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소모성 질환에 이환된 이유자돈에 대해 Porcine cytomegalovirus DNA Polymerase 유전자 검출과 분석
김지언,김지영,楚佳奇,채미경,장경수,김명철,박창식,전무형 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-
Porcine cytomegalovirus (PCMV) causes piglet deaths, runting, inclusion body rhinitis, respiratory and reproductive disorders in swine herd, resulting in the significant economic losses in the swine industry. Recently, in the field of pig-to-human xenotransplantation, PCMV has been indicated as a potential xenogeneic pathogen with the risk for infection transmitted from the xenograft donor to the recipient. In this study, PCMV DNA polymerase gene was detected in the sera and nasal swabs from 30 heads of the weaned piglets affected with various wasting diseases and 10 heads of normal healthy piglets using polymerase chain reaction (PCR), and the diagnostic efficacy of PCR was evaluated. The prevalence of the PCR-positive by specimens from the diseased piglets were 83.3% in sera and 33.3% in nasal swabs. In the normal healthy group, the PCR-positive rates of sera and nasal swabs were 40% and 30%, respectively. Ten piglets (25.0%) out of 40 showed the simultaneously positive results in both of sera and nasal swabs. According to this result, it was found that the serum specimen was the most appropriate sample for detection of PCMV by PCR. The nucleotide sequence homology of DNA polymerase gene of PCMV KS1 as compared with the reference strain of PCMV (GenBank accesson no.AF027217) was 99.0%.
혈액투석 환자의 가족지지, 무력감과 자가간호와의 관계 연구
이강오,이미숙,백영주 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1
This study was designed to investigate the correlations between family support, Powerlessness. and self-care of hemodialysis patients. One hundred thirty seven hemodialysis patients with chronic renal failure from 2 university hospitals, 2 general hospitals, and 2 medical cilinics in Kwang-ju. were accidental sampled. The data were collected from September 16 to 30, 1995. by the questionnaire method. The instrment used for measuring family support was Kang's Family Support Scale, powerlessness was developed by the researcher from the literature review, and self-care was developed by Kim and Youm and was modified by the resecher. The data were analyzed by t-test, ANOVA, and Peatson's correlation coefficient. The results of the study were as follows: 1. Average family support score of subjects was 33.71. 2. Average powerlessness score of subjects was 70.03. 3. Average seof-care score of subjects was 63.28. 4. Relatinoships between general characteristics and variables were as follows 1) There was sighificant difference between family income and family support(F=6.90.p=.000). 2) Three were significant difference betweem present family income and family support(F=6.90, p=.000), 3) There was significant difference between medical insurance and self-care (t= 2.52, p=.013). 5. Correltions betweem family support, powerlessness, and self-care were as follows 1) The first hypothesis, "the higher the level of family support in patients on hemodialysis, the lower the level of powerlessness will be," was supported(r=-.233. p=.022). 2) the second hypothesis, "the higher the level of family support in patients on hemodialysis, the higher the level of self-cate will be." was supported(r=.235, p=.019). 3) The third hypothesis, "the lower the level of powerlessness in patients on hemodialysis, the higher the level of self-cate will be," was not supported(r=-.033. p=.740).
Jang, Kyung Mi,Choe, Byung-Ho,Choe, Jae Young,Hong, Suk Jin,Park, Hyo Jung,Chu, Mi Ae,Cho, Seung Man,Kim, Jung Mi The Korean Society of Pediatric Gastroenterology 2015 Pediatric gastroenterology, hepatology & nutrition Vol.18 No.1
Purpose: The aim of this study is to investigate the changing prevalence rate of Helicobacter pylori infection in children, of different age groups, with recurrent abdominal pain over a 10-year period. Methods: Children with recurrent abdominal pain who visited the pediatric outpatient clinic at university hospital were screened for H. pylori. Children were divided into 3 age categories of 4-5, 6-11, and 12-16 years. To study the changes in the annual prevalence rates of H. pylori infection, the study period was divided into 3 time periods: 2004-2007, 2008-2010, and 2011-2014. Urea breath test was performed for all children aged 4-16 years, with a cut-off value of 4.0‰ for children aged ${\geq}6$ years and 7‰ for children aged <6 years. Results: A total of 2,530 children (1,191 boys) with a mean age of $10.0{\pm}3.0years$ (range, 4.0-16.9 years) were included in the study. The total prevalence of H. pylori infection was 7.4% (187/2,530). The prevalence rate of H. pylori infection in children with recurrent abdominal pain was 8.0% (70/873) in 2004-2007, 7.7% (51/666) in 2008-2010, and 6.7% (66/991) in the 2011-2014. Nevertheless, a significant difference was observed in the prevalence rate between children <12 years old and ${\geq}12$ years of age (p=0.018). Conclusion: The prevalence of H. pylori infection in Korean children with recurrent abdominal pain was 7.4%, showing no significant decrease in the last 11 years; however, the prevalence rate in children <12 years old was significantly lower than that in those ${\geq}12$ years old.
최소영(So Young Choi),김세중(Sei Joong Kim),조영업(Young Up Cho),박재영(Jae Young Park),박정미(Jeong Mi Park),주영채(Young Chae Chu),최윤미(Yun Mee Choe),최선근(Sun Keun Choi),허윤석(Yoon Seok Heo),이건영(Keon Young Lee),안승익(Seung 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.5
Purpose: Apocrine carcinoma of the breast is rare and there is confusion about the criteria of its histopathologic diagnosis. The purpose of this study is to investigate the clinical and pathologic characteristics of the disease. Methods: 9 patients diagnosed with apocrine carcinoma or apocrine carcinoma in situ and 1,009 patients diagnosed with non-apocrine carcinoma of the breast from April 1999 to March 2008 were retrospectively analyzed. Results: The mean age of the patients with apocrine carcinoma was 52.3 year. 5 patients (55.6%) among 9 patients with apocrine carcinoma were postmenopausal. There were 2,1 and 6 patients with stage 0, Ⅰ and Ⅱ disease, respectively according the TNM stage. These demographic and clinical differences between the patients with apocrine carcinoma and non-apocrine carcinoma were not significant. Only four patients (44.4%) were preoperatively diagnosed with apocrine carcinoma or apocrine carcinoma in situ. By surgical biopsy, additional 5 patients were diagnosed as apocrine carcinoma. In the immunohistochemical study, Bcl-2 was positive in one (12.5%) of 8 patients. p53 was positive in 4 (44.4%) of 9 patients. Expressions of estrogen and progesterone receptor were positive only in two patients (22.2%) with weakly positive staining. Androgen receptor was positively expressed in all cases (100%) of apocrine carcinoma. Overexpression of c-erb-B2 was detected in four patients. Conclusion: Treatment modality and prognosis of apocrine carcinoma are similar as non-apocrine carcinoma. But its preoperative diagnosis is more difficult than that of non-apocrine carcinoma and it shows different expression of hormone receptor. Further study is needed for the development of new hormonal therapy using androgen.
Chu, Jia-Qi,Kim, Su-Mi,Lee, Kwang-Nyeong,Oem, Jae-Ku,Ko, Young-Joon,Lee, Hyang-Sim,Kim, Yong-Joo,Park, Jee-Yong,Kim, Kwang-Jae,Parida, Satya,Oh, Yooni,Paton, David J.,Joo, Yi-Seok,Kim, Byounghan,Park, The Korean Society for Microbiology 2012 Journal of Bacteriology and Virology Vol.42 No.3
Interferon is an important cytokine that plays a critical role in the initial host defense against viral infection. Recombinant human adenoviruses expressing human interferon-${\alpha}$ (Ad-$HIFN{\alpha}$) or pig interferon-${\beta}$ fused with interleukin-18 (Ad-$PIFN{\beta}$-IL18) were constructed and used to induce an early protective response against foot and mouth disease (FMD). To analyze the antiviral effect, bovine thyroid and porcine kidney IBRS-2 cells and ICR mice were treated with Ad-$HIFN{\alpha}$, Ad-$PIFN{\beta}$-IL18, and cocktail of Ad-$HIFN{\alpha}$ and Ad-$PIFN{\beta}$-IL18. The survival rate of suckling mice was monitored after foot and mouth disease virus (FMDV) challenge following intra-peritoneal (IP) administration of appropriate adenovirus. Indirect antigen ELISA was performed to evaluate inhibition of FMDV replication following challenge with the FMDV O, A, or Asia 1 serotypes in vitro. These recombinant adenoviruses reduced the replication of FMDV in susceptible cells, thereby decreasing the fatality in mice, suggesting that they can be a useful control method for the early protection against FMD infection in livestock after field trial.