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흰쥐의 비장에서 분리한 림프구를 이용한 형광백혈구 안저촬영술
정미란,이숙희,황정용,양연식 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2
Background: The study on retinal blood flow has been continuously pursued and recently new methods such as targeted dye delivery, fluorescent vesicle system, laser Doppler velocimetry and acridine orange staining method has been presented. The authors developed a new method, fluorescein leukocyte angiography using a scanning laser ophthalmoscope which include external staining of leukocyte with fluorescein dye and reintroducing this fluorescent leukocyte into the blood flow. However, visualization of the leukocytes was limited since the leukocytes used were from the peripheral blood in a small animal. Methods: The authors removed leukocytes from the spleen and stained these leukocytes which were reintroduced into the blood flow to observe the retinal and choroidal blood circulation. In four pair of rats, one group was injected with the leukocytes of another rat's spleen and the other group were injected with the leukocytes of each own's individual spleen and all underwent angiography. Results: There were only few lymphocytes visualized in the group of rats which eceived allo-injection of leukocytes and in the other group the lymphocytes were numerous and also had a longer existence. Conclusions: In small animals like rats the visualization of the lymphocytes used from the spleen was better than the those from the peripheral blood and lymphocytes from one own's spleen was useful for longer periods of visualization.
정미란,차정단,윤순일,한종현,이영은 동아시아식생활학회 2005 동아시아식생활학회지 Vol.15 No.1
Fig(Ficus carica L.) which belongs to Moraceae family has been used as digestion promoter, cure for ulcerative inflammation and eruption in Korea. Figs have very short preservation period and can be kept only 1 week even in the refrigeration system. The possibility of wine-making from Korean figs was tested by analyzing the fermentation characteristics, proximate analysis and free sugar contents of wine made of slices with 20% sugar addition. Ethanol fermentation of the figs by Saccharomyces cerevisiae was done rapidly. The ethanol contents, pH, total acidity and sugar content were 12.1%, 3.91, 0.42% and 9.9 °Brix, respectively. The results from the sensory evaluation were as follows. The wine made from the sliced figs were better than that from fig juices in their sensory scores. The wine made with frozen figs was not different from that made with fresh ones. To improve the quality of wine, the addition of dried leaf powder in the concentration of 100 ppm were tried and found it was superior to the one made without leaf.
서울지역 일부 과체중 및 적절체중 학령기 아동의 신체계측, 체지방률, 혈액지표 및 영양소 섭취 상태의 비교 분석 연구
이정숙,이정윤,임현정,조미란,차성호,조여원 대한영양사협회 2003 대한영양사협회 학술지 Vol.9 No.4
This study was carried out to compare the characteristics of the over weight elementary school students with those of desirable-weight children. Anthropometric parameters such as height, weight, BMI body fat percentile, triceps skin fold thickness were measured. Dietary assessment and blood analysis were performed. The average ages of over weight children and desirable-weight children were 10.9f2.5 and 10.2±2.8 years, respectively. The means body fat percentile of over weight children and desirable-weight children were 27.5±3.7% and 20.2± 3.8%. respectively. Plasma levels of TG. total cholesterol, LDL cholesterol, and HDL cholesterol of over weight children and desirable-weight children were 179.3±30.0. 104.9f26.6, 52.3f6.7 and 178.3±84.l㎎/dl and those of desirable-weight children were 86.1±43.5, 183.7f16.5, 101.0f2.1 and 67.7±20.0㎎/dl respectively. Plasma TG levels of over weight children were significantly higher than those of desirable weight chddren. On the other hand plasma HDL-cholesterol levels of over weight children were significantly lower than those of desirable-weight children Plasma levels of GOT ,and GPT were in normal range in both group. However, GPT level of over weight children was &her than that of desirable weight children. Plasma levels of albumin, globulin and BUN were all in normal range and no differences were found in both groups. Hematologic data did not show any difference between two group except WBC, KBC and Hgb levels which were significantly higher in over weight group than those of desirable-weight children. DAY nutrients intake of over weight children and desirable-weight children were very similar and they were around the Korean KDA levels for each nutrients. However, the intake of calcium of both groups were little over 50% of KDA. The consumption of d e b fiber was very low and the cholesterol intake was very high shorn that the habitual meals of Korean school children were not well balanced.
Yun, Mi-Ran,Kim, Dong-Eun,Heo, Hye-Jin,Park, Ji-Young,Lee, Ji-Young,Bae, Sun-Sik,Kim, Chi-Dae The Korean Society of Pharmacology 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.6
The preventive effects of gene transfer of human copper/zinc superoxide dismutase (Cu/ZnSOD) on the development of cerebral vasospasm after subarachnoid hemorrhage (SAH) were examined usin a rat model of SAH. An experimental SAH was produced by injecting autologous arterial blood twice into the cisterna magna, and the changes in the diameter of the middle cerebral artery (MCA) were measured. Rats subjected to SAH exhibited a decreased diameter with an increased wall thickness of MCA that were significantly ameliorated by pretreatment with diphenyleneiodonium (DPI, $10{\mu}M$), an inhibitor of NAD(P)H oxidase. Furthermore, application of recombinant adenovirus ($100{\mu}l$ of $1{\times}10^{10}$ pfu/ml, intracisternally), which encodes human Cu/ZnSOD, 3 days before SAH prevented the development of SAH-induced vasospasm. Our findings demonstrate that SAH-induced cerebral vasospasm is closely related with NAD(P)H oxidase-derived reactive oxygen species, and these alterations can be prevented by the recombinant adenovirus-mediated transfer of human Cu/ZnSOD gene to the cerebral vasculature.
Mi Ran Yun,Hye Mi Park,Kyo Won Seo,Chae Eun Kim,Jung Wook Yoon,Chi Dae Kim 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.2
Although anti-atherogenic effects of cilostazol have been suggested, its effects on the expression of SR in macrophages are unclear. This study investigated the role of cilostazol on CD36 expression of murine macrophages enhanced by HNE, a byproduct of lipid peroxidation. The stimulation of macrophages with HNE led to an increased expression of CD36, which was significantly attenuated by NAC, an antioxidant. Moreover, the increased production of ROS by HNE was completely abolished by NADPH oxidase inhibitors, DPI and apocynin, as well as by the 5-LO inhibitor, MK886, but not by inhibitors for other oxidases. This suggested that NADPH-oxidase and 5-LO were major sources of ROS induced by HNE. In addition, HNE-enhanced expression of CD36 was reduced by these inhibitors, which indicated a role for NADPH oxidase and 5-LO on CD36 expression. In our present study, cilostazol was a significant inhibitor of ROS production, as well as CD36 expression induced by HNE. An increase in NADPH oxidase activity by HNE was significantly attenuated by cilostazol, however cilostazol had no effect on HNE-enhanced 5-LO activity. Together, these results suggest that cilostazol attenuates HNE-enhanced CD36 expression on murine macrophages thorough inhibition of NADPH oxidase-derived ROS generation.
Yun, Mi-Ran,Kim, Jong-Jae,Lee, Sun-Mi,Heo, Hye-Jin,Bae, Sun-Sik,Kim, Chi-Dae The Korean Society of Pharmacology 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.2
Endothelial activation and subsequent recruitment of inflammatory cells are important steps in atherogenesis. The increased levels of cell adhesion molecules (CAM) have been identified in diabetic vasculatures, but the underlying mechanisms remain unclear. To determine the relationship among vascular production of superoxide, expression of CAM and diabetes, superoxide generation and expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E- and P-selectin in the aorta from control (C57BL/6J) and diabetic mice (ob/ob) were measured. In situ staining for superoxide using dihydroethidium showed an increased superoxide production in diabetic aorta, accompanied with an enhanced NAD(P)H oxidase activity. Immunohistochemical analysis revealed that the endothelial expression of ICAM-1 ($3.5{\pm}0.4$) and VCAM-1 ($3.8{\pm}0.3$) in diabetic aorta was significantly higher than those in control aorta ($0.9{\pm}0.5$ and $1.6{\pm}0.3$, respectively), accompanied with the enhanced expression of gp91phox, a membrane subunit of NAD(P)H oixdase. Furthermore, there was a strong positive correlation (r=0.89, P<0.01 in ICAM-1 and r=0.88, P<0.01 in VCAM-1) between ICAM-1/VCAM-1 expression and vascular production of superoxide. The present data indicate that the increased production of superoxide via NAD(P)H oxidase may explain the enhanced expression of CAM in diabetic vasculatures.
Mi Ran Yun,Dong Eun Kim,Hye Jin Heo,Ji Young Park,Ji Young Lee,Sun Sik Bae,Chi Dae Kim 대한생리학회-대한약리학회 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.6
The preventive effects of gene transfer of human copper/zinc superoxide dismutase (Cu/ZnSOD) on the development of cerebral vasospasm after subarachnoid hemorrhage (SAH) were examined using a rat model of SAH. An experimental SAH was produced by injecting autologous arterial blood twice into the cisterna magna, and the changes in the diameter of the middle cerebral artery (MCA) were measured. Rats subjected to SAH exhibited a decreased diameter with an increased wall thickness of MCA that were significantly ameliorated by pretreatment with diphenyleneiodonium (DPI, 10μM), an inhibitor of NAD(P)H oxidase. Furthermore, application of recombinant adenovirus (100μl of 1⁓10<SUP>10</SUP> pfu/ml, intracisternally), which encodes human Cu/ZnSOD, 3 days before SAH prevented the development of SAH-induced vasospasm. Our findings demonstrate that SAH-induced cerebral vasospasm is closely related with NAD(P)H oxidase-derived reactive oxygen species, and these alterations can be prevented by the recombinant adenovirus-mediated transfer of human Cu/ZnSOD gene to the cerebral vasculature.
Yun, Mi Ran,Lim, Sun Min,Kim, Seon-Kyu,Choi, Hun Mi,Pyo, Kyoung-Ho,Kim, Seong Keun,Lee, Ji Min,Lee, You Won,Choi, Jae Woo,Kim, Hye Ryun,Hong, Min Hee,Haam, Keeok,Huh, Nanhyung,Kim, Jong-Hwan,Kim, Yong American Association for Cancer Research 2018 Cancer research Vol.78 No.12
<P>Epigenetic deregulation drives acquired resistance to ALK inhibitors in ALK-positive lung cancer.</P><P>Anaplastic lymphoma kinase (ALK) inhibitors are highly effective in patients with <I>ALK</I> fusion–positive lung cancer, but acquired resistance invariably emerges. Identification of secondary mutations has received considerable attention, but most cases cannot be explained by genetic causes alone, raising the possibility of epigenetic mechanisms in acquired drug resistance. Here, we investigated the dynamic changes in the transcriptome and enhancer landscape during development of acquired resistance to ALK inhibitors. Histone H3 lysine 27 acetylation (H3K27ac) was profoundly altered during acquisition of resistance, and enhancer remodeling induced expression changes in both miRNAs and mRNAs. Decreased H3K27ac levels and reduced miR-34a expression associated with the activation of target genes such as AXL. Panobinostat, a pan-histone deacetylase inhibitor, altered the H3K27ac profile and activated tumor-suppressor miRNAs such as miR-449, another member of the miR-34 family, and synergistically induced antiproliferative effects with ALK inhibitors on resistant cells, xenografts, and <I>EML4-ALK</I> transgenic mice. Paired analysis of patient samples before and after treatment with ALK inhibitors revealed that repression of miR-34a or miR-449a and activation of AXL were mutually exclusive of secondary mutations in ALK. Our findings indicate that enhancer remodeling and altered expression of miRNAs play key roles in cancer drug resistance and suggest that strategies targeting epigenetic pathways represent a potentially effective method for overcoming acquired resistance to cancer therapy.</P><P><B>Significance:</B> Epigenetic deregulation drives acquired resistance to ALK inhibitors in ALK-positive lung cancer. <I>Cancer Res; 78(12); 3350–62. ©2018 AACR</I>.</P>