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채널 식각형 비정질 실리콘 박막 트랜지스터에서 배면에 수소 이온 도핑효과
장진,최종현,이경하,임병천,김창수 慶熙大學校 레이저 工學硏究所 1997 레이저공학 Vol.8 No.-
We have studied the effect of the hydrogen ion doping on the free surface of back channel etched a Si:H TFTs. The hydrogen ion doping on the back channel etched TFT reduces the off-state photo leakage current by one order of magnitude. The reduction of the photo-leakage current is due to the creation of defect states at the free surface by hydrogen ion doping. After hydrogen ion doping on the free surface, the field effect mobility change little, but the threshold voltage increases, which is due to the state creation in a-Si:H by ionized H ions. Furthermore, the off-state leakage current under frontlight illumination can be reduced by 2 orders magnitude by hydrogen ion doping on the back channel of a Si:H TFT.
온라인 전자 지도안 시스템의 구축 및 활용에 관한 연구
천종필,백장미,한선관,이철환 한국컴퓨터교육학회 2003 컴퓨터교육학회 논문지 Vol.6 No.1
본 연구자들은 ICT 활용 교육을 위한 초등교육 지도안을 온라인상에서 작성하고 활용할 수 있는 Web기반 전자지도안 시스템을 개발하였다. 개발된 온라인 전자지도안 시스템 은 ICT 교수-학습 과정안 자료를 데이터베이스화하여 체계적으로 관리할 수 있도록 하였으며, 교수-학습 과정안의 공유, 활용, 저장성의 극대화를 도모하여 학교 정보화에 이바지할 수 있다. 이렇게 개발된 시스템이 현장에서 활용되면서 나타난 교육적 효과 및 문제점을 분석하여 해결 방안을 제시하는 것은 시스템의 개발 못지않게 중요하다고 할 수 있다. 따라서 본 연구에서는 첫째, 본 시스템 개발을 위한 ICT 활용 교수·학습 과정안 형태의 구안과정과 둘째, 본 시스템의 설계와 구현 방법의 개요, 그리고 셋째, 초등학교 현장에서 적용하면서 나타난 시스템의 효과와 문제점 분석 및 개선방안을 제시하였다 또 연구를 통하여 초등교육에서 사용하게 될 전자 교육 시스템의 개발 과정 및 활용 상의 고려사항과 문제점의 해결 방안에 대한 교육적 근거를 제공하였다. The researchers developed On-line Lesson Planner System so that teachers can make a lesson plan using ICT(Information & Communication Technology) on line. Developed On-line Lesson Planner System can make ICT using lesson plans store in the database, manage them systematically and help maximize share, use and storage of the lesson plans. It can contribute to the school informatization. It is important to suggest solution through analyzing the educational effects and problems appeared during applying to this developed system in real fields. Thus, this study suggests first, procedure of designing the lesson plan using ICT for the development of this system, second, the summary of designing and embodying methods, and third, the improvement and analysis of the effects and problems revealed in elementary school fields. This study provided educational grounds of the solution to the problems and consideration of this On-line Lesson Planner system.
( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3
Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)
김대성,노성택,이장천,임규상,신미란,우원홍,문연자 한국전통의학연구소 2006 한국전통의학지 Vol.15 No.1
The aim of this study was to investigate the effect of ethanol extract of Fagopyrum escuentum(FE) on the melanogenesis. To determine whether ethanol extract of FE suppress melanin synthesis in cellular level, B16F10 melanoma cells were cultured in the presence of different concentrations of FE ethanol extract. In the present study, the author examined the effects of FE ethanol extract on cell proliferation, melanin contents, tyrosinase activity. Cell proliferation was slightly increased by treatment with ethanol extract of FE (25-200 ㎍/ml). The ethanol extract of FE effectively suppressed melanin contents at a dose of 100 ㎍/ml. It was observed that the color of cell pellets was totally whitened compared with the control. The ethanol extract of FE inhibited tyrosinase activity, regulate melanin biosynthesis as the key enzyme in melanogenesis. These results suggest that the ethanol extract of FE exerts its depigmenting effects through the suppression of tyrosinase activity. And it may be a potent depigmetation agent in hyperpigmentation condition.
Lee, Su-Yeon,Lee, Hui-Young,Song, Jae-Hwi,Kim, Goon-Tae,Jeon, Suwon,Song, Yoo-Jeong,Lee, Jae Sung,Hur, Jang-Ho,Oh, Hyun Hee,Park, Shi-Young,Shim, Soon-Mi,Yoo, Hyun Joo,Lee, Byung Cheon,Jiang, Xian-Che American Diabetes Association 2017 Diabetes Vol.66 No.10
<P>Sphingolipids have been implicated in the etiology of chronic metabolic diseases. Here, we investigated whether sphingolipid biosynthesis is associated with the development of adipose tissues and metabolic diseases. SPTLC2, a subunit of serine palmitoyltransferase, was transcriptionally upregulated in the adipose tissues of obese mice and in differentiating adipocytes. Adipocyte-specific SPTLC2-deficient (aSPTLC2 KO) mice had markedly reduced adipose tissue mass. Fatty acids that were destined for the adipose tissue were instead shunted to liver and caused hepatosteatosis. This impaired fat distribution caused systemic insulin resistance and hyperglycemia, indicating severe lipodystrophy. Mechanistically, sphingosine 1-phosphate (S1P) was reduced in the adipose tissues of aSPTLC2 KO mice, and this inhibited adipocyte proliferation and differentiation via the downregulation of S1P receptor 1 and decreased activity of the peroxisome proliferator-activator receptor gamma. In addition, downregulation of SREBP (sterol regulatory element-binding protein)-1c prevented adipogenesis of aSPTLC2 KO adipocytes. Collectively, our observations suggest that the tight regulation of de novo sphingolipid biosynthesis and S1P signaling plays an important role in adipogenesis and hepatosteatosis.</P>
Detection of an intermediate during the unfolding process of the dimeric ketosteroid isomerase
Jang, Do Soo,Lee, Hyeong Ju,Lee, Byeongdu,Hong, Bee Hak,Cha, Hyung Jin,Yoon, Jinhwan,Lim, Kwanseop,Yoon, Ye Jeong,Kim, Jehan,Ree, Moonhor,Lee, Hee Cheon,Choi, Kwan Yong Elsevier 2006 FEBS letters Vol.580 No.17
<P><B>Abstract</B></P><P>Failure to detect the intermediate in spite of its existence often leads to the conclusion that two-state transition in the unfolding process of the protein can be justified. In contrast to the previous equilibrium unfolding experiment fitted to a two-state model by circular dichroism and fluorescence spectroscopies, an equilibrium unfolding intermediate of a dimeric ketosteroid isomerase (KSI) could be detected by small angle X-ray scattering (SAXS) and analytical ultracentrifugation. The sizes of KSI were determined to be 18.7Å in 0M urea, 17.3Å in 5.2M urea, and 25.1Å in 7M urea by SAXS. The size of KSI in 5.2M urea was significantly decreased compared with those in 0M and 7M urea, suggesting the existence of a compact intermediate. Sedimentation velocity as obtained by ultracentrifugation confirmed that KSI in 5.2M urea is distinctly different from native and fully-unfolded forms. The sizes measured by pulse field gradient nuclear magnetic resonance (NMR) spectroscopy were consistent with those obtained by SAXS. Discrepancy of equilibrium unfolding studies between size measurement methods and optical spectroscopies might be due to the failure in detecting the intermediate by optical spectroscopic methods. Further characterization of the intermediate using <SUP>1</SUP>H NMR spectroscopy and Kratky plot supported the existence of a partially-folded form of KSI which is distinct from those of native and fully-unfolded KSIs. Taken together, our results suggest that the formation of a compact intermediate should precede the association of monomers prior to the dimerization process during the folding of KSI.</P>
Erratum to: “Amelioration of Streptozotocin-Induced Diabetes by Agrocybe chaxingu Polysaccharide”
Lee, Byung Ryong,Lee, Yeom Pyo,Kim, Dae Won,Song, Ha Yong,Yoo, Ki-Yeon,Won, Moo Ho,Kang, Tae-Cheon,Lee, Kwang Jae,Kim, Kyung Hee,Joo, Jin Ho,Ham, Hun Ju,Hur, Jang Hyun,Cho, Sung-Woo,Han, Kyu Hyung,Lee Springer-Verlag 2013 Molecules and cells Vol.36 No.1
이영조,이명철,강위창,이명묵,이동수,정준기,강원준,천기정,장명진 대한핵의학회 2000 핵의학 분자영상 Vol.34 No.1
Purpose: Dipyridamole stress myocardial perfusion SPECT could predict prognosis, however, long-term follow-up showed change of hazard ratio in patients with suspected coronary artery disease. We investigated how long normal SPECT could predict the benign prognosis on the long-term follow-up. Materials and Methods: We followed up 1169 patients and divided these patients into groups in whom coronary angiography were performed and were not. Total cardiac event rate and hard event rate were predicted using clinical, angiographic and SPECT findings. Predictive values of normal and abnormal SPECT were examined using survival analysis with Mantel-Haenszel method, multivariate Cox proportional hazard model analysis and newly developed statistical method to test time-invariance of hazard rate and changing point of this rate. Results: Reversible perfusion decrease on myocardial perfusion SPECT predicted higher total cardiac event rate independently and further to angiographic findings. However, myocardial SPECT showed independent but not incremental prognostic values for hard event rate. Hazard ratio of normal perfusion SPECT was changed significantly (p<0.001) and the changing point of hazard rate was 4.4 years of follow up. However, the ratio of abnormal SPECT was not. Conclusion: Dipyridamole stress myocardial perfusion SPECT provided independent prognostic information in patients with known and suspected coronary artery disease. Normal perfusion SPECT predicted least event rate for 4.4 years. (Korean J Nucl Med 2000;34:39-54)
Amelioration of Streptozotocin-Induced Diabetes by Agrocybe chaxingu Polysaccharide
Lee, Byung-Ryong,Lee, Yeom-Pyo,Kim, Dae-Won,Song, Ha-Yong,Yoo, Ki-Yeon,Won, Moo-Ho,Kang, Tae-Cheon,Lee, Kwang-Jae,Kim, Kyung-Hee,Joo, Jin-Ho,Ham, Hun-Ju,Hur, Jang-Hyun,Cho, Sung-Woo,Han, Kyu-Hyung,Lee Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.4
The aim of this study was to investigate the preventive effect of Agrocybe chaxingu polysaccharide on streptozocin (STZ)-induced pancreatic ${\beta}$-cells destruction. Agrocybe chaxingu polysaccharide markedly reduced nitric oxide (NO) production and iNOS expression levels in RINm5F cells in a dose-dependent manner. In addition, Agrocybe chaxingu polysaccharide significantly inhibited iNOS expression and blood glucose levels in STZ-induced diabetic mice. Moreover, immunohistochemical analysis revealed that it enhanced pancreatic ${\beta}$-cells resistance to destruction by STZ. These results suggest that Agrocybe chaxingu polysaccharide may have value as a therapeutic agent against diabetes mellitus.