노년기 주관적 연령과 건강노화와의 관계: 연령집단별 분석

최은영 ( Choi Eun Young ),조성은 ( Cho Sung Eun ),오영삼 ( Oh Young Sam ),장희수 ( Chang Hee Su ),김영선 ( Kim Young Sun ) 한국보건사회연구원 2017 保健社會硏究 Vol.37 No.1

The purpose of this study is to examine the relationship between subjective age (whether one subjectively perceives himself as `the elderly` or `not the elderly`) and healthy aging. Using data from the 2014 National Elderly Survey (KIHASA), this study selected a total of 9,653 participants consisting of young-olds (aged 65-74) and old-olds (aged 75-84) For both the young-old and the old-old, multiple regression analyses were conducted to examine the research model. In the young-old population, one`s considering oneself as “non-elderly” was significantly associated with higher cognitive functioning, fewer chronic diseases, lower depressive symptoms, and higher level of social engagement. On the other hand, in the old-old population, one`s considering oneself as “non-elderly” was associated only with higher cognitive functioning, and not with the other domains of healthy aging. The findings suggest that subjective age can be considered as an important predictors of older adults` healthy aging. These findings indicate that the association between subjective age and healthy aging has a different pattern depending on the age group.

연령집단에 따른 노인의 허약(Frailty) 예측요인 분석

조성은 ( Cho Sung Eun ),최은영 ( Choi Eun Young ),오영삼 ( Oh Young Sam ),김영선 ( Kim Young Sun ),김성복 ( Kim Seong Bok ) 한국보건사회연구원 2017 保健社會硏究 Vol.37 No.3

This study aims to investigate the predictors of frailty in different age groups. To address this purpose, this study used the 2014 Survey of the Living Conditions of the Elderly (SLCE). In the research model, 4,123 older adults aged 75 and older were included from the SLCE. All participants were subdivided into two age groups based on their age; the young old group (75-85) and the old-old group (85+). The young old group consisted of 1,453 (43%) pre-frail older adults and 1,268 (37%) frail older adults; the old-old group consisted of 304 (40%) pre-frail older adults and 396 (52%) frail older adults. Our regression analysis showed that in the young-old, being female, lower levels of education, having more chronic diseases, having fall experience, higher depression, lower cognitive functioning significantly predicted transition to pre-frailty from non-frail status. In the old-old, being female, higher depression, lower level of social activity were significant predictors. On the other hand, predictors of transition to frailty from pre-frail status in the young-old were being female, higher age, being unemployed, having more chronic diseases, having fall experience, higher depression, lower cognitive functioning. In the old-old, predictors of transition to frailty from pre-frail status were only higher age, having more chronic disease, higher depression, and lower cognitive functioning. The research findings can be used as a reference point in the making of strategies for preventing frailty.

당뇨병과 동반된 화농성 간농양의 임상상 및 예후인자

오은숙,강무일,이원영,오기원,임동준,이소영,이정민,고승현,김성래,안유배,손현식,윤건호,차봉연,이광우,손호영,강성구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

연구배경: 감염질환은 혈관질환과 함께 당뇨병의 중요한 사망원인의 하나이며, 혈당조절이 불량할수록 감염 빈도가 증가됨은 잘 알려져 있다. 간농양의 발생이 있어서도 당뇨병은 중요한 기저질환 중의 하나이다. 일반적으로 간농양의 가장 흔한 원인균은 Escherichi coli라고 알려져 있으나, 최근 당뇨병을 가진 간농양 환자에서 Klesiella pneumoniae의 검출이 증가되고 있다. 또 최근 연구에 의하면 K.pneumonie가 간농양의 가장 흔한 원인균이며, K. pneumoniae에 의한 간농양은 K.pneumoniae 이외의 균주에 의한 간농양보다 당뇨병과 밀접히 관련되어 있다고 보고된 바 있다. 이에 저자들은 간농양 환자를 대상으로 당뇨병환자의 빈도를 알아보고, 그 원인균 및 특징을 비당뇨병 환자들의 경우와 비교해 보고자 하였다. 방법: 1992년 1월부터 1999년 6월까지 방사선학적 검사 혹은 수술에 의해 간농양이 확인되거나, 경피적 천자나 수술을 통한 배농액 배양, 혹은 혈액 검사에서 원인균이 증명된 182명의 환자를 대상으로 후향적 임상고찰을 실시하였다. 결과: 화농성 농양을 가진 167명의 환자(남:94명, 여:73명)중 당뇨병을 가진 환자는 54명 (남:30명, 여:24명)으로 32.3%를 차지하였다. 환자의 평균나이는 당뇨군에서 62.1 ± 13.4세, 비당뇨군에서는 55.1 ±15.5세로 당뇨군에서 높았으며(p=0.0021), 남녀간의 평균나이 비교 시 두 군 모두 여성의 나이가 의미있게 높았다. 비당뇨군에 비하여 당뇨군의 경우 저알부민혈증의 빈도와 aspartate transaminase가 증가되어있었다. 원인균주는 K. pneumoniae (당뇨군54%, 비당뇨군 39.1%), E. coli(당뇨군 17.5%, 비당뇨군 18.8%), Pseudomonas aeruginosa, Streptococcus viridans, Enterococcus 순이었으며 두 군간의 의미는 차이는 없었으나 K. pneumoniae의 경우 다른 균종에 비해 단독감염의 빈도가 높았다(82.8%). 사망률은 당뇨군에서 16.7%, 비당뇨군에서 7.1%로 당뇨군에서 의미있게 높았으며(p=0.019), 당뇨군에서의 사망환자는 모두 패혈증이 동반되어 있었다. 당뇨환자의 사망군은 생존군에 비해 당뇨병 이환기간이 길고 혼합감염의 빈도가 높았다(p=0.046). 검사실 소견에서는 총 빌리루빈 및 알카리성 포스파타제의 증가가 관찰되어 있었다. 결론: E. coli가 간농양의 주된 원인균이라는 기존 보고와는 달리 당뇨군과 비당뇨군 모두 K. pneumoniae가 간농양의 주된 원인균이었다. 또한 당뇨 유병기간이 길고 당뇨조절이 불량한 환자에서 혼합감염이며 총 빌리루빈 및 알카리성 포스파타제의 증가등과 같은 위험인자가 존재할 경우 사망률이 증가될 수 있으므로 이들 군에서는 적극적인 치료가 필요할 것으로 사료된다. Background: Liver abscesses are commonly associated with underlying disease, particularly diabete mellitus. The number of the liver abscesses caused by Klebslella pneumoniae in diabetic patient has been increased in Korea nowadays. This study was conducted to clarify the clinical presentation and prognostic factors of pyogenic liver abscesses, especially in diabetic patients and to determine the proportion of K. pneunomiae as a pathogen in liver abscess in Korea. Methods: Medical records of 167 patients treated for pyogenic liver abscess from January, 1992 through June, 1999 were reviewed retrospectively in detail. Major Pathogenic organism, clinical manifestations, prognostic factors, the importance of diabetes mellilus as an underlying disease and its effect on clinical features and prognosis were analyzed. Results: Among 167 cases of pyogenic liver abscess, underlying diabetes mellitus was present in 32.3%. The mean age of patients was 62.7 13.4 years in diabetic liver abscess group and 55.1 15.5 years in non-diabetic liver abscess group. Most liver abscesses were cryptogenic in origin or secondary to the billary tree diseases. The clinical presentations among the two groups were not significantly different. When compared to patients without diabetes, patients with diabetes had significantly higher proportions of hypoalbuminemia and elevated aspartate transaminase level. The most common organism of the pyogenic abscess was K. pneumoniae in both groups. Percutaneous drainage of the abscess with appropriate antibiotics was the most commonly used therapeutic modality in liver abscess. The mortality rate of diabetic liver abscess is 16.1 % and 7.1% in nondiabetic liver abscess. Complications, especially septicemla, were found more frequently in patients with diabetes than in patients without diabetes (64.8% vs 28.3%, septicemia : 31.5% vs 9.7%). The factors influencing mortality in the diabetic liver abscess were disease duration, mixed infection, presence of septicemia, elevated bilirubin and alkaline phosphatase. Conclusions: In contrast to prior report that the E. coli was the most common pathogen in liver abscess, we found that K. pneumoniae was the most common organism cultured in liver abscess. Diabetic patients have more complications and higher mortality than patients without diabetes. Early detection and proper treatment are needed to improve the outcome for diabetic patient with liver abscess.

물질남용 치료프로그램 후 재범여부에 대한 예비적 추적조사 연구

김현수,조선미,오은영,임기영,정영기,윤웅장,이영미 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 본 연구는 물질사범에게 시행되는 수강명령 프로그램의 효과를 재범률을 중심으로 살펴보고자 한 것이다. 방 법: 이 연구의 대상집단은 보호관찰소에서 의뢰받은 물질남용자집단이다. 이들은 법원으로부터 보호관찰, 수강명령, 치료명령, 사회봉사 등을 부과받았다. 총 104명의 대상자집단을 치료프로그램을 이수한 수강군과 비수강군으로 나누었으며 이들에 대한 재범률을 조사하였다. 결 과: 프로그램을 이수한 수강군이 비수강군에 비해 재범률이 낮았다(p<.05). 또한 단기 수강군과 장기수강군의 재범률의 차이를 조사하였는데 대상자 집단의 수가 적기 때문에 장기 수강군의 효과가 통계적으로 입증되지는 않았다. 결 론: 우리는 물질남용자에 대한 정책이 보다 교육적으로 변화할 것을 본 논문을 통하여 제시하려 하였으며 정부 및 법무부는 물질남용자에게 교육과 치료를 제공해주어야만 한다. Objectives: Using recidivism rate, we investigated the outcome after our substance abuse treatment program had been implemented. Methods: Our target population was substance abuse criminals referred by probational office. They either received the parole and probation order, treatment order or social service order from the court. We divided 104 substance abuse criminals into treatment group and non-treatment group. We examined their recidivism rate. Results: We reached a conclusion that treatment group had lower recidivism rate than non-treatment group(p<.0.5). We examined the effectiveness of short-term and long-term programs. However, no effectivess of long-term program was found because the sabject number was too small. Conclusion: We suggest that the strategies for substance abuse should be changed to more educative ones. The Government and Ministry of Justice must provide education and treatment to the substance abuse criminals.

L1210 세포증식에 대한 Glycyrrhizin의 억제작용 기전

殷載淳,徐龍勳,權鎭,柳東和,吳贊鎬,蘇俊魯,全焄,黃甲洙 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

The purpose of this research was to investigate the mechanism of inhibitory action of Glycyrrhizin(GZ) on the proliferation of mouse leukemia cell-line, L1210 cells. The cytotoxic activity was tested using a colorimetric tertrazolium assay(MTT assay), the apoptosis was tested using flow cytometry. Nitric oxide(NO) production form mouse peritoneal macrophage was tested using a Griess method and the phagocytosis of human polymorphonuclear cells was tested using a lucigenin chemiluminescence. GZ ingibited the proliferation of L1210, BALB/c 3T3 cells and mouse thymocytes at 50 ug/ml/ GZ did not affect nitric oxide production from mouse peritoneal macrophages in vitro, but ingibited nitric oxide production from lipopolysaccharide and y-interferon treated macrophages. Macrophages of GZ-administered mice accelerated NO production. The proliferation of L1210 cells apoptosis of L1210 cells were induced by co-culture with macrophage of GZ-administered mice. The apoptosis of L1210 cells were induced by co-culture with macrophage of GZ-administered mice. GZ increased the phagocytosis of human polymorphonuclear cells. These results suggest that GZ inhibit the proliferation of L1210 cells not only as a direct cytotoxic agent o tumor cells, but also by the enhancement of NO production and phagocytic activity.

거주자 의식을 고려한 중층 고밀도 집합주택의 계획에 관한 연구

오승은,이영수 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(계획계)

The study is an attempt to explore user's preference of design elements for the Medium-height and High density collective Housings Planning. The purpose of the research is to suggest design guidelines for the collective Housings Planning applicating high-rise multi purpose housings' advantages. The analysis of the user's preference is resulted in necessary of considering activity and union senses in housings. Therefore, that housing can be planned with convenience facilities for the dwellers and circulation plan purpose for feeling in intimacy and amenity. The commercial and public space planning which behavior overlap and go through become to feel active in the housings.

Toxoplasma 감염 가토의 임파구 아세포화 반응에 대한 연구

오창진,이영하,나영언,신대환 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

This study was performed to observe the differences of lymphocyte blastogienic responses in rabbits infected with Fukaya and Me49 strain of Toxoplasma gondii. Rabbits were subcutaneously inoculated with mouse brain emulsion containing 50 cysts of each strain of Toxoplasma gondii. A total of 9 male rabbits was used. From the 1st week after inoculation, blastogenic responses of peripheral blood lymphocytes treated with concanavalin A (Con. A, 10.0㎍/ml), lipopolysaccharide(LPS, 25.0㎍/ml) and Toxoplasma lysate(20.0㎍/ml) respectively were examined by [methyl-^3H]-thymidine incorporation assay at l week interval for 8 weeks. The results obtained in this study were as follows: 1. The blastogenic responses of the Con. A-treated and Toxoplasma lysate-treated lymphocytes from rabbits infected with Fukaya and Me49 strain of Toxoplasma gondii respectively were significantly declined as compared with those of the contol rabbits(p<0.05). No significantly differences were revealed in the blastogenic responses of the experimental group each other. 2. The blastogenic responses of the LPS-treated lymphocytes from rabbits infected with Fukaya and Me49 strain of Toxoplasma gondii respectively were not significantly declined as compared with those of the contol mice. No significantly differences were revealed in the blastogenic responses of the experimental group each other. The results suggested that there were no significantly differences in the blastogenic responses to Con. A, LPS and Toxoplasma lysate of each strain of Toxoplasma gondii infected rabbits. But the experimental group was a significant depression in blastogenic responses to Con. A and Toxoplasma lysate as compared with those of control group.

돈분 퇴비단 여과 액비가 ‘Salanova’ 상추의 생육과 기능성 물질농도에 미치는 영향

김은영, 박봉주, 오명민 忠北大學校 農業科學硏究所 2012 農業科學硏究 Vol.28 No.3

In this study, the availability of pig slurry composting and biofiltration (PSCB) solution as an alternative for synthetic nutrient solution was determined by monitoring the growth and phytochemicals of lettuce (Lactuca sativa L. cv. ‘Salanova’). This study was conducted from 16 September 2011 to 31 October 2011. PSCB solution treatments were consisted of 1 time dilution (52N), 13 times dilution (4N), 26 times dilution (2N), and 52 times dilution (1N) which were based on the nitrogen concentration of a commercial liquid fertilizer for leafy vegetables (control). Subirrigation system was used to cultivate lettuce plants in pots containing commercial growing medium. As a result, all growth characteristics were the highest at control. Among PSCB treatments, PSCB 52N induced severe growth disorder at 28 days after transplanting (DAT) probably due to too high salinity. PSCB 1N also retarded the growth of ‘Salanova’ lettuce plants. This may be caused by high pH and/or imbalanced other mineral concentration except nitrogen of PSCB solution. In contrast, polyphenolic compounds with antioxidant properties were more abundant in lettuce with PSCB solution than control. However, further study is required to determine the certain factors of PSCB on the induction of phytochemical biosynthesis pathway. In conclusion, additional strategies should be developed to use PSCB solution as nutrient solution in greenhouses.

실시간 분광 엘립소메트터를 이용한 a-Si박막의 crystallization현상 연구

오영록,최은호,이기용,방경윤,안일신,김옥경 한양대학교 이학기술연구소 2004 이학기술연구지 Vol.7 No.

실시간 측정과 in-situ 측정을 하기 위해 실시간 분광 엘립소메트터 (real-time spectroscopic rotating compensator ellipsometer) 를 제작 방법을 연구하였다. 높은 온도 에서 얻어지는 Poly-Silicon은Glass에 변형이 생기므로 저온에서의 Poly-Silicon을 만들기 위하여 ni기판에 a-Si 박막을 성장 시킨후 그위에 투명전극을 올려 300℃ 이하의 저온에서 Ni과 투명전극에 전기장을 걸어 주었을때 a-Si이 Poly-Silicon 으로 바뀌는 crystallization 현상을 직접 제작한 ellipsometer 를 이용하여 실시간으로 관찰하였다. We make real-time spectroscopic rotating compensator ellipsometer for real time measurement and in-situ measurement. We study a method to make Poly silicon after depositing amomhous silicon thin film by dc sputter system at different temperature and pressure. Amorphous silicon films of 30㎚ thickness were deposited on the Ni substrate, and then ITO films of 20㎚ thickness were deposited on the a-Si films. The sampie were crystallized below 300℃ in the electric field applied between the Ni and ITO.

버퍼층 및 열처리 효과가 CoFe/Cu 다층박막의 자기저항에 미치는 영향

오미영,송은영,이장로,김희중,김경민,김미양 숙명여자대학교 자연과학연구소 1996 자연과학논문집 Vol.- No.7

DC magnetron sputtering방법에 의해 Corning glass기판 위에 ?? 형태로 다층박막을 제작하여 버퍼층 종류(Fe, Cu, Cr, Ta)와 두께, 비자성층인 Cu두께 변화에 관한 자기저항비의존성을 조사하였다. 또한 이들 시료에 대하여 열처리를 행한 후 열처리가 이 시료의 구조, 자기적 성질 및 자기저항에 미치는 영향을 조사하였다. Fe버퍼층의 두께가 60Å일 때 극대 자기저항비가 14%인 자기저항이 관찰되었고 Fe버퍼층과 Cr버퍼층을 갖는 시료를 비교한 경우 자기저항비는 그다지 차이가 없으나 Fe버퍼층이 있는 경우에 더 큰 포화자기장 및 자기 이력현상을 나타내었다. 250℃까지의 시료에 대한 열처리는 다층박막의 주기성을 유지한채 더 큰 결정립을 갖게 하여 자기저항비는 증가하였으나 그 이상의 온도에서는 계면 혼합 및 계면 확산에 의한 감소를 나타내었다. Giant magnetoresistance (GMR) and magnetic properties of CoFe/Cu multilayers prepared by dcmagnetron sputtering has been studied. We investigated the effect of Fe buffer layer thickness, different buffer layers, and annealing condition on GMR. For the 60Å Fe buffer layer thickness, maximum MR ratio 14% was found. When we have used different buffer layers, multilayers with Cr and Fe buffer show similar GMR magnitude, but multilayers with an Fe buffer have much higher saturation fields and hysteresis. The study of the dependence of the MR behaviors on annealing temperature, the MR ratio was increased to 250℃, but reduced at the temperature higher than 300℃ because of the interfacial diffuse.