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Mohamed-Amine Jabri,Soumaya Hajaji,Ameni Omrani,Meriam Ben Youssef,Hichem Sebai 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.9
Anthocyanins are the major polyphenols in myrtle berries seeds aqueous extract (MBSAE). This studyinvestigates the protective potentials of MBSAE against obesity lipotoxicity and inflammation induced by a high-fat diet(HFD). It also describes the underlying mechanisms involved in its protective effects, with special attention to myocardialreactive oxygen species (ROS) production. Male Wistar rats were fed HFD for 6 weeks to induce obesity. MBSAE(100 mg/kg, b.w., p.o.) was orally administered to HFD-fed rats. Anti-obesity effects were triggered by the inhibitory action ofthe MBSAE against the weights of the body, its relative heart and the total abdominal fat. Treatment with MBSAE alsorestored the lipid profile to baseline compared with the HFD rats and lowered also the white blood cells count, includingneutrophils, lymphocytes, and basophils number as well as cytokines (tumor necrosis factor-a, interleukin [IL]-6, and IL-1b)levels in the rats serum, thus improving the tissue inflammatory status associated with obesity. Exposure of rats to HFD during6 weeks induces a myocardial oxidative stress as assessed by deleterious effects on lipoperoxidation state, antioxidant enzyme(SOD, CAT, and GPx) activities as well as sulfhydryl groups and GSH rates. Of importance, our study shows also that HFDprovokes a heart ROS (H2O2, OH, and O2-) overload. Of interest, all these oxidative heart disturbances were clearly endedby MBSAE treatment. Therefore, consumption of MBSAE as a natural extract may be a potential therapeutic strategy to treatobesity-associated diseases.