Sarcomatoid Carcinoma Arising from Mature Cystic Teratoma

Ho-Chang Lee1, Seung-Myoung Son, Yong-Moon Lee, Ji Hae Koo, Song-Yi Choi, Ok-Jun Lee, Eun-Hwan Jeong 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

Malignant transformation of mature cystic teratoma (MCT) is rare. Sarcomatoid carcinoma is a neoplasm comprising malignant mesenchymal cells and a conventional carcinomatous area. Here, we report on a case of sarcomatoid carcinoma arising from an MCT in the left ovary of a 45-year-old female. A unilocular cyst consistent with MCT was observed; however, a nodule within the cyst was confirmed from the resected ovary. Microscopically, the nodule showed both squamous cell carcinoma and pleomorphic sarcomatous components admixing with each other. Lining epithelial cells at the periphery of the main tumor showed squamous metaplasia. When a sarcomatous component is observed in the ovary tumor, it is important to find a squamous cell component, either benign or malignant.

Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

한국 성인의 경추부 추간판 높이와 깊이에 대한 연구

이상호,장의성,정승은,신송우,강호영 대한척추신경외과학회 2004 Neurospine Vol.1 No.1

Objective: Currently, normal data of cervical disc height and depth of Korean adults are not available. The objective of this study is to compile a Korean normative database of the disc height and depth of the cervical spine, valid for healthy Korean adults. Methods: All the volunteers were attached a coin on the anterior midline of the neck. From the lateral X-ray films of the cervical spine, anterior and middle disc height and anteroposterior disc depth from C2-3 to C6-7 were measured. The magnification of radiographic films as compared with real measurement of the coin was taken into consideration. Analysis of data was done by use of independent sample t-test, Pearson's correlation, and one-way analysis of variance(ANOVA). Results; A normal database for the dimensions of cervical discs was compiled from 42 lateral views of healthy Korean adults. There were 20 males(mean age, 29,6 years; mean height, 174.3 cm) and 22 females(mean age, 27,4 years; mean height, 161.2 cm). The means of anterior height, middle height and anteroposterlor depth of cervical disc space were 4.09mm, 5,82mm, and 16,86mm for men and 3,40 mm, 5.30 mm, and 14.86 mm for women, respectively, The height of C4-5 disc space was highest at the middle disc space from C2-3 to C6-7. Conclusion: This study will contribute to the clinical diagnosis, treatment and development of instruments of cervical disc diseases for Korean patients with cervical disc diseases.

Glycyrol의 면역세포 활성효과 및 항진균 효과

이주영,박지혜,김송이,이주희,한용문 동덕여자대학교 종합약학연구소 2006 동덕약학연구지 Vol.10 No.-

In this study, we determined proliferate effect on T-lymphocytes and antifungal activity of glycyrol that was isolated from Glycyrrhizae Radix (Leguminosae). In addition, immunoadjuvant activity of glycyrol was determined. Results showed that Gylcyrol (GCR) suppressed the proliferation of murine splenocytes that were treated with Concanavalin A (Con A). In case of the immunoadjuvant effect, glycyrol had no enhancement on antibody production. Data from experiments of antifungal activity in vitro, the component resulted in inhibition of Candida albicans growth. The antifungal effect appeared to be more potent than fluconazole. These data indicate that Glycyrol has no specific immunological effect on T- and B-cells, but the component contains antifungal activity.

마르그리트 뒤라스와 최윤의 작품들에 나타난 '공간' 비교연구

이송이 한국 프랑스어문교육학회 2003 프랑스어문교육 Vol.15 No.-

Les textes de M. Duras, de Ch'oe Yun permettent au lecteur de de´couvrir que des voix se correspondent, d'une ge´ne´ration a` l'autre, d'un continent a` l'autre. La re´ite´ration de certains the`mes et le retour obsessionnel de quelques images manifestent des tendances analogues dans ces deux univers romanesques. La migration entre deux environnements culturels tout a` fait diffe´rents, dans le ve´cu de M. Duras, correspond, d'une certaine fac¸on, a` l'influence de la litte´rature franc´aise dans celui de Ch'oe Yun. La comception spe´culaire pre´vaut dans le traitement de l'espace dans les textes de Marguerite Duras et de Ch'oe Yun. Les lieux ouvrent sur un re´seau de correspondances complexes et re´versibles avec les personnages. Ils fonctionnent comme des e´le´ments d'identification de ces figures flottantes qui fro^lent l'anonymat ou ils disparaissent sous une configuration humaine. De me^me que Lahore n'est autre que le vice-consul, la jeune fille de La`-bas, sans bruit, tombe un pe´tale se re´duit au double de Kwangju. Ce processus de de´placement et de substitution e´tablit un syste`me d'analogies et d'interfe´rences entre les corps et les lieux. Il se produit un e´change permanent qui permet d'impre´gner l'espace de signification corporelle et d'attribuer au corps une valeur spatiale. Le texte de M. Duras aime repre´senter le corps fe´minin comme espace et sa relation fusionnelle avec les lieux. Ainsi, les re´gions ou` erre la mendiante du Vice-consul s'assimilent a` son corps. Ch'oe Yun, quant a` elle, voit souvent le corps comme une matie`re poreuse dans laquelle s'enfouissent les e´ve´nements qui y laissent leur empreinte. Le corps de la jeune fille folle dans La`-bas, sans bruit, tombe un pe´tale, se pre´sente ainsi comme le lieu de re´sonance ou` chaque incident se re´percute en e´chos. Les images inde´cises ou mobiles marquent souvent les lieux. Ainsi, les frontie`res spatiales du dedans et du dehors, de l'inte´rieur et de l'exte´rieur s'abolissent chez M. Duras et Ch'oe Yun. Les indications ge´ographiques qui n'ont gue`re de valeur indicielle conjurent le mime´tique dans certains textes de M. Duras et de Ch'oe Yun. Ce mode de pre´sentation de l'espace favorise l'unification des lieux, aussi nombreux que disparates, et souligne la similitude d'espaces que diffe´rencient leur nom, leur forme, et leur situation. Cette configuration d'espace inscrit l'espace dans une organisation spe´culaire et maintient une inde´termination autour des lieux et des objets parcourus, appre´hende´s par les personnages. Dans cette perspective, Hiroshima, lieu de concentration de la douleur, se re´duit au reflet de Nevers et le village natal de Mains Vertes correspond au Po^le Nord.. La configuration des lieux corporels, l'identite´ spatiale des personnages et le brouillement des limites de l'espace chez nos e´crivains te´moignent, d'une certaine fac¸on, du grand re^ve archai¨que de retour au corps maternel. Ainsi, refus des formes e´tablies, ambigui¨te´ fondamentale, les textes de M. Duras et de Ch'oe Yun font retentir une voix d'une inconcevable contre´e, inte´rieure a´ soi mais inconnue. Ce lieu de l'Autre est l'espace d'une parole fe´minine ou´ coexistent l'he´te´roge´ne´ite´ pulsionnelle et la musique maternelle que le langage n'a pas su retenir.

[리뷰] 위반의 서부극, 어긋난 멜로드라마 : 이안 감독, 『브로크백 마운틴』

이송이 부산대학교 인문학연구소 2006 코기토 Vol.60 No.-

프린지 페스티벌의 효율적 운영방안에 관한 연구

김규현,이송이 경희대학교 디자인연구원 2005 예술· 디자인학연구 Vol.7 No.2

After the invention of a direct circuit in 1958 and since then we've came to live in the 21st Century's Information Industry Age called as the second Industrial Revolution. This direct circuit overlaps with so tiny circuit patterns within small silicon pieces that are undistinguishable seeing through human eyes as a result of bonding together with culture in discovering and inventing important all science (physics, chemistry, mathematics, optical science, electronic Engineering). This phenomenon has been set as human beings start to begin drawing such diagrams unintended' and those beautiful and intense images have been achieved as a result of technological development of Microchip diagrams' possessing exactness. Point and line's peculiar spacing characteristics, repetition, exactness and color are like a few best arts of our time that are enough to give more than artistic impression as the same power of splendid patterns that inspire and induce zest to us. This study discusses with the aesthetic beauties found in the electronic products' unseen precise functions aiming at logically and intuitionally planned in small high-tech chips' diagrams.

성역할, 의복동조성이 유행추구성향과 혁신추구성향에 미치는 영향

김연희;서민정;윤송이;이규혜 한양대학교 2006 韓國 生活 科學 硏究 Vol.26 No.1

Conformity and nonconformity in dress are the two driving forces that make diffusion of new styles. More fundamental personal attributes that affect individuality in dress are masculine or feminine sex roles. Researchers reported that little differences were found between men and women in terms of conformity values. Fashion and clothing products are related to hedonic shopping and major hedonic shopping orientations in clothing shopping behavior of college students were often reported. This study was aimed to empirically test the effect of personality traits of masculinity-femininity on nonconformity and conformity in dress; the effects of nonconformity and conformity on major hedonic shopping orientations. A survey questionnaire was developed for the empirical research. Data from 181 students were used for statistical analysis using structural equation modeling. A conceptual model with masculinity and femininity as two exogenous variables, two shopping orientations as endogenous variables and nonconformity-conformity as two mediating variables were analyzed. Results confirm the significant structural paths from masculinity to nonconformity, from femininity to conformity and from nonconformity to novelty-seeking and conformity to fashion seeking) were statistically significant. The results of this study suggested that The personality traits and shopping orientation were antecedents and consequences of nonconformity-conformity in dress and clearer relationships do exist in the flow.

대학생들의 자기이미지가 의복 혁신성과 동조성에 미치는 영향

서민정;김연희;윤송이;서문숙;이규혜 한양대학교 2008 韓國 生活 科學 硏究 Vol.28 No.1

The purpose of this study was to examine self images as antecedents of clothing innovativeness and conformity. A survey questionnaire was made for the empirical research. 206 university students living in Seoul metropolitan area participated in the study. The data were analyzed using factor analysis, Chi-square, t-test, ANOVA, and stepwise regression. The self image measures were classified six factors (free, affirmative, self-centered, traditional, sensual, and feminine image). According to regression analysis, fashion innovativeness was affected by free, traditional, sensual image, and conformity was only influenced by traditional image. Respondents were classified into four groups by innovativeness and conformity scores; Low innovativeness/Low conformity group(LI/LC), Low innovativeness/High conformity group(LI/HC), High innovativeness/Low conformity group(HI/LC), and High innovativeness/High conformity group(HI/HC). For LI/LC consumers, innovativeness was affacted by the sensual self image. For LI/HC consumers, and innovativenss was affected by the feminine self image. The conformity of HI/LC were influenced by traditional self image.

DR4-Ser424 <i>O</i>-GlcNAcylation Promotes Sensitization of TRAIL-Tolerant Persisters and TRAIL-Resistant Cancer Cells to Death

Lee, Hyeonjeong,Oh, Yumin,Jeon, Young-Jun,Lee, Song-Yi,Kim, Hyunjoo,Lee, Ho-June,Jung, Yong-Keun American Association for Cancer Research 2019 Cancer Research Vol.79 No.11

<P>This study reports that a novel posttranslational modification by O-GlcNAcylation of TRAIL-R1 (DR4) plays a crucial role in enabling both apoptotic and necroptotic cell death induction by TRAIL.</P><P><B></B></P><P>TNF-related apoptosis-inducing ligand (TRAIL) resistance, including nongenetically acquired tolerance in cancer persister cells, is a major obstacle to translating TRAIL therapy into patients with cancer. However, the underlying mechanisms remain to be elucidated. Here, we show that DR4/TRAIL-R1 is <I>O</I>-GlcNAcylated at Ser424 in its death domain to mediate both apoptosis and necrosis upon TRAIL ligation. We found that DR4–Ser424 mutations, identified from our cell-based functional screen using a cancer patient–derived cDNA expression library and from The Cancer Genome Atlas, caused TRAIL resistance in various human cancer cell lines. Using <I>O</I>-GlcNAc transferase knockdown cells, DR4-preferred versus DR5-preferred cancer cells, and a DR5-neutralizing antibody, we evaluated the essential role of DR4-specific <I>O</I>-GlcNAc modification in TRAIL cytotoxicity. In contrast to DR4, DR5 was not <I>O</I>-GlcNAcylated by TRAIL treatment, discriminating DR4 from DR5-mediated signaling. Apart from genetic changes in DR4-Ser424, we further classified various cancer cell lines originated from stomach, colon, lung, and glioblastoma according to their sensitivity to and receptor preference upon TRAIL death signaling and generated TRAIL-tolerant persister-derived DLD-1<SUP>PER</SUP> cells. Among these, we discovered that DR4 was not modified by <I>O</I>-GlcNAc in most of the TRAIL-resistant cancer cells and DLD-1<SUP>PER</SUP> cells. Interestingly, promoting DR4 <I>O</I>-GlcNAcylation intentionally using 2-deoxy-<SMALL>D</SMALL>-glucose or a high concentration of glucose sensitized those resistant cancer cells to TRAIL. The <I>O</I>-GlcNAcylation–defective DR4 failed to form DISC/necrosome and could not translocate to aggregated platforms for receptor clustering. Our findings demonstrate that DR4 <I>O</I>-GlcNAcylation is crucial for TRAIL death signaling, providing new opportunities for TRAIL therapy overcoming TRAIL resistance in cancers.</P><P><B>Significance:</B></P><P>This study reports that a novel posttranslational modification by <I>O</I>-GlcNAcylation of one of the two human TRAIL receptors with a death domain, TRAIL-R1 (DR4), plays a crucial role in enabling both apoptotic and necroptotic cell death induction by TRAIL.</P>