http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Melé,ndez-Ló,pez, Samuel G.,Herdman, Scott,Hirata, Ken,Choi, Min-Ho,Choe, Youngchool,Craik, Charles,Caffrey, Conor R.,Hansell, Elisabeth,Chá,vez-Munguí,a, Bibiana,Chen, Yen Tin American Society for Microbiology 2007 EUKARYOTIC CELL Vol.6 No.7
<B>ABSTRACT</B><P>Cysteine proteinases are key virulence factors of the protozoan parasite <I>Entamoeba histolytica</I>. We have shown that cysteine proteinases play a central role in tissue invasion and disruption of host defenses by digesting components of the extracellular matrix, immunoglobulins, complement, and cytokines. Analysis of the <I>E. histolytica</I> genome project has revealed more than 40 genes encoding cysteine proteinases. We have focused on <I>E. histolytica</I> cysteine proteinase 1 (EhCP1) because it is one of two cysteine proteinases unique to invasive <I>E. histolytica</I> and is highly expressed and released. Recombinant EhCP1 was expressed in <I>Escherichia coli</I> and refolded to an active enzyme with a pH optimum of 6.0. We used positional-scanning synthetic tetrapeptide combinatorial libraries to map the specificity of the P1 to P4 subsites of the active site cleft. Arginine was strongly preferred at P2, an unusual specificity among clan CA proteinases. A new vinyl sulfone inhibitor, WRR483, was synthesized based on this specificity to target EhCP1. Recombinant EhCP1 cleaved key components of the host immune system, C3, immunoglobulin G, and pro-interleukin-18, in a time- and dose-dependent manner. EhCP1 localized to large cytoplasmic vesicles, distinct from the sites of other proteinases. To gain insight into the role of secreted cysteine proteinases in amebic invasion, we tested the effect of the vinyl sulfone cysteine proteinase inhibitors K11777 and WRR483 on invasion of human colonic xenografts. The resultant dramatic inhibition of invasion by both inhibitors in this human colonic model of amebiasis strongly suggests a significant role of secreted amebic proteinases, such as EhCP1, in the pathogenesis of amebiasis.</P>
The Effect of Slenderness on the Design of Diagrid Structures
Mele, Elena,Imbimbo, Maura,Tomei, Valentina Council on Tall Building and Urban Habitat Korea 2019 International journal of high-rise buildings Vol.8 No.2
Diagrid structures have emerged in recent decades as an innovative solution for tube tall buildings, capable of merging structural efficiency and aesthetic quality. This paper investigates the effect of the building slenderness (grossly quantified by means of the aspect ratio, i.e., the ratio between the height and the plan dimension) on the structural behavior and on the optimal design parameters of diagrid tall buildings. For this purpose, building models with different slenderness values are designed by adopting preliminary design criteria, based on strength or stiffness demands; in addition, a design method based on a sizing optimization process that employs genetic algorithms is also proposed, with the aim to compare and/or refine the results obtained with simplified approaches.
Graphene FETs based on high resolution nanoribbons for HF low power applications
David Mele,Sarah Mehdhbi,Dalal Fadil,Wei Wei,Abdelkarim Ouerghi,Sylvie Lepilliet,Henri Happy,Emiliano Pallecchi 대한금속·재료학회 2018 ELECTRONIC MATERIALS LETTERS Vol.14 No.2
In this paper we present high frequency field effect transistors based on graphene nanoribbons arrays (GNRFETs). Thenanoribbons serve as a channel for the transistors and are fabricated with a process based on e-beam lithography and dryetching of high mobility hydrogen intercalated epitaxial graphene. The widths of the nanoribbons vary from 50 to 20 nm,less than half those measured in previous reports for GNRFETs. Hall measurements reveal that the devices are p-doped, withmobility on the order of 2300 cm2/Vs. From DC characteristics, we find that the maximum ratio IMAX/IMIN is 5 obtained at50 nm ribbons width. The IV characteristics of the GNRFETs are slightly non-linear at high bias without a full saturation. Therefore, despite the aggressive scaling of the graphene nanoribbon width, a bandgap is still not observed in our measurements. The high frequency performances of our GNRFETs are already significant at low bias. At 300 mV drain sourcevoltage, the highest intrinsic (extrinsic) cut-off frequency ftreaches 82 (18) GHz and the extrinsic maximum oscillationfrequency fmaxis 20 GHz, which is promising for low power applications.
Development of Thermoelectric Module Based on Dense Ca3Co4O9 and Zn0.98Al0.02O Legs
Paolo Mele,Hiroyuki Kamei,Hiroyuki Yasumune,Kaname Matsumoto,Koji MIYAZAKI 대한금속·재료학회 2014 METALS AND MATERIALS International Vol.20 No.2
Ca3Co4O9 (p-type) and Zn0.98Al0.02O (n-type) pellets were prepared by conventional sintering (CS) and SparkPlasma sintering (SPS) starting from the oxides. The best p-type sample was SPS Ca3Co4O9 obtained frompre-sintered pellets, with electrical conductivity σ = 144 S/cm and Seebeck coefficient S = 172 μV/K at800 °C, while thermal conductivity κ = 2.00 W/m×K and figure of merit ZT = 0.23. The best n-type samplewas CS Zn0.98Al0.02O showing σ = 83 S/cm and S = -268 μV/K at 800 °C, while κ = 5.03 W/m×K andZT = 0.127. The output power of a module based on SPS Ca3Co4O9 and CS Zn0.98Al0.02O legs was 2.26 mW(with T = 500 °C, ΔT = 248 °C).