A Case of Venlafaxine-Induced Interstitial Lung Disease

Oh, Serim,Cha, Seung-Ick,Kim, Hyera,Kim, Minjung,Choi, Sun Ha,Seo, Hyewon,Park, Tae-In The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.77 No.2

A patient treated with venlafaxine for major depression developed an interstitial lung disease (ILD) with the characteristic clinical, radiological and pathological features of chronic hypersensitivity pneumonitis. A high resolution computed tomography scan demonstrated ground glass opacity, mosaic perfusion with air-trapping and traction bronchiectasis in both lungs. The pathological findings were consistent with a nonspecific interstitial pneumonia pattern. Clinical and radiological improvements were noted after the discontinuation of venlafaxine and the administration of a corticosteroid. This report provides further evidence that the anti-depressant venlafaxine can cause ILD.

CASE REPORT : A Case of Venlafaxine-Induced Interstitial Lung Disease

( Serim Oh ),( Seung Ick Cha ),( Hyera Kim ),( Min Jung Kim ),( Sun Ha Choi ),( Hye Won Seo ),( Tae In Park ) 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.77 No.2

A patient treated with venlafaxine for major depression developed an interstitial lung disease (ILD) with the characteristic clinical, radiological and pathological features of chronic hypersensitivity pneumonitis. A high resolution computed tomography scan demonstrated ground glass opacity, mosaic perfusion with air-trapping and traction bronchiectasis in both lungs. The pathological findings were consistent with a nonspecific interstitial pneumonia pattern. Clinical and radiological improvements were noted after the discontinuation of venlafaxine and the administration of a corticosteroid. This report provides further evidence that the anti-depressant venlafaxine can cause ILD.

아스퍼거 증후군 혹은 고기능 자폐 학생의 사회성 중재에 대한 선행연구 고찰

오세림(Oh, Serim) 한국자폐학회 2008 자폐성 장애연구 Vol.8 No.1

사회성 기술 결함은 아스퍼거 증후군(AS)이나 고기능 자폐(HFA) 학생들의 주 결함으로 여겨져 왔다. 이에 본 연구는 이 학생들을 대상으로 사회성 증진 중재를 실시한 선행연구를 분석하여 연구의 동향을 알아보고 중재 방법 및 중재의 목표가 된 행동들에 대해 알아보고자 하였다.

문해활동 중심의 극놀이 중재가 통합된 발달지체 유아의 문해행동에 미치는 영향

오세림(Serim Oh),이소현(SoHyun Lee) 한국언어청각임상학회 2002 Communication Sciences and Disorders Vol.7 No.2

문해력은 유아들의 이후의 학업성취 뿐만아니라 여가생활에도 많은 영향을 미치므로 공식적인 학교 교육이 시작되기 이전, 즉 유아기에 습득되어야 하는 능력으로 간주되어 왔다. 그러나 장애유아들의 경우 문해교육은 간과되어온 실정이고, 실시한다 해도 1 : 1 교수나 반복 연습과 같이 기술 지향적이었다는 문제점이 있었다. 이에 대한 대안으로 자연적 환경에서의 교수, 기능적인 읽기 및 쓰기 학습, 실제로 문자가 사용되는 상황에서의 교수 등이 제시되고는 있으나 이에 대한 연구는 부족한 실정이며 한국 특수교육 현장에서는 더욱 그러하다. 따라서, 본 연구에서는 기존의 유아교육에서 바람직한 실제로 연구되어온 문해 자료와 문해 활동을 극놀이 활동에 도입하는 방법을 발달지체 유아들의 요구에 맞도록 수정하고 교사의 개입을 삽입하여 실시하는 문해활동 중심의 극놀이 중재가 발달지체 유아들의 문해행동에 미치는 영향을 알아보았다. 이를 위해 일반 어린이집에 통합되어 있는 만 5세, 6세의 발달지체 유아 3명에 대하여 대상자간 중다 간헐기초선 설계에 의한 문해활동 중심의 극놀이 중재를 실시하였으며, 이에 따라 문해행동이 증가하는지, 중재 효과가 일반화 되는지, 중재가 제거된 후에도 실험효과가 유지되는지를 알아보았다. 연구 결과에 의하면 문해활동 중심의 극놀이 중재는 세 명의 대상유아들의 문해행동을 증가시켰고, 이러한 중재의 효과는 구조화되지 않은 교실의 자유놀이 시간으로도 일반화되었으며, 중재가 제거된 후에도 유지된 것으로 나타났다. Intervention using literacy- related activities in symbolic play has been suggested as one of the effective methods of enhancing literacy for typically developing young children. This study examined the effect s of intervention using literacy- related activities in symbolic play of three young children with developmental delays. Intervention was conducted with multiple probe baseline design across three participant s. To implement the intervention, literacy- related activities in symbolic play have been carried out with the participant s for 15 minutes. The method of partial interval time sampling has been used to collect data for 10 minutes each session. To collect generalization data, literacy behavior s of the participant s were observed in the classroom free- play setting immediately after the inter - vention sessions. Follow- up data were collected three weeks after the termination of the intervention. The result s obtained from the present study are as follows: (1) The total rate of literacy behavior s increased in all three participant s by implementing intervention using literacy- related activities in symbolic play; (2) the increase in the literacy behavior s was generalized to unstructured situation(children s classroom) in all three participant s; (3) these effect s were maintained three weeks beyond the intervention in all three participant s. Details of the result s and discussions relevant to them are provided in terms of future use of the intervention used in this study to increase literacy behavior s of young children with developmental delays.

보수적 시나리오 분석을 통한 농촌 지역의 비소 오염 지하수의 위해성 평가

오세림(Serim Oh),이진용(Jin-Yong Lee),문상호(Sang-Ho Moon),장지욱(Jiwook Jang),정은주(Eunju Jeong) 대한지질학회 2022 대한지질학회 학술대회 Vol.2022 No.10

Assessment of 7 trace elements in serum of patients with nontuberculous mycobacterial lung disease

Oh, Jongwon,Shin, Sun Hye,Choi, Rihwa,Kim, Serim,Park, Hyung-Doo,Kim, Su-Young,Han, Sun Ae,Koh, Won-Jung,Lee, Soo-Youn Elsevier 2019 Journal of trace elements in medicine and biology Vol.53 No.-

<P><B>Abstract</B></P> <P>Nontuberculous mycobacterial (NTM) lung diseases are an emerging cause of pulmonary infection, becoming more common in the clinical setting as incidence of NTM lung diseases steadily increases worldwide. Trace elements are essential micronutrients and are known to play many important roles in infectious diseases. We investigated the concentrations of trace elements in patients with NTM lung disease and compared these values to patients with pulmonary tuberculosis and healthy controls. A case-control study was conducted to evaluate the serum trace element concentrations in 95 patients with NTM lung disease, 97 patients with pulmonary tuberculosis, and 99 healthy control subjects. The serum concentrations of 7 trace elements (cobalt, copper, chromium, manganese, molybdenum, selenium, and zinc) were measured using inductively coupled plasma-mass spectrometry. We also analyzed demographic data, clinical outcomes, and other biochemical parameters. The median serum concentrations of copper and molybdenum were higher in patients with NTM lung disease (109 vs. 91 μg/dL, p < 0.001 and 1.70 vs. 0.96 μg/L, p < 0.001). In contrast, the median serum concentrations of selenium and zinc were significantly lower in patients with NTM lung disease than in healthy controls (105 vs. 115 μg/L, p < 0.001 and 94 vs. 102 μg/dL, p < 0.001). Compared to patients with pulmonary tuberculosis, the serum concentrations of molybdenum and zinc were higher in patients with NTM lung disease, while cobalt and copper concentrations were lower (p < 0.001). Correlations among trace element concentrations were observed (copper and zinc, <I>r</I> = −0.367; cobalt and molybdenum, r = −0.360; selenium and zinc, <I>r</I> = 0.335; and manganese and zinc, <I>r</I> = 0.327, respectively). None of the 7 trace elements were associated with treatment outcomes. Patients with NTM lung disease showed different serum trace element concentrations. Our study indicates that altered trace element status is associated with mycobacterial disease. Further study investigating the clinical significance of individual trace elements and their association with nutritional status in patients with NTM lung disease would be required.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Seven trace elements (Co, Cu, Cr, Mn, Mo, Se, and Zn) were evaluated in NTM patients. </LI> <LI> Serum concentrations of Se and Zn were significantly lower in NTM patients. </LI> <LI> Cu, Se, and Zn showed correlations with CRP, albumin, and total cholesterol. </LI> <LI> The altered trace element status is associated with NTM lung disease. </LI> </UL> </P>

아동학대 온톨로지 개발

정익중(Chung, Ick-Joong),이세림(Lee, Serim),오세현(Oh, Sehyeon),김지선(Kim, Jisun),전종설(Chun, JongSerl),강현아(Kang, Hyunah),노충래(Nho, Choong Rai) 한국아동복지학회 2021 한국아동복지학 Vol.70 No.4

코로나19 팬데믹 이후 아동학대의 피해는 전 세계적으로 모두 증가하는 추세이며 그 영향과 심각성은 매우 크다. 그러나 여전히 대부분의 아동학대 연구들은 전통적인 사회조사방법론에 의존하고 있다. 본 연구의 목적은 Noy와 McGuinness(2001)의 온톨로지 개발 방법을 활용하여 아동학대 온톨로지를 개발함으로써 아동학대와 관련된 소셜 빅데이터를 수집하고 분석하기 위한 틀을 구축하는 것이다. 본 연구에서는 텍스톰과 R 4.1.0을 활용하여 2019년의 인터넷 뉴스 3,090개와 학술연구 295개의 자료에서 총 25,092개의 키워드를 추출하였다. 이후 키워드 전처리 과정을 거쳐 최종적으로 총 4,077개의 키워드가 본 아동학대 온톨로지에 포함되었다. 연구결과, 온톨로지는 (1) 대상(피해자, 가해자, 관련자), (2) 유형(학대, 유기 및 방임, 매매), (3) 요인(보호요인, 위험요인), (4) 특성(학대징후, 장소, 시간, 가해 수법, 기타 특성), (5) 영향(개인 문제, 가족 및 환경 문제), (6) 대응방안(개인적 대처, 예방, 복지적 개입, 사법적 개입, 관련 조직) 범주로 구성되었다. 본 연구는 아동학대의 다양한 영역을 모두 포괄하는 온톨로지를 처음으로 개발함으로써 앞으로 아동학대 분야의 소셜 빅데이터 분석의 초석을 마련하였다는 점에서 의의가 있다. Child abuse has been increasing rapidly globally especially since the outbreak of the Covid-19 pandemic. However, studies on child abuse still tend to rely on the traditional research methods. This study was intended to develop a child abuse ontology as a first step toward social big data collection and analysis. Following Noy and McGuinness’ (2001) seven-stage development process of ontology, 25,092 keywords were extracted from 3,090 online news and 295 research articles published in 2019 using Textom and R 4.1.0. After undertaking pre-processing, 4,077 keywords in total were included in the child abuse ontology. The results yielded domains for (a) participants (victims, perpetrators, and the persons concerned); (b) types (abuse, neglect, and trafficking); (c) factors (protective factors and risk factors); (d) characteristics (signs, place, time, methods, and distinct features); (e) impacts (individual, family, and environmental problems); and (f) countermeasures (coping strategies, prevention, welfare intervention, judicial intervention, and organizations involved). The findings provide a child abuse ontology that embraces multi-faceted domains of this issue for the first time, thus laying the groundwork for social big data analysis on the topic of child abuse.

Clinical Relevance of Bronchial Anthracofibrosis in Patients with Chronic Obstructive Pulmonary Disease Exacerbation

Kim, Hyera,Cha, Seung-Ick,Shin, Kyung-Min,Lim, Jae-Kwang,Oh, Serim,Kim, Min Jung,Lee, Yong Dae,Kim, Miyoung,Lee, Jaehee,Kim, Chang-Ho The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.77 No.3

Background: Bronchial anthracofibrosis (BAF), which is associated with exposure to biomass smoke in inefficiently ventilated indoor areas, can take the form of obstructive lung disease. Patients with BAF can mimic or present with an exacerbation of chronic obstructive pulmonary disease (COPD). The purpose of the current study was to investigate the prevalence of BAF in Korean patients with COPD exacerbation as well as to examine the clinical features of these patients in order to determine its clinical relevance. Methods: A total of 206 patients with COPD exacerbation were divided into BAF and non-BAF groups, according to computed tomography findings. We compared both clinical and radiologic variables between the two groups. Results: Patients with BAF (51 [25%]) were older, with a preponderance of nonsmoking women; moreover, they showed a more frequent association with exposure to wood smoke compared to those without BAF. However, no differences in the severity of illness and clinical course between the two groups were observed. Patients in the BAF group had less severe airflow obstruction, but more common and severe pulmonary hypertension signs than those in the non-BAF group. Conclusion: Compared with non-BAF COPD, BAF may be associated with milder airflow limitation and more frequent signs of pulmonary hypertension with a more severe grade in patients presenting with COPD exacerbation.

Multimarker Prognostication for Hospitalized Patients with Community-acquired Pneumonia

Yeon Lee, So,Cha, Seung-Ick,Seo, Hyewon,Oh, Serim,Choi, Keum-Ju,Yoo, Seung-Soo,Lee, Jaehee,Lee, Shin-Yup,Kim, Chang-Ho,Park, Jae-Yong Japanese Society of Internal Medicine 2016 Internal medicine Vol.55 No.8

Evaluation of hydrochemical characteristics and hydraulic connectivity using fluorescent mineral tracer test in karst region of Samcheok, Korea

장지욱(Jiwook Jang),이진용(Jin-Yong Lee),오세림(Serim Oh),김영인(Young-In Kim) 대한지질학회 2022 지질학회지 Vol.58 No.3