근막 결손의 복원과 자궁천골인대 고정을 통한 전자궁적출술 후 질탈출의 성공적 교정

문화숙(Hwa Sook Moon),최진국(Jin Koo Choi),김경서(Kyung Seo Kim),박근식(Kyun Sik Park),황지영(Ji Young Hwang),문성은(Sung Eun Moon),한지원(Ji Won Han),김상국(Sang Gook Kim),김상갑(Sang Gap Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.7

목적 : 본 연구는 전자궁적출술 후 질탈출을 부위-특이적인 결함의 개념에 입각하여 치골경부 근막과 직장질 격막의 연결을 통한 골반내 근막의 복원과 자궁천골인대 고정술을 이용한 질탈출의 성공적인 수술적 교정의 방법과 결과를 보고하고자 한다. 연구 방법 : 1999년부터 2001년 8월까지 자궁적출술 후 질궁탈출 증상으로 문화병원 산부인과를 내원, 탈출된 질의 근막을 재건시킨 다음, 이를 자궁천골인대에 고정시킴으로써 질의 부위-특이적인 교정술을 받은 3명의 환자를 대상으로 하였다. 3명중 1명은 개복술을 하였고 2명은 내시경 수술을 하였다. 결과 : 환자의 연령 분포는 49-67세였으며, 수술시간은 평균 113분 (105-125)이었다. 세 환자 모두 수술 후 질의 상태가 해부학 및 기능적으로 정상이었으며, 9일째 특이사항 없이 퇴원하였다. 수술 후 HRT를 시행한 1명을 포함한 3명 모두 각각 24개월, 12개월, 7개월간의 추적 검사에서도 특이한 합병증이나 재발 없이 좋은 경과를 보였다. 결론 : 골반 근막 결손의 복원과 자궁천골인대 고정술은 전자궁적출술 후 질탈출의 교정에 매우 안전하고 효과적이며, 기능적인 방법으로 사료되며, 자궁천골인대를 질탈출 교정에 이용한 연구는 본 연구가 국내에서 처음이다. Objective : To report the method and efficacy of the site specific-defects repair in the endopelvic fascia and uterosacral ligament suspension for the correction of posthysterectomy vaginal vault prolapse. Methods : This study was performed in 3 patients with posthyterectomy vaginal vault prolapse who underwent the surgery for the reconstruction of endopelvic fascia and the correction of vault prolapsed vagina by using uterosacral ligament suspension at the department of Obstetrics and Gynecology in Moon-Hwa Hospital. Among them, 1 patient was treated by laparotomy, and 2 patients were treated by laparoscope. Results : The age of patients ranged from 49 to 67 years. The mean operation time was 111 minutes (105-120 minutes). The status of postoperative vagina was normal in all 3 patients, who were discharged 9 days after operation without symptoms. No complication or recurrence were found in them despite long-term follow-up for 24 months, 12 months, 7 months, respectively after operation. One patient has been treated with HRT therapy. Conclusion : The reconstruction of the defect of endopelvic fascia and uterosacral ligament fixation may be very safe, effective, and functional in the correction of vaginal vault prolapse. This study reports the treatment of vaginal vault prolapse using uterosacral ligament within Korea for the first time.

느타리속 버섯류의 영양성분 및 생리활성

엄수나(Suna Um),진경언(Gyoung-ean Jin),박계원(Kye Won Park),유영복(Young-bok Yu),박기문(Ki-Moon Park) 한국식품과학회 2010 한국식품과학회지 Vol.42 No.1

일반 느타리 13품종과 색상 느타리 5품종을 사용하여 아미노산 및 polyphenol, β-glucan 함량을 분석하고, 생리활성으로 항산화 및 항암, 항고혈압, 항혈전, 항당뇨, 항염활성을 측정하였다. 느타리버섯 18종의 아미노산 분석결과 전반적으로 감칠맛을 내는 glutamic acid 함량이 비교적 많이 함유되어 있었고, 필수아미노산 성분도 고르게 분포되어 있었다. Polyphenol 함량에서는 전 품종에서 20 mg% 함량이상을 나타냈으며, 노랑느타리(R)가 39.13±0.82 mg%로 가장 높았다. β-glucan 함량은 노랑느타리(R)에서 37.67±0.22%로 가장 높았으며, 그 외에 원형1(C), 장안PK(A)에서 각각 28.75±0.61%, 27.95±0.33%의 순으로 나타났다. 전자공여능에서는 노랑느타리(R) 버섯의 DPPH IC50값이 2.93±0.44 mg/mL로 가장 낮아 항산화 활성이 가장 우수한 것으로 나타났으며, 세포독성 실험에서는 노랑느타리(R) 에탄올 추출물 1% 처리시 신장 암세포에 대해 36.90%의 세포 억제율을 보였다. ACE 저해활성의 경우 노랑느타리(R) 에탄올 추출물 1%농도에서 60.5±0.2%의 저해율이 측정되었고, 흑평(B) 56.7±1.1%, 여름(H) 52.4±1.3% 수준으로 나타났다. 항혈전 활성에서는 3%농도에서 흑평(B)과 삼복(G)을 제외한 나머지 느타리버섯 에탄올 추출물에서 50%이상의 용해 활성을 보였으며 노랑느타리(R)에서 거의 plasmin과 동등한 활성을 나타냈다. 항당뇨 활성에서는 노랑느타리(R)의 경우 50.5±0.8%의 비교적 높은 효소저해율이 측정되었고, 항염활성에서는 노랑느타리(R)에서 68.4±0.3%의 억제율이 측정되었다. 이상의 결과로 일반 느타리 13 품종과 육종 재배된 색상 느타리 5품종 중 노랑느타리(R)가 가장 우수한 생리활성을 나타내 향후 기능성 소재로의 활용가능성이 기대되었다. In this study, the anti-oxidant, anti-tumorigenic, anti-hypertensive, anti-thrombic, anti-diabetic, and antiinflammatory properties of 18 different species of genus Pleurotus were investigated. In addition, the amino acid, β-glucan, and polyphenol content were also measured. All species contained more than 20 mg% of polyphenol with the highest contents found in Pleurotus cornucopiae var. citrinopileatus (yellow pleurotus) (39.13±0.82 mg%). The β-glucan contents was also the highest in yellow Pleurotus (37.67±0.22%) followed by Won-Hyeong1 (C, 28.75±0.61%) and Jang-an PK (A, 27.95±0.33%). The yellow Pleurotus exhibited the highest antioxidant activity as assessed by the DPPH scavenging rate with an IC50 value of 2.94±0.44 mg/mL. Ethanol extracts from the yellow Pleurotus treated at 1% concentration showed cytotoxic activity up to 36.9% in the human embryonic kidney 293T cell lines. The yellow Pleurotus also showed the highest inhibitory effects on ACE activity (60.52±0.2%). Finally, the yellow Pleurotus exhibited anti-diabetic and antiinflammatory properties as shown by inhibition of α-amyloglucosidase activity (50.5±0.8%) and nitric oxide production (68.4±0.3%). Taken together, our data indicate the yellow pleurotus is a promising functional food ingredients.

상수원수 수질변화에 따른 전오존 처리효과 및 경제성 평가

최동훈 ( Dong Hoon Choi ),박진식 ( Jin Sik Park ),문추연 ( Choo Yeun Moon ),이재용 ( Jae Yong Lee ),유동춘 ( Dong Choon Ryu ),장성호 ( Seong Ho Jang ),권기원 ( Ki Won Kwon ),이수애 ( Soo Ae Lee ) 한국환경과학회 2013 한국환경과학회지 Vol.22 No.4

This study, changes in raw water quality is to indicate on the efficiency of ozone treatment of each pollutant as compared to derive the appropriate operating measures. The appropriate selection for injection rate of pre-ozone and did not inject pre-ozone assess changes in the water. When good water quality, you not injected of pre-ozone to evaluate the economic efficiency of electricity and put the most cost-effective ozone concentration were evaluated. Evaluation remove organic matter and chlorophyll-a concentration level in experiments with each factor of the water DOC> 2.5㎎ / L, THMFP> 70㎍ / L, Chl-a> 30㎎/㎥or less constant process, if you do not need to put pre-ozone showed little impact. It also does not put you in pre-ozone appropriate produce enough power rate savings was calculated as approximately 90 million won. Ability to remove organic materials and the ability to produce disinfection byproducts, and cost-effective decisions by considering the concentration of injection if pre-ozone 1 mg/L was investigated by the appropriate concentration of ozone injection.

Enhancement of Radiosensitivity by DNA Hypomethylating Drugs through Apoptosis and Autophagy in Human Sarcoma Cells

( Moon-taek Park ),( Sung-dae Kim ),( Yu Kyeong Han ),( Jin Won Hyun ),( Hae-june Lee ),( Joo Mi Yi ) 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.1

The targeting of DNA methylation in cancer using DNA hypomethylating drugs has been well known to sensitize cancer cells to chemotherapy and immunotherapy by affecting multiple pathways. Herein, we investigated the combinational effects of DNA hypomethylating drugs and ionizing radiation (IR) in human sarcoma cell lines both in vitro and in vivo. Clonogenic assays were performed to determine the radiosensitizing properties of two DNA hypomethylating drugs on sarcoma cell lines we tested in this study with multiple doses of IR. We analyzed the effects of 5-aza-dC or SGI-110, as DNA hypomethylating drugs, in combination with IR in vitro on the proliferation, apoptosis, caspase-3/7 activity, migration/invasion, and Western blotting using apoptosis- or autophagy-related factors. To confirm the combined effect of DNA hypomethylating drugs and IR in our in vitro experiment, we generated the sarcoma cells in nude mouse xenograft models. Here, we found that the combination of DNA hypomethylating drugs and IR improved anticancer effects by inhibiting cell proliferation and by promoting synergistic cell death that is associated with both apoptosis and autophagy in vitro and in vivo. Our data demonstrated that the combination effects of DNA hypomethylating drugs with radiation exhibited greater cellular effects than the use of a single agent treatment, thus suggesting that the combination of DNA hypomethylating drugs and radiation may become a new radiotherapy to improve therapeutic efficacy for cancer treatment.

Role of the modified Saengmaeksan(mSMS) in L-NAME-induced hypertension model

Jin Ki Jung,Hobin Moon,Won Hee Nam,Yun-Hwan Kang,Se-Jin Kim,Young Mi Seok,Hyun Hee Leem,Ji-Woon Jeong,Yu Jin Park,Min Ju Kim,Chae Suk Ra,Jiyoung Seo,Hye Won Shin,Bo Gyung Jang,Hyo Jung Kim 한국실험동물학회 2022 한국실험동물학회 학술발표대회 논문집 Vol.2022 No.7

Irradiation of the Intrathoracic Esophagus : prone versus supine treatment positions

Moon, Sun Rock,Kim, Hye Jung,Won, Jong Jin 圓光大學校 韓醫學硏究所 1992 圓光醫科學 Vol.8 No.1-2

식도암의 방사선치료시 원발병소에 60 Gy이상의 방사선량을 조사하면서 근접한 척수의 조사선량을 46 Gy 이하로 제한하는 것은 식도와 척수의 해부학적 근접성때문에 많은 문제점을 가지고 있다. 치료계획시 환자가 복와위를 취하게하면 식도는 척수로부터 다소 멀어져 치료계획시 잇점이 있는 것으로 알려져 있다. 저자들은 총 10명의 환자들을 대상으로 앙와위와 복와위로 동시에 방사선치료계획을 시행하여 두방법의 장단점을 비교하였다. 각각의 자세에서 조영제를 삼키면서 전후방 및 측방으로 단순촬영을 시행하여 조영제가 차있는 식도의 내강 중심으로부터 척수까지의 거리를 기관분기점(Carina) 및 6 ㎝ 상방, 6 ㎝ 하방과 12 ㎝ 하방의 횡단면에서 계측하였다. 각각의 위치에서의 평균식도전위는 1.6(+0.9) ㎝, 1.3(+0.8) ㎝, 1.7(+1.0) ㎝ 및 1.9(+1.1) ㎝이었고 계측된 총 40위치에서의 전위범위는 0에서 4.3 ㎝ 이었으며 평균전위는 1.6 ㎝ 이었다. 복와위에 의한 치료시 병소부위와 장상주변장기의 선량분포를 비교하기 위해 전예에서 복와위와 앙와위의 삼차원적 산량분포를 6문조사법과 8문조사법을 이용하여 예측하였으며 선량분포의 예측은 전산화 치료계획장치를 이용하였다. 6문조사법이나 8문조사법 모두에서 북와위시 앙와위에 비해 동일한 종양조사선량을 유지하면서 주변장기인 척수의 조사선량을 효과적으로 감소시킬 수 있었다. The treatment of esophageal cancer is made difficult by the close proximity of the esophagus to the spinal cord and the requirement to treat the esophageal target volume to doses greater than or equal to 60 Gy while limiting the spinal cord dose to less than or equal to 46 Gy. By placing the patient in the prone position, the esophagus can be displaced away from the spinal cord. We explored the results of this commonly used technique on 10 patients who have undergone simulation in both supine and prone positions. Both AP and lateral orthogonal radiographs were obtained in both positions. The distance between contrast material in the esophagus and spinal cord was noted in at least four transverse planes through the thoracic esophagus on each of the 10 patients. The four transverse planes were located at 3 cm above the carina, at the carina, 3 cm below the carina and 6 cm below the carina. The mean displacement (±1 SD) of the esophagus away from the spinal cord when the patient was in the prone position compared to supine at each of these levels was 1.3 (±0.8)㎝, 1.6 (±0.9) ㎝, 1.7 (±1.0) ㎝, and 1.9 (±1.1) ㎝. The range of displacement for all 40 displacement determinations was 0 to 4.3 ㎝ with a mean of 1.6 ㎝. To evaluate further the consequences of prone positioning on treatment planning and doses received to target volumes and critical structures, we performed 3-dimensional treatment planning with a patient in both prone and supine position. The requirements were to achieve a tumor volume dose of 60 Gy while keeping the spinal cord dose below 46 Gy. Two types of conventional treatment plans were examined in prone and supine positions. A 6-field plan consisted of delivery of 40 Gy through a large 3-field beam arrangement followed by delivery of 20 Gy through a similar 3-field cone down. An 8-field plan involved the delivery of 30 Gy through AP/PA beams followed by a 3-field beam arrangement to 40 Gy and a subsequent 3-field cone-down for the final 20 Gy. Regarding the primary consideration of coverage of target volume with avoidance of spinal cord, prone positioning was superior to supine positioning whether 6- or 8-field arrangements were used.

Free Paper Session : LC & Liver Fibrosis ; Hepatic vein arrival time using a microbubble contrast enhanced ultrasonography in non-invasive assessment of the severity of portal hypertension in cirrhotic patients (초)

( Moon Young Kim ),( Ki Tae Suk ),( Soon Koo Baik ),( Hyoun A Kim ),( Hong Jun Park ),( Hyo Keun Jeon ),( So Yeon Park ),( Bo Ra Kim ),( Jin Heon Hong ),( Ki Won Jo ),( Sang Ok Kwon ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)

Predictive value of pretreatment risk group and baseline LDH levels in MDS patients receiving azacitidine treatment

Moon, Joon Ho,Kim, Shi Nae,Kang, Byung Woog,Chae, Yee Soo,Kim, Jong Gwang,Baek, Jin Ho,Park, Jae Hoo,Song, Moo Kon,Chung, Joo Seop,Won, Jong Ho,Lee, Sang Min,Joo, Young Don,Kim, Yeo Kyeoung,Kim, Hyeon Springer-Verlag 2010 Annals of hematology Vol.89 No.7

데드리프트와 업라이트로우 시 운동강도에 따른 근활성도 평가

( Won Jun Cho ),( Ju Won Song ),( Myung Soo Choi ),( Nam Yim Kim ),( Ryong Kim ),( Chang Min Lee ),( Jae Heon Hong ),( Gun Woo Kang ),( Young Jin Moon ) 한국운동역학회 2021 한국운동역학회지 Vol.31 No.4

Objective: The purpose of this study was to evaluate 16 muscles activity according to three exercise intensity when performing Deadlift and Upright row. Method: To accomplish the purpose of the study, subjects (n=10) were performed Electromyography (EMG) measurement for 16 different muscles. The experimental movements were Deadlift and Upright row, measured five times for each intensity (40%, 60%, 80%) of 1RM. This study normalized the EMG values through RVC for comparative analysis. Results: The results were summarized as follows: As a result of Deadlift, there was significant difference in the mean EMG value according to the exercise intensity in all muscles except RA, PM and BB (p<.05). As a result of Upright row, There was significant difference in the mean EMG value according to the exercise intensity in all muscles except BF, TA, GN, RA and UT (p<.05). Conclusion: This study allowed us to know the activities of major muscles according to the exercise intensity for 16 different muscles when performing Deadlift and Upright row.

Diabetes-Free Survival in Patients Who Underwent Islet Autotransplantation After 50% to 60% Distal Partial Pancreatectomy for Benign Pancreatic Tumors

Jin, Sang-Man,Oh, Seung-Hoon,Kim, Soo Kyoung,Jung, Hye Seung,Choi, Seong-Ho,Jang, Kee-Taek,Lee, Kyu Taek,Kim, Jae Hyeon,Lee, Myung-Shik,Lee, Moon-Kyu,Kim, Kwang-Won Lippincott Williams Wilkins, Inc. 2013 Transplantation Vol.95 No.11

BACKGROUND: Several retrospective studies with short-term follow-up have demonstrated a low rate of new-onset diabetes after distal pancreatectomy for benign pancreatic tumors. We sought to determine the long-term diabetes-free survival of patients who underwent islet autotransplantation (IAT) after distal pancreatectomy and to identify any associations between the isolation parameters of autologous islets and diabetes-free survival. METHODS: Among the 37 nondiabetic patients who underwent 50% to 60% partial pancreatectomy, 20 underwent IAT (IAT group; median follow-up period, 61 months). In the IAT group, diabetes-free survival was determined based on annual oral glucose tolerance tests, fasting blood glucose, and hemoglobin A1C. RESULTS: The 7-year diabetes-free survival rate was 51% in the IAT group (median follow-up period, 61 months) and 45% in the 37 study subjects. Diabetes-free survival was significantly prolonged when islet yield per gram of pancreas weight was more than 5154 islet equivalents (IEQ)/g, even in patients with prediabetes and high insulin resistance who had a markedly high rate of diabetes development. The proportion of patients with impaired glucose tolerance at 2 years after distal pancreatectomy was 12 of 16 in the control group, 6 of 7 in patients with islet yields of less than 5154 IEQ/g, and 3 of 11 in patients with islet yields of more than 5154 IEQ/g (P=0.019). CONCLUSIONS: Partial (50%–60%) pancreatectomy for benign pancreatic tumors had a major metabolic consequence, especially in patients with prediabetes and high insulin resistance. In this setting, prolonged diabetes-free survival was observed in patients who underwent IAT when a high islet yield per gram of pancreas was achieved.