백일해 백신이 Streptozotocin 유발성 당뇨백서의 당대사에 미치는 영향

박상기,문경래,박춘호,김갑승,박영봉,이병래,양남웅 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

Streptozotocin(STZ) may produce a permanent form of insulin-dependent diabetes (IDD) in experimental animals. This STZ-induced diabetes has become an useful model to study the pathogenesis of IDD in man primarily because it approximate clinical findings and also because it lends itself easily to controlled manipulation. The diabetogenic activity of STZ, however, is known to be modified by several agents such as nicotinamide, diazoxide, adrenergic blockers and pertussis vaccine (PV). The present study was undertaken to observe the protective effect of PV or boiled pertussis vaccine(bPV; incubating the PV at 80℃ for 30 minutes) against the development of IDD induced by STZ in young rats, and also the effect of PV on the activities of glycolytic & gluconeogeneic enzymes in both liver and muscle of rat. PV at a dose of 1.2×10^(10) microorganism was administrated intrapntoneally on 3days before & 7days after a single injection of STZ (GO㎎/㎏ body wt). The blood glucose and insulin levels were measured at 1st wk, 2nd wk, 4th wk, 6th wk and 8th wk after STZ injection, and the enzyme activities were exemined at 8th wk. The following results were obtained. 1. No significant difference was noted in blood glucose levels between STZ group and STZ+PV or STZ+bPV groups (P>0.05). 2. Blood insulin levels in STZ group decreased significantly from 2nd wk(P<0.05). Compared with STZ group, blood insulin levels in STZ+PV & STZ+bPV groups were higher, but not a significant value except at 2nd wk in STZ+PV grouP (P<0.05). 3. Compared with STZ group, hepatic glycolytic enzyme activities were significantly increased in STZ+PV or STZ+bPV groups, and muscular glycolytic enzyme activities were significantly increased in STZ+PV or STZ+bPV groups. 4. Compared with STZ group, hepatic gluconeogeneic enzyme activities were significantly increased in STZ+PV or STZ+bPV groups. These results suggest that the PV has somewhat protective effects on blood insulin levels and tissue glycolytic enzyme activities in rats, but it could not reduced blood glucose levels significantly, probably because of excessive increase of hepatic gluconeogeneic enzymes.

장독소원성 대장균생산 내열성장독소의 장액분비자극에 대한 각종 약제의 억제효과

양남웅(Nam Ung Yang),박정평(Jung Pyong Park),이현국(Hyun Kook Rhee),주세혁(Se Hyuk Ju) 大韓微生物學會 1991 大韓微生物學會誌 Vol.26 No.3

운동의 심리·사회적 혜택

양명환,남사웅 濟州大學敎 體育科學硏究所 1999 체육과학연구 Vol.5 No.-

The participation in regular physical exercise can have positive effect on psycho-sociological changes as well as physiological-biochemical changes. Findings in literature concerning the special relationship between psychological wellbeing and regular physical activity have suggested that physical activity may modify state variable such as anxiety and depression. There is evidence that in addition to reducing levels of anxiety and depression. exercise can improve such psychological paramaters as self-confidence. feelings of control. self-determination. self-sufficiency. Exercise as an effective tool in promoting psychological wellbeing, positive and negative addiction to exercise are discussed. In sociological aspects. we have discussed socialization via sport. In general. sport proponents frequently claim that sport produce such desirable traits as democratic citizenship, moral character, adjusted personality. respect for constituted authority. cultivation of discipline. But at the other critics have condemned modern sport for excessive violence. overemphasis on winning. and exploitation of individuals. We have discussed in terms of these contrasting perspective. Whether traits. skills. and value learned in a specific sport context will carry over to other contexts depends upon several dimensions of social interaction.

환자, 병원 및 자연환경에서 분리된 녹농균의 감수성 분포와 혈청형

양남웅 中央醫學社 1989 中央醫學 Vol.54 No.3

Nocardia Otitidiscaviarum에 의한 피하농양 1예

양남웅,이현국,박정평,박영진,문대수,장숙진 대한감염학회 1991 감염 Vol.23 No.2

A 61-year-old-Korean woman suffering from hypopituitarism accompanied by thyroid insufficiency, adrenal insufficiency, Diabetes mellitus was examined for subcutaneous abscess on her left inner thigh. The causative organism was identified as Nocardia otitidiscaviarum. To our knowledge, the present case in the first known Korean case of primary cutaneous nocardiosis caused by Nocardia otitidiscaviarum.

CAPD 환자에서 복강대식세포의 탐식능과 살균능에 관한 연구

남철우 ( Nam Cheol U ),최영식 ( Choe Yeong Sig ),차태준 ( Cha Tae Jun ),안수열 ( An Su Yeol ),양상호 ( Yang Sang Ho ),박상은 ( Park Sang Eun ),이시래 ( Lee Si Lae ),유경식 ( Yu Gyeong Sig ),장명웅 ( Jang Myeong Ung ),주운수 ( Ju U 대한내과학회 1992 대한내과학회지 Vol.42 No.4

연구배경 : 지속성 복막투석 환자에서 복막방어 기전인 복강내의 opsonin 활성도 및 복강대식세포이 탐식능과 살균능의 저하가 복막염의 발생빈도를 높이는데 영향을 줄 것이다. 방법: 복막염 발생빈도가 높은 환자 9명과 복막염 발생빈도가 낮은 환자 9명을 대상으로 혈청 및 복강내의 IgG 농도를 측정하였고, 복강대식세포의 C. albicans에 대한 탐식능과 세포내 살균능 및 IgG 투여후에 탐식능과 살균능을 측정하였다. 결과 : 1) 대상환자의 평균연령, 평균복막투석 기간은 양군 사이에 유의한 차이가 없었고, 1인당 년간 복막염의 발생빈도는 HPI군이 5.2회, LPI군이 1.3회로 HPI군에서 유의하게 높았다(p<0.005). 2) 혈청 총단백의 값은 LPI군이 6.5g/dl로 HPI군의 5.9g/dl 보다 유의하게 높았으나(p<0.05), albumin, IgG, IgA, IgM, C3, C4 및 말초 백혈구수와 백혈구 백분율수의 값은 양군 사이에 유의한 차이가 없었다. 3) 복강세포수와 그것의 생존력은 양군 사이에 비스하였고 IgG값은 HP군의 6.3 ㎎/dl에 비해 LPI군은 7.4㎎/dl로 LPI군에서 더 높은 경향이 있었다. 4) 복강대식세포가 C. albicans와 접촉후 30분, 1시간, 2시간째의 탐식율은 HPI군이 각각 46.0, 55.6, 55.9%였으며 LPI군은 각각 47.7, 56.2. 62.6%로 LPI군이 HPI군에 비해 높은 경향이 있어고, 30분에서 2시간째까지 양군 모두에서 계속 증가하였다. 5) 복강대식세포의 C.albicans에 대한 세포내 살균율은 30분, 1시간, 2시간째에 HPI군이 가각 11.6, 17.5, 22.8 %였으며, LPI군은 각각 16.1, 22.6, 29.6%로 LPI군이 HPI군에 비해 유의하게 높았고 (p<0.05), 30분에서 2시간째까지 양군 모두에서 계속 증가하였다. 6) HPI군에서 IgG 0.025㎎을 혼합액에 첨가한 후 30분, 1시간, 2시간째의 탐식율은 각각 56.1, 61.3, 64.6%였고 살균율은 각각 15.3, 22.0, 24.9%로 2시간째의 살균율을 제외하고 투여전에 비해 유의하게 증가하였고(p<0.05), 30분에서 2시간째까지 계속 증가하였다. 7) LPI군에서 IgG 0.025㎎을 혼합액에 첨가한 후 30분, 1시간, 2시간째에 탐식율은 각각 57.4, 64.1, 65.5%였고 살균율은 각각 18.7, 28.9, 33.1%로 2시간째의 살균율을 제외하고 투여전에 비해 유의하게 증가하였고(p<0.05), 30부에서 2시간째가지 계속 증가하였다. 결론 : CAPD 환자에서 복강대식?W의 C. albicans에 대한 탐식능과 살균능은 hrakrdua이 많이 발생하는데 환자와 적게 발생하는 환자 사이에 유의한 차이가 없었으나, 더 많은 예에서 연구 검토되어야 할 것이고, IgG를 투여함으로써 탐식능과 살균능을 증가시킬 수 있었다. Background : Impairment of peritoneal defense mechanisms; i.e. opsonization, phagocytosis and intracellular killing would correlate with the high peritonitis rate in a subgroup of continuous ambulatory peritoneal dialysis (CAPD) patients. Methods : Serum and peritoneal IgG concentration, the phagocytosis and intracellular killing of Candida albicans (C. albicans) by peritoneal macrophages were measured in 9 patients with high peritonitis incidence (HPI: more than 3 episodes in 6 months) and 9 patients with low peritonitis incidence (LPI: less than 2 episodes in 12 months) on CAPD. Also, after addition of IgG, the phagocytosis and intracellular killing were measured. Results : 1) The average incidence of peritonitis was 5.2 ep./pt./yr. in HPI group and 1.3 ep./pt./yr. in LPI group(p<0.05). 2) Serum albumin, IgG, IgA, IgM, C3 and C4 levels and peripheral blood leukocyte counts with differentials were similar in both groups. 3) The IgG levels in peritoneal effluent was 6.3 ㎎/㎗ in HPI group and 7.4 ㎎/㎗ in LPI group. The numbers and viability of peritoneal cells were similar in both groups. 4) Percentages of uptake of C. albicans by peritoneal macrophages at 30 minutes, 1 hour and 2 hours after incubation were 46.0, 55.6 and 55.9, respectively, in HPI group and 47.7, 56.2 and 62.6, respectively, in LPI group. Percentages of intracellular killing at 30 minutes, 1 hour and 2 hours were 11.6, 17.5 and 22.8, respectively, in HPI group and 16.1, 22.6 and 29.6, respectively, in LPI group. The percentage of uptake in HPI group was slightly lower as compared with LPI group althougth the difference was not significant. However, the percentage of intracellular killing in HPI group was significantly lower than that in LPI group(p<0.05). 5) After IgG was administered, percentages of both uptake and intracellular killing increased significantly in both groups (p<0.05). Conclusion: The concentration of serum and peritoneal IgG and the rates of in vitro uptake and intracellular killing of Candida albicans by peritoneal macrophages were not different significantly between HPI group and LPI group. The uptake and intracellular killing rates could be improved by immunoglobulin administrations in both groups.

전자기학의 인과율위배 문제에 대한 불교철학적 접근

현남규,양영울 濟州大學校 基礎科學硏究所 1995 基礎科學硏究 Vol.8 No.1

하전입자들의 운동방정식을 풀어보면 10-23초이내의 시간 영역에 있어서는 인과율 위배 현상이 나타난다. 그러나 이 현상에 대하여서는 물리적으로나 서양철학적으로는 적절한 해석이 되지 않고 있다. 그런데 불교철학의 공사상은 경험세계에서는 논의되기 힘든 개념으로 알려져 왔지만, 인과율 부정이란 면에서의 공사상의 전개와 인과율 위배란 점에서의 하전입자의 운동방정식의 해에 대한 해석 상의 문제에 있어서 서로 유사점을 발견할 수가 있으며 상호 보완이 가능함을 알 수 있다. 즉 조적전자기학의 인과율위배란 관점에서 보았을 때에는 '무자성', '공'이란 개념으로 접근할 필요가 있음을 제시한다고 볼 수 있을 것이며, 불교철학의 입장에서는 공사상을 적용시키기에 적합한 대상을 정량적으로 말할 수 있을 것으로 생각된다. The equation of motion in classical charged particles caused unphysical problem of violation of causality. Because the acausal effects are limited to the interval of the order of ????? sec and the lack of causality cannot be observed in the laboratory, we can say that the model satisfies the requirement of macroscopic causality. But these equation of motion apparently violates microscopic causality. Thus to analyze the microscopic causality violation. We have reviewed the theory of cusality in western philosophy and buddhist philosophy. In this process, we have found that the philosophy about the microscopic causality violation and the thought of Nagarjuna may serve as complementary one to the other. Physicist feel the need of the concept of the nature of void(공성) and buddhist philosophers feel the need of quantitative analysis.

동시인과와 타키온 교환을 통한 물질의 상호작용

현남규 ( Nam Gyu Hyun ),양영웅 ( Young Ung Yang ) 한국과학철학회 2002 과학철학 Vol.5 No.1

Build and Performance Test of a 3-cell Solid Oxide Fuel Cell Stack

Cho, Nam-Ung,Hwang, Soon-Cheol,Han, Sang-Moo,Yang, Choong-Jin The Korean Ceramic Society 2007 한국세라믹학회지 Vol.44 No.8

A 3-cell stacked anode-supported solid oxide fuel cell was designed and fabricated to achieve a complete gas seal and the facile stacking of components. The stack was assembled with a unit cell with $10{\times}10cm^2$ area, and each cell was interconnected by a stainless steel 430 separator using a proprietary sealant sheet. The stack performance was examined at various gas flow rates of $H_2+3.5vol%\;H_2O$, and air at a fixed temperature of $800^{\circ}C$. No gas leakage was found from the sealing between cells and inter-connects within a measurement system in this research during a prolonged time of 500 h in operation. The test resulted in an open circuit voltage of 3.12 V, a peak power of 149 W, and a power density of $0.61W/cm^2$, while the long term durability of the power showed 19.1% degradation during the prolonged time of 500 h when tested at $800^{\circ}C$.

양자역학의 인과성과 실재성 문제에 대한 불교철학적 접근

현남규,양영웅 濟州大學校 基礎科學硏究所 1996 基礎科學硏究 Vol.9 No.1

The theoretical implication of quantum mechanics shows that in the microscopic systems there would be no such things that are completely independent from observation. It is true that there were some who argued that by the measurement problem we become forced to introduce human consciousness into physical reality or at least into a description of physical reality. Bell's theorem shows us that two seemingly 'independent' measurements should be thought to be correlated with each other. This mathematically proven theorem, published in 1964, later had some experimental supports. Thus one of the philosophical conclusions induced from this may be as follows; on the one hand, we have to deny, by the special theory of relativity, that the two measurement processes in the two labs have causal influences on each other, and in spite of that, on the other hand, we should accept that the two measurement processes are, in a sense, inseparable. This shows us a possibility of self-referentials for the description of physical reality. At least we could learn, from the situations, that the result of saying something on a microscopic physical system is correlated with the result of saying some other thing on it. Without considering the point, we could not describe the quantum world. Thus even in the theoretical aspect of physics, there could be some room for the self-referential structrue to be discussed.[1] Although nobody knows what a new, revised physics would be like, we can say that it may have a self referential structure. Therefore we wanted to find out some correlations in the problem of causality and reality in quantum mechanics with that in buddhist philosophy, since we think that it may be helpful to the forthcoming new physics. There were the pre-Buddhist concept of causation such as 'self causation' and 'external causation' Buddha found these concepts to be limited and inadequate to express reality. This was not because reality as he saw it was indescribable or transcendental but because people used these concepts to express only a part of reality, the part that fit their metaphysical predictions. Rejecting an Absolute or a transempirical reality. Buddha confined himself to what is empirically given. He recognized causality as the reality and made it the essence of his teaching. But Sarvastivadins engaged in endless analysis of dharmas into their minutest forms and accepted the view that dharma is a point in space and time: the buddhist school in India came to accept the theory of atoms and the theory of moment. Thus they came to believe in an underlying substratum considered to be eternal. Afterward Nagarjuna refuted the Sarvastivada concept of reality and wrote a book, starting from fundamental proposition in Buddhist philosophy that there is nothing in this empirical world that is not causally produced [2] and his idea has been well progressed toward the thought of Zen Buddhism in China. In this thesis we have found that there are some similarities in the problem of causality and reality in quantum mechanics with those of early buddhist philosophy. To sum up, in the theory of quantum physics we need not necessarily persist on the 'causality of Einstein', but may introduce the causality of Buddha(=causality as the reality).