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Sang Ik Han,Suk Bok Bae,Tae Joung Ha,Myong Hee Lee,Ki Chang Jang,Woo Duck Seo,Geum Yong Park,Hang Won Kang 한국육종학회 2011 한국육종학회지 Vol.43 No.2
The groundnut or cultivated peanut (Arachis hypogaea L.) in Korea consists of 36 domestic varieties which have been developed and registered as cultivars for the public during last 25 years. To screen and identify of Korean peanut varieties and genetic resources, we present a simple and reliable method. A methodology based on simple sequence repeat (SSR) markers developed and widely used for prominent gene identification and variety discrimination. For identification of those 36 Korean peanut varieties, 238 unique peanut SSR markers were selected from some previously reported results, synthesized and used for polymerase chain reaction (PCR). Data were taken through acryl amide gel electrophoresis and changed into proper formats for application of data mining analysis using Biomine (all-in-one functional genomics data mining program). Consequently, twelve SSR primers were investigated and revealed the differences between those 36 varieties. These primer pairs amplified 27 alleles with an average of 2.3 allele per primer pair. In addition, those results showed genetic relationship by classification method within 36 varieties. The approach described here could be applied to monitoring of our varieties and adapting to peanut breeding program.
( Sang-geul Lee ),( Dong Hyun Sinn ),( Gye-seong Choi ),( Jong Man Kim ),( Tae Wook Kang ),( Min Woo Lee ),( Dongho Hyun ),( Wonseok Kang ),( Geum-youn Gwak ),( Yong-han Paik ),( Moon Seok Choi ),( Jo 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: For single small hepatocellular carcinoma (HCC), different therapeutic modalities can be tried for patients with preserved liver function. We aim to identify prognostic factors associated with overall survival, that can be used to guide treatment selection. Methods: Between 2010 and 2013, we analyzed 896 patients who received resection, radiofrequency (RF) ablation or transarterial chemoembolization (TACE) as a first-line therapy for single, small (<3cm) HCC. We first identified risk factors associated overall survival in patients who were treated with RF ablation, and then compared long-term outcome according treatment modalities, stratified based on risk factors. Results: Among 425 patients treated with RF ablation, tumor size and PIVKA-II levels were independent factors associated with overall survival. When patients were stratified according to the tumor size and PIVKA-II levels, overall survival of patients treated with RF ablation was significantly different by subgroups (group 1: tumor sized = 2 cm with low PIVKA-II levels (< 30 mAU/ml); group 2: tumor sized 2-3 cm with low PIVKA-II levels (< 30 mAU/ml) or tumor sized = 2 cm with elevated PIVKA-II levels (= 30 mAU/ml); group 3: tumor sized 2-3cm with elevated PIVKA-II levels (= 30 mAU/ml)). When compared to resection, overall survival of those treated with RF ablation was not different to those who received resection in group 1 or group 2, but was significantly lower in group 3. When compared to TACE, those treated with RF ablation showed better survival in group 1 or group 2, but was not different in group 3. Conclusions: Tumor size and PIVKA-II levels were associated with overall survival of patients treated with RF ablation. When patients were stratified according to tumor size and PIVKA-II levels, different long-term outcome by treatment modalities was observed. Our data suggests that these two factors can be a valuable factors in choosing first-line treatment option for single small HCC.
Chemosensitivity testing based on gene expression profiling in patients with ovarian cancer
( Geum Seon Sohn ),( Hyeong Ju Kim ),( Ji Yun Lee ),( Jinkyoung Kong ),( Ji Hee Choi ),( Hanbyoul Cho ),( Eun Ji Nam ),( Sang Wun Kim ),( Sunghoon Kim ),( Jae Hoon Kim ),( Young Tae Kim ),( Doo Byung 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: To evaluate the association between clinical response of treatment agents and results of chemosensitivity testing in ovarian cancer. 방법: Tissue was obtained from 21 ovarian cancer patients and gene expression was evaluated by quantitative real-time polymerase chain reaction (PCR). Selected gene panel with expression of specific genes in the pathways that are related to drug responses in ovarian cancer were analyzed( AKT, Aurora A, BCRP, CD31, ERCC1, GSTpi, HER2, MDR1, Mitosin, PI3 Kinase, RRM1, Survivin, TOP1, TOP2A, TS, VEGF, VEGFR2, XIAP, P73). Gene expression were matched with therapeutic agent including Platinum, Taxanes, Bevacizumab, Gemcitabine, Topoisomerase I Inhibitors, Topoisomerase II Inhibitors, Cyclophosphamide, Herceptin, and 5-fluorouracil for chemosensitivity. 결과: Chemosensitivity testing revealed sensitivity rate of 66%, 81%, 96%, 56% and 61% for Platinum, Taxanes, Topoisomerase I Inhibitors, Topoisomerase II Inhibitors, and Bevacizumab, respectively. Treatment response rate was 70% (Complete Response: 40%, Partial Response: 30%). Treatment response was not significantly increased in the platinum sensitive patients (p=0.613), and overall response rate did not significantly differ according to the chemosensitivity test. 결론: This study may provide useful information in optimizing individual chemotherapy in the treatment of ovarian cancer.
( Geum Soog Kim ),( Seung Eun Lee ),( Tae Sook Jeong ),( Chun Geun Park ),( Jung Sook Sung ),( Jung Bong Kim ),( Yoon Pyo Hong ),( Young Chul Kim ),( Kyung Sik Song ) 한국응용생명화학회(구 한국농화학회) 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4
β-Sitosterol (1), betulinic acid (2), and 3β-hydroxy-20(29)-lupen-28-oic acid methyl ester (3) were isolated from the herbal parts of Lythrum salicaria. Compounds 2 and 3 were isolated for the first time from L. salicaria and they showed inhibitory activities on both hACAT1 and hACAT2. These results suggested that L. salicaria, which contains triterpenes 2 and 3, might be effective in the prevention and treatment of hypercholesterolemia or atherosclerosis due to its inhibitory effect on hACAT.
Lee, Geum-Hwa,Ahn, Taeho,Kim, Do-Sung,Park, Seoung Ju,Lee, Yong Chul,Yoo, Wan Hee,Jung, Sung Jun,Yang, Jae-Seong,Kim, Sanguk,Muhlrad, Andras,Seo, Young-Rok,Chae, Soo-Wan,Kim, Hyung-Ryong,Chae, Han-Jun American Society for Microbiology 2010 Molecular and cellular biology Vol.30 No.7
<B>ABSTRACT</B><P>Bax inhibitor 1 (BI-1), a transmembrane protein with Ca<SUP>2+</SUP> channel-like activity, has antiapoptotic and anticancer activities. Cells overexpressing BI-1 demonstrated increased cell adhesion. Using a proteomics tool, we found that BI-1 interacted with γ-actin via leucines 221 and 225 and could control actin polymerization and cell adhesion. Among BI-1<SUP>−/−</SUP> cells and cells transfected with BI-1 small interfering RNA (siRNA), levels of actin polymerization and cell adhesion were lower than those among BI-1<SUP>+/+</SUP> cells and cells transfected with nonspecific siRNA. BI-1 acts as a leaky Ca<SUP>2+</SUP> channel, but mutations of the actin binding sites (L221A, L225A, and L221A/L225A) did not change intra-endoplasmic reticulum Ca<SUP>2+</SUP>, although deleting the C-terminal motif (EKDKKKEKK) did. However, store-operated Ca<SUP>2+</SUP> entry (SOCE) is activated in cells expressing BI-1 but not in cells expressing actin binding site mutants, even those with the intact C-terminal motif. Consistently, actin polymerization and cell adhesion were inhibited among all the mutant cells. Compared to BI-1<SUP>+/+</SUP> cells, BI-1<SUP>−/−</SUP> cells inhibited SOCE, actin polymerization, and cell adhesion. Endogenous BI-1 knockdown cells showed a similar pattern. The C-terminal peptide of BI-1 (LMMLILAMNRKDKKKEKK) polymerized actin even after the deletion of four or six charged C-terminal residues. This indicates that the actin binding site containing L221 to D231 of BI-1 is responsible for actin interaction and that the C-terminal motif has only a supporting role. The intact C-terminal peptide also bundled actin and increased cell adhesion. The results of experiments with whole recombinant BI-1 reconstituted in membranes also coincide well with the results obtained with peptides. In summary, BI-1 increased actin polymerization and cell adhesion through Ca<SUP>2+</SUP> regulation and actin interaction.</P>