NO(Nitric Oxide)에 의한 이자의 외분비 조절작용

한유미,김병무,민본홍,박인선 대한해부학회 2000 Anatomy & Cell Biology Vol.33 No.5

C -11 및 F - 18 표지 콜린의 합성과 체내동태에 관한 연구

전권수,유국현,김상욱,임상무,홍성운,서용섭,양승대,안순혁,허민구 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.3

Objectives: Recently, [methyl-(11)^C]-(β-Hydroxyethyl)trimethylammonium ([(11)^C]choline) has been discovered to be a very effective tracer in imaging various human tumors using positron emission tomography. Because of the short half-life of C-11, it is very difficult to use in a routine imaging procedure and needs a frequent synthesis of [(11)^]choline. This can be supplemented by the substitution of [(11)^Ccholine with [methyS-18]fluorocholine. Here, we would like to report cell uptake and biodistribution of [(11)^Ccholine and [(18)^F]fluorocholine as a basic study. Methods [(11)^C]Choline was prepared by the treatment of [(11)^C]CHzI with N,N-dimethylaminoethanol and [18F]fluorocholine was synthesized from reaction of CHzBr[18F]F with N,N-dimethylaminoethanol. The radiochemical purity was checked by high performance liquid chromatography (HPLC). The biodistribution of [(11)^C]choline and [(18)^F]fluorocholine was determined in balb/c mouse at 5 min, 20 min, 40 min and 80 min. The cell uptake wa measured using glioma (9L) and colon adeocarcinoma (SW620). Results: The radiochemical purity was more than 98% after purification. In the liver, uptake did not change over time the uptake was 20/ID/g for [C]choline and 13%ID/g for [(18)^F]fluorocholine. In the kidney, radioactivity decreased over tirne the uptake was 15%1D/g for [(11)^Ccholine and 20%ID/g for [(18)^F]fluorocholine, 80 min post-injection. The cell uptake of [(11)^Ccholine was 4.93% for glioma (9L) and 18.69F for colon adenocarcinoma (SW620). For [(18)^F]fluorocholine, 1.77% for glioma (9L) and 2.77% for colon adenocarcinoma (SW620). Conclusion: [(11)^CCholine and [(18)^F]fluorocholine showed a different cell uptake tendency, depending on cancer cell line. (Korean J Nucl Med 200135:185-191)

Factors Influencing the Acrylamide Content of Fried Potato Products

Jin, Yong-Ik,Park, Kyeong-Hun,Chang, Dong-Chil,Cho, Ji-Hong,Cho, Kwang-Su,Im, Ju-Sung,Hong, Su-Young,Kim, Su-Jeong,Nam, Jung-Hwan,Sohn, Hwang-Bae,Yu, Hong-Seob,Chung, Ill-Min The Korean Society of Environmental Agriculture 2016 한국환경농학회지 Vol.35 No.4

BACKGROUND: Acrylamide (CAS No. 79-06-1) is known to be a carcinogenic compound, and is classified as a Group 2A compound by the International Agency for Research on Cancer (IARC, 1994). Acrylamide can be generated during the browning process via the non-enzymatic Maillard reaction of carbohydrates such as reducing sugars and of amino acids such as asparagine, both of which occur at a temperature above $120^{\circ}C$. Potato tubers contain reducing sugars, and thus, this will affect the safety of processed potato products such as potato chips and French fries. In order to reduce the level of acrylamide in potato processed products, it is therefore necessary to understand factors that affect the reducing sugar content of potatoes, such as environmental factors and potato storage conditions, as well as understanding factors affecting acrylamide formation during potato processing itself. METHODS AND RESULTS: Potatoes were cultivated in eight regions of Korea; For each of these different environments, soil physico-chemical characteristics such as pH, electrical conductivity, total nitrogen, available phosphate, and exchangeable cation content were measured and correlations with potato reducing sugar content and potato chip acrylamide levels were examined. The reducing sugar content in potato during storage for three months was determined and acrylamide level in potato chip was analyzed after processing. The storage temperature levels were $4^{\circ}C$, $8^{\circ}C$, or $10^{\circ}C$, respectively. The acrylamide content of chips prepared from potatoes stored at $10^{\circ}C$ or $20^{\circ}C$ for one month was analyzed and the different frying times were 2, 3, 5, and 7 min. CONCLUSION: This study showed that monitoring and controlling the phosphate content within a potato field should be sufficient to avoid producing brown or black potato chips. For potatoes stored at low temperatures, a reconditioning period ($20^{\circ}C$ for 20 days) is required in order to reduce the levels of reducing sugars in the potato and subsequently reduce the acrylamide and improve chip coloration and appearance.

中學 科學敎育의 探究學習에 대한 評價問項 開發 (Ⅱ)

閔庚德,楊洪準,李善行,鄭遠佑,이병교,金裕漢,羅長薰 경북대학교 과학교육연구소 1985 科學敎育硏究誌 Vol.9 No.-

This study was accomplished to develope the evaluation items for inquiry learning in the 2nd grade Middle School Science for the consecutive study of the evaluation items for inquiry learning in the 1st grade Middle School Science(U-Hang Ki et al, 1984). In this study, paper and pencil test items and performance test items are made by analyzing the abilities of inquiry according to the contents and four basic experiments from each unit in the 2nd grade Middle school science. These evaluation items were applied to tke five classes of the 2nd grade of middle school to test their validity. It is desirable that performance test schuld be used for the evaluation for the abilities of inquiry which can not be evaluated by paper and pencil test. In the evaluation methods of performance test, tester evaluation, peer evaluation and self-evaluation can be applied to the science class in a multi-student class. In higher grade, however tester evaluation is more desirable than peer and self evaluation. It is found that peer evaluation and self-evaluation make possible the perfect study by feedback.

장중첩증을 동반한 맹장 지방종 1예

홍의실,나병규,김민옥,유일영,채지영,채희복,윤세진,이상전,송형근,박길선,정현용 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

대장 지방종은 주로 우측 결장에 호발하고 특히 회맹판 부위와 맹장 부위에 호발한다. 또한 50~60대에 빈도가 높고 증상이 있는 환자에서 장중첩증이 높게는 40~50%에서 보고되고 있어 성인 장중첩증의 원인으로 중요한 비중을 차지한다. 특히 성인 장중첩증 및 장폐쇄의 중요 원인인 악성 종양과 임상 양상이 유사하여 감별진단이 중요하다. 저자들은 반복적인 복통을 주소로 내원한 환자에서 맹장의 4×5㎝의 점막하 지방종이 말단 회장부위와 반복적인 장중첩중이 발생했던 1례를 부분 절제술로 치료하여 양호한 임상 경과를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Lipomas are one of the most common benign nonepithelial tumors of the colon which are often detected incidentally by radiologic investigation or on operation. These tumors are usually without specific symptoms. Colonic lipomas occur most often in the right colon, particularly in the ileocecal valve and the cecum. Most patients are asymptomatic. but tumors larger than 2 cm tend to produce a change in bowel habit. abdominal pain. rectorrhagia and complications including luminal obstruction or intestinal intussusception. Diagnosis can be made by colonoscopy abdominal CT. MRI, or barium enema. We report a case of lipoma of the cecum that originated in the submucosa and presented as a intussusception in a 50-year-old woman with a brief review of the literature.

주야 교대 근무가 편두통에 미치는 영향 : 한림대학교 의료원 간호사 연구 Hallym Medical Center Nurse Study

주민경,유경호,마효일,김윤중,김주용,송흥기,이병철 대한두통연구회 2004 두통 Vol.5 No.1

노인 복지관 실내 색채 현황에 관한 연구

김유리,민찬홍 동덕여자대학교 디자인연구소 2003 디자인포럼21 Vol.6 No.-

현재 전 세계적인 노령인구의 급격한 증가는 노인 문제를 심각한 사회문제로 대두시켰고 이는 국내의 상황과도 별반 다를 바가 없다. 이런 문제점을 해결하기 위한 방안으로 지역 주민의 노인부양을 덜어주며 노인들의 여가 생활을 지원해 사회적 격리 문제를 해결하고 정서적, 사회적 유대감을 조성할 수 있는 여건을 만들어 주는 노인 종합 복지관의 중요성이 부각되고 있다. 경제활동이 없는 노인들은 노인복지관 내 취미공간의 서비스 프로그램의 다양화와 노인들 간의 친목과 유대관계가 이루어지는 공간으로 가정에서 거주하는 시간 이외에 대부분의 시간을 복지관에서 기거한다. 따라서 실 사용자인 노인들의 시 · 지각뿐만 아니라 심리적인 영향을 고려하여 편안하고 안락한 환경을 제공할 수 있는 보호소와 여가 생활을 하는데 있어서 흥미를 유발하고 지속적인 활동이 이루어 질 수 있도록 하는 환경이 제공되어야 한다. 실내 내부 환경 요소로 작용하는 것에는 색채, 조명, 소음 등 여러 가지가 있으며 이러한 요소들은 독단적으로 영향을 주기보다는 상호 복합적으로 작용한다. 인간은 오감 중에 80% 이상을 시각적 자극에 의해 정보를 얻고 감성이 자극받는다는 사실을 미루어 볼 때 실내 환경에서 색채가 얼마나 중요한지 알 수 있다. 특히 노인은 노화와 질병으로 시 · 지각 능력이 일반인에 비해 떨어지는 것을 감안하여 시각적 만족을 주는 심미적인 색채의 사용과 색채 심리, 치료에 이용되는 색채를 복지관에 적용한다면 현 복지시설에 대한 노인들의 만족도와 이용능률을 향상시킬 수 있을 것이다. 본 연구는 노인에게 합당한 색채 환경을 제시하고자 하는 후속 연구에 앞서 서울에 있는 다섯 곳의 노인 종합 복지관을 조사 대상으로 현재의 노인 종합 복지관의 실내 색채를 조사 분석하여 노인 복지관의 실내 색채 현황을 조사 분석하여 그 문제점을 파악하는데 있다. In present, the sudden increase in old-aged population became the serious problem of the worldwide concern and same thing happens here. The general welfare institution for the aged is divided into two sections in wide view, a supporting section that lighten the local dweller's obligation of supporting and the hobby section that supporting the usage of rest of their life time. The old and retired aged people spend their almost time in the space where they can meet the others and make relationship in additional have the variety programs for their hobby life is the actual circumstance. Consequently it's environment for their comfortable living designed according to the regard of not only the old aged(real residents)'s sight and sensation but also the mental effects and environment for stimulating their interests, keeping up the activity must be offered. The fact that a human being get information and stimulates his sensitivity more than 80% from visual influence makes us to know how important the color in indoor environment is. Furthermore the old people have less sight and mental faculties compare with normal young people because of symptoms of senility and sickness. So if we consider this peculiarity and apply to welfare facilities study about color that also used to color psychology and cure then we can improve satisfaction and coefficient of utilization of the aged about welfare facilities nowadays. I checked out 5 general welfare institution for the aged to present compatible color environment to old people. This study precedes the following study which is focused on the proposal of suitable or appropriate color circumstance for old age. Upon inquire and analysis on interior color into 5 general welfare facilities for old age in Seoul, the study aims at analyzing the present status of those welfare facilities and understanding the current problem.

韓國産 蓼(여뀌)科 植物에 관한 本草學的 硏究 (I)

柳泓善,宋昊埈,辛民敎,金裕鎭,金台晛 한국전통의학연구소 1998 한국전통의학지 Vol.8 No.2

For the purpose of developing Korean Herbalogy with the plants of Polygonaceae which grow wild and is planted in Korea, the these and writings on herbalogy, from literature of successive generations, have been thoroughly investigative and the results obtained were as follows: 1. There were totaled to 16 genera and 156 species in Korea and among them medicinal plants are 12 genera, 47 species, some 30% in total, but the number of species may be added because of the similiar plants. 2. According to the oriental names which can be used for medical purpose, the medicinal plants belonging to the Polygonaceae family were classified as Herba 21, Radix 12, Foilum 8, Lignum 5, Flos 4, Fructus 5, Ramulus 2 and Semen 1. Thus it was noticed that Herba was the main kind. 3. According to sum of 156 species in Polygonaceae family, they were classified into Persicaria genera 63, Polygonum genera 23, Rumex genera 22, Bistorta genera 14, Aconogonum genera 6, Fagopyrum genera 5, Bilderdykia genera 4, Amblygonum genera 3, Reynoutria genera 3, Rheum genera 3, Pleuropterus genera 2, Pleuropteropyrum genera 2, Tovara genera 2, Ampelygonum genera 1, Homalocladium genera 1 and Oxyria genera 1. Thus it was noticed that Persicaria genera was the main kind, some 40.3% in total. 4. According to nature and flavour of medicinal plants, they were classified into cold, cool; 23 each, warmth, heat; 11 each, balance 11 and unidentified 5. Thus it was noticed that cold, cool is the main in nature and flavour of medicinal plants. From this result, it was revealed that the plants for medical purpose in Polygonaceae was 30% of the whole, in which HERBA was mostly abundunt and toxic plants was slightly poisonous that it will be used for clinical treatments more easily. It is considered that many experiements and clinical approaches must be continued to use Polygonaceae plants widely.

괴사성 장염 환아의 금식기간 결정을 위한 Iohexol의 유용성 : Iohexol의 위장과 투여 후 채취한 소변을 전산화단층촬영법을 이용

정유진,홍성완,류민현,정철주,문경래 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Background: Necrotizing enterocolitis is the most common gastrointestinal emergency in the neonates and its course is often fulminating with progressive lethargy. The purpose of this study is to determine the period of NP0(non per os) treatment in the patients with neonatal necrotizing enterocolitis. Matenal and methods: For determining the normal range of CT(Computerized tomography) attenuation coefficients of urine from normal neonates, 60 normal neonates participated in this study. And urine specimens from 16 patients with stage IIB necrotizing enerocolitis were obtained 8-12 hours after the instillation of iohexol enterally. The attenuation coefficients of each urine specimen were determined with CT. Periodic examinations were performed at an interval of two days. As soon as the values of attenuation coefficients reached the normal range, we discontinued NPO treatment. Results: The mean period of NPO treatment of 16 patients with stage IIB necrotizing enterocolitis was 11.1 days. The NPO period of 6 patients were 8 days, two were 10 days, four were 12 days, one was 14 days and three were 16 days. Conclusion: By means of this study, we were able to determine the period of NPO treatment on a case by case basis. The authors think that CT examination of the obtained urine after the instillation of iohexol may be a good method to determine the period of NPO treatment.

유리섬유강화 복합절연재료의 열화특성에 관한 연구

이규철,유근민,김경석,박홍태 울산대학교 1996 공학연구논문집 Vol.27 No.2

본 연구에서는 주위 환경 열화에 따른 복합절연재료의 절연특성과 수명을 향상시키기 위해 고온에서 흡습량을 변화시켰을 때와 탈습량을 변화시켰을 때 흡십시료와 탈습시료의 전기적 특성 및 기계적 특성을 조사하였다. 유리섬유 각층의 흡습상수는 각각 1층에서 0.0117, 2층에서 0.0123, 3층에서 0.0152를 나타냈다. 전기적 특성 및 기계적 특성은 복합재료의 흡습에 따라 크게 떨어졌다. 70℃에서 습기가 완전히 건조되어도 흡습전의 전기적 및 기계적 특성을 얻기가 어려운 것으로 나타났다. 수분에 의해 발생한 복합절연재료내에 존재하는 많은 결함들은 에폭시 메트릭스와 필라사이에 존재하였다. The electrical and mechanical properties of moisture absorbed and moisture desorbed specimens were investigated to improve the insulating characteristics and the reliability of composite materials against environment aging. Moisture absorption constants with the layers of glass fiber showed 0.0117 in 1 layer, 0,0123 in 2 layer and 0.0152 in 3 layer, respectively. Although moisture was removed at 70℃, it was impossible to obtain the initial electrical and mechanical properties. Many defects induced by moisture were observed at the interface between epoxy matrix and filler in composite materials.