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Employment Outlook and Job Promotion Policies in Korea
Woon-Hwan Na,Myoung-Hyun Jung,Chul-Hyun Park 한국장애인재활협회 2003 재활복지 Vol.7 No.2
한국에 있어 세계장애인 10년과 아시아.태평양지역의 장애인 10년은 장애인의 직업재활을 위한 중요한 모멘텀이었다. 한국은 지난 40년간 경제적으로 괄목할 만한 성장을 이루었지만 장애인의 경제적, 사회적, 문화적 측면에서의 발전은 큰 변화가 없다. 그러나 장애인10년과 관련된 국제적 모멘텀은 장애인 직업재활을 비롯한 여러 영역에 많은 변화를 주도하였다. 장애인 고용촉진정책도 1981년 장애인 취업알선사업을 처음으로 시작한 이후 1990년 장애인고용촉진 등에 관한 법률 제정으로 장애인의 고용촉진정책이 상당한 효과를 거두는 듯 하였으나 시간이 경과하면서 효과성에 상당한 문제를 노정하는 것으로 분석되었다. 본 연구는 이와 같은 장애인 고용촉진정책의 현상을 각종 문헌과 보고서를 통해 진단하고 개선방안을 제시하고자 하였다. 본 연구에서 나타난 결론은 장애인의 경증장애 중심의 고용촉진정책과 장애인 고용의 어려움의 근본적인 해결을 위하여는 장애차별법 제정의 필요성이 강력히 대두되었으며, 중증장애인을 위한 보다 다양한 고용이나 직업재활 프로그램 마련이 필요하며, 이를 위해 산, 학, 연의 공동 연구와 프로그램개발이 시급한 문제로 도출되었다.
말굽버섯 추출물이 Streptozotocin으로 유발된 당뇨 흰쥐의 혈당, 지질대사 및 면역세포에 미치는 영향
김나영(Na-Young Kim),정호금(Ho-Kum Jung),박명주(Myoung-Ju Park),김석지(Seog-Ji Kim),김석환(Seok-Hwan Kim),최종원(Jong-Won Choi),이정숙(Jeong-Sook Lee) 한국식품영양과학회 2005 한국식품영양과학회지 Vol.34 No.6
말굽버섯(Fomes fomentarius)이 당뇨에 미치는 영향을 연구할 목적으로 실험동물에 STZ를 투여하여 당뇨를 유발시킨 후 말굽버섯 물추출물과 메탄올 추출물을 2주간 투여하여 혈당, 지질함량 및 면역에 미치는 영향을 검토한 결과는 다음과 같다. 혈당은 당뇨로 인해 증가하였으나 말굽버섯 추출물 투여군에서 유의적으로 감소를 보였다. 혈청과 간의 총콜레스테롤과 중성지방 함량은 말굽버섯 추출물 급여로 DM군에 비하여 현저한 감소를 나타내었다. HDL-콜레스테롤 함량과 GSH-Px의 활성은 말굽버섯 추출물 급여 시에는 DM군과 비교하여 유의한 증가가 나타났다. 혈청 보체 C3의 함량은 대조군에 비하여 DM군에서 유의한 감소를 보였고, DM-FM 200군에서 대조군 수준으로 회복이 관찰되었다. B cell과 T cell은 DM군에서 유의한 감소를 보였고, 말굽버섯 추출물 투여로 유의적으로 증가되었다. Helper T cell과 suppressor T cell의 분포는 DM군에서 유의하게 감소되었으나, 말굽버섯 추출물 투여로 유의한 증가를 나타내었다. 이상의 결과를 종합하여 볼 때 말굽버섯의 물 추출물과 메탄올 추출물은 혈당조절 기능, 지질대사 개선 및 면역작용을 활성화시킴으로서 STZ의 투여로 인한 당뇨의 증상을 완화시키는 것으로 사료된다. This study was conducted to investigate the effect of extract of Fomes fomentarius (FF) on blood glucose, lipid profile, antioxidant enzymes and immune cells in streptozotocin (STZ)-induced diabetic rats. Male Sprague- Dawley rats were divided into control, STZ-induced diabetic group (DM), STZ plus FF water extract treated group (DM-FW 200) and STZ plus FF methanol extract treated group (DM-FM 200). FW (200 ㎎/㎏ BW) and FM (200 ㎎/㎏ BW) were orally administered once a day for 14 days. Admdinistering FW and FM to STZ-induced diabetic rats lowered the blood glucose level. The supplementation of FW and FM suppressed the increase in the total cholesterol and triglyceride levels in the serum and liver of the diabetic rats. The high density lipoprotein-cholesterol level and glutathione peroxidase activity were higher in the FF-supplemented group compared to the diabetic group. Administering FW and FM increased the suppress in the serum complement component C3, whole blood B-cell, T-cell, helper T cell and suppressor T cell of the diabetic rats. Therefore, it could be suggested that FW and FM are alleviated the diabetic complication through enhancing the hyperglycemia and preventing diabetic complications.
Kim Na-Young,Lee Jeong-Sook,Kim Seog-Ji,Park Myoung-Ju,Kim Seok-Hwan The Korean Nutrition Society 2005 Nutritional Sciences Vol.8 No.4
Hepatoprotective effects of the extract of Kochiae fructus (KF), a traditional oriental medicinal plant, were evaluated against carbon tetrachloride($CCl_4$)-induced liver damage in rats. Male Sprague-Dawley rats were divided into control, $CCl_4,\;CCl_4$ plus methanol extract of KF (KFM-$CCl_4$), and $CCl_4$ plus butanol extract of KF (KFB-$CCl_4$) groups. KFM and KFB were orally administered once a day (200 mg/kg body weight) for 14 days. A mixture of 0.2 mL/100 g body weight of $CCl_4$ in olive oil was injected at 30 minutes after the final administration of KFM and KFB. The KFB pretreatment resulted in a significant decrease in the serum transaminase and lactic dehydrogenase levels in the $CCl_4$-treated rats. The $CCl_4$ treatment significantly lowered the activities of glutathione, glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-Px). However, pretreatment with KFM and KFB resulted in a significant increase in the glutathione, GR and GST levels. KFB increased the activities of SOD, catalase and GSH-Px, but KFM did not alter them. Pretreatment with KFM and KFB resulted in a significant decrease in the production of aminopyrine N-demethylase in the $CCl_4$-treated rats. KF extract would appear to contribute to alleviate the adveISe effect of $CCl_4$ treatment by enhancing the hepatic antioxidant defense system.
Occurrence of Pasteuria spp. Associated with Plant-parasitic Nematodes in Korea
조명래,Myoung Soon Yiem,Heung Yong Jeon,Hye Rim Han,Hyung Hwan Kim,Seung Yong Na,Chun Keun Lim 한국응용곤충학회 2005 Journal of Asia-Pacific Entomology Vol.8 No.2
A survey was conducted on the occurrence of Pasteuria spp. associated with plant-parasitic nematodes in greenhouse and open field soils in Korea from 1996 to 2000. Among the 372 soil samples assayed, 20 samples had plant-parasitic nematodes attached with Pasteuria spp. endospores. The nematodes found with Pasteuria endospores and their collection sites were Meloidogyne spp. in Sungju, Cheju, and Yeoju and Helicotylenchus sp., Pratylenchus sp., Heterodera sp., and Aphelenchus sp. in Cheju. Morphological characteristics of the endospores on Meloidogyne incognita juveniles observed under light, scanning and transmission electron microscopes were same as the previous description of Pasteuria penetrans Sayre & Starr 1988.
간성 뇌증의 치료로서 Rifaximin(Normix) 단기간 투여의 효능과 안전성
김명환,이관식,문병수,박인서,송건훈,전재윤,한광협,문영명,백용한,나호균,윤석화 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.1
Background/Aims: A prospective, randomized study was performed to evaluate the efficacy and safety of the short-term administration of rifaximin in the treatment of hepatic encephalopathy. Methods: Of the 64 patients diagnosed as having decompensated liver cirrhosis with hepatic encephalopathy, 39 patients were randomized to receive rifaximin and 25 patients to receive lactulose for seven days. Before and after the treatment we assessed changes in the level of serum ammonia, flapping tremor, patient's mental status, number connection test (NCT), and hepatic encephalopathy indices. Results: In rifaximin-treated group, the mean grade of serum ammonia (1.8→0.9), mental status (1.3→0.3), NCT (3.0→2.0), and flapping tremor (1.7→0.4) were improved after treatment. In the lactulose-treated group, the mean grade of serum ammonia (1.9→1.0), mental status (1.5→0.5), NCT (3.3→2.1), and flapping tremor (1.4→0.3) were improved after treatment. Side effects of abdominal pain (rifaximin group) and excessive diarrheaose group) were noted in 2 cases. The efficacy of treatment was not significantly different between rifaximin and lactulose-treated groups (84.3% vs. 95.3%). Conclusion: Rifaximin was as efficient and safe in the treatment of hepatic encephalopathy as lactulose in terms of efficacy. Rifaximin may be useful drug for the short-term treatment of hepatic encephalopathy.(Korean J Hepatol 2001;7:55-60)