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Ha, Eun Jin,Gwak, Ho-Shin,Rhee, Chang Hun,Youn, Sang Min,Choi, Chang-Woon,Cheon, Gi Jeong The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.54 No.3
Objective : Intracavitary injection of beta-emitting radiation source for control of cystic tumors has been tried with a benefit of localized internal radiation. The authors treated cystic brain tumor patients with Holmium-166-chitosan complex (Ho-166-chico), composed of a beta-emitting radionuclide Holmium-166 and biodegradable chit polymer, and evaluated the safety and effective measurement for response. Methods : Twenty-two patients with recurrent cystic brain tumor and/or located in a deep or eloquent area were enrolled in this pilot study. The cyst volume and wall thickness were determined on CT or MRI to assess radiological response. The activity of Ho-166-chico injected via Ommaya reservoir was prescribed to be 10-25 Gy to the cyst wall in a depth of 4 mm. Results : There was neither complications related to systemic absorption nor leakage of Ho-166-chico in all 22 patients. But, two cases of oculomotor paresis were observed in patients with recurrent craniopharyngioma. Radiological response was seen in 14 of 20 available follow-up images (70%). Seven patients of 'evident' radiological response experienced more than 25% decrease of both cyst volume and wall thickness. Another 7 patients with 'suggestive' response showed decrease of cyst volume without definitive change of the wall thickness or vice versa. All patients with benign tumors or low grade gliomas experienced symptomatic improvement. Conclusion : Ho-166-chico intracavitary radiation therapy for cystic tumor is a safe method of palliation without serious complications. The determination of both minimal effective dosage and time interval of repeated injection through phase 1 trial could improve the results in the future.
박용필,양승호,천민우 동신대학교 2005 論文集 Vol.15 No.-
BSCCO(Bi_(2)Sr_(2)Ca_(n-1)Cu_(n)O_(x)) 초전도 상을 이온 빔 스퍼터와 단일 타겟 DC-magnetron 스퍼터를 사용하여 제작하였다. 상형성은 n=2-3, 3-4 그리고 4-5 사이에서 이루어졌다. 스퍼터링 시 분위기 가스로 산소를 주입 하였고 제작된 박막의 상의 몰 비를 XRD를 이용하여 분석하였다. 각 상의 몰 비를 이용하여 초전도박막의 특성을 변화시킬 수 있음을 알았다. 또한, 각 상을 AFM과 SEM을 사용하여 박막의 표면을 관찰하여 표면의 불순물 상태를 알 수 있었다. BSCCO(Bi_(2)Sr_(2)Ca_(n-1)Cu_(n)O_(x)) superconducting phase were fabricated by an ion beam sputtering and single target dc-magnetron sputtering. Phase intergrowth among n=2-3, 3-4 and 4-5 phases was observed. The molar fraction of each phase in the mixed crystal of the deposited films was determined by X-ray diffraction analyses and investigated as a function of O_(2) gas pressure during sputtering. We investigated the changes of the superconducting properties by molar fraction of each phase. Also, the thin film surface observation was carried out by AFM. According to the result observing the surface of the thin film with SEM, even in case that the formed phase and the composition of the thin film agree, it can be known that there are a number of the precipitates on the surface.
조원서 ( Wonse Jo ),천경민 ( Kyeong-min Cheon ),류근호 ( Keun-ho Rew ) 한국센서학회 2017 센서학회지 Vol.26 No.2
Until now, neuropsychological tests can diagnose the brain dysfunction, however, cannot distinguish the objective data of experiment enough to distinguish the relationships between brain dysfunction and cerebropathia. In this paper, an automatic cognitive test equipment system with 6-axis motion sensors was proposed for the automation of neuropsychological tests. Fist-Edge-Palm(FEP) test and Go-no go test were used to evaluate motor programming of frontal lobe. The motion data from the specially designed motion glove are transmitted wirelessly to a computer to detect the gestures automatically. The healthy 20 and 11 persons are investigated for the FEP and Go-No go test, respectively. The recognition rates of gestures of FEP and Go-No go test are min. 91.38% and 89.09%. In conclusion, the automations of cognitive tests are successful to diagnose the brain diagnostics quantitatively.
규칙적인 운동과 F1, 6DP의 투여가 유산소지구력 및 항산화능에 미치는 영향
이종우(Lee Jong-Woo),하민수(Ha Min-Soo),이천호(Lee Cheon-Ho),박석(Park Sok) 한국체육과학회 2009 한국체육과학회지 Vol.18 No.3
This study investigated effects of regular exercise and F1, 6DP supplement on endurance exercise capacity and antioxidant capacity in rats. Male Sprague-Dawley rats were randomly assigned to one eight groups(n=8): sedentary control group, exercied control group, F1, 6DP supplemented group and exercised F1, 6DP supplement group. F1, 6DP supplemented group, and exercsied F1, 6DP supplement group. Rats were fed experimental diets supplemented with F1, 6DP at the level of 10 ㎎/㎏/day for 4 weeks. Rats of exercised control group, F16-DP supplemented group and exercised F1, 6DP supplement exercised groups performed swimming exercise training at 60 min/day for 4 weeks. Exhaustive swimming time(endurance exercise capacity) was significantly increased in exercised control group, F1, 6DP supplemented group, and exercised F1, 6DP supplement group compared to the value for sedentary control group. Total antioxidant capacity was significantly higher in exercised control group, F1, 6DP supplemented group, and exercised F1, 6DP supplement group than sedentary control group. Free radical release was significantly lower in exercised control group FI, 6DP supplemented group, and exercised F1, 6DP supplement group than sedentary control group, These results indicate that F1, 6DP appear to be effective in enhancing enduranced exercised performance and antioxidant capacity of trained rats.
Sok Park(박석),Ki Woon Sung(성기운),Jin Lee(이진),Cheon Ho Lee(이천호),Young Jun Lee(이영준),Young June Yoo(유영준),Kyoung Shil Park(박경실),Byung Jin Min(민병진),Yong Sub Shin(신용업),Jung Suk Kim(김정석),Hun Jung(정훈) 한국생명과학회 2012 생명과학회지 Vol.22 No.4
본 연구는 비만과 노화가 동시에 유발된 흰쥐에서 12주간의 트레드밀 운동과 L-arginine의 투여가 복부지방량, GH, IGF-Ⅰ, somatostatin, fibrinogen, PAI-1에 미치는 영향을 관찰하고 이를 개선하는데 더욱 효과적인 방법을 제시하는데 그 목적이 있다. 이를 위해 단독 처치 군과 복합 처치 군으로 나누어 실험하여 그 효과를 비교, 분석한 결과 다음과 같은 결론을 얻었다. 1. 복부지방량은 통제집단에 비해 모든 집단에서 유의하게 감소하였다(p<0.01). 2. AG+EX, AG+LA+EX집단에서 통제집단에 비해 GH의 혈중 농도가 유의하게 높게 나타났다(p<0.1). 3. AG+EX, AG+LA+EX집단에서 통제집단에 비해 IGF-Ⅰ의 혈중 농도가 유의하게 증가하였다(p<0.01). The purpose of this study was to investigate the effect of exercise and/or L-arginine on abdominal fat, IGF-1 on GH/IGF-1 axis, fibrinogen, and PAI-1 in aged and obese rats. Male Sprague-Dawley rats were treated with a D-galactose aging inducing agent (50 mg/kg) given intraperitoneally for 12 weeks. Thirty-two male Sprague-Dawley rats were treated and divided into four groups: aging-high fat diet group (AG+HF), AG+HF with L-arginine intake group (AG+LA), AG+HF with exercise group (AG+EX), and AG+EX with L-arginine intake group (AG+LA+EX). The experimental rats underwent treadmill training (60 min/day, 6 days/week at 0% gradient) for 12 weeks. L-arginine was given orally (150 mg/kg/day) for 12 weeks. After the experiment, blood was collected from the left ventricle and abdominal fat was extracted. The results showed that GH was significantly increased in AG+EX and AG+AL+EX. IGF-1 was significantly increased in both the AG+AL+EX and AG+EX group (p<0.05), while fibrinogen and PAI-1 were not significantly different among the groups. Abdominal fat was significantly decreased in the AG+LA, AG+EX, and AG+LA+EX groups (p<0.05) compared with the AG+HF group. In conclusion, this study suggests that exercise alone or L-arginine alone or a combination not only increases the GH and IGF-1 concentration, but also decreases the abdominal fat mass.
정응기,이기환,원용재,박향미,전남수,최준호,구연충,한창덕,은무영,김태산,남민희 Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.
This study was conducted to investigated the major characteristics of genetically modified rice of "Milyang 204" originated from Dongjinbyeo compared to a non-transgenic rice varieties Dongjinbyeo and Junambyeo. Basta resistant transgenic rice lines carrying bar gene produced by the Yeongnam Agricultural Research Institute were evaluated for their agronomic characters. The transgenic Japonica rice of "Milyang 204" showed inferior phenotypic traits compared to a non-transgenic rice variety Dongjinbyeo and Junambyeo. On the basis of UPOV (Union Internationale Pour la Protaection des Obtentions Vegetables) and NSMO(National Seed Management Office) the transgenic "Milyang 204" showed difference in some traits out of some agronomic traits, such as leaf color, angle of flag leaf, number of spikelets, culm length, white core and white belly compared to the nontransgenic varieties rice.