Midazolam 투여시 선행성 건망증 발현에 관한 연구

이정하,김미라,이난영,이상호 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.3

최근 의식하 진정요법에 많이 이용되고 있는 Midazolam의 임상적 효과로는 항불안, 진정, 수면, 항경련, 근이완, 기억상실 등이 있는데, 이중 기억상실효과는 주로 선행성 건망증(anterograde amnesia)으로 약물투여 후 약물의 작용이 지속되는 동안에 경험한 일들을 기억하지 못하는 현상이다. 이는 시술 중 환자의 협조를 얻을 수 있으면서도 시술 후 환자는 시술중의 불편한 과정을 기억하지 못하는 효과를 얻을 수 있다는 임상적 장점이 있다. 본 연구는 Midazolam 투여 시 선행성 건망증의 발현 양상을 평가할 목적으로 약물에 대한 기왕력이 없으며 미국 마취학회 전신상태 평가기준에 따라 1등급으로 판정된 조선대학교 치과대학에 재학중인 학생 15명을 대상으로 위약, 경구용 Midazolam 투여, 주사용 Midazolam의 비강내 투여 후 Snograss와 Vanderwart에 의해 표준화된 260개 그림 시리즈를 이용하여 선행성 건망증의 발현정도를 평가한 결과 다음과 같은 결론을 얻었다. 1. Midazolam의 경구투여와 비강내 투여 시 선행성 건망증의 정도가 위약에 비해 유의하게 높았다 (P<0.01). 2. Midazolam의 비강내 투여시 선행성 건망증의 정도가 경구투여보다 높았으나 유의한 차이는 없었다(P>0.01). 3. Midazolam의 경구투여와 비강내 투여 모두 약물투여 15분 후부터 선행성 건망증을 보이기 시작하여 경구투여시는 45분, 비강내 투여시는 30분에 가장 높은 효과를 보였다. 4. 약물투여 30분이 지나면서 비강내 투여보다 경구투여에서 선행성 건망증의 정도와 진정정도가 더 높았으나 유의한 차이는 없었다(P>0.01). 본 결과로 미루어 보아 Midazolam을 투여한 후 선행성 건망증은 경구투여와 비강내 투여 모두 약물투여 15분 후부터 나타났으며 30분 전까지는 비강내 투여에서 30분이 지나면 경구투여에서 더 높은 효과를 보이는 경향이 관찰된 바, 치과치료시 Midazotam의 경구투여와 비강내 투여를 이용한 의식진정요법을 시행함에 있어 국소마취 등의 고통스러운 과정은 최소약물투여 15분 후 시행하는 것이 향후 치과진료에 대한 환자의 긍정적 자세를 유도하는 데 도움이 되리라 사료된다. The purpose of this study was to assess the anterograde amnesic effect of Midazolam administrated by in-tranasal and oral route. Fifteen healthy volunteers(ASA I) were administrated with placebo, oral Midazolam (15mg), intranasal Midazolam (0.25mg/1kg) every 2 weeks. First picture cards were shown to volunteers before medication. At 15, 30, 45 minutes, other picture cards were shown to volunteers. BP, SpO₂ and sedation scores were measured. After 24 hours, the volunteers were questioned about their memory of pictures. To assess amnesic effect, recall and recognition test were performed using a series of picture cards designed for this purpose. The obtained results were as follows; 1. Compared to placebo, Midazolam group(oral and intranasal) experienced a significant anterograde amnesic effect (P<0.01). 2. There was no difference between oral and intranasal Midazolam (P>0.01). 3. Anterograde amnesic effect of oral and intranasal Midazolam group began at 15minutes. It became increasingly, oral Midazolam group experienced extremely amnesic effect at 45minutes, intranasal Midazolam group was at 30minutes. 4. After 30minutes of Midazolam administration, anterograde amnesia of oral Midazolam group is more effective than intranasal Midazolam group.

광중합기를 이용한 광학적 치아우식활성도 검사법

이난영,김미라,오유향,이창섭,이상호 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.4

레이저와 플라스마 광, 할로겐 광 중합기를 이용하여 각 개인의 우식 활성도를 측정할 수 있는지를 규명하기 위해 7-8세 아동 45명을 대상으로 치아의 순면과 협면에 각 광원을 조사하고 특수 필터를 사용하여 초기 치아우식증으로 판별된 치아의 개수를 측정하여 기존의 우식활성도 측정방법인 dDfFtT rate와 mutans streptococci 측정법 Lactobacilli 측정법과 비교, 평가하고 그 특이도, 민감도, 예측력을 평가하였다. 1. 아르곤 레이저, 플라스마 광, 할로겐 광 조사시 육안검사시 보다 유의하게 많은 초기우식 병소가 관찰되었다(p<0.05). 2. 아르곤 레이저, 플라스마 광, 할로겐 광을 이용한 우식활성도 측정법은 dDfFtT rate와 양의 상관관계(γ= 0.42, 0.41, 0.39)를 보였다(p<0.01). 3. 기존의 우식활성도 측정방법을 기준으로 하여 평가한 결과 특이도와 민감도, 예측력은 모두 레이저가 가장 높았으며 플라스마 광, 할로겐 광 순으로 나타났다. 이상의 결과를 종합하여 볼 때 아르곤 레이저와 플라스마 광, 할로겐 광을 이용한 형광법은 모두 양호한 진단학적 지표를 보여줌으로써 향후 광학적 우식활성검사법으로 활용 가능성이 높을 것으로 사료된다. The purpose of this study was to develop a practical caries activity test by fluorescence using laser, plasma light and halogen light. The subjects of study were 45 children of 7-8 years old. Argon laser, plasma light and halogen light were irradiated to buccal or labial surface of all teeth. Fluorescence of initial carious lesion from teeth was observed through barrier filter and the number of teeth showing lesion was counted. Visual examination for the dDfFtT, mutans streptococci screening test and Lactobacilli colony counting were also done. Data analysis was accomplished by Axelsson's method. The result from the present study can be summarized as follows. 1. Laser, plasma light and halogen light could detect the initial carious lesions better than visual examination(p<0.05). 2. There was positive correlation between laser(r=0.42), plasma light(r=0.41), halogen light(r=0.39) and dDfFtT rate(p<0.01). 3. The specificity, sensitivity and predictive value was showed highest value in laser. but was showed favorable value in plasma light and halogen light. In regard to above results, laser, plasma light and halogen light all considered to be reliable method for determining individual caries activity. And they were also considered to be practical method because it would be simple, inexpensive, and time saving method.

고등학생의 강간통념이 성적 자기주장과 상대통제에 미치는 영향 : 양성평등의식의 매개효과를 중심으로

양난미,이지연 淑明女子大學校 亞細亞女性問題硏究所 2008 아시아여성연구 Vol.47 No.1

본 연구는 기존의 성인대상의 데이트 폭력이나 성폭력의 주요 변인으로 연구되어온 강간통념, 성적 자율성, 상대에 대한 통제 경향 변인들을 중심으로 이 변인들의 수준이 남녀 고등학생에게서 어떤 차이가 있으며 청소년기의 이성교제에서 어떤 관련성을 가지는지 양성평등의식의 매개효과를 중심으로 알아보고자 하였다. 이를 위해 인천광역시 남녀 고등학교 1, 2학년 971명을 표집하여 남녀평등의식, 강간통념 척도, 상대통제 척도, 성적 자율성 척도 등을 내용으로 하는 설문지를 구성하여 실시하였다. 연구결과 남학생의 강간통념 수준은 여학생보다 높았으며 양성평등의식 수준은 여학생보다 통계적으로 유의미하게 낮았다. 또한 남학생의 이성교제에서 양성평등의식은 강간통념과 상대에 대한 통제 경향 사이를 부분매개하고 있었으며 여학생의 이성교제에서 양성평등의식은 강간통념과 성적 자기주장성 사이를 완전매개하고 있었다. 이러한 결과를 바탕으로 본 연구의 시사점과 제한점을 논의하였다.

일개 농촌지역의 지역사회 영양정보에 관한 조사연구 : 경기도 남양주군 수동면을 중심으로 Su-Dong Myun, Nam Yang-Ju Gun, Kyung-Gi Do

계난이,권계숙,송미희,이연주 이화여자대학교 의과대학 1988 梨花醫學誌 Vol.- No.20

From September to November in 1987, the study was conducted a survey of Su-Dong Myun, Nam Yang-Ju Gun, Kyung-Gi Do, a comprehensive rural care demonstration area of Ewha Womans University. The purpose of this survey has been to examine into community nutrition informathrough preventive medicine training of sophomores of medical course. The result were as follows 1) Female respondent was 88.2% of all whose age was the forties and fifties at the highest rate of 22.6% respectively and whose educational level was uneducated at rate of 31.2%. 2) Agriculture(66.7%) was the common householder's occupation whose main income was from their own farm products(67.7%). 3) A family of five(24.7%) and two generations(e.g parent and children) (55.9%) was the most common family. 4) The housewife(98.9%) was the most common cook and 35.5% of all cook was not able have sufficient time to prepare for their meal. 5) On food purchase, main food was largely self provided(65.6%) and subsidiary food with self-provision and outside purchase(51.6%). 6) On the self sufficient food rice(77.4%) was most common as main food and vegetable(81.7%) as subdiary food. 7) On the frequency of purchasing food, main food was about 2-3 times a month, subsidiary food 1-3 times a week. On the market place, main food mainly self sufficient(59.1%) and subsidiary food was largely purchased from the peddlers and market on the move(35.5%) 8) On the means of transportation of purchased food, main food was conveyed by bus or another kinds of vehicles and subsidiary food(52.7%) was in the same way. 9) On the consumer's difficulty in purchasing food, meat and fish were rated 76.3% and vegetable 78.5%, 76.3% of all consumer had difficulty in purchasing meat and fish, 78.5% in purchasing grocery. 10) 94.6% was in possession of electric refrierator and 89.2% possessed their own wells. 11) The respondent had such fuels for cooking as propanegas(66.6%), wood(18.3%) briquet(10.8%). 12) the present state of nutrition was that the mean points was 2.7 in the group 1, 2.2 in the group 2, 3.9 points in the group 3, 2.8 points in the group 4, 3.1 points in group 5 and 2.7 points in the group 6. 13) Most families' favorite food was kimchi or kimchi soup and distasteful was meat including dog meat. 14) 48.4% of all respondents took no interest in taking in adequate nutrition owing to the lack of money and time to spare.

생선묵에 첨가된 전분 함량

김난주,송미선,이기주,전미영,조성희,허은영 효성여자대학교 가정대학 학도호국단 1985 家政大論集 Vol.4 No.-

시판 생선묵 26종을 무작위로 수집해서 전분 함량을 조사한 결과는 아래와 같다. 1. 전분 함량이 5∼10%되는 것이 19.2%, 10∼20%되는 것은 69.2%로서 가장 많았고, 20∼30%나 되는 많은 양의 전분을 첨가한 제품도 11.5%나 되었다. 2. 비교적 값비싼 제품이 전분을 더 많이 첨가하고 있었다. The purpose of this experiment was to investigate the content of starch in the 26kinds of fishcake which were randomly sampled The results of it were as follows ; 1. The highest percentage of those fishcake, the starch containing rate 10~20%, was 69.2% among all of them. The next, the starch containing rate 5~10%, was 19.2% And the last, the starch containing rate 20~30%. was 11.5%. 2. The expensive fishcake, the higher containing rate of starch.

금호강수계 수질과 하천유역의 토양 및 농작물의 중금속루 오염에 관한 연구(II)

金相烈,李萬正,趙康烈,崔閏壽,石敬順,禹美姬,李蘭姬 대구효성 가톨릭 대학교 1984 연구논문집 Vol.29 No.2

Soil are mostly sandy and it has a little clay below 10%. In the fine sand fraction, quartz, plagioclase and alkali-feldspar are dominant in almost all samples. Small amounts of altered-feldspar, muscovite, biotite, hornblende and plant opal are present in some samples. They are mainly derived from weathering prodructs df granite, granodiorite and arkose or is mixture. The clay minerals are mainly expanding or nonexpanding 14A˚minerals, illite and kaolin minerals. Nonexpanding 14A˚minerals seems to be dioctahedral vermicurite which sandwiches gibbsite or chlorite.

간호사의 임상 실무 경험

서문자,손행미,강현숙,권성복,김주현,박영숙,이은희,임난영,조경숙,지성애 성인간호학회 2002 성인간호학회지 Vol.14 No.4

purpose: This study was conducted to describe qualitatively the entities of nurse's experiences in general hospitals and to suggest basic data guiding research on developing Standards of clinical nursing practice in Korea. Method: Fourteen nurses working at general hospitals with over 300 beds in Seoul were interviewed in-depth until saturation using tape-recorders and transcription. Result: The central theme of clinical nursing practice experienced by subjects was "being with clients" that means accepting client's personal character, solving client's needs and providing client-centered nursing. A also "being with clients" was felt to be the responsibility of nurses which was learned from their nursing schools. The nursing strategies performed in order to be with patients were proving skillful nursing techniques, accepting, educating, emotional support, advocating, and self-reflecting, the subjects experienced somewhat problematic affects such as difficulties in interpersonal relationship, work overload, negative image of nursing, deficit of self-confidence for nursing actions, poor working conditions, and unfair treatment. Nurses at the hospital practiced with pride when they felt that they were accepted by clients. Conclusion: Further research is needed to analysis problems in clinical practice and the comparison of nurses' experiences of clinical practice, with nurses' experiences in various settings.

Development of a simple, rapid multiplex PCR method using the 16S rRNA gene to determine the country of origin of Corbicula japonica

Mi-Nan Lee,Su-Young Kim,Yeon jung Park,Eun Soo Noh,Jung Youn Park,Jae Koo Noh,Eun-Mi Kim,Tae-Jin Choi,Jung-Ha Kang 한국수산해양기술학회(구 한국어업기술학회) 2017 한국수산해양기술학회 학술발표대회 Vol.2017 No.11

Clinical Research Article : A survey on informed consent process for epidural analgesia in Labor pain in Korea

( Nan Ju Lee ),( Ji Yeon Sim ),( Mi Soon Lee ),( Won Sik Ahn ),( Sun Sook Han ),( Hwa Mi Lee ) 대한마취과학회 2010 Korean Journal of Anesthesiology Vol.59 No.1

Background: There is a legal obligation to explain the procedure and use of epidural analgesia in labor primarily due to the possibility of potential risks and associated complications. The present study details on the survey carried out to ascertain the current status of obtaining informed consent (IC) for explaining the epidural analgesia in labor. Methods: The present study is based on a survey through a telephone questionnaire that covered all the hospitals in Korea where the anesthesiologists` belonged to and are registered with Korean Society of Anesthesiologists. The questionnaire included questions pertaining to administration of epidural analgesia to a parturient, information on different steps of obtaining an IC, whether patient status was evaluated, when the consent was obtained, and the reasons behind, if the consent had not being given. Results: A total of 1,434 respondents took part in the survey, with a response rate of 97% (1,434/1,467). One hundred seventy-four hospitals had conducted epidural analgesia on the parturient. The overall rate of obtaining IC for epidural analgesia during labor was 85%, of which only 13% was conducted by anesthesiologists. The rate of evaluating preoperative patient status was 74%, of which 45% was conducted by anesthesiologists. Almost all of the consent was obtained prior to the procedure. Conclusions: The rate of obtaining IC for epidural analgesia in labor is relatively high (85%) in Korea. However, it is necessary to discuss the content of the consent and the procedure followed for obtaining IC during the rapid progress of labor. (Korean J Anesthesiol 2010; 59: 34-38)

Green pigmentation on both deciduous and permanent dentition of a biliary atresia patient: A case report

( Mi-ri Kim ),( Sang-ho Lee ),( Nan-young Lee ),( Myeong-kwan Jih ),( Young-mi Yoon ),( Yu-jin Lim ) 조선대학교 구강생물학연구소 2017 Oral Biology Research (Oral Biol Res) Vol.41 No.2

Biliary atresia is a rare disease, and it is defined as partial or total absence of the biliary tract. If not treated, this disease may cause death within 5 years. Treatment methods for biliary atresia include conservative methods and surgical methods, such as a Kasai operation or/ and liver transplantation. Oral symptoms associated with biliary atresia are green pigmented teeth, enamel hypoplasia, rampant caries, enlargement of the pulp chamber and root canals, and delayed eruption of teeth. Among these symptoms, green pigmentation of teeth is the most significant and unesthetic complication affecting a child`s social psychology. The majority of case reports about green pigmented teeth caused by biliary atresia showed that it affected the deciduous dentition rather than the permanent dentition. This case report describes the dental management of a patient with biliary atresia, who had undergone liver transplantation at age two years, and presented with green pigmentation in both deciduous and permanent dentition.