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Lee, Sang-Guk,Yim, Ye Seal,Lee, Yong-ho,Lee, Byung-Wan,Kim, Hyon-Suk,Kim, Kyung-Sup,Lee, Yong-Wha,Kim, Jeong-Ho Elsevier 2018 Diabetes research and clinical practice Vol.140 No.-
<P>Conclusions: The increase in fasting serum AAs can be an early manifestation of insulin resistance. Increased muscle proteolysis induced by insulin resistance and inflammatory cytokines can be a possible mechanism for the rise in serum AA levels. (C) 2018 Elsevier B.V. All rights reserved.</P>
Sung Won Kim,Young Wha Song,Jung Sook Lee 국제물리치료학회 2016 Journal of International Academy of Physical Ther Vol.7 No.2
c-Fos is known to related to synaptic plasticity and apoptosis in damage from ischemia or external injury. The purpose of this study was to investigate whether needle electrode electrical stimulation(NEES) is effective in increasing the number of c-Fos response cells and c-Fos expression in striatum after global ischemia in rats. There were no treatment and occlusion in the control group, global ischemia(GI) group were no treatment after carotid artery occlusion, and needle electrode electrical stimulation(NEES) group were treated with NEES after GI induced. The number of striatum c-Fos response cells and c-Fos protein expression significantly decreased in the NEES group compared to the GI group after 12, 24, 48 hours. The results of the present study suggest that NEES is ineffective in improving global ischemia in rats and may also be ineffective in the globally ischemic human brain.
Sung Uk Baek,Kwang Hyun Kim,Joo Yeon Lee,Kyung Wha Lee 대한안과학회 2018 Korean Journal of Ophthalmology Vol.32 No.2
Purpose: To assess long-term changes in intraocular pressure (IOP) and the development of glaucoma after early phacoemulsification in acute primary angle closure. Methods: Retrospective chart review of acute primary angle closure patients treated with phacoemulsification in attack eyes versus fellow eyes. Within a month after the angle closure attack, all subjects underwent cataract surgery and were divided into two groups: group A received cataract surgery on their attack eyes. Group B also received cataract surgery on their fellow eye after phacoemulsification of the attack eyes. Study outcomes were the prevalence of IOP rise (occurrence of IOP >21 mmHg) and the incidence of newly developed glaucoma. Results: Eighty-nine eyes were included, with 62 attack eyes in group A and 27 fellow eyes in group B. Group A (14 eyes, 22.58%) had a higher cumulative rate of IOP rise than group B (3 eyes, 11.11%) at 12 months (p = 0.001). Newly developed glaucoma was not observed in group B; however, 6 patients in group A developed glaucoma during the 12-month follow-up period (p < 0.001). Conclusions: The attack eyes treated with phacoemulsification showed a significantly higher prevalence of IOP rise and newly developed glaucoma than fellow eyes that received phacoemulsification. These findings suggest that there is a possibility of IOP rise and development of glaucoma even when angle closure and successful IOP control have apparently been achieved after phacoemulsification.
Lee, Kyung Min,Park, Ji Ung,Kwon, Sung Tack,Kim, Suk Wha,Jeong, Eui Cheol Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.5
Background The objective of this article is to evaluate clinical outcomes of combined orbital floor and medial wall fracture repair using a three-dimensional pre-bent titanium implant in an East Asian population. Methods Clinical and radiologic data were analyzed for 11 patients with concomitant orbital floor and medial wall fractures. A combined transcaruncular and inferior fornix approach with lateral canthotomy was used for the exposure of fractures. An appropriate three-dimensional preformed titanium implant was selected and inserted according to the characteristics of a given defect. Results Follow-up time ranged from 2 to 6 months (median, 4.07 months). All patients had a successful treatment outcome without any complications. Clinically significant enophthalmos was not observed after treatment. Conclusions Three-dimensional pre-bent titanium implants are appropriate for use in the East Asian population, with a high success rate of anatomic restoration of the orbital volume and prevention of enophthalmos in combined orbital floor and medial wall fracture cases.
Sang-Eun Park,Min-Yim Park,Po-Keun Han,Sang-Wha Lee* 대한화학회 2006 Bulletin of the Korean Chemical Society Vol.27 No.9
An electrostatic interaction is responsible for the attachment of gold seeds of 1-3 nm onto APTMS (3-aminopropyl trimethoxysilane)-coated silica cores in the formation of gold clusters. A surface plasmon resonance and morphology of gold clusters were significantly affected by the pH of gold colloids prepared by THPC reducing agent. Gold colloids of alkaline pH induced the heterogeneous deposition of gold seeds onto the silica nanoparticles, probably due to the continuous reduction of residual gold ions during the attachment process. Gold colloids of acidic pH induced the monodisperse deposition of gold seeds, consequently leading to the formation of smooth gold layer on the silica nanoparticles surface. The gold nanoshells (core radius = 80 nm) prepared by gold colloids of pH 3.1 exhibited the more red-shift and relatively stronger intensity of plasmon absorption bands, compared with gold nanoshells prepared by alkaline gold colloids of pH 9.7.
( Sung Wook Yang ),( Jung Wha Chung ),( Sang Soo Lee ),( Sukho Hong ),( Seong Min Chung ),( Eun Sun Jang ),( Jin Wook Kim ),( Sook Hyang Jeong ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: Serum level of alpha-fetoprotein (AFP) can elevate in patients with chronic hepatitis B (CHB) without evidence of hepatocellular carcinoma. However, the response of AFP levels to oral nucleos(t)ide analog is not elucidated yet. In this study, we retrospectively assessed the prevalence of high serum AFP levels in CHB patients who were treated with entecavir (ETV), and patterns of AFP changes during the entecavir therapy. Methods: A total of 110 CHB patients who started ETV as an initial antiviral therapy were enrolled in this retrospective study. Pre-treatment clinical , biochemical and virologic parameters were evaluated in relation to the serial AFP levels. Results: The mean baseline AFP value was 41.2 ng/dL. Before ETV therapy (range: 1.3-840 ng/dL). Among the 110 patients, fourty-six (41.8%) showed high pre-treatment AFP values (>10 ng/dl). In the high AFP group, Aspartate transaminase (AST), Alkaline phosphatase (ALP), bilirubin, albumin and prothrombin time (PT) were significantly higher compared to normal AFP group (P=0.021, 0.005, 0.000, 0.001 and 0.004, respective). Only baseline albumin level was significant predictor of high AFP level in multivariate logistic regression analysis (P=0.043, HR=0.00). In high AFP group, The cumulative normalization rates of AFP levels were 26.1%, 73.9% and 91.3% at 18, 36 and 72 weeks, respectively. Serum DNA level was significantly correlated to the time to AFP normalization in a Kaplan-Meier analysis (P=0.039). Conclusions: AFP frequently elevates in CHB patients who undergoes oral nucleoside analog therapy, and baseline albumin level was significantly associated with high AFP level. Normalization of AFP is delayed and about 1/3 shows high AFP levels up to 3 years of ETV therapy. Baseline DNA level was associated with delayed AFP normalization after ETV therapy.
Radioresponse of Hepatocellular Carcinoma-Treatment of Lymph Node Metastasis
Sang Min Yoon,Jong Hoon Kim,Eun Kyung Choi,Seung Do Ahn,Sang-wook Lee,Byong Yong Yi,Young Wha Chung,Young Sang Lee,Dong Jin Seo 대한암학회 2004 Cancer Research and Treatment Vol.36 No.1
PURPOSE: To analyze the radioresponse of hepatocellular carcinomas (HCC), using accurate measurements of the tumor size in extrahepatic lymph node metastasis, and to obtain information for the future treatment of primary intrahepatic lesions. MATERIALS AND METHODS: Fifty-one extrahepatic lymph node metastases from primary HCCs, which could be treated by external radiotherapy alone, were included in this study. The radiation dose ranged from 30 to 51 Gy with fraction sizes of 2.0~3.0 Gy. Responses were determined by measuring the areas on CT scans 0, 1 and 3 months after the completion of radiotherapy. The median follow-up period of the surviving patients was 10 months. RESULTS: The overall response rate was 76%, and the important factors were; total dose of radiation, time dose fractionation (TDF) value and the biologically effective dose (BED). A dose of 45 Gy or higher showed an objective response rate of 93%, and if the TDF value was higher than 90, a similar result was observed. In about half (47%) of the patients the maximum response was observed at 3 months or later. The response duration was observable in 14 patients surviving 12 months or longer. Regrowth of irradiated lesions were observed in 4 (66.7%) patients among those who received less than 45 Gy, and in 4 (50%) among those who were treated with 45 Gy or more. There was a statistically significant difference in the survivals between the responders and non-responders (p=0.008). Gastrointestinal bleeding or ulceration was observed in 8 patients, including 3 with NCI common toxicity criteria grade III or higher. CONCLUSION: Radiotherapy was an effective palliative modality for extrahepatic metastasis in HCCs. A radiation dose of 45 Gy or higher (or a TDF value 〉90), was required for a major response. (Cancer Res Treat. 2004;36:79-84)
Sung-Ho Ahn,Ji-Sung Lee,Mi-Sook Yun,Jung-Hee Han,Soo-Young Kim,Young-Hak Kim,Sang-Hyun Lee,Min-Gyu Park,Kyung-Pil Park,Dong-Wha Kang,Jong S. Kim,Sun U. Kwon 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.1
Background and Purpose We investigated the impact of comorbidity burden on troponin elevation, with separate consideration of neurological conditions, in patients with acute ischemic stroke (AIS). Methods This prospective, observational cohort study consecutively enrolled patients with AIS for 2 years. Serum cardiac troponin I was repeatedly measured, and disease-related biomarkers were collected for diagnosis of preassigned comorbidities, including atrial fibrillation (AF), ischemic heart disease (IHD), myocardial hypertrophy (MH), heart failure (HF), renal insufficiency (RI), and active cancer. The severity of neurological deficits and insular cortical ischemic lesions were assessed as neurological conditions. Adjusted associations between these factors and troponin elevation were determined using a multivariate ordinal logistic regression model and area under the receiver operating characteristic curve (AUC). Cox proportional hazards model was used to determine the prognostic significance of comorbidity beyond neurological conditions. Results Among 1,092 patients (66.5±12.4 years, 63.3% male), 145 (13.3%) and 335 (30.7%) had elevated (≥0.040 ng/mL) and minimally-elevated (0.040–0.010 ng/mL) troponin, respectively. In the adjusted analysis, AF, MH, HF, RI, active cancer, and neurological deficits were associated with troponin elevation. The multivariate model with six comorbidities and two neurological conditions exhibited an AUC of 0.729 (95% confidence interval [CI], 0.698–0.759). In Cox regression, AF, IHD, and HF were associated with adverse cardio-cerebrovascular events, whereas HF and active cancer were associated with mortality. Conclusion Troponin elevation in patients with AIS can be explained by the burden of comorbidities in combination with neurological status, which explains the prognostic significance of troponin assay.