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신경피부멜라닌증 환자의 두개강내에 발생한 원발성 악성 흑색종 : Case Report
노재섭,황금,한용표,김헌주,홍순기,허철,변진수 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.10
An unusual case of neurocutaneous melanosis is presented. The patient had congenital dermal nevi, and displayed multicentric malignant cerebral melanoma associated with hydrocephalus and seizure in adult life. This suggests that a patient with congenital dermal nevus or marked generalized cutaneous pigmentation should be closely observed for the development of malignant melanoma of the nervous system.
외과 영역에 있어서 Venoplant^(R)의 임상적 고찰
김재호,노승무,장일성,배진선,손기섭 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2
The clinical effects of Venoplant^(R) was observed in 30 cases with conditions that a surgical management has been taken. Venoplant^(R) was administered via intravenous root with 2 to 5 ml, 2 to 4 times per one day for postoperatively 3 to 7 days. An overall effectiveness rate was 66.6% and mild nausea was observed in one case. In conclusion, Venoplant^(R) was effective in the edema, pain, and redness on the wound.
장자영,노순국,김송민,김재섭,허영팔,박창균 조선대학교 동력자원연구소 1997 動力資源硏究所誌 Vol.19 No.1
Being adopted the Cellular Systems in Korea, the method of a radio repeater is that the mobile station(MS) can be used only in a service area of the base station(BS). In case that traffic congestion is occured around the specific BS because of an event etc., the traffic blocking rates are being maximized and the subscriber service is being dropped. To improve these problems, we propose an algorithm for a radio repeater network that distributes the traffics of the specific BS, predicted traffic congestion, to an adjacent BS by sharing a service area. And then, we confirm the valid through the simulation.
장자영,노순국,박종천,김재섭,박성렬,박창균 조선대학교 동력자원연구소 1996 動力資源硏究所誌 Vol.18 No.1
To predict accurately an antenna radiation pattern is very important for determining of a service area, base-station location, cell design. In this paper, we have calculated a propagation prediction data of Hata, Egri, Carey, Free Space Loss model by a computer simulation in Kwang-ju downtown, and the data is compared with field test data. As a results, Hata and Egri model are approached to field test data, but considerable errors are detected.Conclusively, we believe that the most accurate prediction model must propose to improve the radio propagation environments for the specified region. For resolve these problems, we are proposed a mew experimental radio wave propagation predict model.
자발성 뇌실질내 혈종에 대한 Hematome과 Urokinase를 이용한 뇌정위적 혈종 흡인술에 대한 임상적 분석
노재섭,변진수,허철,홍순기,김헌주,한용표 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.4
We had tried to perform mechanical aspiration using Hematome and fibrinolytic drainage with Urokinase for treatment of spontaneous intracerebral hematoma(SICH) in 24 patients. Mean initial volume of SICH was 53.65 26.34㎖, mean evacuated amount of SICH after Hematome procedure was 46.25 23.64%, and mean evacuated amount of SICH after fibrinolytic drainage after Urokinase was 74.15 20.89%, compared with pre-operative status. We could aspirate more than 50% of hematoma if the Hematome procedure had been performed within 18 hours after ictus(p=0.0306). The rebleeding rate after Hematome procedure was 8.3%, and overall mortality rate was 12.5%. These results seem to indicate mechanical aspiration using Hematome and fibrinolytic drainage with Urokinase might be one of the useful method for treatment of SICH.
노재경,김계남,윤견일,박이갑,박문규,최용만,한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1984 EMJ (Ewha medical journal) Vol.7 No.4
The nonfunctioning islet cell tumors of pancreas are not associated with obvious sign and symptoms of hormone overproduction. Symptoms, most commonly pain and jaundice, are due to the mass effect of the tumor and invasion of the surrounding structures, and unlike functioning tumors, the location of the tumor has a direct bearing on the patient's symptoms. We have experienced a case of benign nonfunctioning islet cell tumor of the pancreas in 47-year-old female. She was admitted to our hospital due to palpable large mass of her abdomen. She had no obvious sign and symptoms of hormone overproduction. The exploratory laparatomy was done under the impression of retroperitoneal tumor with the information of radiologic finding and abdominal C-T scan. The pathologic diagnosis was benign nonfunctioning is-let cell tumor of the pancreas.
자궁내막암 환자의 임상병리학적 예후인자에 따른 생존율 분석
노재홍(Jae Hong Noh),이지수(Ji Soo Lee),이용승(Yong Seung Lee),이수호(Soo Ho Lee),최중섭(Joong Sub Choi),김영아(Young A Kim),박창수(Chang Soo Park),김병기(Byoung Gie Kim),이제호(Je Ho Lee),배덕수(Duk Soo Bae) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.10
목적 : 자궁내막암 환자의 임상병리학적 양상을 확인하고 예후인자에 따른 생존율을 분석하고자 하였다. 연구 방법 : 1995년 1월부터 2001년 12월까지 삼성서울병원에서 자궁내막암으로 진단 및 치료받은 111의 환자를 대상으로 하였다. 환자들의 의무기록을 통하여 연령, FIGO 수술적 병기, 세포 유형, 종양의 크기, 세포분화도, 자궁근층 침윤정도, 그리고 림프절 전이를 확인하였으며, 환자의 생존 여부는 마지막 병원 방문과 전화 연락을 통하여 조사하여 각각의 예후인자에 따른 생존율을 구하였다. 결과 : 자궁내막암의 중앙 연령은 52세였으며, 연령별 분포는 21세부터 79세까지였다. 임상 병기별 분포는 Ⅰ기가 84예 (82.0%), Ⅱ기가 16예 (8.1%), Ⅲ기가 10예 (9.0%), Ⅳ기가 1예 (0.9%)였다. 치료 방법은 전체 환자 111명 모두 수술적 치료가 시행되었으며, 수술 후 방사선 치료 60예 (54.1%), 수술 후 항암요법 5예 (4.5%)에서 시행되었다. 세포분화도 1이 73예 (65.7%), 2가 19예 (17.1%), 3이 14예 (12.6%)로 나타났으며, 침윤정도는 자궁내막에만 국한되어 있었던 경우가 37예 (33.3%), 1/2 이하인 경우가 47예 (42.3%), 1/2 이상이 26예 (24.3%)를 나타냈고, 림프절 전이는 6예 (5.4%)가 있었다. 전체 자궁내막암 환자 111예의 5년 무병생존울은 86.5%, 5년 생존율은 87.8%였다. FIGO 수술적 병기에 따른 무병 생존율 및 5년 생존율은 각각 제 1기가 92.8%, 93.3%, 제 2기가 80.0%, 80.0%, 제 3기가 57.1%, 85.7%였으며, 그 외에 발생연령, 림프-혈관 침범 유무, 자궁근층의 침범 정도, 림프절 전이 유무, 그리고 C-erb-B2 발현 여부가 생존율에 영향을 미치는 예후 인자였다. 그러나 수술 전 CA-125상승, 자궁경부 세포진 검사 결과, 에스트로겐 수용체나 프로제스테론 수용체의 유무, p53 유전자 유무는 생존율에 통계적으로 유의한 영향을 미치지 않았다. FIGO 병기 제 Ib기와 제Ic기에서 보조적 방사선 치료를 시행한 군은 재발 위험 인자를 가진 군이라는 것을 고려한다면 비슷한 생존율을 나타낸 것은 수술 후 방사선 치료가 재발 방지에 효과적일 수 있다는 가능성을 제시한다고 할 수 있겠다. 결론 : 이상의 결과에서 FIGO 수술적 병기, 세포분화도, 자궁근층 침범정도, 림프-혈관 침범 유무, 림프절 전이, 연령, C-erb-B2의 발현은 자궁내막암 환자에 미치는 유사한 인자라고 추정되었다. Objective : This study was performed to evaluate the clinicopathologic characteristics and prognostic factors of uterine endometrial cancer affecting survival of the patients. Methods : Form Jan. 1995 to Dec. 2001, medical records including operation record and pathologic reports of 111 patients with histologically proven endometrial cancer at Samsung Medical Center were reviewed. The survival of patients was determined by description of last follow up date in medical records or phone calls. Results : The median age of all patients was 52 years and the most common presenting symptom was abnormal vaginal bleeding (74.0%). Histologic type of endometrioid adenocarcinoma was the most common (90%) type of all endometrial cancers. The grades were classified into G1 (65.7%), G2 (17.1%), G3 (12.6%) and unknown (4.5%). The FIGO surgical stage was also classified into stage I (75.7%), stage Ⅱ (14.4%), stage Ⅲ (9.0%), and stage Ⅳ (0.9%). All patients were treated by primary surgery and postoperative adjuvant therapy including radiation therapy (54.1%), chemotherapy (4.5%) was applied. The overall 5-year disease free survival rate (DFSR) was 86.5% and overall 5-year survival rate was 87.8%. The age (p=0.04), grade (p=0.04), myometrial invasion (p=0.047), FIGO surgical stage (p=0.0067), lymph node metastasis (p=0.0001), lymphovascular space invasion (p=0.01) and C-erb B2 (p=0.04) were significant prognostic factors by univariate analysis. Conclusion : The age, grade, myometrial invasion, FIGO surgical stage, lymph node metastasis, lymphovascular space invasion and C-erb B2 were significant prognostic factors of uterine endometrial cancer affecting survival of the patients.
The Effect of Acute Stress on Esophageal Motility and Gastroesophageal Reflux in Healthy Humans
( Hong Sub Lee ),( Chung Kyun Noh ),( Kwang Jae Lee ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.1
Background/Aims Little research has been done to evaluate the effect of stress in exacerbating the symptoms associated with gastroesophageal reflux (GER). We aimed to investigate the effect of acute stress on esophageal motility and GER parameters in healthy volunteers. Methods A total of 10 (M:F = 8:2, median age 34 years-old) healthy volunteers without any recurrent gastrointestinal symptoms participated in this study. They underwent esophageal high-resolution manometry with 10 wet swallows (Experiment I) and esophageal impedancepH monitoring (Experiment II) in the basal period and in the stress period. In the stress period, either real stress or sham stress was given in a randomized cross-over design. The stress scores, symptom severity, and pulse rates were measured. Results The stress scores and the severity of nausea were significantly greater under real stress, compared with sham stress. The percentages of weak, failed, rapid, premature, and hyper-contractile contractions were not significantly altered during real stress and during sham stress, compared with the basal period. The median resting pressure of the lower esophageal sphincter and distal contractile integral of esophageal contractions did not differ in the stress period, compared with the basal period. Contractile front velocity and distal latency of esophageal peristaltic contractions were significantly changed during real stress, which was not observed during sham stress. GER parameters were not significantly altered during real stress and during sham stress. Conclusion Although acute auditory and visual stress seems to affect esophageal body motility, it does not induce significant motor abnormalities or increase GER in healthy humans. (J Neurogastroenterol Motil 2017;23:72-79)