in vivo study using a Mongolian gerbil (Meriones unguiculatus) model were performed. Also, the safety of herbal compounds was evaluated by animal study. As a result of inhibitory zone test, Meliae fructus extract demonstrated strong anti-H. pylori activities. Also, as results of in vivo animal studies, Meliae fructus demonstrated strong therapeutic effects against H. pylori infection according to the criteria of histological examination and rapid urease test. As results of the safety study, after 28 days treatment of the Meliae fructus extract, the animals were not detected any grossly and histological changes. These results demonstrate that it can be successfully cured against H. pylori infection and protected from H. pylori-induced pathology with Meliae fructus. It could be a promising native herbal treatment for patients with gastric complaints including gastric ulcer caused by H. pylori.