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      • KCI등재

        Gesture, Gaze, and Bodily Cues in Mandarin Conversation: Two Case Studies

        Lee,Jee-won 한국사회언어학회 2012 사회언어학 Vol.20 No.1

        Lee, Jee-won. 2012. Gesture, Gaze, and Bodily Cues in Mandarin Conversation: Two Case Studies. The Sociolinguistic Journal of Korea 20(1). pp. 213-234. This study uses discourse analysis to illustrate some ways that non-verbal actions such as gaze, facial expression, and gesture work to contextualize the speech delivered in conversation. These bodily cues also enable participants to organize interactions as collaborative creations of meaning rather than simply a turn-by-turn exchange of speech. This study uses two excerpts from Mandarin Chinese conversations to illustrate how non-verbal cues help speakers and recipients to engage in collaborative action with one another. Speakers give recipients information about their stances vis-à-vis the speech they produce, and recipients use this information to manage their reactions to the speech they hear. Non-verbal actions also allow both parties to mutually regulate the flow of conversation. In both examples, it becomes clear that gaze, facial expression, and gesture are important elements of spoken interaction and that conversation as a whole should be understood as a contextual web of meaning that includes speech, body language, and overall social interaction.

      • SCOPUSKCI등재

        Genetic Characterization of Haemagglutinin 1 Domain of Influenza B Viruses Isolated in Korea during $1988{\sim}1999$

        Shin, Gu-Choul,Na, Byoung-Kuk,Lee, Joo-Yeon,Ahn, Jung-Bae,Park, Jong-Won,Lee, Jin-Soo,Kim, Jee-Hee,Kim, Woo-Joo,Kang, Chun The Korean Society for Microbiology 2003 Journal of Bacteriology and Virology Vol.33 No.4

        Although Korean influenza virus isolates have been genetically associated with the vaccine strains of the corresponding year, influenza B viruses have prevailed almost every year in Korea during the past decades. We have 'analyzed the genetic characteristics and evolutionary patterns of the haemagglutinin (HA) 1 domains of influenza B viruses isolated during 1988-1999 using direct RT-PCR and sequencing. Phylogenetic analysis of influenza B viruses isolated in Korea indicated that antigenically and genetically distinguishable strains of the lineage II and lineage III variants had been cocirculated. Variants prevailed in early 1990s are represented in 1996/97 and 1998/99 and some different variants have been co circulated geographically and prevailed concurrently in Korea. All HA1s of Korean isolates have amino acid substitutions mainly in the region between position 124 and 310, which was previously proposed an immunodominant region. Insertion-deletion patterns of the HA gene revealed that Korean influenza B viruses were evolved from Lee40 with different manner between lineage II and III viruses. Lineage III viruses were also divided into two groups as conserved group and inserted group, in relation to Lee40. But lineage II viruses had evolved with directional pattern. Antigenic index proposed that influenza B isolates prevailed since 1996/97 seasons might had emerged from the antigenic variants of a Seo1697-like virus and that new variants might appear from the lineage II viruses resulting in persistent prevalence in Korea.

      • Visual Hallucination and Pattern of Brain Degeneration in Parkinson's Disease

        Lee, Woong-Woo,Yoon, Eun Jin,Lee, Jee-Young,Park, Sun-Won,Kim, Yu Kyeong S. Karger AG 2017 Neuro-degenerative diseases Vol.17 No.2

        <P><B><I>Background and Objectives:</I></B> The incidence of visual hallucination (VH) increases with Parkinson's disease (PD) progression, and its development is thought to be related to a specific neurodegenerative process in PD. This study aimed to reveal brain degeneration related to VH in PD by analyzing neuroimaging data obtained from patients in their different stages of PD. <B><I>Methods:</I></B> Data from 48 PD patients - 21 nondemented without VH (PNV group), 10 nondemented with VH (PV group), and 17 demented with VH (PVD group) - and 30 age-matched healthy controls (HC group) were analyzed. Voxel-based morphometry and tract-based spatial statistics were conducted. Previous magnetic resonance volumetric studies on VH in PD were collectively reviewed. <B><I>Results:</I></B> The PV group showed gray matter atrophy in the right inferior parietal lobule and supramarginal gyrus compared with the HC and PNV groups. The PVD group showed a wider range of gray matter atrophies in the temporo-parieto-occipital regions than those in the PV group. White matter changes seemed to be an earlier event than gray matter changes. Fractional anisotropy values diffusely decreased in all three PD subgroups compared with the HC group without significant differences between the PD subgroups. Mean diffusivity was not different between the PNV and HC groups but increased in the parieto-temporal region in the PV group and increased diffusely in the PVD group, additionally including the fronto-occipital regions. A review of previous studies supported our observations. <B><I>Conclusions:</I></B> Gray matter degenerations from the parieto-temporal junction to the parieto-occipital and temporo-occipital regions may be responsible for VH on the typical timeline of PD progression.</P>

      • KCI등재

        Case Report : A case of Terminal Deletion of Chromosome 10P

        ( Jee Hae Cho ),( Ji Eun Park ),( Min Kyung Ko ),( Eun Ju Kim ),( Ji Kwon Park ),( Soon Ae Lee ),( Jong Hak Lee ),( Won Young Paik ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.7

        Chromosome 10p deletion (partial monosomy 10p) is rare chromosomal disorder. It was first reported in 1970. Since then, as far as we know, about 45 patients have been described. The main feature of this syndrome are craniofacial dysmorphism, congenital heart disease, vesicoureteral abnormalities, and developmental delay. We have experienced a prenatal case of Chromosome 10p terminal deletion by doing cytogenetic study due to high Down syndrome risk on quadruple test and cleft lip on prenatal ultrasonography. Conventional cytogenetic result from cord blood was 46,XY,del(10)(p13), molecular cytogenetic techniques using bacterial artifi cial chromosome array comparative genomic hybridization and fl uorescence in situ hybridization analysis result was 46,XY,del(10)(p14)(NEBL-). To our knowledge, this karyotype may be the first report in Korea. We present this case with brief review of literature.

      • Retinol binding protein 4 and insulin resistance in apparently healthy elderly subjects

        Lee, Ji-Won,Im, Jee-Aee,Park, Ki Deok,Lee, Hye-Ree,Shim, Jae-Yong,Lee, Duk-Chul Elsevier 2009 Clinica chimica acta Vol.400 No.1

        <P><B>Abstract</B></P><P><B>Background</B></P><P>Insulin resistance (IR) increases with advancing age, yet the underlying mechanism is not well established. Although adipocytokine retinol binding protein 4 (RBP4) was recently shown to be linked to IR, their relationship remains controversial and relatively little information exists regarding their roles in the elderly subjects. We investigated the association between RBP4 and IR in obese and nonobese elderly subjects.</P><P><B>Methods</B></P><P>A total of 111 (68 nonobese and 43 obese) apparently healthy elderly subjects, aged 75.9±4.8?y were included. IR was determined by homeostasis model assessment (HOMA-IR). Serum RBP4 was measured by enzyme-linked immunosorbent assay.</P><P><B>Results</B></P><P>In all subjects, RBP4 levels were positively correlated with fasting insulin, HOMA-IR, and triglycerides. However, after subgroup analysis, RBP4 levels were positively correlated with fasting glucose, fasting insulin, and HOMA-IR in the obese group only. In step-wise multiple linear regression analysis, RBP4 was found to be independently associated with triglyceride levels in the nonobese group and independently associated with HOMA-IR in the obese group.</P><P><B>Conclusions</B></P><P>The reason for the differing metabolic role of RBP4 in obese and nonobese elderly subjects remains uncertain, but our findings suggest that RBP4 may be linked to IR and lipid metabolism, at least in the elderly.</P>

      • Basic, HCC basic : O-029 ; Enhanced inactivation of immortalized hepatic stellate cell line by the synergistic effect of combination of HMG CoA reductase inhibitor and selective COX-2 inhibitor

        ( Jee Won Hwang ),( Hyung Joon Yim ),( Hyun Jung Lee ),( Sun Jae Lee ),( Eileen L. Yoon ),( Sang Jun Suh ),( Ji Hoon Kim ),( Jong Eun Yeon ),( Soon Ho Um ),( Kwan Soo Byun ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

        Background: Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to collagen accumulation during chronic liver disease. The NS-398 (a selective COX-2 inhibitor) is a potential drug of chemoprevention and treatment of liver fibrosis by inhibiting HSC activation. The simvastatin (a HMG CoA reductase inhibitor) revert the myofibroblasts-like phenotype of HSC towards a more quiescent phenotype. We investigated the anti-fibrotic and pro-apoptotic mechanisms in synergistic effects of both drugs as using the human hepatic stellate cell line. Methods: The immortalized human hepatic stellate cell line, LX-2 was cultured. The cells were treated with control, simvastatin, NS-398, and combination of simvastatin and NS-398 for 24 and 48 hours. Cellular DNA synthesis was evaluated by measuring BrdU incorporation. Expression of proteins including cell cycle regulators such as p21, cyclinD1 and Akt, NF-kB, caspase-3, caspase-9 as apoptotic factors, α -smooth muscle actin (α-SMA) were measured in Western blot analysis. Results: In BrdU-proliferation assay, combination of two drugs effectively inhibited the proliferation rate compared to monotherapy. The combination of two drugs resulted in a greater decrease of procaspase-3, -9, Akt and NF-kB than monotherapy depend on the concentration of two drugs. In addition, the combination of NS-398 and simvastatin significantly promote the inactivation of HSCs by reducing the amounts of α-SMA protein. Conclusions: We suggested that both of two drugs have synergistic effects that anti-proliferative, pro-apoptotic and anti-fibrotic effects on activated HSCs. The mechanism of synergistic pro-apoptotic effect seems to be mediated through inhibition of NF-kB/Akt pathway and caspase activity.

      • KCI등재

        Effect of Repeated Oral Health Education on the Oral Health of Preschool Children

        ( Jee-won Lee ),( Ha-na Choi ) 한국치위생과학회 2017 치위생과학회지 Vol.17 No.5

        This study aimed to investigate the effect of repeated oral health education on the oral health of preschool children. This study classified the control group of children of 5∼6 years of age where the oral health education was conducted one time, and the experiment group where the oral health education was conducted 4 times. The oral health conditions of each group and their risk of developing dental caries were also assessed. No significant difference was observed in the participants in terms of general characteristics, oral health conditions, risk of developing dental caries, and oral health behavior after oral health education. The two groups did not show a significant difference (p<0.001) in dental plaque index before and after oral health education, and showed a significant difference (p<0.001) according to the number of education sessions. Before oral health education, the participants in both groups were brushing their teeth incorrectly. However, after the third session, 56.7% of the participants in the experimental group and 9.4% in the control group used the correct method of tooth brushing. A significant difference was observed between the two groups (p<0.05). In addition, when the tooth-brushing time was compared, the two groups showed a significant difference (p<0.001), and a significant difference was observed in terms of the number of education sessions (p<0.05). In summary, repeated oral health education had significant influences on the dental plaque index, tooth-brushing method, brushing occlusal surfaces, and tooth-brushing time. Therefore, when oral health education is carried out, repeated oral health education in children is more effective than one-time oral health education as reflected in the changes in dental plaque index and oral health behavior. Moreover, oral health education is considered effective in changing the oral health behavior of children when conducted at least 3 times.

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