서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

韓國 現代 公演場建築의 使用者評價에 관한 硏究

이태은,유길준 동아대학교 건설기술연구소 2000 硏究報告 Vol.24 No.2

The main purpose of this study is to give the basic information for the planning of the theater through the taxonomy of the needs of performing artists in various genre. The results of this study are as follows: 1) the evaluation points of performing artists are below than average. It means that there are many things to improve in such parts of the performing environment as acoustics, lightings, stage hygiene, narrow distance between front and rear seat, a dead angle zone in auditorium, excessively wide stage and auditorium, lack of convenience facility and lack of green room etc. in today's Korean theaters. 2) Korean theater have the tendency that intensifies variety and contiguity in the composition of the main space. It is needed to have the stage and auditorium types which improve the variety, flexibility and contiguity. 3) The purpose and characteristics of use must be considered in the planning and investment of theater buildings. It must be possible to promote the adaptability for various genre of performing arts in multipurpose theater which are majority of today's domestic theater buildings. And the development and adoption of the floor plan types for specialized theaters are also needed. It gives better sympathy between performing artist and audience, and helpful for the accommodation of various performing arts. 4) The planning directions for the theater must have the various ways of approach which are specialized and multi-used according to the size of city, population and location etc. 5) The theater for the future needs to have the flexible main space which never restraint writer's and producer's imagination, and it also demands the equipmentizing of theater building to accommodate various performing arts and to make the interchange between various genre possible in transitional period.

높은 지향성을 갖는 Air Line 결합기 설계

길준범,이성원,최영호,박종임,안달,박준석 호서대학교 반도체제조장비국산화연구센터 2000 학술대회 자료집 Vol.2000 No.1

본 논문에서는, 일반적인 스트립 구조의 결합기가 갖는 문제 즉, 높은 온도에서 나쁜 특성을 보이는 문제점을 극복하고자 Air Line Type의 결합기를 구현하였다. 또한 이 결합기는 24dB이상의 지향성을 가지고 있다. 해석을 위해 짝수 모드와 홀수 모드 해석법을 사용하였고, EM-Simulation으로 확인한 특성과 실제 제작된 20dB, 30dB Cellular 대역(800∼900MHz) Air Line 결합기의 결고 특성은 좋은 일치를 보여주고 있다. 또한 최대 장점인 온도 특성은 온도 데이터를 통하여 온도에 강한 특성을 보임을 알 수 있다.

이황화탄소 중독자들의 노출중단 이후의 심박동수 변이

이상윤,조성일,백도명,변창범,김미정,박경근,임상혁,양길승,황창국,전형준 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 2000년도에 이황화탄소 중독증 환자들과 대조군의 심박동수 변이를 비교하여 이황화탄소 중독증 환자들의 심박동수 변이가 대조군에 비해 유의하게 낮다는 연구보고가 있었다. 당시의 연구가 이황화탄소 노출이 중단된 상태에서 이황화탄소 중독자들의 건강 문제를 연구했다는 점에 의의가 있으나 연구 결과를 해석하는데 있어 제한점들이 있었다. 이 연구는 2000년도에 수행하였던 연구의 제한점을 극복하고 이황화탄소 노출이 중단된 이후의 이황화탄소 중독자들의 심혈관계 상태를 심박동수 변이를 이용하여 평가해보고자 하였다. 방법: 이황화탄소 중독증으로 진단받은 환자 122명과 환자군의 연령대와 성별 빈도에 따라 무작위 추출한 112명을 대조군으로 선정하였다. 자기 기입식 설문지와 건강검진을 통해 연령, 성별, 신장, 체중, 흡연, 음주, 규칙적 운동, 질병력, 직업력, 흉부 방사선 촬영, 심전도 측정을 실시하였다. 연구 대상자들은 의자에 앉힌 상태에서 5분 동안 심박동수 변이를 측정하였다. 이 연구에서 측정한 심박동수 변이 지표들은 정상 RR간격의 표준편차(standard deviation of all norma-to-normal intervals, SDNN), 인접한 RR간격들의 차이를 제곱의 합의 평균의 제곱근(square root of the mean of the sum of squares of differences between adjacent normal-to-normal intervals, RMSSD). 저주파영역(low frequency power, LF: 0.04~0.15Hz), 고주파 영역 (high frequency power, HF:0.15~0.4Hz), 전체 주파수 강도(total power, TP), 저주파/고주파 비 (LF/HF ratio)이다. 결과: 단변량 분석에서 이황화탄소 중독자들의 모든 심박동수 변이 지표들이 대조군에 비하여 낮았다. 다중선형회귀분석에서 이황화탄소 중독은 RMSSD를 유의하게 감소시키는 것으로 나타났다.(P<0.05). 결론: 이 연구는 이황화탄소 노출이 중단된 상태에서도 이황화탄소 중독자들에게 심혈관계와 관련된 건강문제가 있을 수 있음을 시사한다. Objectives: A previous study conducted in 2000 measuring the heart rate variability (HRV) of carbon disulfide (CS_(2))-poisoned subjected suggested that their HRV was reduced after exposure cessation. However, the study was limited by the following procedural limitations: (1) only 71 CS_(2)-poisoned subjects participated, (2) no females participated, and (3) the CS_(2)-poisoned subjects were older than the controls. This study was therefore conducted to overcome these limitations of the earlier study. Methods: The study subjects comprised 122 retired workers with CS_(2) poisoning and the same number of age- and sex-matched controls. Information on individual age, sex, height, wight, smoking history, alcohol drinking, regular exercise, medical and occupational history, chest x-ray, and ECG recording of the two groups was collected though a self-administered questionnaire and a medical examination. Standard Deviation of NN intervals (SDNN), Root-Mean-Square of Successive Differences (RMSSD), Total Power (TP), Low Frequency (LF), High Frequency (HF), and LF/HF ratio were measured as HRV indices for 5 minutes in the sitting position. Results: Univariate analysis revealed that all HRV indices of CS_(2)-poisoned subjected were lower than those of the controls. Multiple linear regression analysis showed that CS_(2) poisoning had negative association with all HRV indices and that its association with RMSSD was statistically significant(P<0.05). Conclusions: This study suggests that CS_(2)-poisoned subjects continue to have reduced HRV, even though the exposure has ceased.

韓國 現代公演場建築의 空間 構成 特性에 關한 硏究

이태은,유길준 동아대학교 건설기술연구소 2000 硏究報告 Vol.24 No.1

The purpose of this study is on understanding of typological and physical characteristic of stage and auditorium composition in korean modern theater architecture and giving the basic information for theater building plan through the analysis of detailed floor plans and sections of investigation objects. The results of considerations are as follows : In spite of short history, korean theater architecture has had outstanding progress from the early 1970 through the end of 1990, showing typological special characteristic in floor plan types which concentrates megaphone type in auditorium and proscenium type and one side encounter type in stage structure. Even if korean theater architecture shows some limited tendency of selection which fixes on the type of multipurpose hall but it also shows intensification of performing space, variety of use and stronger contiguity between stage and auditorium which are optimistic progress in theater architecture.

肺吸蟲症 診斷에 있어서 ELISA법의 應用에 관한 硏究

崔銑吉,李駿商,林漢鍾 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.1

Human paragonimiasis is one of the common trematode diseases and of very important public health problem in Korea. Although many techniques have been deviced for immunological diagnosis of paragonimiasis, they exhibit low sensitivity and specificity. In this study the enzyme-iinked immununosorvent assay (ELISA) was employed in the diagnosis of human paragonimiasis using Paragonimus VBS(veronal buffered saline) antigen, peroxidase conjugated anti-human Ig G and ortho-phenylenediamine as a substrate by micromethod according to technique of Voller et al. (1979) and McLaren et aI. (1978) with minor modifications. Sera tested were categorized into 106 paragonimiasis, 20 clonorchiasis, 12 taeniasis, 10 toxoplasmosis, 10 hymenolepiasis and 10 non-infected human cases. The results obtained are as follows: 1. In the preliminary study optimal dilutions of conjugate, stock antigen and serum were 1/5,000, 1/400 and 1/400 respectively. 2. The O.D. (optical density) values of the ELISA in the sera of paragonimiasis cases using stock antigen and VBS antigen were 1.291±0.731 and 1.466±0.813, respectively, and the mean O.D. values in the sera of paragonimiasis cases using VBS antigen were not significantly different from that of stock antigen in sensitivity. (p<0.001) Results showed a standard sensitivity in the application of the ELISA in the diagnosis of human paragonimiasis using VBS antigen. 3. The mean O.D. values of the ELISA in 106 sera of paragonimiasis cases were 1.243±0.863 and those of other parasite infection groups and non-infected human group were 0.487±0.549 in clonorchiasis, 0.513±0.521 in taeniasis, 0.158±0.235 in hymenolepiasis, 0.222±0.235 in non-infected human group and that in paragonimiasis was significantly higher than those of other groups. 4. Distribution of the O.D. values of the ELISA, 86 (81.1%) out of 106 paragonimiasis sera, 3 out of 52 other parasite infection group sera and none out of 10 non-infected human group showed highter than that of the positive serum of 1.000 at 488nm) O.D. value. In conclusion, results of this study suggest that the ELISA is more applicable and reproducible in the diagnosis of human paragonimiasis than other immunological tests used especially in seroepidemiological study.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

신경인성방광에서 요역동학적 고찰

노준,전상준,정치영,이기봉,이길용,소영석,김철성,장대수 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and objectives : A disparity between clinical and urodynamic findings is commonly found and its application to the clinical management of neurogenic bladder is pratically as well embrassing as it reading. We investigated urodynamic study for the diagnosis and management of neurogenic bladder. Materials and methods : From July 1997 to June 2001, total of 83 patients of neurogenic bladder were evaluated by urodynamic study. Results : urodynamically, there were 20 cases(24%) showing detrusor hyperreflexia with detrusor external sphincter dyssynergia(DESD), 12 cases(15%) detrusor areflexia with low compliance. A disparity between the clinical and urodynamic assessment was noted in 26 cases(31%), clinically severe symptom with complication was particularily common in detrusor hyperreflexia with DESD, detrusor areflexia with low compliance and catheter indwelling patients. Conclusion : In neurogenic bladder, clinically symptom with complication was particularly common in detrusor hyperreflexia with DESD, detrusor areflexia with low compliance and catheter indwelling patients.

古代中國人의 醫療體操에 관한 硏究

朴吉俊,李東鍵 東亞大學校 附設 스포츠科學硏究所 1993 스포츠科學硏究論文集 Vol.11 No.-

The purpose of this study is on searching out the medical gymmastics of ancient chienese. The major point considered in the thesis follow ; 1. The process of formation in the medical gymnastics of ancient chinese has been formed by Taoist school as a means of the secret of long life. 2. The aspect of development in the medical gymmastics of ancient chinese gas been developed the art of「To-In」with the history of 5000 year. This is named 「Gi-Gang」in the present-day. 3. The medical gymnastics of taegae Lee in Korean philosophy of human nature and natural laws turn out「Pal-Dan-Kumd」in the medical gymnastics of ancient chinese.

작은 피질하 병변에 대한 정위적 개두술 및 경-구 접근법

손병철,김문찬,이관성,박춘근,홍용길,강준기 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.12