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Zheng, Zhen Nu,Lee, Soon-W. Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.6
Two lanthanide complexes, $[Ln(NO_3)_2(H_2O)_3(L)_2](NO_3)(H_2O)$ {Ln = Eu (1), Tb (2); L = 2-(4-pyridylium)-ethanesulfonate, $(4-pyH)^+-CH_2CH_2-SO_3^-)$}, were prepared from lanthanide nitrate and 4-pyridineethanesulfonic acid in $H_2O$ under microwave-heating conditions. Complexes 1 and 2 are isostructural, and the lanthanide metal in both complexes is coordinated to nine oxygen atoms. The pyridyl nitrogen in the ligand is protonated to give a zwitter ion that possesses an $NH^+$ (pyridyl) positive end and an $SO_3^-$ negative end. All O-H and N-H hydrogen atoms participate in hydrogen bonds to generate a two-dimensional (complex 1) or a three-dimensional network (complex 2). Complex 1 exhibits an intense red emission, whereas complex 2 exhibits an intense green emission in the solid state at room temperature.
Zhen Nu Zheng,이순원 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.6
Two lanthanide complexes, [Ln(NO_3)_2(H_2O)_3(L)_2](NO_3)(H_2O) {Ln = Eu (1), Tb (2); L = 2-(4-pyridylium)-ethanesulfonate, (4-pyH)^+-CH_2CH_2-SO_3^–)}, were prepared from lanthanide nitrate and 4-pyridineethanesulfonic acid in H_2O under microwave-heating conditions. Complexes 1 and 2 are isostructural, and the lanthanide metal in both complexes is coordinated to nine oxygen atoms. The pyridyl nitrogen in the ligand is protonated to give a zwitter ion that possesses an NH^+ (pyridyl) positive end and an SO_3^– negative end. All O−H and N−H hydrogen atoms participate in hydrogen bonds to generate a two-dimensional (complex 1) or a threedimensional network (complex 2). Complex 1 exhibits an intense red emission, whereas complex 2 exhibits an intense green emission in the solid state at room temperature.
김용주,Zhen Nu Zheng,Hyuck Hee Lee,이순원 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.9
Dinuclear Ni(II)–thiophene halides, which contain linear bridging thienylenes, trans,trans-[(PR_3)_2(X)Ni–Y–Ni(X)(PR_3)_2] {X = Cl, Br; H2Y = 5,5'-dichloro-2,2'-bithiophene (H2bth); H2tth = 5,5''-dichloro-2,2':5',2''-terthiophene (H_2tth)} were prepared by the oxidative addition of dihalobithiophene (H_2bth) or dihaloterthiophene (H_2tth) to [Ni(COD)_2] in the presence of tertiary phosphines. Subsequent reactions of NaN_3 with the dinuclear Ni(II)–thiophene chlorides gave the corresponding Ni(II)–azido complexes, trans,trans-[(PR_3)_2(N_3)Ni–Y–Ni(N_3)(PR_3)_2], whose reactivity toward trimethylsilyl pseudohalides such as trimethylsilyl isothiocyanates and cyanides was investigated. In addition, the reaction of trans-[BrNi(PEt_3)_2–C_4H_2S–C_4H_2S–CHO], a thienyl Ni(II) complex containing a terminal aldehyde group, with phosphonium ylide was examined.
Sun Hwa Han,Zhen Nu Zheng,Sung Il Cho,이순원 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.6
Three isostructural lanthanide coordination polymers, [Ln(L)3(H2O)2](H2O)3 {Ln = Eu (1), Tb (2), Gd (3); L = trans-3-(3-pyridyl)acrylate, (3-py)–CH=CH–COO}, were prepared from HL, lanthanide nitrate, and NaOH in H2O by microwave heating. In all coordination polymers, the metal is bonded to eight oxygen atoms, and all pyridyl nitrogen atoms do not coordinate to the metals. All polymers have a 1-D loop-connected chain structure. The hydrogen atoms in the aqua ligands and lattice water molecules all participate in the hydrogen bonds of the O–H···O or O–H···N type. The hydrogen bonds connect the 1-D chains to create a 2-D network. Polymer 1 exhibited red luminescence in the solid state at room temperature.
Han, Sun-Hwa,Zheng, Zhen Nu,Cho, Sung-Il,Lee, Soon-W. Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.6
Three isostructural lanthanide coordination polymers, $[Ln(L)_3(H_2O)_2](H_2O)_3$ {Ln = Eu (1), Tb (2), Gd (3); L = $trans$-3-(3-pyridyl)acrylate, (3-py)-CH=CH-COO}, were prepared from HL, lanthanide nitrate, and NaOH in $H_2O$ by microwave heating. In all coordination polymers, the metal is bonded to eight oxygen atoms, and all pyridyl nitrogen atoms do not coordinate to the metals. All polymers have a 1-D loop-connected chain structure. The hydrogen atoms in the aqua ligands and lattice water molecules all participate in the hydrogen bonds of the O-$H{\cdots}O$ or O-$H{\cdots}N$ type. The hydrogen bonds connect the 1-D chains to create a 2-D network. Polymer 1 exhibited red luminescence in the solid state at room temperature.
A Fusion Protein of Derp2 Allergen and Flagellin Suppresses Experimental Allergic Asthma
Wenzhi Tan,Jin Hai Zheng,Tra-My Nu Duong,고영일,이시은,이준행 대한천식알레르기학회 2019 Allergy, Asthma & Immunology Research Vol.11 No.2
Purpose: The house dust mite (HDM) is one of the most important sources of indoor allergens and a significant cause of allergic rhinitis and allergic asthma. Our previous studies demonstrated that Vibrio vulnificus flagellin B (FlaB) plus allergen as a co-treatment mixture improved lung function and inhibited eosinophilic airway inflammation through the Toll-like receptor 5 signaling pathway in an ovalbumin (OVA)- or HDM-induced mouse asthma model. In the present study, we fused the major mite allergen Derp2 to FlaB and compared the therapeutic effects of the Derp2-FlaB fusion protein with those of a mixture of Derp2 and FlaB in a Derp2-induced mouse asthma model. Methods: BALB/c mice sensitized with Derp2 + HDM were treated with Derp2, a Derp2 plus FlaB (Derp2 + FlaB) mixture, or the Derp2-FlaB fusion protein 3 times at 1-week intervals. Seven days after the final treatment, the mice were challenged intranasally with Derp2, and airway responses and Derp2-specific immune responses were evaluated. Results: The Derp2-FlaB fusion protein was significantly more efficacious in reducing airway hyperresponsiveness, lung eosinophil infiltration, and Derp2-specific IgE than the Derp2 + FlaB mixture. Conclusions: The Derp2-FlaB fusion protein showed a strong anti-asthma immunomodulatory capacity, leading to the prevention of airway inflammatory responses in a murine disease model through the inhibition of Th2 responses. These findings suggest that the Derp2-FlaB fusion protein would be a promising vaccine candidate for HDM-mediated allergic asthma therapy.
Kim, Yong-Joo,Lee, Hyuck-Hee,Zheng, Zhen Nu,Lee, Soon-W. Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.9
Dinuclear Ni(II)-thiophene halides, which contain linear bridging thienylenes, trans,trans-[$(PR_3)_2$(X)Ni-Y-Ni(X)$(PR_3)_2$] {X = Cl, Br; $H_2Y$ = 5,5'-dichloro-2,2'-bithiophene ($H_2bth$); $H_2tth$ = 5,5"-dichloro-2,2':5',2''-terthiophene ($H_2tth$)} were prepared by the oxidative addition of dihalobithiophene ($H_2bth$) or dihaloterthiophene ($H_2tth$) to [$Ni(COD)_2$] in the presence of tertiary phosphines. Subsequent reactions of $NaN_3$ with the dinuclear Ni(II)-thiophene chlorides gave the corresponding Ni(II)-azido complexes, trans,trans-[$(PR_3)_2(N_3)$Ni-Y-Ni$(N_3)(PR_3)_2$], whose reactivity toward trimethylsilyl pseudohalides such as trimethylsilyl isothiocyanates and cyanides was investigated. In addition, the reaction of trans-[$BrNi(PEt_3)_2-C_4H_2S-C_4H_2S$-CHO], a thienyl Ni(II) complex containing a terminal aldehyde group, with phosphonium ylide was examined.
Kim, Hyun‐,Kyung,Lee, Jung‐,Hyun,Kim, Yong‐,Joo,Nu Zheng, Zhen,Lee, Soon W. WILEY‐VCH Verlag 2013 European journal of inorganic chemistry Vol.2013 No.28
<P><B>Abstract</B></P><P>Dinuclear (π‐allyl)palladium chlorides, [(π‐allyl)Pd(μ‐Cl)]<SUB>2</SUB>, were cleaved by N‐heterocyclic carbenes (NHCs) to give mononuclear (π‐allyl)palladium–NHC chlorides, [(π‐allyl)Pd(Cl)(NHC)] (<B>1</B>–<B>6</B>) [NHC = 1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene (IPR), 1,3‐bis(2,6‐diisopropylphenyl)‐4,5‐dihydroimidazol‐2‐ylidine (SIPR), 1,3‐bis(2,4,6‐trimethylphenyl)imidazol‐2‐ylidene (IMes)]. Complexes <B>1</B>–<B>6</B> were subsequently treated with aqueous NaN<SUB>3</SUB>, KSCN, KOCN, and CF<SUB>3</SUB>COOAg to produce the corresponding mononuclear (π‐allyl)palladium–NHC pseudohalogen complexes, [(π‐allyl)Pd(X)(NHC)] (X = N<SUB>3</SUB>, NCS, SCN, NCO, CF<SUB>3</SUB>COO) (<B>7</B>–<B>30</B>). These products could also be obtained by treating dinuclear pseudohalogen‐bridged Pd complexes, [(π‐allyl)Pd(μ‐X)]<SUB>2</SUB>, which were prepared by replacing the μ‐Cl ligand in [(π‐allyl)Pd(μ‐Cl)]<SUB>2</SUB>, with aqueous NaN<SUB>3</SUB>, KSCN, KOCN, or CF<SUB>3</SUB>COOAg, followed by cleavage with the NHCs. Reactions of [(π‐allyl)Pd(N<SUB>3</SUB>)(NHC)] with organic isothiocyanates (R–NCS) or CH<SUB>3</SUB>O(CO)C≡CO(CO)CH<SUB>3</SUB> resulted in selective 1,3‐dipolar cycloaddition into the Pd–azido bond to give heterocyclic compounds. By contrast, analogous reactions of [(η<SUP>3</SUP>‐allyl)Pd(N<SUB>3</SUB>)(IPr)] with an organic isocyanide (R–NC: R = <I>tert</I>‐butyl, benzyl) gave the adduct [(η<SUP>3</SUP>‐allyl)Pd(N<SUB>3</SUB>)(IPr)]<B>·</B>(R–NC) as the only product or a mixture of the adduct and a dipolar cycloaddition product, [(η<SUP>3</SUP>‐allyl)Pd{CN<SUB>4</SUB>(R)}(IPr)], depending on the isocyanides used. Finally, a series of (π‐allyl)Pd–NHC pseudohalogen complexes, [(π‐allyl)Pd(X)(NHC)], exhibited high catalytic activity in Suzuki–Miyaura cross‐coupling reactions of aryl chlorides with arylboronic acids.</P>