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Hajji, Apif M.,Lewis, Michael Phil Korea Institute of Construction Engineering and Ma 2013 Journal of construction engineering and project ma Vol.3 No.2
Earthwork activities are typically performed by heavy duty diesel (HDD) construction equipment that consumes large quantities of diesel fuel use and emits large quantities of pollutants, including nitrogen oxides (NOx), particulate matters (PM), hydrocarbon (HC), carbon monoxide (CO), and carbon dioxide ($CO_2$). This paper presents the framework for a model that can be used to estimate the production rate, activity duration, total fuel use, and total pollutants emissions for earthwork activities. A case study and sensitivity analysis for an excavator performing excavations are presented. The tool is developed by combining the multiple linear regressions (MLR) approach for modeling the productivity with the EPA's NONROAD model. The excavator data from RSMeans Heavy Construction Data were selected to build the productivity model, and emission factors of all type of pollutants from NONROAD model were used to estimate the total fuel use and emissions. The MLR model for the productivity rate can explain 92% of the variability in the data. Based on the model, the fuel use and emissions of excavator increase as the trench depth increase, but as the bucket size increase, the fuel use and emissions decrease.
Using Mobile and Web Applications to Conduct HIV Researching NYC Neighborhoods
Bae, Minwoo,Rivera, Alexis,Lewis, Michael D.,Fuller, Crystal M. 한국디지털디자인협의회 2013 (사)한국디지털디자인협의회 conference Vol.2013 No.8
Pharmacists in retail settings are beginning to emerge as a resource in the prevention and treatment of HIV. Community pharmacies are venues for HIV prevention services including HIV testing, risk reduction counseling and more recently antiretroviral therapy drug monitoring and compliance counseling. Their role is especially important and could have a positive impact in urban areas where there are still high rates of HIV infection and chronic disease. We also find the greatest disparities in access to healthcare and health education by race and income in our largest metropolitan cities like New York. The need for technology and innovation to improve health outcomes for all residents is critical in a changing healthcare environment. The iPEPcare research project began in 2010 and development of the application began early last year (Jan_2012). It is now in the process of going into field-testing this summer with a group of 4 pharmacists and 2 physicians.
Design and Analysis of 3D-MAPS (3D Massively Parallel Processor with Stacked Memory)
Dae Hyun Kim,Athikulwongse, Krit,Healy, Michael B.,Hossain, Mohammad M.,Moongon Jung,Khorosh, Ilya,Kumar, Gokul,Young-Joon Lee,Lewis, Dean L.,Tzu-Wei Lin,Chang Liu,Panth, Shreepad,Pathak, Mohit,Minzhe IEEE 2015 IEEE Transactions on Computers Vol. No.
<P>This paper describes the architecture, design, analysis, and simulation and measurement results of the 3D-MAPS (3D massively parallel processor with stacked memory) chip built with a 1.5 V, 130 nm process technology and a two-tier 3D stacking technology using 1.2 \microm-diameter, 6 \micro m-height through-silicon vias (TSVs) and 3.4\nbsp\microm-diameter face-to-face bond pads. 3D-MAPS consists of a core tier containing 64 cores and a memory tier containing 64 memory blocks. Each core communicates with its dedicated 4KB SRAM block using face-to-face bond pads, which provide negligible data transfer delay between the core and the memory tiers. The maximum operating frequency is 277 MHz and the maximum memory bandwidth is 70.9 GB/s at 277 MHz. The peak measured memory bandwidth usage is 63.8 GB/s and the peak measured power is approximately 4 W based on eight parallel benchmarks.</P>
Bergmeijer, Thomas O.,Reny, Jean-Luc,Pakyz, Ruth E.,Gong, Li,Lewis, Joshua P.,Kim, Eun-Young,Aradi, Daniel,Fernandez-Cadenas, Israel,Horenstein, Richard B.,Lee, Ming Ta Michael,Whaley, Ryan M.,Montane Elsevier 2018 American Heart Journal Vol.198 No.-
<P><B>Rationale</B></P> <P>The P2Y<SUB>12</SUB> receptor inhibitor clopidogrel is widely used in patients with acute coronary syndrome, percutaneous coronary intervention, or ischemic stroke. Platelet inhibition by clopidogrel shows wide interpatient variability, and high on-treatment platelet reactivity is a risk factor for atherothrombotic events, particularly in high-risk populations. <I>CYP2C19</I> polymorphism plays an important role in this variability, but heritability estimates suggest that additional genetic variants remain unidentified. The aim of the International Clopidogrel Pharmacogenomics Consortium (ICPC) is to identify genetic determinants of clopidogrel pharmacodynamics and clinical response.</P> <P><B>Study design</B></P> <P>Based on the data published on www.clinicaltrials.gov, clopidogrel intervention studies containing genetic and platelet function data were identified for participation. Lead investigators were invited to share DNA samples, platelet function test results, patient characteristics, and cardiovascular outcomes to perform candidate gene and genome-wide studies.</P> <P><B>Results</B></P> <P>In total, 17 study sites from 13 countries participate in the ICPC, contributing individual patient data from 8,829 patients. Available adenosine diphosphate–stimulated platelet function tests included vasodilator-stimulated phosphoprotein assay, light transmittance aggregometry, and the VerifyNow P2Y<SUB>12</SUB> assay. A proof-of-principle analysis based on genotype data provided by each group showed a strong and consistent association between <I>CYP2C19</I>*2 and platelet reactivity (<I>P</I> value=5.1 × 10<SUP>−40</SUP>).</P> <P><B>Conclusion</B></P> <P>The ICPC aims to identify new loci influencing clopidogrel efficacy by using state-of-the-art genetic approaches in a large cohort of clopidogrel-treated patients to better understand the genetic basis of on-treatment response variability.</P>
Treatment of patients with severe traumatic brain injury: a 7-year single institution experience
Corrado P. Marini,Patrizio Petrone,John McNelis,Erin Lewis,Anna Liveris,Michael F. Stiefel 대한신경집중치료학회 2021 대한신경집중치료학회지 Vol.14 No.1
Background: This study was designed to compare the efficacy of multimodality monitoring and goal-directed therapy protocol (MM&GDTP), in patients with Glasgow Coma Scale (GCS) scores ≤8 with the conventional intracranial pressure (ICP)-cerebral perfusion pressure (CPP) treatment. Methods: The study was divided into two time periods, a 2-year historic period in which severe traumatic brain injury (sTBI) patients were treated with an ICP-CPP targeted strategy and a 5-year intervention period during which MM&GDTP was utilized. Patients with unsurvivable brain injuries were excluded. Variables of interest included mechanism of injury, age, sex, hemodynamics, GCS score, abbreviated injury score–head (AIS-H), Marshall Class, injury severity score, decompressive craniectomy, ventilator/intensive care unit days, length of stay, predicted mortality by corticosteroid randomization after significant head injury model, functional outcome, and mortality. Results: The study group comprised 810 sTBI patients, aged 14–93 years, admitted during a 7-year period; of these patients, 67 and 99 AIS-H≥4 and Marshall Class ≥III were included in control and intervention groups, respectively. The control group was treated with an ICP-CPP targeted approach, while the intervention group with an MM&GDTP. At presentation and after resuscitation, patients in the intervention group required a higher CPP to reach the endpoints of therapy. The MM&GDTP decreased mortality from 34.3% to 23.2%, yielding a 32.3% improvement in overall survival and improved functional outcome as measured by Glasgow Outcome Scale >3 (MM&GDTP vs. ICP-CPP: 50/99 vs. 15/67, P=0.003). Conclusion: Institution of MM&GDTP targeted to threshold-defined values improves functional outcomes and may reduce mortality among patients with sTBI compared to that of patients receiving an ICP-CPP–based treatment.
E. Mitchell Seymour,Ignasia I. Tanone,Daniel E. Urcuyo-Llanes,Sarah K. Lewis,Ara Kirakosyan,Michael G. Kondoleon,Peter B. Kaufman,Steven F. Bolling 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.12
Metabolic syndrome can precede the development of type 2 diabetes and cardiovascular disease and includes phenotypes such as obesity, systemic inflammation, insulin resistance, and hyperlipidemia. A recent epidemiological study indicated that blueberry intake reduced cardiovascular mortality in humans, but the possible genetic mechanisms of this effect are unknown. Blueberries are a rich source of anthocyanins, and anthocyanins can alter the activity of peroxisome proliferatoractivated receptors (PPARs), which affect energy substrate metabolism. The effect of blueberry intake was assessed in obesity-prone rats. Zucker Fatty and Zucker Lean rats were fed a higher-fat diet (45% of kcal) or a lower-fat diet (10% of kcal)containing 2% (wt/wt) freeze-dried whole highbush blueberry powder or added sugars to match macronutrient and calorie content. In Zucker Fatty rats fed a high-fat diet, the addition of blueberry reduced triglycerides, fasting insulin, homeostasis model index of insulin resistance, and glucose area under the curve. Blueberry intake also reduced abdominal fat mass,increased adipose and skeletal muscle PPAR activity, and affected PPAR transcripts involved in fat oxidation and glucose uptake/oxidation. In Zucker Fatty rats fed a low-fat diet, the addition of blueberry also significantly reduced liver weight, body weight, and total fat mass. Finally, Zucker Lean rats fed blueberry had higher body weight and reduced triglycerides, but all other measures were unaffected. In conclusion, whole blueberry intake reduced phenotypes of metabolic syndrome in obesityprone rats and affected PPAR gene transcripts in adipose and muscle tissue involved in fat and glucose metabolism.