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( So Ri Kim ),( Yong Chul Lee ),( Dong Im Kim ),( Yang Keun Rhee ),( Heung Bum Lee ),( Seoung Ju Park ),( Chi Ryang Chung ),( Seung Yong Park ),( Mi Ran Kang ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Oxidative stress is well known to be implicated in the development of asthma. The mitochondrial respiratory chain is a major site of intracellular reactive oxygen species (ROS) generation and, at the same time, an important target for the damaging effects of ROS. Mito-Tempo is a specific mitochondrial ROS inhibitor and it is known to be associated with opening of mi-tochondrial permeability transition pore and inhibition of cell necroptosis or apoptosis. However, there is little information on the protective effects of Mito-Tempo on the inflammatory airway disorders including bronchial asthma and its acute exacerbation. We investigate the effects of Mito-tempo on the allergic airway inflammation and hyperresponsiveness using the mice sensitized with OVA and LPS and then challenged with OVA (OVALPS-OVA mice). The OVALPS-OVA mice showed the typical features of neutrophilic asthma; increased airway inflammatory cells, the pathologic changes, the increased levels of Th2 cytokines in lungs of OVALPS-OVA mice, increased mitochondrial ROS generation, and increased bronchial hyperresponsiveness. Interestingly, we found that in OVALPS-OVA mice, Mito-Tempo, a novel mitochondrial targeting agent significantly reduced the increases in inflammatory cytokines, mitochondrial ROS generation, airway inflammation, and bron-chial hyperresponsiveness. These findings indicate that mitochondrial dysfunction including oxidative damage may be im-plicated in the pathogenesis of bronchial asthma and provide the therapeutic potential of a mitochondrial targeting agent, Mito-Tempo, for bronchial asthma.
( Mi Sun Kim ),( Tae Jun Park ),( Ji Youn Park ),( Hye Ran Kim ),( Sun Yi Park ),( Kyoung Chan Park ),( Jean Paul Ortonne ),( Hee Young Kang ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Wnt signaling plays a role in the differentiation as well as the development of melanocytes. Using a microarray analysis, hyperpigmentary skin of melasma expressed high levels of Wnt inhibitory factor-1 (WIF-1) compared to perilesional normal skin. Objectives: In this study, we investigated the expression and functional role of WIF-1 in melanocytes. Methods: The expressions and fuctions of WIF-1 were assessed by Immunohistochemical staining, RT-PCR, western blot analysis, and immunocytochemical staining. Using a lentivirus system, WIF-1 was overexpressed in normal human melanocytes. siRNA system was used for WIF-1 downregulation. Ex vivo skin organ culture and promoter analysis were performed. Results: WIF-1 was expressed in both the melanocytes of normal human skin and in cultured melanocytes. The upregulation of WIF-1 on cultured normal human melanocytes significantly induced expressions of MITF and tyrosinase, which were associated with increased melanin content and tyrosinase activity. Consistent with the stimulatory effect of WIF-1, WIF-1 siRNA reduced melanogenesis in the cells. Moreover, WIF-1 increases pigmentation in melanocytes co-cultured with WIF-1 overexpressed fibroblasts and of organ-cultured human skin. Conclusion: These findings suggest that melanocytes express WIF-1 constitutively in vivo and in vitro and that WIF-1 promotes melanogenesis in normal human melanocytes. WIF-1 may have a role of increased melanogenesis in melanocytes of melasma skin.
A New Hybrid, Dark Pink Spotted Type Phalaenopsis ‘Pink Marble’
Mi Seon Kim,Young Ran Lee,Hye Kyung Rhee,Sang Kun Park,Hak Ki Shin,Hyang Young Jung,Jin Hee Lim 한국원예학회 2011 원예과학기술지 Vol.29 No.5
A new hybrid, Phalaenopsis ‘Pink Marble’ was made by the National Institute of Horticultural and Herbal Science, Rural Development Administration, in 2005. This hybrid was selected from self-crossed progenies of P. ‘21-1’ (collected number) in 1999. In 2001, one line was selected based on the aspects such as flower color, leaf shape, flower stalk, and vigorous growth. Trials were conducted from 2003 to 2005 for evaluation and selection of this cultivar. ‘Pink Marble’ had a medium flowering habit and a dark pink spot (RHS, RPN74B) on white petal and sepal when fully opened. The number of flowers on each peduncle was 7.5, and flower diameter was 52.3 cm. The general impression of petals and sepals is a plate shape. The thick sepal could extend the long flowering time. The average length of leaf and peduncle were 16.5 cm and 6.8 cm, respectively. It had a half-erect leaf form, and was a fast-growing cultivar. This hybrid is relatively easy to clone.
Park, Jin-Kyu,Ki, Mi-Ran,Lee, Eun-Mi,Kim, Ah-Young,You, Sang-Young,Han, Seon-Young,Lee, Eun-Joo,Hong, Il-Hwa,Kwon, Soon-Hak,Kim, Seong-Jin,Rando, Thomas A,Jeong, Kyu-Shik Pergamon Press ; Elsevier Science Ltd ; Elsevier S 2012 CELL TRANSPLANTATION Vol.21 No.11
<P>Recently, adipose tissue-derived stem cells (ASCs) were emerged as an alternative, abundant, and easily accessible source of stem cell therapy. Previous studies revealed losartan (an angiotensin II type I receptor blocker) treatment promoted the healing of skeletal muscle by attenuation of the TGF-β signaling pathway, which inhibits muscle differentiation. Therefore, we hypothesized that a combined therapy using ASCs and losartan might dramatically improve the muscle remodeling after muscle injury. To determine the combined effect of losartan with ASC transplantation, we created a muscle laceration mouse model. EGFP-labeled ASCs were locally transplanted to the injured gastrocnemius muscle after muscle laceration. The dramatic muscle regeneration and the remarkably inhibited muscular fibrosis were observed by combined treatment. Transplanted ASCs fused with the injured or differentiating myofibers. Myotube formation was also enhanced by ASC(+) satellite coculture and losartan treatment. Thus, the present study indicated that ASC transplantation effect for skeletal muscle injury can be dramatically improved by losartan treatment inducing better niche.</P>