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중추신경계에서의 효모 가수분해물이 음식섭취조절기전에 미치는 영향
이승언,정경희,김미자,배윤정,장은재 동덕여자대학교 2004 생활과학연구 Vol.9 No.-
Saccharomyces cerevisiea, which has been known as antistress compounds, was hydrolyzed by proteinase producing SCP-20. The addition effects of SCP-20 on the food intake regulation mechanism were studied measuring the expression amount of neurotransmitters, such as NPY and NOS, which can increase food intake in hypothalamus, and CCK, which can decrease food intake by using immunohistochemistry method. The 0, 2, and 5 g/kg SCP-20 was orally administrated to the experimental animals for one week. The expression of NPY and NOS was increased in the group of 5 g/kg administrated animals while that of CCK was increased in the group of 2 g/kg administrated animals. The results of this study suggested that SCP-20 may influence the control mechanism of oral dose-dependently. Further studies are needed to elucidate the roles of SCP-20 on the changes of food intake regulation controlling neurotransmitters.
이연숙,오승혜,이의준 연세대학교 대학원 1986 延世論叢 Vol.22 No.1
The purpose of this study was to identify developmental phase of the color concept of Korean children according to age, sex. The present experiment was conducted during June, 1985. Subjects were 616children ranged form 3-year old to 15-year old, who were attending to Child Development Research Institute of Y University, E indergarten,E Demonstration Elementary School College of E Womans University, A Middle School. The materials used in the experiment were 24 colored papers selected through a pilot study. The experiment was designed to identify the children's color concepts by presenting the 24 colored papers.
Cycloheximide가 옥수수(Zea mays L.) 잎의 노화과정에 미치는 영향
權炳奎,李承姸 경북대학교 과학교육연구소 1989 科學敎育硏究誌 Vol.13 No.-
The present study was investigated to clarify the changes of chlorophyll (a,b) and soluble protein content, absorption spectrum, PSⅡ activity and CP-complex in senescence of corn (Zea mays L.) leaves induced by cycloheximide at different concentrations and times. The leaf disks were placed in darkness at 25℃ ± 2℃. After leaf disks were treated with cycloheximide at various concentrations, the chlorophyll content was measured on the 4th. day. Cycloheximide clearly showed strong preservation of chlorophyll at the concentration of 0.01-1mM. Cycloheximide at 0.001mM did not prevent the chlorophyll degradation. Cycloheximide(0.1mM) prevented the loss of chlorophyll. About 70% of initial content of Chl. a and 71% initial content of Chl. b remained on the 6th. day. The absorption spectra of DMSO extracts from corn leaf disks that had been incubated for 4 days in distilled water or 0.1mM cycloheximide were measured. When leaf disks were incubated with cycloheximide, both the peaks for the red band of chlorophyll and the carotenoid band remained fairly extent. Cycloheximide(0.1mM) prevented the loss of soluble protein, and about 70% of initial content of soluble protein remained on the 6th. day. Cycloheximide(0.1mM) treatment inhibited the rate of DCIP photoreduction by 60%. When CP-complexes and thylakoid polypeptide were separated by SDS-PAGE, CP Ⅰ, CPⅡa, LHCP bands were disappeared, FP band was quantitatively increased, and thylakoid polypeptide bands were partly disappeared, with cycloheximide(0.1mM) treatment. Therefore, cycloheximide prevented the loss of chlorophyll and soluble protein, destroyed thylakoid membrane of chloloplast, and inhibited PSⅡ activity.
김미라,백병주,김재곤,이승익,양연미 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.4
저자는 1998년 6월과 7월에 전북대학교병원 소아치과에 내원한 초진환자중 설문지에 응답할 수 있는 환자 50여명과 보호자 100명을 대상으로 불소에 대해 어느정도 인식하고 있는지 알아보고자 설문지를 이용하여 조사하여 다음과 같은 결론을 얻었다. 1. 불소의 치과에서의 사용여부에 대한 인식정도는 환자 26%, 보호자 51%, 전체적으로 42.7%를 보였다. 2. 불소의 우식예방효과에 대한 인식정도는 환자 86%, 보호자 85%, 전체적으로 85.7%의 높은 비율을 보였다. 3. 이에 반해 불소도포희망 여부에 대하여 환자 46%, 보호자 44%만이 긍정적으로 답하였다. 4. 불소를 이용하거나 도포한 경험은 환자 60%, 보호자 55%로 낮은 비율을 보였다. 5. 불소의 우식예방효과에 대한 인식여부와 실제이용 정도는 일치하지 않았다. 이에 치과 종사자 및 대중매체를 통해 보다 적극적인 불소사용의 교육이 이루어진다면 불소이용은 증가할 것이다. At the department of Pediatric Dentistry in Chonbuk National University Hospital, authors conducted a survey of 50 new patients and 100 new parents regarding fluoride in order to discover what they think about fluoride. The results obtained were as follows ; 1. It answered patients 26%, parents 51% and total 42.7% in knowledge about the use of fluoride in dental clinics. 2. The knowledge about caries prevention effect of fluoride is high ; patients 86%, parents 85% and total 85.3% 3. The patients and parents who wanted to use fluoride are 46%, 44% respectively 4. The patients and parents who experienced fluoride are 60%, 55% respectively 5. It is not correspond the knowledge about caries prevention effect of fluoride and the practical method of application These results suggest that the number of patients and parents who use fluoride will increase if we advise them adequately
Flavobacterium meningosepticum에 의한 균혈증 1예
장성원,유진홍,진승원,김선우,김연식,박순민,이대훈,최민호,최주연,신완식,강문원,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1
1996년 6월 카톨릭대학교 부천성가병원에 뇌경색으로 입원했던 61세 남자 환자의 혈액에서 Flavobacterium meningosepticum을 분리하였다. 환자는 폐렴을 동반한 패혈증의 예로 ceftriaxone과 metronidazole을 투여하였으나 입원 48시간만에 사망하였다. Flabovacterium meningosepticum is a rae cause of nosocomial infection which shows multi-drug resistance. It mainly invades patients with impaired immunity. Recently, we experienced a case of F. meningosepticum bacteremia in a patient with chronic debilitated state owing to stroke. The clinical progress was so rapid that he died within 48 hours. Blood culture revealed F. meningosepticum which showed characteristic yellow colony in blood agar plate.
Antiestrogenic Effects of Marijuana Smoke Condensate and Cannabinoid Compounds
Lee Soo Yeun,Oh Seung Min,Lee Sang Ki,Chung Kyu Hyuck The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.12
The antiestrogenic effects of marijuana smoke condensate (MSC) and three major cannabinoids, i.e., $\bigtriangleup^{9}$-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN), were evaluated using in vitro bioassays, viz., the human breast cancer cell proliferation assay, the recombinant human estrogen receptor (ER) competitive binding assay, and the reporter gene assay. The inhibitory effects on estrogen were also examined using the ethoxyresorufin-Odeethylase (EROD) assay, the aromatase assay, and the 17$\beta$-estradiol ($E_{2}$) metabolism assay. The results showed that MSC induced the antiestrogenic effect via the ER-mediated pathway, while THC, CBD, and CBN did not have any antiestrogenic activity. This suggests that the combined effects of the marijuana smoke components are responsible for the antiestrogenicity of marijuana use. In addition, MSC induced the CYP1A activity and the $E_{2}$ metabolism, but inhibited the aromatase activity, suggesting that the antiestrogenic activity of MSC is also related to the indirect ER-dependent pathway, as a result of the depletion of the in situ $E_{2}$ level available to bind to the ER. In conclusion, pyrogenic products including polycyclic aromatic hydrocarbons (PAHs) in the non-polar fraction, which is the most biologically active fraction among the seven fractions of MSC, might be responsible for the antiestrogenic effect.
Lee, Seung-Sik,Lee, Kyun-Oh,Jung, Bae-Gyo,Chi, Yong-Hun,Yoo, Ji-Young,Lee, Ji-Yeun,Lee, Jung-Ro,Park, Soo-Kwon,Kang, Soon-Suk,Jang, Ho-Hee,Lee, Sang-Yeol Korean Society for Biochemistry and Molecular Biol 2001 Journal of biochemistry and molecular biology Vol.34 No.4
Even though three isotypes of thioredoxins (-f, -m and -h types) have been identified in a variety of plant cells, there are only a few reports on thioredoxin-h that were recently identified. In this study, a cDNA encoding a h-type of thioredoxin was isolated from a cDNA library of Chinese cabbage, and named here CTrx-h. An open reading frame of the gene contained a polypeptide of 133 amino acids with a conserved active center, WCGPC, which appeared in all of the thioredoxin proteins. A deduced amino acid sequence of the CTrx-h showed the highest sequence identity with those of Arabidopsis thioredoxin-h2 (75.2%) and thioredoxin-h5 (46.6%) proteins, but it shared a low sequence homology to other isotypes of plant thioredoxinm and thioredoxin-f. The CTrx-h protein that is expressed in E. coli represented not only an insulin reduction activity, but also electron transferring activity from NADPH to thioredoxin-dependent peroxidase. A genomic Southern blot analysis using the cDNA insert of CTrx-h revealed that the gene consisted of a small multigene family in Chinese cabbage genome. On the contrary to other thioredoxin-h proteins that were widely distributed in most tissues of the plant, the CTrx-h was predominantly expressed in flowers. The expression was very low in other tissues. The data of the Northern blot analysis suggests that the CTrx-h may have other functions in flower development or differentiation, in addition to its defensive role.