영구형 항서맥 심박조율기 환자의 장기추적관찰

최현석,이무용,최영진,최성준,김효수,손대원,오병희,이명묵,박영배,최윤식,이영우,이명용 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.5

팔공산화강암과 주변 접촉변성암에 관한 암석학적 연구

이상원,이춘희,정증효 釜山大學校 師範大學 1996 교사교육연구 Vol.33 No.-

Palgongsan granite considered to be a rapid cooling shallow-level intrusion, exhibits textural and mineralogical changes from margin toward core. In petrochemistry it is characteristic of I-type granitoid representing calc-alkaline differentiation trend, which is discriminated active continental arc granitoid in tectonomagmatic environment. In Q-Ab-Or-An system norm compositions of the Palgongsan granite are plotted near low-temperature trough, and concentrated on the minimum melt curve (700℃). Palgongsan granite intruded and metamorphosed sedimentary rocks to hornfelses forming contact metamorphic aureoles (average 1.5 km width). Contact aureoles are divided into inner and outer zone, which are respectively biotite and chlorite zone, indicating albite-epidote hornfels facies. The mineral assemblages are chlorite-muscovite in chlorite zone and biotite-muscovite(-chlorite), epidote-chlorite, actinolite-chlorite and actinolite -epidote-chlorite in biotite zone. Metamorphic temperature is as low as to be estimated about 350℃ in chlorite zone and 400℃ or higher in biotite zone.

Agrobacterium tumefaciens를 이용한 bialaphos 저항성 형질전환 벼의 개발

이효연,이춘환,김호일,한원동,최지은,김진호,임용표 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-

비선택성 제초제인 bialaphos는 고등식물에 있어서 glutamine 합성을 억제하여 식물체를 고사시킨다. Acetyltransferase에 의해 encoding된 bialaphos 저항성 유전자는 세균 Streptomyces hygroscopicus SF1239로부터 cloning된 것을 사용하였다. Bialaphose 저항성 유전자를 Agrobacterium 감염법을 이용하여 국내에서 재배되는 벼(동진)에 도입한 결과 약 30%정도의 형질전환 식물체를 얻을 수 있었다. T_1세대의 17개체는 hygromycin과 bialaphos에 대한 저항성 유전형질이 3 : 1로 분리되었다. 또한 Southern 분석을 실시한 결과 wild type의 식물체에서는 Bar 유전자의 검출을 볼 수 없었으나 형질전환 식물체의 경우 Bar 유전자의 검출이 가능하였다. T_3 세대의 형질전환 식물체와 wild type의 식물체를 포장상태에서 비선택성 제초제인 바스타를 살포하고 3주 후에 관찰한 결과 형질전환 식물체는 외형적으로 아무런 피해를 받지 않고 정상적으로 생장하였으나, wild type의 식물체와 잡초는 모두 고사하였다. 이상의 결과를 종합해보면 hygromycin과 bialaphos 저항성 유전자는 Agrobacterium 감염법을 이용하여 단자엽 식물인 벼에 도입할 수 있다는 것을 보여준 것이며, 또한 bialaphos 저항성 유전자가 식물에 도입됨으로써 비선택성 제초제에 대한 저항성 식물을 개발 할 수 있다는 것을 보여 주었다. The bialaphos is a potent inhibitor of glutamine synthease in higher plants and is used as a non-selective herbicide. We have used the bialaphos resistant gene (Bar) encoding for an acetyltransferase isloated from Streptomyces hygroscopicus SF1293. Callus derived from mature seeds of rice (Oryza sativa L. cv. Dong Jin) were co-cultivated with Agrobacterium tumefacieus EHA101 carring a plasmid pGPTV-HB containing genes for hygromycin resistance (HygR) and Bar. Transgenic plants showing in vitro resistance to 50 mg/L hygromycin and 10 mg/L bialaphos were obtained by using a two-step selection/regeneration procedure. Transformation efficiency of rice was about 30% which was as high as reported in other dicotyledons. Progenies (T_1 generation) derived from primary transformant of 17 lines were segreagated with a 3 resistant:1 sensitive ratio in medium containing hygromycin and bialaphos. Stable integration of Bar gene into chromosomal DNA was proven by Southern blot analysis of genomic DNA isolated from T_2 progenies. Transgenic plants (T_3) grown in the field were resistant to bialaphos (Basta) at a dosage lethal to wild type plants.

중등체육교사의 수업현황및 학교체육실태

민춘기,이명효,임종은 忠南大學校體育科學硏究所 1994 體育科學硏究誌 Vol.12 No.1

In this study, researcher examined 50 phys:(a) teachers to check the dismissing class caused by teachers official trip and rate of missing lecture and supplementary lecture of physical class. Also, the researcher analysised the learning contents classified by learning territory and mode condusions and suggestions like followings. 1. The rate of physical teachers' official trip is outstanding on October by 166per a month (M=3.32) And September, May, July, June are followed 2. After comparing 28 teachers' official trip rate in the charge of an athletic club 22 teachers' official trip rate not in charge of an athletic club, it was shown that the former was higher than in O. T. R except for April, May November, December, Feburary between two group showed meaningful distinction (P〈0.05, P〈0.01) 3. In the rate of missing lecture and supplementary lecture of physical class, average dismissing class caused by physical teachers official trip was 22.06, and 32.42 for teachers in the charge of athletic club and 8.86 for teachers not in charge of athletic of athlectic club. This fact was considered as meaningful clistinction (P〈0.05) 4. After analysing the learning contents by grade, it was known that ball games were carried on most often by all grade. Gymnastic, tracks and athlectic theory class were followed. Outdoor activity, recreation activity, health edacation, audio-Visual education were hardly carried out but a few hours.

중이온 빔 조사에 의한 담배의 돌연변이 유도와 내염성 식물의 선발

배창휴,Abe, Tomoko,민경수,김동철,정재성,이춘환,임용표,이효연 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-

중이온 빔을 이용한 방사선 돌연변이의 기초자료를 얻고자 담배의 수분·수정 직후의 원배에 100 Gy의 중이온빔을 조사하여 M_1세대의 종자를 얻었다. NaCI 2.0과 2.5%를 포함된 MS배지에 M_1 세대의 종자를 파종하여 17개통의 NaCI 저항성 식물체를 선발하였다. 저항성 식물체는 BY-4품종에 ^14N빔을 조사한 처리구에서만 관찰되었다. M_1 세대의 저항성 식물체의 경우 영양생장기간 중에는 외형적 변이가 관찰되지 않았으나 생식생장기의 화기에 있어서는 다양한 변이가 관찰되었다. 특히 암술 수술의 길이의 변화, 꽃잎의 변화, 불완전 화분립, 줄기당 꽃의 착생수 감소 등의 변이가 발생하였다. M_1 세대에서 17개의 NaCI저항성 계통 중에서 8계통은 M_2 세대에도 저항성형질이 발현되었고, 또한 M_2 세대의 3계통은 Mannitol이 포함된 배지에서 저항성을 보여주었다. Tobacco proembryos were irradiated with 100 Gy of heavy-ion beams (^14N, ^20Ne : 135 Mev/u) after 24 to 96 hours of pollination as a mutagen and screened M_1 generation for morphological mutants and salt-tolerant plants. Morphological and physilolgical characteristics of the salt-tolerant plants derived from the irradiated proembryo are discussed in this report. Mutants irradiated porembryos with the beams after pollination produced various kinds of morphological variation. A total of 17 salt-tolerant plants were selected from tobacco cultivar (BY-4) by treatment with ^14N beam. Shapes of filament and pollen grain of most salt-tolerant plants were abnormal compared with non-irradiated wild type, and seeds weight and fertility obviously decreased. The germination rates of the several M_2 lines on the saline and the mannitol condition were higher than that of wild type.

Tussilago farfara L. augments TRAIL-induced apoptosis through MKK7/JNK activation by inhibition of MKK7-TIPRL in human hepatocellular carcinoma cells

LEE, HYO-JUNG,CHO, HYUN-SOO,JUN, SOO YOUNG,LEE, JEONG-JU,YOON, JI-YONG,LEE, JAE-HYE,SONG, HYUK-HWAN,CHOI, SANG HO,KIM, SOO-YONG,SALOURA, VASSILIKI,PARK, CHOON GIL,KIM, NAM-SOON Spandidos Publications 2014 Oncology Reports Vol.32 No.3

Correlation of commute time with the risk of subjective mental health problems: 6th Korean Working Conditions Survey (KWCS)

Lee Hyo Choon,양은혜,Shin Soon Su,Moon Seoung Ho,Song Nan,Ryoo Jae-Hong 대한직업환경의학회 2023 대한직업환경의학회지 Vol.35 No.1

Background: Studies conducted so far on the link between commute time and mental health among Koreans remain insufficient. In this study, we attempted to identify the relationship between commute time and subjective mental health using the 6th Korean Working Conditions Survey (KWCS). Methods: Self-reported commute time was divided into four groups: ≤ 30 (group 1), 30–60 (group 2), 60–120 (group 3), and > 120 minutes (group 4). Subjective depression was defined as a score of 50 points or less on the WHO-5 well-being index. Subjective anxiety and fatigue were defined as answering ‘yes’ to the questionnaire on whether they had experienced it over the past year. The analysis of variance, t-test, and χ2 test was used to analyze the differences among the characteristics of the study participants according to commute time, depression, anxiety, and fatigue. Odds ratios (ORs) and 95% confidence intervals (CIs) for depression, anxiety, and fatigue according to commute time were calculated using multivariate logistic regression models adjusted for sex, age, monthly income, occupation, company size, weekly working hours, and shift work status. Results: Long commute times showed increased ORs and graded increasing trends for depression, anxiety, and fatigue. The ORs for depression increased significantly in group 2 (1.06 [1.01–1.11]), group 3 (1.23 [1.13–1.33]), and group 4 (1.31 [1.09–1.57]) compared to group 1 (reference). The ORs for anxiety increased significantly in group 2 (1.17 [1.06–1.29]), group 3 (1.43 [1.23–1.65]) and group 4 (1.89 [1.42–2.53]). The ORs for fatigue increased significantly in group 2 (1.09 [1.04–1.15]), group 3 (1.32 [1.21–1.43]), and group 4 (1.51 [1.25–1.82]). Conclusions: This study highlights that the risk of depression, anxiety, and fatigue increases with commute time.

The fate of recurred hepatocellular carcinoma after curative primary liver resection; are still patholgic aggressiveness and milan criteria important?

Hyo-Sin Kim,Jaehong Jeong,Kwang-Woong Lee,Kyung-Suk Suh,Nam-Joon Yi,Jong Man Kim,Sanghoon Lee,Choon Hyuck David Kwon,Jae-Won Joh,Suk-Koo Lee 한국간담췌외과학회 2015 한국간담췌외과학회 학술대회지 Vol.2015 No.9

Case Reports : Severe Acute Fibrinous and Organizing Pneumonia with Acute Respiratory Distress Syndrome

( Hyo Jae Kang ),( Sun Mi Choi ),( Yun Jeong Jeong ),( Jong Sun Park ),( Sei Won Lee ),( Ho Il Yoon ),( Jae Ho Lee ),( Choon Tack Lee ),( Young Jae Cho ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.71 No.5

Acute fibrinous and organizing pneumonia is a newly recognized pattern of acute lung injury. A 49-year-old female presented with a cough and worsening dyspnea on exertion. She had no history of smoking and no specific past medical history except exposure of home humidifier containing sterilizer. A chest computed tomography scan showed patchy consolidation with fibrosis in the right lower lobe and ill-defined centrilobular ground glass opacity in both lungs. The pathological findings were patchy areas of lung parenchyma with fibrin deposits in the alveolar ducts and alveoli, and fibrin balls with hemosiderin deposition in the alveolar spaces. The histological pattern of our case is differentiated from diffuse alveolar damage by the absence of hyaline membranes, and from eosinophilic pneumonia by the lack of eosinophils. In our case, the patient was treated with corticosteroid pulse therapy. However, the clinical course became aggravated and she died within two weeks.

The Association of Smoking Status and Clustering of Obesity and Depression on the Risk of Early–Onset Cardiovascular Disease in Young Adults: A Nationwide Cohort Study

Choon-Young Kim,Cheol Min Lee,Seungwoo Lee,Jung Eun Yoo,Heesun Lee,Hyo Eun Park,Kyungdo Han,Su-Yeon Choi 대한심장학회 2023 Korean Circulation Journal Vol.53 No.1

Background and Objectives: To evaluate the impact of smoking in young adults on the risk of cardiovascular disease (CVD) and the clustering effect of behavioral risk factors such as smoking, obesity, and depression. Methods: A Korean nationwide population-based cohort of a total of 3,280,826 participants aged 20–39 years old who underwent 2 consecutive health examinations were included. They were followed up until the date of CVD (myocardial infarction [MI] or stroke), or December 2018 (median, 6 years). Results: Current smoking, early age of smoking initiation, and smoking intensity were associated with an increased risk of CVD incidence. Even after quitting smoking, the risk of MI was still high in quitters compared with non-smokers. Cigarette smoking, obesity, and depression were independently associated with a 1.3–1.7 times increased risk of CVD, and clustering of 2 or more of these behavioral risk factors was associated with a 2–3 times increased risk of CVD in young adults. Conclusions: In young adults, cigarette smoking was associated with the risk of CVD, and the clustering of 2 or more behavioral risk factors showed an additive risk of CVD.