http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Hyun-Seok,Livinghouse, T.,SeoMoon, Dong,Lee, Phil-Ho Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.7
It was demonstrated that Y[N(TMS)2]3, the neutral yttrium-diamine complex 13 and yttrium-NPS complexes 15 are efficient precatalysts for intramolecular hydroamination of aminoalkynes involving primary amines. Complex 13 and 15 were quantitatively prepared in situ by direct metalation of the ligands 4 and 9 with 1 equiv of Y[N(TMS)2]3 in benzene-d6 at 120 oC for 5 days and 10 days, respectively, via elimination of (TMS)2NH. 5-Exo- and 6-exo-dig intramolecular hydroamination of aminoalkynes using catalyst 12 and 13 proceeded smoothly to give nitrogen-contained cyclic products in good to excellent yields in all cases. In the case of 7- exo-dig intramolecular hydroamination, the desired product was produced in 41% and 48% yields despite the gem-dimethyl effect. However, treatment of catalyst 15 with aminoalkynes (19 and 22) having a methyl substituent at the carbon adjacent to triple bond and 6-exo-dig intramolecular hydroamination of 21 failed to give the desired products. Zirconium-catalyzed intramolecular hydroamination of aminoallenes (25, 27, and 31) with 5 mol% 16 afforded 2-(trans-1-propenyl)pyrrolidine, 2-isopropylenepyrrolidine, and 2-(trans-1- propenyl)piperidine in 96%, 95%, and 93% yield, respectively. However, subjecting 25 to 5 mol% 15 was unsuccessful to produce the desired product.
Hyunseok Kim,T. Livinghouse*,Dong Seomoon,Phil Ho Lee* 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.7
It was demonstrated that Y[N(TMS)2]3, the neutral yttrium-diamine complex 13 and yttrium-NPS complexes 15 are efficient precatalysts for intramolecular hydroamination of aminoalkynes involving primary amines. Complex 13 and 15 were quantitatively prepared in situ by direct metalation of the ligands 4 and 9 with 1 equiv of Y[N(TMS)2]3 in benzene-d6 at 120 oC for 5 days and 10 days, respectively, via elimination of (TMS)2NH. 5-Exo- and 6-exo-dig intramolecular hydroamination of aminoalkynes using catalyst 12 and 13 proceeded smoothly to give nitrogen-contained cyclic products in good to excellent yields in all cases. In the case of 7-exo-dig intramolecular hydroamination, the desired product was produced in 41% and 48% yields despite the gem-dimethyl effect. However, treatment of catalyst 15 with aminoalkynes (19 and 22) having a methyl substituent at the carbon adjacent to triple bond and 6-exo-dig intramolecular hydroamination of 21 failed to give the desired products. Zirconium-catalyzed intramolecular hydroamination of aminoallenes (25, 27, and 31) with 5 mol% 16 afforded 2-(trans-1-propenyl)pyrrolidine, 2-isopropylenepyrrolidine, and 2-(trans-1-propenyl)piperidine in 96%, 95%, and 93% yield, respectively. However, subjecting 25 to 5 mol% 15 was unsuccessful to produce the desired product.
A new and general one-pot synthesis of propargyl alcohols from esters
Chae, Min Jung,Jeon, Ah Ram,Livinghouse, Tom,An, Duk Keun Royal Society of Chemistry 2011 Chemical communications Vol.47 No.11
<P>Intermediates easily prepared by partial reduction of various esters with LDBBA as a reducing agent smoothly react with lithium acetylides to give propargyl alcohols, without isolation of partial reduction intermediates, in good yields (73–83%).</P> <P>Graphic Abstract</P><P>Intermediates easily prepared by partial reduction of various esters with LDBBA as a reducing agent smoothly react with lithium acetylides to give propargyl alcohols, without isolation of partial reduction intermediates, in good yields (73–83%). <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc04597g'> </P>
Kim, Hyunseok,Lee, Phil Ho,Livinghouse, Tom Royal Society of Chemistry 2005 Chemical communications Vol.2005 No.41
<P>A neutral Zr(<SMALL>IV</SMALL>) complex has been shown to be an effective precatalyst for intramolecular alkene hydroaminations that provide cyclic amines in good to excellent yields.</P> <P>Graphic Abstract</P><P>A neutral Zr(<SMALL>IV</SMALL>) complex has been shown to be an effective precatalyst for intramolecular alkene hydroaminations that provide cyclic amines in good to excellent yields. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b505738h'> </P>
Kim, Hyunseok,Kim, Young Kwan,Shim, Jun Hwan,Kim, Misook,Han, Mijung,Livinghouse, Tom,Lee, Phil Ho WILEY-VCH Verlag 2006 Advanced Synthesis & Catalysis Vol.348 No.18
<P>The thiophosphinic amide 2 was prepared in 68 % yield by the reaction of 2,2-dimethyl-1,3-propanediamine with diisopropylchlorophosphine followed by the addition of sulfur. Attachment of the proligand 2 to zirconium was achieved by direct metalation with Zr(NMe<SUB>2</SUB>)<SUB>4</SUB> in benzene-d<SUB>6</SUB> or toluene-d<SUB>8</SUB> to afford complex 3 via elimination of dimethylamine. The neutral Zr(IV) complex 3 has been shown to be an effective precatalyst for intramolecular alkene hydroaminations that provide cyclic amines in good to excellent yields. A variety of chiral ligands (20, 22, 24, and 25–30) were prepared for asymmetric internal alkene hydroaminations. Metalation of chiral ligands to yttrium was accomplished with Y[N(TMS)<SUB>2</SUB>]<SUB>3</SUB> in benzene-d<SUB>6</SUB> or toluene-d<SUB>8</SUB> to give complexes. Treatment of 7 with 5 mol % of 33 in benzene-d<SUB>6</SUB> (25 °C, 18 h) or toluene-d<SUB>8</SUB> (25 °C, 15 h) afforded 2,4,4-trimethylpyrrolidine 14 in 95 % yield (61 % ee).</P> <B>Graphic Abstract</B> <P> <img src='wiley_img/16154150-2006-348-18-ADSC200606171-content.gif' alt='wiley_img/16154150-2006-348-18-ADSC200606171-content'> </P>