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Leite Luciano Bernardes,Soares Leôncio Lopes,Portes Alexandre Martins Oliveira,Soares Thayana Inácia,da Silva Bruna Aparecida Fonseca,Dias Taís Rodrigues,Costa Sebastião Felipe Ferreira,Guimarães-Ervi 대한고혈압학회 2024 Clinical Hypertension Vol.30 No.-
Background Under the adverse remodeling of the right ventricle and interventricular septum in pulmonary arterial hypertension (PAH) the left ventricle (LV) dynamics is impaired. Despite the benefts of combined aerobic and resist‑ ance physical trainings to individuals with PAH, its impact on the LV is not fully understood. Objective To test whether moderate-intensity combined physical training performed during the development of PAH induced by MCT in rats is benefcial to the LV’s structure and function. Methods Male Wistar rats were divided into two groups: Sedentary Hypertensive Survival (SHS, n=7); and Exercise Hypertensive Survival (EHS, n=7) to test survival. To investigate the efects of combined physical training, another group of rats were divided into three groups: Sedentary Control (SC, n=7); Sedentary Hypertensive (SH, n=7); and Exercise Hypertensive (EH, n=7). PAH was induced through an intraperitoneal injection of MCT (60 mg/kg). Echocardiographic evaluations were conducted on the 22nd day after MCT administration. Animals in the EHS and EH groups participated in a combined physical training program, alternating aerobic (treadmill running: 50 min, 60% maximum running speed) and resistance (ladder climbing: 15 climbs with 1 min interval, 60% maximum carrying load) exercises, one session/day, 5 days/week for approximately 4 weeks. Results The physical training increased survival and tolerance to aerobic (i.e., maximum running speed) and resist‑ ance (i.e., maximum carrying load) exertions and prevented reductions in ejection fraction and fractional shortening. In addition, the physical training mitigated oxidative stress (i.e., CAT, SOD and MDA) and inhibited adverse LV remod‑ eling (i.e., Collagen, extracellular matrix, and cell dimensions). Moreover, the physical training preserved the ampli‑ tude and velocity of contraction and hindered the reductions in the amplitude and velocity of the intracellular Ca2+ transient in LV single myocytes. Conclusion Moderate-intensity combined physical training performed during the development of MCT-induced PAH in rats protects their LV from damages to its structure and function and hence increases their tolerance to physi‑ cal exertion and prolongs their survival.
The value of PET/CT for cytoreductive surgery selection in recurrent ovarian carcinoma
Rafael Leite Nunes,Flávio Rodrigues Teixeira,Thiago Pereira Diniz,Carlos Chaves Faloppa,Henrique Mantoan,Alexandre Andre Balieiro Anastacio da Costa,Glauco Baiocchi 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.3
Objective: To evaluate the value of positron emission tomography/computed tomography (PET/CT) in predicting no residual disease (NRD) after secondary cytoreductive surgery (SCS) compared with MSK criteria, the iMODEL, and the AGO score. Methods: We analyzed 112 patients with platinum-sensitive ovarian carcinoma who underwent SCS. We excluded patients for whom PET/CT was not performed, those without sufficient data, and who received chemotherapy before SCS. Ultimately, 69 patients were included. Results: Variables that correlated with NRD were peritoneal carcinomatosis index (odds ratio [OR]=0.91; 95% confidence interval [CI]=0.83–0.99; p=0.044), European Cooperative Oncology Group Performance Status (ECOG) 0 (OR=8.0; 95% CI=1.34–47.5; p=0.022), and ≤2 lesions by PET/CT (OR=4.36; 95% CI=1.07–17.7; p=0.039). Of the patients with ≤2 lesions by PET/CT, 48 (92.3%) underwent complete SCS. The sensitivity, positive predictive value, negative predictive value, and accuracy of PET/CT for NRD were 85.7%, 92.3%, 33.3%, and 81.2%, respectively. NRD was achieved after fulfilling the MSK criteria, iMODEL and AGO Score in 89.1%, 88.1% and 85.9%, respectively. The accuracy of the MSK criteria, iMODEL, and AGO score in predicting NRD was 87%, 83.3%, and 77.3%, respectively. The PET/CT findings agreed well with the AGO score and iMODEL. The addition of PET/CT to these models increased the NRD rates (92.2%, 91.8%, and 89.4% for MSK+PET/CT, iMODEL+PET/CT, and AGO+PET/CT, respectively), but lowered their accuracy. Conclusion: We observed NRD in 92.3% of patients with ≤2 lesions by PET/CT, with an accuracy of 81.2%. PET/CT did not increase the accuracy of the MSK criteria, iMODEL, or AGO score models.
Ariane Leite Rozza,Thiago de Mello Moraes,Hélio Kushima,Domingos Sávio Nunes,Clélia Akiko Hiruma-Lima,Cla´udia Helena Pellizzon 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.9
This study aimed to evaluate the gastroprotective mechanism of action of the essential oil of Croton cajucara Benth. (Euphorbiaceae) stem bark in ethanol-induced gastric ulcers and its in vitro anti–Helicobacter pylori activity. The involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, nitric oxide, and nonprotein sulfhydryl compounds in the gastroprotective effect was determined in male Wistar rats. The minimum inhibitory concentration against H. pylori was determined in vitro. The results were analyzed by analysis of variance followed by the Dunnett test, and a P value less than 0.05 was considered to represent a statistically significant difference. C. cajucara decreased ethanol-induced ulcer area in 100% of ulcers and decreased the histologic lesions. In the C. cajucara group, the area marked by heat-shock protein-70 was significantly higher than the area in the control group; this finding was not seen for vasoactive intestinal peptide. C. cajucara could not maintain glutathione levels close to those in the sham group. The gastric ulcer area of rats treated with the sulfhydryl compound blocker was decreased, but the ulcer area of rats treated with nitric oxide synthase inhibitor showed no alteration. The minimum inhibitory concentration obtained for C. cajucara was 125 μg/mL. These findings suggest that sulfhydryl compounds and heat-shock protein-70, but not nitric oxide, glutathione, or vasoactive intestinal peptide, are involved in the C. cajucara gastroprotective effect against ethanol-induced gastric ulcers.
( Lucia Leite Lais ),( Sancha Helena De Lima Vale ),( Camila Alves Xavier ),( Alfredo De Araujo Silva ),( Tolunay Beker Aydemir ),( Robert J Cousins ) 한국임상영양학회 2016 Clinical Nutrition Research Vol.5 No.1
To evaluate the effect of diet on metabolic control and zinc metabolism in patients with type 2 diabetes mellitus (T2DM). One-week balanced diet was provided to 10 Brazilians patients with T2DM. Nutritional assessment, laboratorial parameters and expression of zinc transporter and inflammatory genes in peripheral blood mononuclear cells (PBMC) were performed. Healthy non-diabetic subjects of the same demographic were recruited to provide baseline data. Diabetic patients had higher body mass index and greater fasting plasma glucose, plasma tumor necrosis factor α (TNFα) and plasma interleukin 6 (IL6) levels compared with healthy subjects. In addition, the expression of transporters 4 (ZnT4) mRNA was lower and IL6 mRNA was higher in PBMC of these diabetic patients than in healthy subject. One week after a balanced diet was provided, fasting plasma glucose decreased significantly as did TNFα, IL6 and Metallothionein 1 (MT1) mRNAs. No change was observed in zinc transporter expression in PBMC after the dietary intervention. A healthy eating pattern maintained for one week was able to improve metabolic control of diabetic patients by lowering fasting plasma glucose. This metabolic control may be related to down-regulation of zinc-related transcripts from PBMCs, as TNFα, IL6 and MT1 mRNA.
Phillippe LEITE,Ambar NARAYAN,Emmanuel SKOUFIAS 연세대학교 빈곤문제국제개발연구원 2015 Journal of Poverty Alleviation and International D Vol.6 No.1
We compare the ex ante simulation of the impacts of conditional cash transfer (CCT) programs against the ex post estimates of impacts obtained from experimental evaluations. Using the data on program-eligible households in treatment areas from the same baseline surveys used for the experimental evaluations of CCT programs in Mexico and in Ecuador, we use a micro-simulation model to derive ex ante estimates of the impact of the programs on enrollment rates and poverty. Our estimates reveal that ex ante predictions of certain impacts of CCT programs using the micro-simulation model match up well against the benchmark estimates of ex post experimental studies. The findings seem to support the use of this model to assess the potential impact and cost efficiency of a CCT program ex ante, for the purpose of informing decisions about the design of the program.
Heliene Leite Ribeiro Porto,Antonio Carlos Leal de Castro,James Werllen de Jesus Azevedo,Leonardo Silva Soares,Cássia Fernanda Chagas Ferreira,Marcelo Henrique Lopes Silva,Helen Roberta Silva Ferreira 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.7
Concentrations of calcium, iron, potassium, magnesium, phosphorus, zinc, copper, selenium and nickel were determined in the muscle tissue of seven species of fish (Plagioscion squamosissimus, Geophagus surinamensis, Prochilodus lacustres, Curimata sp., Schizodon dissimilis, Ageneiosus ucayalensis and Hypostomus plecostomus) collected from the lower course of the Itapecuru River in the state of Maranhão, Brazil. The samples were digested in a nitricperchloric solution and analyzed using an inductively coupled plasma atomic emission spectrometer, with the construction of specific calibration curves for each element. The highest concentrations of constituent minerals were found for phosphorus, potassium, nickel and magnesium (399.83, 144.60, 90.20 and 29.49mg 100 g−1, respectively) in G. surinamensi, P. lacustres and Curimata sp. The lowest concentrations were found for copper, zinc, iron and selenium (0.12, 0.51, 1.05 and 8.31mg 100 g−1, respectively) in Curimata sp., S. dissimilis, A. ucayalensis and P. squamosissimus. The concentrations of all minerals can be considered low and are below the maximum limit established by Brazilian legislation for the human ingestion of fish meat. A comparison of the seven species of fish investigated revealed no statistically significant differences regarding the concentrations of minerals, suggesting that size and different dietary habits do not exert an influence on absorption. The low concentrations of metals, such as Fe, Cu, Zn and Ni, may be related to the environmental conditions of the mouth of the river, which receives ocean inputs that produce particular tide cycles with a strong dispersion capacity, thereby diminishing residence time in the water column and reducing the availability of these metals to species of fish.
Souza Gabriela Leite de,Moura Camilla Christian Gomes,Silva Anielle Christine Almeida,Marinho Juliane Zacour,Silva Thaynara Rodrigues,Dantas Noelio Oliveira,Bonvicini Jéssica Fernanda Sena,Turrioni An 대한치과보존학회 2020 Restorative Dentistry & Endodontics Vol.45 No.4
Objectives: This study aimed to synthesize nanocrystals (NCs) of zinc oxide (ZnO) and calcium ion (Ca2+)-doped ZnO with different percentages of calcium oxide (CaO), to evaluate cytotoxicity and to assess the effects of the most promising NCs on cytotoxicity depending on lipopolysaccharide (LPS) stimulation. Materials and Methods: Nanomaterials were synthesized (ZnO and ZnO:xCa, x = 0.7; 1.0; 5.0; 9.0) and characterized using X-ray diffractometry, scanning electron microscopy, and methylene blue degradation. SAOS-2 and RAW 264.7 were treated with NCs, and evaluated for viability using the MTT assay. NCs with lower cytotoxicity were maintained in contact with LPS-stimulated (+LPS) and nonstimulated (−LPS) human dental pulp cells (hDPCs). Cell viability, nitric oxide (NO), and reactive oxygen species (ROS) production were evaluated. Cells kept in culture medium or LPS served as negative and positive controls, respectively. One-way analysis of variance and the Dunnett test (α = 0.05) were used for statistical testing. Results: ZnO:0.7Ca and ZnO:1.0Ca at 10 µg/mL were not cytotoxic to SAOS-2 and RAW 264.7. +LPS and −LPS hDPCs treated with ZnO, ZnO:0.7Ca, and ZnO:1.0Ca presented similar NO production to negative control (p > 0.05) and lower production compared to positive control (p < 0.05). All NCs showed reduced ROS production compared with the positive control group both in +LPS and −LPS cells (p < 0.05). Conclusions: NCs were successfully synthesized. ZnO, ZnO:0.7Ca and ZnO:1.0Ca presented the highest percentages of cell viability, decreased ROS and NO production in +LPS cells, and maintenance of NO production at basal levels.
( Samuel Bellini Leite ),( Alfredo Pereira Jr ) 서울대학교 인지과학연구소 2013 Journal of Cognitive Science Vol.14 No.4
The Global Workspace Theory (GWT) proposed by Bernard Baars (1988) along with Daniel Dennett`s (1991) Multiple Drafts Model (MDM) of consciousness are renowned cognitive theories of consciousness bearing similarities and differences. Although Dennett displays sympathy for GWT, his own MDM does not seem to be fully compatible with it. This work discusses this compatibility, by asking if GWT suffers from Daniel Dennett`s criticism of what he calls a “Cartesian Theater”. We identified in Dennett 10 requirements for avoiding the Cartesian Theater. We believe that some of these requirements are violated by GWT, but not all, hence there is partial incompatibility with MDM, and it is nonsense to answer if GWT is or is not a Cartesian Theater. However, by asking such question we conclude that the issues around this discussion involve fuzzy claims about degrees of consciousness and we show how the Neuro-Astroglial Interaction Model (NAIM) is fit for solving such conceptual issues.