통근통행자의 다목적지 통행수요의 특성 분석

윤대식,이정엽 영남대학교 지역발전연구소 1998 새마을지역개발연구 Vol.22 No.-

The main objective of this research is to analyze urban workers' multi-destination travel choice behavior. For this research, two alternative travel pattern choice models were empirically estimated by using a survey data collected from Kyongsan and Yeungchun City. For this research, two alternative nested logit model structures were employed. These two alternative model strums are based on two different behavioral hypotheses. One is hypothesized that urban workers' daily travel pattern choice behavior is represented by two stages of choices With single-destination or multi-destination travel pattern choice as the higher stage, and the number of tours as the lower stage. The other model is hypothesized that urban workers' daily travel pattern choice behavior is represented by two stages of choices with single-destination or multi-destination travel pattern choice as the higher stage, and the number of stops as the lower stage. From the empirical results, it is found to be more sensible to represent urban workers' daily travel patterns as the nested logit model structure with single-destination or multi-destination travel pattern choice as the higher stage, and the number of tours as the lower stage.

20세기 한국의 농업기상재해 특징

심교문,이정택,이양수,김건엽 한국농림기상학회 2003 한국농림기상학회지 Vol.5 No.4

Recently, both climate change and unusual meteorological disasters are becoming a more frequent and serious threat to agricultural production. Destruction of the stabilizing base of agricultural productivity in Korea is a concern. This study provides basic information for stabilizing agricultural production by clarifying and analyzing the features of agro-meteorological disasters which have occurred recently in Korea. The occurrence of meteorological disasters has increased rapidly since the 1940s. A 19-fold increase in occurrence is noted over the past 60 years from 1941 to 2000. Meteorological disasters occurred mostly in August, then in July, and least often in October. In terms of regional occurrences, the frequency of meteorological disasters was the highest in Gangwon (751 times) and in Jeonnam (703 times) provinces, and the lowest in Jeju (459 times) province for the 97 years from 1904 to 2000. Agro-meteorological disasters which caused the most serious damage to cropland were rain storms and typhoons for the 10 years from 1991 to 2000, and they occurred 52 and 18 times during this period, respectively. Agro-meteorological disasters occurred mainly during the summer season (from June to September) when major crops are cultivated in Korea.

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

Different Persistence of Isaria javanica Isolate in Potted Greenhouse Soil

Jeong Seon Yu,Jin Ju Yun,Byung Ju Lee,Jeong Hwa Huang,Jeong Jun Kim,Ji Hee Han,Sang Yeob Lee 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04

Entomopathogenic fungus is a useful control agent to sucking type insect such as whitefly and aphid. The fungi are influenced by some environmental factors such as relative humidity, temperature and UV and cause slow and fluctuation in pest control efficacy. Especially, UV kills conidia or spores of entomopathogenic fungi and a mycopesticide using fungi has short control period in field. UV intensity changes from season to season. Survival rate of entomopathognic fungi treated may differ from seasons and will show different control efficacy. Therefore, we conducted a study to estimate the persistence of an Isaria javanica isolate, which was already reported as sweet potato whitefly control agent, in potted greenhouse soil planted different crops. The number of survival spore decreased gradually and differ from seasons.

Variations of Seed Dormancy and Dry-heat Tolerance in Barley Varieties with Different Grain Types

Seung-Yeob Lee,Jeong-Ho Ahn,Joong-Ho Lee,Seong-Sig Choe,Dong-Jin Lee 한국국제농업개발학회 2007 韓國國際農業開發學會誌 Vol.19 No.2

마이크로 부품 조립부 6축 얼라인어의 초정밀 제어

이정재(Jeong-Jae Lee),유용환(Yong-Hwan Yoo),이창우(Chang-Woo Lee),송준엽(Jun Yeob Song),정재화(Jae-Hwa Jeong),이수훈(Soo-Hun Lee),이문구(Moon G. Lee) 한국생산제조학회 2010 한국공작기계학회 춘계학술대회논문집 Vol.2010 No.-

마이크로 부품 조립부 6축 얼라인어의 초정밀 제어

이정재(Jeong-Jae Lee),유용환(Yong-Hwan Yoo),이창우(Chang-Woo Lee),송준엽(Jun Yeob Song),정재화(Jae-Hwa Jeong),이수훈(Soo-Hun Lee),이문구(Moon G. Lee) 한국생산제조학회 2010 한국생산제조시스템학회 학술발표대회 논문집 Vol.2010 No.4

Molecular phylogenetic correlations of Brucella canis isolates in South Korea

Jin-Ju Lee(Jin-Ju Lee),Seong-Yeob Kim(Seong-Yeob Kim),Si-Chul Kim(Si-Chul Kim),Eun-Ji Yum(Eun-Ji Yum),Yoon-Jeong Seo(Yoon-Jeong Seo),Jeong-Soo Choi(Jeong-Soo Choi),Soon-Seek Yoon(Soon-Seek Yoon) 한국예방수의학회 2022 한국예방수의학회 학술대회자료집 Vol.2022 No.-

Mapping of Quantitative Trait Loci Associated with Viviparous Germination in Rice

Lee, Seung-Yeob,Ahn, Jeong-Ho,Cha, Young-Soon,Yun, Doh-Won,Lee, Myung-Cheol,Eun, Moo-Young The Korean Society of Crop Science 2006 Korean journal of crop science Vol.51 No.6

The viviparous germination (VG) with lodging caused the yield reduction and quality deterioration in rice. We carried out the evaluation of VG tolerance (on the 40th day after heading) and mapping QTLs associated with VG tolerance using the recombinant inbred lines (M/G RILs) from a cross between Milyang 23 (japonica/indica) and Gihobyeo (japonica). The VG rates of Milyang 23 and Gihobyeo were 0.0 and 7.0%, respectively. The averaged VG rate of 162 M/G RILs was 7.7%, and their range was from 0.0 to 50.9%. Of the 162 RILs, 144 lines were tolerant less than 10%, and 18 lines were susceptible more than 10%. Using the M/G RIL Map, three QTLs associated with the viviparous trait were detected on chromosome 2 (qVG 2-1 and qVG 2-2) and 8 (qVG 8). qVG 2-1 was linked to RM 32D and RZ 166, and had LOD score of 2.97. qVG 2-2 was tightly linked to E13M59.119-Pl and E13M59.M003-P2, and showed higher LOD score of 3.41. qVG 8 was linked to RM33 and TCT116, and had LOD score of 2.67. The total phenotypic variance explained by the three QTLs was about 24.4% of the total variance in the population. The detection of new QTLs associated with VG tolerance will provide important informations for the seed dormancy, low temperature germination, or comparative genetics.

Short-Term and Long-Term Effects of Entecavir versus Lamivudine in Patients with Hepatitis B Virus-Related Decompensated Cirrhosis

( Jeong Won Jang ),( Jeong Ju Yoo ),( Young Seok Kim ),( Hyun Young Woo ),( Chung Hwan Jun ),( Sung Kyu Choi ),( Chang Hyeong Lee ),( Tae Yeob Kim ),( Yu Rim Lee ),( Won Young Tak ),( Jong Young Choi 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Background: Selection of high versus low potency antiviral drugs and the impact of maintained virologic response (MVR) on short-term and long-term outcome in patients with hepatitis B virus (HBV)-related decompensated cirrhosis are poorly established. This study aimed to evaluate the outcome regarding antiviral potency and HBV suppression in such patients followed for 10 years. Methods: This was an ancillary analysis of data collected in a prospective, multicenter study in which patients with first-onset decompensation were recruited since 2005. Eligible patients were HBV subjects who immediately initiated either entecavir or lamivudine at enrollment. The primary endpoint was liver transplantation (LT)-free survival. Other endpoints included the incidence of hepatocellular carcinoma (HCC) and changes in the Child-Turcotte-Pugh (CTP) and MELD scores on follow- up. Results: Of the 1,595 original cohorts, 295 (179 entecavir-treated and 116 lamivudine-treated patients) who met the eligibility criteria were included in this analysis. Overall, the median LT-free survival of the entire patients was 7.7 years. During the follow-up, 51 (17.3%) and 76 (25.8%) died or underwent LT before and after 6 months, respectively. Multiple decompensated complications and CTP class C were independent predictors of short-term mortality, whereas age and MVR remained independently predictive of long-term survival. The type of anti- HBV medications was not predictive of survival, but early and maintained VR predicted short-term and long-term survival, respectively. Particularly, MVR still significantly improved long-term survival for both the entire and baseline risk factor-adjusted groups. When stratified across the HBV DNA levels during follow-up, patients achieving maintained HBV suppression < 20 IU/mL exhibited a significantly better 10-year survival than those with fluctuating levels up to 200, 2,000, and persistently high >20,000 IU/mL (82.5%, 33.9%, 74.1%, and 45.9%, respectively; P<0.004). MVR resulted in significant improvement in hepatic function over time, but only marginal reduction in HCC development. Conclusions: Early and maintained suppression of HBV <20 IU/mL with anti-HBV therapy yields significant short- and long-term clinical benefits in decompensated patients. The survival benefits from MVR appear to be derived from progressive improvement in liver function rather than a reduction in HCC incidence.