Duplication 9p Syndrome 1례

이미경,노영래,김영훈,백청순,신미경,이진,장필상,김진택,이권행,황경태 대한소아과학회 2002 小兒科 Vol.45 No.9

95년도 주요 감정사례 및 실적에 관한 분석

박성우,이광영,김영운,최영남,이정필 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-

혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

TGA를 이용한 산화구리계 탈황제의 반응 특성 규명

이혁수,강민필,이효송,이영우 충남대학교 공업교육연구소 2001 論文集 Vol.24 No.1

Reduction and sulfidation reactivities of mixed metal oxides were investigated by using a TGA. Mixed metal oxides consisted of CuO as the main active material, SiO₂ as the support material and both MoO₃ and Fe₂O₃ as the additives. Each material was chosen based on the literature survey. CS (CuO/SiO₂) sorbents were prepared to investigate the effect of support material, and consisted of various composition of CuO and SiO₂. CMS (CuO-MoO₃/SiO₂) and CFS (CuO-Fe₂O₃/SiO₂) sorbents were prepared to investigate the effect of additives and consisted of various composition of CuO and additive. In CMS and CFS sorbents, a support material was 25wt% SiO₂ because the previous study showed that 25wt% SiO₂ was needed to maintain the activity in multicycle experiment. Simple physical mixing method was chosen as the sorbent preparation method. Chatterjee-Conrad method was used to evaluate activation energies of sorbents from TGA data. The activation energy of CS sorbents decreased in reduction reaction and increased in sulfidation reaction as SiO₂ content increased. Fe₂O₃ was more favorable than MoO₃ as an additive material in terms of reduction reaction rate.

여자체조 평균대 종목의 Start value와 Bonus Point에 관한 연구 : 1997. 세계 선수권대회 참가선수를 중심으로 The 33rd World Championship of Gymnastics in 1997)

이필영 龍仁大學校 1998 용인대학교 논문집 Vol.16 No.-

The purpose of this study is to analyze the balance beam performance of twelve participants including 2 Korean and 2 Japanese in the 33rd World Championship of Gymnastics employing VTR analysis technique. The followings are results of analysis: First, there are no differences in numbers of value part between Korean gymnasts and international gymnasts. Second, 5 of 84 in B value parts and 9 of 88 in C value parts were favored. 16 times of Flic flac and 12 times of Salto backward stretched - step out were performed. It is interpreted that these two are used to get speed and bouncing force to Acrobatic series and Dismount. In C value parts more gymnastic parts than acrobatic were performed as special connection. Third, in D value parts, 14 of 48 was performed, and it is interpreted that various selections will help to met additional bonus point of special connection. 12 parts in Acrobatic were selected, while two in gymnastic was selected. Forth, special connection employed various series which show a participant's characteristics including jump and leap. Final for each event showed big differences of 0.40 to 0.50 points between Korean gymnasts and international gymnasts. Fifth, Korean gymnasts left much to be desired in connection of skills, dexterity, and various performance to get bonus points. In conclusion, this result revealed that theoretical research and practical efforts are required to demonstrate performance with accuracy, dexterity, and creativity.

충청 지방의 미친굿

이필영 漢陽大學校 民族學硏究所 1998 民族과文化 Vol.7 No.-

자궁원발성 비호지킨 악성림프종 -3예 보고-

박찬필,고영혜,이중달,박문일,김경태,조삼현 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.3

Comparative double blind test에 의한 抗아메바劑 Ro7-0207(Tiberal), Metronidazole 및 Dehydroemetine의 治效成績의 比較

李午政,全鍾暉,朴弼遠,朴壽泳 대한감염학회 1974 감염 Vol.6 No.1

Introduction New and better substances are still being sought for the treatment of amoebiasis. The aim of this trial is to assess the effectiveness and tolerance of Tiberal and oral dehydroemetine in patients with oligosymptomatic (or mild) intestinal amoebiasis comparing with that of metronidazole which are known to be an active amoebicide. Selection of cases. Lately, classical symptomatic amoebiasis accompanying mucus-bloody stool and tenesmus could be seldom experienced at urban areas in this country. At here the majority of intestinal amebiasis is manifested by loose stools containing mucus, pus or blood (rare), and also by a rapid response to antibioties, but with frequent episods of recurrence caused by diet-failure or alcohol drinking. Among 187 cases of mild enterocolitis which were suspected as being mild intestinal amoebiasis clinically, authors selected amoeba-positive 60 cases and additional 7 cases which were included later in this clinical trial study. The 7 drop-outs in the original study were replaced by these additional 7 cases. The clinical trials were carried out at the St. Mary's Hospital, Catholic Medical College, Seoul, Republic of Korea. During 12 month (April 25, 1973-May 17, 1974), we treated 60 cases of so-called oligosymptomatic amoebiasis with above mentioned three amoebicides. 60 ambulatory cases suffering from mild GI troubles were admitted into the trial (liable to recurrent diarrhoeal stools including mucus, or pus with tenesmus, and also to lower abdominal discomfort of mild pain) those were suspected clinically as having intestinal amoebiasis with carriers of E. histolytica (trophozoits and/or cysts in the feces). Oligosymptomatic amoebiasis group, in this clinical trial study, consisted of 34 males and 26 females ranging from 17 to 62 years of age. All were adolescents or adults and their age distribution was shown in Table 1. Methodology on this clinical trials. We have carried out so-called the comparative double blind trials with Tiberal versus Metronidazole versus oral Dehydroemetine in symptomatic amoebiasis of mild grade. The trial drugs were given also without the knowledge of either the one who gave it or the one who got it in this comparative double blind study. Both (drug examiner) doctors and (drug examined) patients have had no knowledge of each drug. Pharmacist responded to doctor's prescription with code numbers. After the completion of the study the exact name of a drug were publically drawn from the code numbers and the purpose of double blind study was attained. In this study an arrangement for a drug administration schedule was set by as pharmacist exclusively. 60 patients were assigned to one of the three drugs by proper randomization so that 20 patients received tiberal and 20 metronidazole and 20 oral dehydroemetine. After the trial, code numbers of the drugs were identified; nos. 1, 6, 10, 14, 19, 23, 25, 27, 28, 29, 33, 34, 35, 36, 44, 45, 47, 51, 53, and 54 were tiberal; 8, 9, 11, 12, 13, 15, 16, 18, 20, 22, 32, 39, 41, 48, 49, 50, 52, 55, 56, and 57 were metronidazole, and nos. 2, 3, 4, 5, 7, 17, 21, 24, 26, 30, 31, 37, 38, 40, 42, 43, 46, 58, 59 and 60 were oral dehydroemetine. Evaluation The therapeutic effects were assessed by the clinical evolution and by stool parasitology (direct examination and concentration method) performed on day 3 and 6 on treatment, and then at the end of treatment (8-10 day) and one month after the initial treatment. This made a total 4 to 5 parasitological examination per patient, including one examination required for diagnosis prior to treatment. At the same time aspect and consistency of the stool were registered. The effect of the drugs on other protozoa found in the stools were also reported. The tolerance were assessed by clinical findings and laboratory studies made in limited cases at least before and after treatment unless otherwise stated. Blood count, BUN, Alkaline phosphatase, SGP, TECG and urinalysis were performed as laboratory controls. Authors have established following evaluation criteria for this clinical study. Radical cure: free of symptoms with no vegetative or cystic forms of E. histolytica in stool on 3 successive tests. Biological cure: no cystic forms of E. histolytica in stool on 3 successive tests, but persistence of some intestinal disturbances. Relapse: apparent cure or improvement (with negative of 3 successive tests) followed by recurrence with vegetative amoeba on direct smear within 30 days. (re-infection may be included) Failure: the trophozoites or cystic form of E. histolytica has persisted for treatment periods, with some intestinal troubles. Methods of treatment and parasitologic examination In each group one third of the patients received 2 capsnles of 250mg. Tiberal thrice daily for 7 days, one third received 2 tablets of 250 mgmetronidazole thrice daily for 7 days, and one third received 2 tablets of 10 mgdehydroemetine thrice daily for 7 days as the only specific drug. No associated drugs were given together for symptomatic relief in all cases. The reason why fixed 7 days dose were delivered to every cases was based on convenience of stool examination and equalizing the number of days for therapy. The therapeutic drugs were delivered usually for 2 days dose (1st prescription), 3 days dose and 2 days dose (3rd prescription) successively, therefore stool examination had been done on 3rd, 6th and 8-10th day of therapy. Clinical results In oligosymptomatic amoebiasis, 20 cases each were treated with doses of 1,500mg/day of Tiberal and metronidozole for 7 days respectively, and 20 cases were treated with doses of 60mg/day of dehydroemetine for 7 days. The total doses administered were 10,5g, 10,5g, and 420mg respectively in a period of 7 days. Among tiberal group 19 cases were found to be negative after therapy whereas there was 1 with parasitological failure. The clinical effect was fast in 95% of the cases. Effective cure was achieved in 17 whereas symptoms persist in 3 patients among 20 cases. There were 1 failure and 2 late relapse. Comparing data of therapeutic results with that of metronidazole and dehydroemetine were shown in Table 2 & 3. Table 3 shows the negativity rate of trophozoits or cystic form of E. histolytica in stools according to therapeutic periods of trial drugs received. The data would indicated that 5 days dose could not be enough to eradicate the parasites even in the susceptible cases. The result data of clinical improvement and clearance of E. histolytica in patient stool among drug trial groups were shown in Table 4. The cases treated with Tiberal showed no clinical signs on average 4,9 days and negative amoeba in stool on average 4,1 days of therapeutic periods, comparing with on average 5,8 days and 4,1 days in metronidazole-treated group, and on average 6,3 days and average 4,5 days in dehydroemetine-treated group respectively. Authors put in order the therapeutic procedures and their result of failed or relapsed cases with unplanned measures in table 5. These data could be obtained after the completion of the comparative double blind study by the code numbers which were publically drawn afterwards. These therapeutic procedures had been made just incidentally, not by prior plan. 2 cases, 4 cases and 3 cases could get finally effective cure by doubling doses of 7 days course of Tiberal, metronidazole and dehydroemetine respectively. 1 failed case treated with dehydroemetine and 1 another failed case with tiberal could get effective cure by additionally receiving metronidazole and dehydroemetine respectively. 2 failed cases treated with metronidazole could be cleared of parasites by adding tiberal effectively. Adverse reactions were noticed in 20% each of the patients treated with Tiberal and also with metronidazole, and 25% of those treated with dehydroemetine. They were all transient and never severe. There was not a single case who was discontinued on therapy owing to its side-effects. No significant change of laboratory data was noticed by the administration of trial drugs. Brief summary Tiberal, metronidazole and dehydroemetine (oral) were all recognized as highly efficacious anti-amoebic drugs in this clinical studies. On account of following standpoints 1) clearance of parasites in stool 2) clinical symptomatic relieving 3) drug tolerance 4) rate of relapse and failure 5) side-effects, Tiberal could be received much more recognition than metronidazole and dehydroemetine did. P. S. Authors has experienced other 10 cases of amoebiasis among in patients (5 moderate severe intestinal amoebiasis, 4 liver abscesses and 1 lung abscess) treated with Tiberal and metronidazole with excellent therapeutic results, without any sequelae or relapse.