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The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development
Oh, Se-Yeong,Kim, Ju Young,Park, Changwon Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.12
Appropriate vessel development and its coordinated function is essential for proper embryogenesis and homeostasis in the adult. Defects in vessels cause birth defects and are an important etiology of diseases such as cardiovascular disease, tumor and diabetes retinopathy. The accumulative data indicate that ETV2, an ETS transcription factor, performs a potent and indispensable function in mediating vessel development. This review discusses the recent progress of the study of ETV2 with special focus on its regulatory mechanisms and cell fate determining role in developing mouse embryos as well as somatic cells.
Molecular Culprits Generating Brain Tumor Stem Cells
( Se Yeong Oh ),( Hyunggee Kim ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2013 Brain Tumor Research and Treatment Vol.1 No.1
Despite current advances in multimodality therapies, such as surgery, radiotherapy, and chemotherapy, the outcome for patients with high-grade glioma remains fatal. Understanding how glioma cells resist various therapies may provide opportunities for developing new therapies. Accumulating evidence suggests that the main obstacle for successfully treating high-grade glioma is the existence of brain tumor stem cells (BTSCs), which share a number of cellular properties with adult stem cells, such as self-renewal and multipotent differentiation capabilities. Owing to their resistance to standard therapy coupled with their infiltrative nature, BTSCs are a primary cause of tumor recurrence post-therapy. Therefore, BTSCs are thought to be the main glioma cells representing a novel therapeutic target and should be eliminated to obtain successful treatment outcomes.
Yun Yeong Oh,Se Yeong Hamm,Sang Yong Chung,Byeong Dae Lee 대한환경공학회 2013 Environmental Engineering Research Vol.18 No.3
The infiltration of rainwater into the surface soil is highly dependent on hydraulic variables, such as the infiltration rate, capillary fringe, moisture content, and unsaturated/saturated hydraulic conductivity. This study estimates the hydraulic conductivity (K) of fluvial deposits at three sites on the right and left banks of Nakdong River in Gyeongbuk Province, South Korea, including the Gumi, Waegwan, and Seongju bridge sites. The K values of 80 samples from 13 boreholes were estimated by using six grain-size methods (Hazen, Slichter, Kozeny, Beyer, Sauerbrei, and Pavchich formulae). The Beyer, Hazen, and Slichter methods showed a better relationship with K values along with an effective grain size than did the other three methods. The grain-size, pumping test, and slug test analyses resulted in different K values, but with similar K values in the grain-size analysis and pumping test. The lower K values of the slug test represent the uppermost fine sand layer.
오윤영 ( Yun Yeong Oh ),함세영 ( Se Yeong Hamm ),이충모 ( Chung Mo Lee ),( Wei Ming Laing ),김규범 ( Gyoo Beom Kim ),김문수 ( Moon Su Kim ) 대한지질공학회 2014 지질공학 Vol.24 No.4
본 연구에서는 1930년대 평양 대동강 유역의 남측(탄산염지역)과 북측(비탄산염지역)의 지하수와 지표수의 수질(pH, CaO, Fe, HCO3-, SO42-)을 비교 하였다. 그 결과 남측이 북측에 비해 pH와 SO42-의 농도는 높았고 HCO3-와 Fe의 농도는 낮게 나타났다. 이는 점토층 유기물의 산화에 의해 발생한 수소가 무기염류의 금속이온을 치환하여 산을 형성하는 반응에 그 원인이 있는 것으로 판단된다. The chemical properties and composition (pH, CaO, Fe, HCO3 -, and SO4 2-) of groundwater (GW) and surface water (SW) from the northern (non-carbonate bedrock) and southern (carbonate bedrock) sections of the Daedong River, Pyeongyang were analyzed and compared period of the 1930s. In the southern section, the GW and SW has a higher pH and SO4 2- concentration, but lower HCO3 - and Fe levels than in the north. This finding reflects a reaction that formed acid by replacing metal ions in inorganic salts by hydrogen, which resulted from the oxidation of organic material in a clay layer.