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A Case of Verruca Obliterating the Punctum
Minji Woo,Sungwon Yang,Jin Hwan Park,Hwa Lee,Sehyun Baek 대한검안학회 2018 Annals of optometry and contact lens Vol.17 No.3
Purpose: To report a case of verruca vulgaris appeared over punctum without involving conjunctival lesion. Case summary: A 36-year-old woman presented with tearing of her left eye. On slit lamp examination, about 5mm-sized round papilloma inside of the punctum of the left lower eyelid was observed. The mass was obstructing the entire punctum. Excisional biopsy was performed with snip punctoplasty. In pathology exam, koilocytes were observed. Polymerase chain reaction (PCR) test showed the positive result of HPV types 6 and 11. Conclusions: Verruca vulgaris could appears in the punctum and nasolacrimal drainage system without any conjunctival lesion.
Woo, Minji,Kim, Mijeong,Noh, Jeong Sook,Park, Chan Hum,Song, Yeong Ok Korean Society of Food Science and Technology 2018 Food Science and Biotechnology Vol.27 No.1
This study investigated the effect of kimchi on hepatic lipid metabolism and inflammatory response. Low-density lipoprotein receptor knockout mice fed high cholesterol diet (HCD) with an oral administration of kimchi methanol extracts (KME, $200mg\;kg\;bw^{-1}day^{-1}$) or distilled water for 8 weeks (n = 10 per group). Compared with the control group, plasma and hepatic lipid concentrations were lower in the kimchi group (p < 0.05), which was confirmed with hepatic histological examination by Oil Red O staining. Hepatic expressions for fatty acid synthesis were downregulated whereas those for beta-oxidation were upregulated in the kimchi group (p < 0.05). Hepatic expressions for cholesterol synthesis were decreased but those for cholesterol export was increased in the kimchi group (p < 0.05). Moreover, kimchi intake reduced expression for inflammatory cytokines (p < 0.05). Kimchi exerted beneficial effects on HCD-induced hepatic damage by suppressing lipid synthesis and inflammation, and facilitating fatty acid oxidation and cholesterol excretion.
Woo, Minji,Kim, Mijeong,Noh, Jeong Sook,Song, Yeong Ok Elsevier 2017 Journal of Functional Foods Vol.32 No.-
<P><B>Abstract</B></P> <P>This study was examined inhibitory effects of kimchi with antioxidant, lipid lowering, and antiinflammatory activities on hepatic steatosis by suppression of endoplasmic reticulum (ER) stress in high cholesterol diet (HCD)-fed low-density lipoprotein receptor knockout mice. Animals were fed HCD for 8weeks with oral administration of kimchi methanol extracts (200mg/kgbw/day) (kimchi group, n=10) or distilled water as a vehicle (control group, n=10). In kimchi group, hepatic lipid peroxidation was reduced. Protein expression of ER stress molecules such as GRP78, p-PERK, p-eIF2α, XBP1, and CHOP were decreased. In addition, protein expression of anti-apoptotic molecules were increased, but those for the pro-apoptotic molecules were decreased. Protein expression of antioxidant enzymes regulated by Nrf2 was elevated. Histological analysis showed that hepatic steatosis, inflammation, and apoptosis in the kimchi group were less severe. In conclusion, hepatic steatosis induced by HCD can be alleviated by kimchi via suppressing ER stress.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Kimchi, fermented food with health benefits reduced hepatic lipid peroxidation. </LI> <LI> Endoplasmic reticulum stress-related molecules decreased by kimchi intake. </LI> <LI> Antioxidant enzymes increased by kimchi intake. </LI> <LI> Kimchi inhibited pro-apoptotic molecules and elevated anti-apoptotic molecules. </LI> <LI> Histological analysis supported kimchi suppressed hepatic steatosis. </LI> </UL> </P>
Minji Woo,Mijeong Kim,Jeong Sook Noh,Chan Hum Park,Yeong Ok Song 한국영양학회 2017 Nutrition Research and Practice Vol.11 No.6
BACKGROUND/OBJECTIVES: Endoplasmic reticulum (ER) stress is positively associated with atherosclerosis via elevating macrophage cell death and plaque formation, in which oxidative stress plays a pivotal role. Antioxidative, lipid-lowering, and anti-atherogenic effects of kimchi, a Korean fermented vegetable, have been established, wherein capsaicin, ascorbic acid, quercetin, 3-(4‘-hydroxyl-3’,5‘-dimethoxyphenyl)propionic acid, and lactic acids were identified. In this study, mechanisms of action of kimchi methanol extracts (KME) on fatty streak formation via suppression of ER stress and apoptosis in aorta were examined in low-density lipoprotein receptor knockout mice. MATERIALS AND METHODS: Mice fed a high cholesterol diet with an oral administration of KME (KME group, 200 ㎎·㎏-bw-1·day-1) or distilled water (control group) for 8 weeks (n = 20 for group). Plasma lipid and oxidative stress levels were evaluated. Protein expression was measured by western blot assay. Fatty streak lesion size and the degree of apoptosis were examined in the aorta. RESULTS: Compared to the control group, in the KME group, plasma lipids levels were decreased and oxidative stress was alleviated (P < 0.05). Protein expression levels of nuclear factor (erythroid-derived 2)-like 2-mediated antioxidants in aorta were increased whereas those for ER stress markers, glucose regulated protein 78, phospho-protein kinase RNA-like ER kinase, phospho-eukaryotic initiation factor 2 subunit α, X-box binding protein 1, and C/EBP homologous protein were decreased in the KME group (P < 0.05). Moreover, apoptosis was suppressed via downregulation of phospho-c-Jun N-terminal kinase, bcl-2-associated X protein, caspases-9, and -3 with a concomitant upregulation of anti-apoptotic protein, B-cell lymphoma 2 (P < 0.05). Fatty streak lesion size was reduced and the degree of apoptosis was less severe in the KME group (P < 0.05). CONCLUSIONS: In conclusion, antioxidant activity of KME might prevent fatty streak formation through, in part, inhibition of ER stress and apoptosis in aortic sinus where macrophages are harbored.
Woo, Minji,Noh, Jeong Sook,Cho, Eun Ju,Song, Yeong Ok American Chemical Society 2018 Journal of agricultural and food chemistry Vol.66 No.19
<P>This study investigated the inhibitory effects of kimchi bioactive compounds against endoplasmic reticulum (ER) stress-induced apoptosis in amyloid beta (Aβ)-injected mice. Mice received a single intracerebroventricular injection of Aβ<SUB>25-35</SUB>, except for the normal group. Mice were subjected to oral administration of 10 mg of capsaicin, 50 mg of 3-(4′-hydroxyl-3′,5′-dimethoxyphenyl)propionic acid (HDMPPA), 50 mg of quercetin, 50 mg of ascorbic acid, or 200 mg of kimchi methanol extract (KME) per kilogram of body weight for 2 weeks (<I>n</I> = 7 per group). In the in vitro blood-brain barrier (BBB) permeability test, all bioactive compounds penetrated the BBB except ascorbic acid. The protein expression level of APP, BACE, and p-Tau elevated by Aβ injection was decreased by kimchi bioactive compounds (<I>P</I> < 0.05). Quercetin, HDMPPA, and KME decreased oxidative stress, as indicated by ROS and TBARS levels (<I>P</I> < 0.05). The protein expression level of ER stress markers GRP78, p-PERK, p-eIF2α, XBP1, and CHOP and the proapoptotic molecules Bax, p-JNK, and cleaved caspases-3 and -9 decreased (<I>P</I> < 0.05). In contrast, the protein expression level of antiapoptotic molecules Bcl2 and cIAP increased (<I>P</I> < 0.05). These results were supported by histological analysis.</P> [FIG OMISSION]</BR>
Atypical Orbital Cellulitis Caused by Methicillin-Resistant Staphylococcus aureus: Two Cases
Minji Woo,Jinhwan Park,Sehyun Baek 대한검안학회 2018 Annals of optometry and contact lens Vol.17 No.1
Purpose: To report two cases of orbital methicillin-resistant Staphylococcus aureus (MRSA) cellulitis. Summary: We report two cases of orbital methicillin-resistant Staphylococcus aureus (MRSA) cellulitis with the unusual origins of nosocomial MRSA infection after facial osmetic procedures (forehead fat graft and canthoplasty) and community-acquired MRSA infection after trauma. Orbital swelling was patients chief complaint and rapid necrotic change of fat tissue or diffuse soft tissue infiltration was presented. Intraoperative wound cultures grew MRSA in both patents. After treatment of systemic antibiotics all symptoms were gradually improved. Conclusion: Severe and rapid necrotic change in the soft tissue, including orbital fat and levator muscle, can be an important sign of MRSA infection.
Sesame Oil Attenuates Renal Oxidative Stress Induced by a High Fat Diet
Minji Woo,Seongkyung Han,Yeong Ok Song 한국식품영양과학회 2019 Preventive Nutrition and Food Science Vol.24 No.2
The antioxidative effects of the bioactive compounds enriched sesame oil (e.g. lignans and tocopherols) are well established. This study aims to elucidate whether sesame oil could reduce renal oxidative stress induced by a high fat diet (HFD). Mice received HFD for 12 weeks (n=7 per group), which was prepared by adding 20% (w/w) lard (lard group) or sesame oil (sesame group) to the chow diet, respectively. Compared with mice in the lard group, renal lipid levels of those in the sesame group were reduced, shown by decreases in protein expression of transcription factors and enzymes involved in fatty acid synthesis (sterol regulatory element-binding protein-1 and acetyl coenzyme A carboxylase α) and an increase in -oxidation (peroxisome proliferator-activated receptor α and carnitine palmitoyltransferase I) (P<0.05). In the sesame group, levels of peroxynitrite and thiobarbituric acid reactive substances were also reduced, whereas the level of glutathione was increased. In addition, there was elevated protein expression levels of antioxidant enzymes regulated by nuclear factor-like 2, such as superoxide dismutase, glutathione peroxidase, and glutathione S-transferase (P<0.05), and decreased expression for nuclear factor kappa B and cyclooxygenase 2 (P<0.05). These results suggest that sesame oil could ameliorate HFD-induced renal damage by suppressing oxidative stress and inflammation.