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Kang, Tong Ho,Oh, Hye Rim,Jung, Sun Moon,Ryu, Jong Hoon,Park, Mee Won,Park, Yong Kon,Kim, Sun Yeou Pharmaceutical Society of Japan 2006 Biological & pharmaceutical bulletin Vol.29 No.2
<P>Several neurological disorders such as Alzheimer's and Parkinson's diseases have been attributed to γ-aminobutyric acid (GABA) depletion in the brain. In order to provide a pharmacological basis for the neuroprotective actions of the enhanced accumulation of GABA in mulberry leaves (ML) against cerebral ischemia <I>in vitro</I> and <I>in vivo</I>, a process was developed to enhance the accumulation of GABA in mulberry leaves (GAML) as a result of the various anaerobic treatments. The GABA concentrations were changed by N<SUB>2</SUB> gas purging, the reaction temperature, reaction time, pH and the leaf size. GABA enhanced the potential of neuroprotection in the PC12 cells damaged by H<SUB>2</SUB>O<SUB>2</SUB>-induced oxidation. GAML reduced the cytotoxicity in the PC12 cells against oxygen glucose deprivation-induced cerebral ischemic condition. The neuroprotective effect of GAML was further demonstrated <I>in vivo</I> using middle cerebral artery occlusion brain injury model. GAML significantly decreased the infarct volume of the brain compared with than control group. Overall, these results suggest that the anaerobic treatment of ML makes GAML enhance the neuroprotection effect against <I>in vivo</I> cerebral ischemia such as <I>in vitro</I>.</P>
Adenomyoepithelioma of the Breast: Which Mimicking Malignancy on Ultrasound Elastography
Shin Young Kim,Sun Huh,Hye Rim Park,Mee Hye Oh 순천향대학교 순천향의학연구소 2019 Journal of Soonchunhyang Medical Science Vol.25 No.1
Adenomyoepithelioma (AME) is a rare breast lesion with balanced proliferation of both epithelial and myoepithelial cells. Patients usually present with a solitary mass without pain and nipple discharge. Although the tumor is generally considered benign, it has potential for local recurrence, metastasis, or malignant change. Approximately 150 cases have been reported in the medical literature, of which 40 cases were malignant or potentially malignant. But among them, elastographic findings have been reported in only two cases and still remain unclear. Herein, we now present a case of breast AME with emphasis on elastography.
Giant cell Reparative Granuloma of the Middle Phalanx of the Index Finger
박종석,최호림,이상선,오미혜,문명상,Park, Jong-Seok,Choi, Ho-Rim,Lee, Sang-Seon,Oh, Mee-Hye,Moon, Myung-Sang The Korean Musculoskeletal Tumor Society 2007 대한골관절종양학회지 Vol.13 No.2
거대 세포 육아종(Giant cell reparative granuloma)는 흔하지 않는 양성 종양으로 상악골이나 하악골에서 흔하다. 그러나 수지에서는 매우 드물다. 저자들는 21세된 남자 환자로 인지에서 발생한 거대 세포 육아종을 보고하고자 한다. 조직학적으로 거대 세포 육아종이었다. Giant cell reparative granuloma (GCRG) is an uncommon benign lesion that is most commonly found in the mandible and maxialla, and is a very rare condition in finger. We report an unusual case of GCRG arising in the index finger of a 21-year-old man. Histology was characteristic of giant cell reparative granuloma.
Kim, Bong Jik,Ueyama, Takehiko,Miyoshi, Takushi,Lee, Seungmin,Han, Jin Hee,Park, Hye-Rim,Kim, Ah Reum,Oh, Jayoung,Kim, Min Young,Kang, Yong Seok,Oh, Doo Yi,Yun, Jiwon,Hwang, Sang Mee,Kim, Nayoung K D BMJ Publishing Group Ltd 2019 Journal of medical genetics Vol.56 No.12
<P><B>Background</B></P><P>Diaphanous-related formin 1 (DIA1), which assembles the unbranched actin microfilament and microtubule cytoskeleton, is encoded by <I>DIAPH1</I>. Constitutive activation by the disruption of autoinhibitory interactions between the N-terminal diaphanous inhibitory domain (DID) and C-terminal diaphanous autoregulatory domain (DAD) dysregulates DIA1, resulting in both hearing loss and blood cell abnormalities.</P><P><B>Methods and results</B></P><P>Here, we report the first constitutively active mutant in the DID (p.A265S) of humans with only hearing loss and not blood cell abnormality through whole exome sequencing. The previously reported DAD mutants and our DID mutant (p.A265S) shared the finding of diminished autoinhibitory interaction, abnormally upregulated actin polymerisation activity and increased localisations at the plasma membrane. However, the obvious defect in the DIA1-driven assembly of cytoskeleton ‘during cell division’ was only from the DAD mutants, not from p.A265S, which did not show any blood cell abnormality. We also evaluated the five DID mutants in the hydrophobic pocket since four of these five additional mutants were predicted to critically disrupt interaction between the DID and DAD. These additional pathogenic DID mutants revealed varying degrees of defect in the DIA1-driven cytoskeleton assembly, including nearly normal phenotype during cell division as well as obvious impaired autoinhibition, again coinciding with our key observation in DIA1 mutant (p.A265S) in the DID.</P><P><B>Conclusion</B></P><P>Here, we report the first mutant in the DID of humans with only hearing loss. The differential cell biological phenotypes of DIA1 during cell division appear to be potential determinants of the clinical severity of <I>DIAPH1-</I>related cytoskeletopathy in humans.</P>
Alterations in Social Brain Network Topology at Rest in Children With Autism Spectrum Disorder
Narae Yoon,Youngmin Huh,Hyekyoung Lee,Johanna Inhyang Kim,Jung Lee,Chan-Mo Yang,Soomin Jang,Yebin D. Ahn,Mee Rim Oh,Dong Soo Lee,Hyejin Kang,Bung-Nyun Kim 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.12
Objective Underconnectivity in the resting brain is not consistent in autism spectrum disorder (ASD). However, it is known that the functional connectivity of the default mode network is mainly decreased in childhood ASD. This study investigated the brain network topology as the changes in the connection strength and network efficiency in childhood ASD, including the early developmental stages. Methods In this study, 31 ASD children aged 2–11 years were compared with 31 age and sex-matched children showing typical development. We explored the functional connectivity based on graph filtration by assessing the single linkage distance and global and nodal efficiencies using resting-state functional magnetic resonance imaging. The relationship between functional connectivity and clinical scores was also analyzed. Results Underconnectivities within the posterior default mode network subregions and between the inferior parietal lobule and inferior frontal/superior temporal regions were observed in the ASD group. These areas significantly correlated with the clinical phenotypes. The global, local, and nodal network efficiencies were lower in children with ASD than in those with typical development. In the preschool-age children (2–6 years) with ASD, the anterior-posterior connectivity of the default mode network and cerebellar connectivity were reduced. Conclusion The observed topological reorganization, underconnectivity, and disrupted efficiency in the default mode network subregions and social function-related regions could be significant biomarkers of childhood ASD.