양식 은어의 미포자충 감염예에 대한 병리조직학적 관찰

조병열,강형길,강효주,류갑민,이재영,박남규,허민도 한국어병학회 2003 한국어병학회지 Vol.16 No.1

1998년 9월 말경, 경남 지역의 양식 은어(Plecoglossus altivelis)에서 미포자충증이 발생하였다. 채집 당시, 하루 약 200마리씩의 폐사가 10일째 진행되고 있었으며 약 10%의 누적폐사율을 나타내었다. 병어는 입올림을 하거나 기면 상태에 있었으며, 대부분 체색흑화 및 복부팽만 소견을 보이고 있었다. 아가미, 아가미 뚜껑, 각종 내장, 복강벽 및 생식소에 직경 1~3㎜의 흰색 결절이 다수 형성되어 있었다. 감염 어종, 기생충의 형태 및 xenoma 분포 장기의 다양성에 근거하여 Glugea plecoglossi에 의한 감염증으로 추정되었다. 병리조직학적 검사를 실시한 결과, 광범위한 장기에 걸쳐 xenoma를 형성하고 있었으나 xenoma 인접조직에 변성 변화는 없었다. 아가미 새변, 비장, 두신 및 체신의 조혈영역에 심한 울혈 소견이 인정되었고, 간장, 심근 및 신세뇨관 국소에는 응고 내지 액화괴사 소견이 확인되었다. 따라서, xenoma의 인접조직에 대한 물리화학적인 영향보다는 xenoma형성 장기 및 조직에 야기된 국소 순환장애가 은어의 폐사와 직접적인 관련을 갖는 것으로 사료되었다. On September in 1998, a microsporidian infection was recognized in ayu, Plecoglossus altivelis, farmed on Kyongnam province of South Korea. Cumulative mortality was around 10% in 10 days. Infected fish which were piping for air near the surface of the water or in the asphyxic, lethargic condition revealed darkening of body and abdominal distention. Numerous whitish nodules up to 3㎜ in size were observed throughout most of body organs and tissues including gill, operculum, peritoneal wall and organs. Xenomas were also histologically confirmed in multiple internal organs with the evidences suggesting circulatory disturbance. Based on the morphology of spore and xenoma, and the distribution of xenomas in organs and tissues, this disease was diagnosed to be a microsporidiosis caused by Glugea plecoglossi. The mortality might be deeply related to the local circulatory disturbance by xemonas rather than the mechano-chemical effect of xenomas on adjacent tissues.

손상받은고양이 줄무늬체에서 축삭반응에 관한 미세구조적 연구

양남길,조영열,안의태,고정식,박경호,김진국 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.3

머리에 방사선상해를 입은 흰쥐의 운동조절계에 대한 전자현미경적 연구 - Ⅱ. 방사선조사를 받은 흰쥐 뇌송과체의 미세구조에 대한 연구

조태승,양남길,안의태,고정식 대한해부학회 1991 Anatomy & Cell Biology Vol.24 No.1

알코올이 흰쥐 소뇌피질의 복합당질에 미치는 영향에 관한 조직화학적 연구

조지은,정길남,조운복 부산대학교 과학교육연구소 2006 교사교육연구 Vol.45 No.-

This study was performed to investigate the effects of 10% alcohol on the changes of histological structure and glycoconjugates in rats cerebellar cortex. Sprague-Dawley rats weighing about 200~250 g were divided into control and 10% alcohol treated groups. The treated group with 10% alcohol was divided into 4 subgroups; 1, 2, 4 and 6 weeks alcohol treatment. To investigate the distribution and change of glycoconjugates, nine biotinylated lectins (DBA, SBA, PNA, BSL-1, RCA-1, sWGA, UEA-1, LCA and Con A) were applied according to the avidin-biotin-peroxidase complex methods. The morphological changes in the cerebellar cortex of the 10% alcohol groups were significant compared with the control group. In 10% alcohol groups for 2 and 4 weeks, molecular layer of cerebellar cortex was separated, and number of cells in molecular layer and Purkinje layer decreased. Purkinje cell layer and granular layer were separated. There were extended separation between molecular layer and granular layer matrix, abnormal multiplication and extention of layers. Especially, nerve cells showed histopathological lesions, such as lysis, depression and crush. Because of cerebellar Purkinje cell degeneration, Purkinje cell was fallen apart or got buried in granular layer. In 10% alcohol groups for 6 weeks, size of cerebellar cortex decreased and number and size of cells were also decreased. The change in RCA-1 binding was similar to both drinking and control groups. sWGA binding compared with the control group was decreased 2 and 4 weeks alcohol drinking groups, but showed tendency to increase in 6 weeks group. All lectins binding except sWGA and RCA-1 appeared tendency to increase in drinking groups, especially, LCA binding was notably increased in 6 weeks alcohol drinking group. In conclusion, the present study suggests that alcohol induce significant changes in the morphological structures and glycoconjugates in the rat cerebellar cortex. 흰쥐 소뇌피질의 형태적 구조와 복합당질에 알코올이 미치는 영향을 규명하기 위해 체중 200~250g의 Sprague-Dawley계 흰쥐를 대조군과 알코올음용군으로 나누고 알코올음용군은 10% 알코올을 계속 음용시켜 1주군, 2주군, 4주군, 6주군으로 나누어 연구하였다. 소뇌 피질의 복합당질의 양상을 9종의 biotinylated lectin(DBA, SBA, PNA, RCA-1, sWGA, UEA-1, LCA, Con A, BSL-1)으로 관찰하였다. 알코올음용군에서 소뇌피질의 형태적인 변화를 관찰한 결과 음용기간에 따라 현저한 변화가 나타났다. 알코올음용 1주군에서 대조군과 유의미한 변화가 나타나지 않았으나, 알코올음용 2주 및 4주군의 소뇌피질의 분자층 세포들과 조롱박세포의 수가 크게 줄어들었으며 조롱박층이 과립층과 분리되는 경향이 나타났고 분자층과 과립층 기질이 나누어지며 비정상적인 증식 및 층의 확장 경향이 나타났다. 특히 신경세포들이 용해되거나 신경세포의 모양이 찌그러지고 함몰되는 현상이 나타났으며, 소뇌 조롱박세포의 변성으로 조롱박 세포가 탈락되어지거나, 과립층에 묻혀 구분되지 않는 현상도 나타났다. 알코올음용 6주군에서는 전체적인 소뇌피질의 크기 감소와 더불어 신경세포의 수와 크기가 크게 감소하며 조롱박세포의 함몰, 찌그러짐, 용해현상이 심하게 나타나며 신경세포 이상증식에 의한 다층화가 나타났다. 알코올음용군 흰쥐 소뇌피질의 세포들의 복합당질에 대한 렉틴결합양상은 RCA-1의 경우 대조군에 비해 변화가 없었으나, sWGA는 알코올음용 2주군, 4주군에서 대조군에 비해 감소되었다가 알코올음용 6주군에서 회복되는 경향을 보였다. 그 외 렉틴반응은 증가하는 경향을 나타내었으며 특히 LCA는 알코올음용 6주군에서 많이 증가하였다. 이상의 결과로 보아 알코올섭취는 소뇌피질의 신경세포의 형태적 변화 그리고 복합당질 대사에 심한 영향을 미치는 것으로 사료된다.

상사성을 고려한 배수재 설치 연약점토 지반의 원심모델링

유남재,홍영길,정길수,조한기 강원대학교 산업기술연구소 2007 産業技術硏究 Vol.27 No.A

This paper is results of experimental research on the effect of application of similarity related to permeability of soil on the consolidation behavior as centrifuge modeling of consolidation is performed with the centrifuge model facility. In this research, the permeability of soil was controlled by changing the viscosity of porewater as the mixed water with glycerin was used during the centrifuge model experiments. The effect of drainage path on consolidation was investigated by installing the vertical drains. A serise of centrifuge model tests with conditions of single vertical and radial horizontal drainage were carried out. Kaolinite and Jumunjin standard sand were used as soft clay and surcharges respectively during tests. For testing condition of single vertical drainage considering similarity of permeability, it was found that consolidation with mixed porewater with glycerin was delayed in comparisons with test results with water only. For conditions of horizontal drainage with vertical drains, a low permeability by changing the viscosity of pore water resulted in delayed degree of consolidation at an initial stage of consolidation. But, it predicted not much differences in settlement as long as the consolidation time was sufficiently long enough to finish consolidation. Consequently, it was found that similarity in permeability should be considered to be critical for the case of centrifuge model experiments related to consolidation with long drainage path.

심근부종으로 표현된 과호산구증에 동반된 호산구성 심근염 1예

심미승,안영미,조홍근,신길자,정남식,조상호 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.2

Automating Quality system - New Rules for Pattern Identification in Control Charts

( Nam Gil Cho ) 고려대학교 공학기술연구소 1996 생산기술연구소보 Vol.3 No.-

Validity of the Transverse Abdominis Thickness Change for Abdominal Draw-in Maneuver Using Biofeedback Sensor

Nam-Goo Kang(Nam-Goo Kang),Jong-Gil Seo(Jong-Gil Seo),Won-Nyeong Cho(Won-Nyeong Cho),Jin-Wook Sung(Jin-Wook Sung) 한국임상움직임치료학회 2022 한국임상움직임치료학회지 Vol.2 No.2

Background Transverse abdominis (TrA) is an important local muscle that plays an essential role in the core. Ultrasound imaging is a reliable and valid technique for analyzing TrA muscle thickness. However, this method requires skilled operators. Biofeedback devices have achieved similar clinical outcomes to ultrasound. Even so, few studies have examined the validity of this biofeedback. Objectives This study aimed to assess whether changes in waist circumference, as determined by changes in the thickness of TrA detected with a stretch sensor made with a biofeedback device, produce results similar to those obtained through ultrasound. Methods Nineteen healthy participants were recruited for this study. Ultrasound measurement of the thickness of TrA was compared with the simultaneous measurement of the stretch sensor biofeedback device. Results Acceptable validity was found between the thickness of the TrA and the stretch sensor displayed on-screen waist circumference (Pearson correlation = -0.69, p = 0.03). Conclusions The study confirmed that changes in the grape bar on the screen of the stretch sensor application could be employed as a suitable indicator for assessing the changes to the thickness of the TrA muscle.

호산구증가증과 PDGFRB 유전자 재배열을 보인 골수 종양 1예

조남길 ( Nam Gil Cho ),김대진 ( Daejin Kim ),심민정 ( Minjung Shim ),정소영 ( So Young Chong ) 대한내과학회 2017 대한내과학회지 Vol.92 No.1

본 증례에서 알 수 있듯이 PDGFRB 골수증식 종양에서 im-atinib의 사용은 과호산구증가증의 자연 경과에 지대한 영향을 미쳤다. 과거 imatinib을 사용하지 않던 환자들의 경우 2년 생존율이 55% 정도였던 것에 비해 imatinib을 사용하는 경우 10년 생존율이 90%로 극적인 상승이 있었다. 따라서 과호산구증가증 보이는 경우 PDGFRB 재배열을 동반한 골수 종양에 대한 고려가 반드시 필요하며 분자유전학적으로 PDGFR재배열을 보일 경우 즉시 imatinib의 치료가 필요하다. Myeloid neoplasia with eosinophilia and platelet-derived growth factor receptor beta (PDGFRB) rearrangements is an uncommon Philadelphia-negative myeloproliferative neoplasm. Their most common morphological diagnosis is chronic myelomonocytic leukemia with eosinophilia, which is associated with t(5;12)(q33;p13) and results in the formation of the ETV6-PDGFRB fusion gene. Here, we report a 49-year-old man with a myeloid neoplasm with a PDGFRB rearrangement, who was incidentally diagnosed with hyperleukocytosis and eosinophilia during a health screening. A chromosome analysis of a bone marrow sample revealed 46, XY, t(5;12)(q33;p13), and fluorescence in situ hybridization analysis revealed the PDGFRB gene rearrangement. The patient was treated with imatinib and subsequently achieved complete hematological and molecular remission. (Korean J Med 2017;92:79-83)

Integrated Graphical Presentation of Fabric Sound and Mechanical Properties

Cho, Gil-Soo,Lim, Nam-Kyoo,Yang, Yoon-Jung 한국섬유공학회 2010 FIBERS AND POLYMERS Vol.11 No.3

This paper proposes a new model capable of predicting frictional sounds of woven fabrics, knitted fabrics and vapor permeable water repellent fabrics by measuring the relationships between their sound parameters and mechanical properties. We conducted an experiment in which fabric frictional sounds were recorded and analyzed. A total of 217 specimens consisting of woven fabrics, knitted fabrics, and vapor permeable water repellent fabrics were sampled, and their frictional sounds recorded using a Sound Quality System. Sound parameters of fabrics including SPL (Sound Pressure Level), Loudness (Z), Sharpness (Z), and mechanical properties by Kawabata Evaluation System (KES) were obtained. The relation between sound parameters and mechanical properties were analyzed by multiple regressions. Specimens were divided into 3 clusters using mechanical properties selected by stepwise selection method, and the mechanical properties of each cluster were investigated. Specimens were classified into clusters having high level of SPL and Loudness (Z), high level of Sharpness (Z), and middle level of Loudness (Z) and Sharpness (Z), which means that sound parameters are well verified by mechanical properties of the specimens. Mechanical properties relevant to each sound parameter were mapped on two dimensional spaces by integrated graphical presentation. SPL showed high positive correlation coefficients with MMD and LT. Loudness (Z) was well predicted by 2HG5 and Sharpness (Z) by MIU.