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Modulation of Poly(b-amino ester) pH-Sensitive Polymers by Molecular Weight Control
Min Sang Kim,이두성,최은경,김진석,Heon-Joo Park 한국고분자학회 2005 Macromolecular Research Vol.13 No.2
The main objective of this study was to modulate pH-sensitive polymers (poly(-amino esters)) by con trolling their molecular weight during their synthesis. These pH-sensitive and biodegradable polymers were synthe sized by Michael-type step polymerization. 1,4-Butane diol diacrylate was used as the unsaturated carbonyl compound and piperazine as the nucleophilic compound. Various molecular weight polymers were obtained by varying the mol ratio of piperazine/1,4-butane diol diacrylate. The synthesized polymers were characterized by 1H-NMR and their molecular weights were measured by gel permeation chromatography(GPC). The dependence of the molecular weight on the mol ratio was evaluated by the titration method. Also, the pH dependent turbidity of the polymers was determined by UV-Vis spectrophotometry. This pH dependent property of the polymers could be very useful for preparing drug carriers that are sensitive to pH.