http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
La, Jun-Ho,Sung, Tae-Sik,Kim, Hyun-Ju,Kim, Tae-Wan,Kang, Tong-Mook,Yang, Il-Suk WJG Press 2008 WORLD JOURNAL OF GASTROENTEROLOGY Vol.14 No.5
<P>To investigate whether peripheral corticotropin releasing hormone (CRH), which is up-regulated in intestinal inflammation, mediates the post-inflammatory visceral hypersensitivity in a rat model of colitis.</P>
La-Sim Bae(La-Sim Bae),Ryun-Seok Oh(Ryun-Seok Oh),Jun-Ho Choi(Jun-Ho Choi) 한국화재소방학회 2023 International Journal of Fire Science and Engineer Vol.37 No.1
At present, the standard for installing evacuation equipment that enables occupants to evacuate on their own is determined by the use of a building and its floor area. However, according to the “Installation Maintenance and Safety Control of Fire-Fighting Systems Act” and “Fire Safety Standards for evacuation equipment”, the installation standard for evacuation equipment mentions only the minimum number of equipment to be installed based on the floor area. Thus, this installation standard fails to reflect the corresponding number of occupants in a building and the effectiveness of the evacuation equipment. Thus, there is a high probability that most of the evacuation equipment installed based on the “one-size-fits-all” legal regulation will not guarantee the safety of occupants in case of a fire. To address this, the performance evaluation of the effectiveness of evacuation and the distribution ratio of equipment per occupant needs to be prioritized. Therefore, we conduct mock experiments on the descending lifeline and elevating evacuation equipment to analyze their efficiencies. Moreover, we propose a model for calculating the evacuation time for the descending lifeline and elevating evacuation equipment based on the experimental results. Furthermore, we conduct effectiveness evaluation by using the evacuation equipment. The results show that most people cannot be evacuated using the evacuation equipment. That is, evacuation equipment was determined to be insufficient for ensuring safety as per the current standard. Therefore, the installation of evacuation equipment according to its efficiency and capacity is considered necessary.
Jun Ki Min,Mi La Cho,Seok Chan Kim,Youn Soo Lee,Sang Heon Lee,Sung Hwan Park,Yeon Sik Hong,Chul Soo Cho,Ho Youn Kim 대한내과학회 1999 The Korean Journal of Internal Medicine Vol.14 No.1
A 13-year-old girl presented with multiple skin abscesses. She was diagnosed as having juvenile dermatomyositis (DM) at the age of 7 years. She had suffered from recurrent skin infections, atypical pruritic dermatitis and pneumonia since the age of 8 years
Hydroxychloroquine이 T 세포의 Fas Ligand 대사에 미치는 영향
민준기 ( Jun Ki Min ),이희진 ( Hee Jin Lee ),이원선 ( Won Sun Lee ),박상희 ( Sang Hee Park ),민소연 ( So Youn Min ),조미라 ( Mi La Cho ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.2
Objective: Hydroxychloroquine (HCQ) is a drug that has been used to treat autoimmune disorders such as rheumatoid arthritis arid systemic lupus erythematosus. However, the specific mechanism for its pharmacologic action has been largely unknown. It has been reported that dysregulation of lymphocytic apoptosis mediated by Fas ligand (FasL) and Fas is associated with the development of autoimmune diseases and HCQ induces apoptosis in peripheral blood lymphocytes. These reports suggest that HCQ may exert its pharmacologic effects through the modulation of FasL and Fas. Therefore, we are intended to investigate the effects of HCQ on the regulation of FasL and Fas. Methods: Jurkat cells or peripheral blood mononuclear cells (PBMNC) were treated with varying concentrations of HCQ. Semiquantative reverse transcription-polymerase chain reaction, Western blotting, flow cytometry, and ELISA were used for this study. Results: HCQ at nontoxic concentrations(50~150μM) caused a dose dependent increase of FasL mRNA expression and FasL in cell lysates. HCQ inhibited the release of intracellular 40 kDa FasL by Jurkat cells which were pulse-stimulated with PHA (50㎍/㎖). Jurkat cells activated with PHA increased membrane bound FasL (mFasL) expression (24.5±4.3%), however Jurkat cells pretreated with HCQ(150μM) followed by PHA administration did not further increase mFasL expression (26.8±1.6%). Addition of different concentrations of HCQ to the cultured PBMNC stimulated with PHA for 24 hours showed increase of soluble FasL (sFasL). The levels of sFasL treated with HCQ zero, 50, 150 and 300μM for 24hours were 38.6±3.0, 43.4±5.1, 77.0±3.6(P<0.05) and 72.3±8.lpg/㎖(P<0.05) respectively. However, fas metabolism was not affected by HCQ. Conclusion: These results suggest that HCQ may exhibit its pharmacological effects by upregulation of FasL gene expression and increased production sFasL without any influence on the Fas metabolism of T cells.
The adequacy of conization in the management of adenocarcinoma in situ of the uterine cervix(초)
한호섭 ( Ho Suap Hahn ),( Mi La Kim ),( Seok Geun Yoon ),( Woo Chul Kim ),( Hong Jun Choi ),( Sung Ran Hong ),( Hy Sook Kim ),( Yong Soon Kwon ),( In Ho Lee ),( Kyung Taek Lim ),( Ki Heon Lee ),( Jae Uk 대한산부인과학회 2009 대한산부인과학회 학술대회 Vol.95 No.-
설호준 ( Ho Jun Seol ),황승균 ( Sung Kyun Hwang ),최윤라 ( Yoon La Choi ),지제근 ( Je G Chi ),정희원 ( Hee Won Jung ) 대한뇌종양학회 2002 대한뇌종양학회지 Vol.1 No.2
Subependymoma is a rare, slow growing, rarely recurrent tumor. We report a case of recurrent subependymoma with subependymal seeding. An intraventricular tumor in the left temporal horn was detected in a 48-year-old female who presented with a 4-year history of dizziness and memory disturbance. Following near total surgical resection, a tumor diagnosis of subependymoma was confirmed by scattered clusters of isomorphic nuclei embedded in a dense fibrillary matrix of glial cell processes. Twenty six months after surgery, follow-up(F/U) magnetic resonance(MR) imaging revealed tumor recurrence in the previous site which necessitated linear accelerator radiosurgery(LINAC). A further 21 months later, F/U MR imaging showed recurrent, multiple, enhanced, nodular lesions in the enlarged left lateral ventricle for which the patient underwent reoperation. Radiological and operative findings revealed local relapse with subependymal seeding. The pathological finding was similar to that of the previous tumor and compatible with subependymoma. Immunohistochemical studies revealed that glial fibrillary acidic protein(GFAP) was positive and CD-99 was negative. The patient underwent radiation therapy for the residual tumor. This case history suggests that symptomatic residual tumors require close observation even though the clinical course of subependymoma is usually benign.
LEE, JUN-HEE,CHO, MI-LA,KIM, JU-IN,MOON, YOUNG-MEE,OH, HYE-JWA,KIM, GEUN-TAE,RYU, SUN,BAEK, SEUNG-HOON,LEE, SUN-HEE,KIM, HO-YOUN,KIM, SUNG-IL The Journal of Rheumatology 2009 The Journal of rheumatology Vol.36 No.4
<B>Objective.</B><P>To examine the effect of interleukin 17 (IL-17) on the expression of Toll-like receptor (TLR)-2, 4, and 9 in collagen-induced arthritis (CIA) in mice.</P><B>Methods.</B><P>On Days 28 and 32 after induction of CIA in mice, phosphate-buffered saline (PBS group) or IL-17 (IL-17 group) was injected into both knee joints. On Day 35, mice were sacrificed. The severity of knee joint arthritis, synovial inflammation, and bone destruction was measured by a scoring system using macrography and histological analysis. Synovial expression of TLR-2, 4, 9, IL-17, IL-1ß, tumor necrosis factor-α (TNF-α), and IL-6 was determined by real-time PCR and immunohistochemistry. Synoviocytes of CIA mice were cultured with IL-17 and with neutralizing antibodies to cytokine, and the expression of TLR-2, 4, 9, IL-1ß, TNF-α, and IL-6 was determined by real-time RT-PCR.</P><B>Results.</B><P>In CIA mice, knee arthritis scores, synovial inflammation, bone destruction scores, and expression of synovial TLR-2, 4, and 9, IL-17, IL-1ß, TNF-α and IL-6 were higher in the IL-17 and PBS groups than in normal DBA1 mice. These variables were also significantly higher in the IL-17 group than in the PBS group. In CIA synoviocytes, IL-17 increased the expression of TLR-2, 4, and 9, and this effect was significantly alleviated by neutralizing antibodies to IL-17, IL-1ß, and IL-6.</P><B>Conclusion.</B><P>IL-17 aggravates joint inflammation and destruction, and increases the synovial expression of TLR-2, 4, and 9 by increasing IL-1ß and IL-6. These results imply that the IL-17-induced increase in expression of TLR-2, 4, and 9, and IL-1ß and IL-6 production are involved in the IL-17-induced aggravation of arthritis.</P>
Kim, Ho-Youn,Kim, Wan-Uk,Cho, Mi-La,Lee, Suk-Kyeong,Youn, Jee-hee,Sung-Il Kim*,Wan-Hee Yoo**,Jae-Ho Park***,Min, Jun-Ki,Lee, Sang heon,Park, Sung-Hwan,Cho, Chul-Soo 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-
Objective : To determine the presence of specific immune recognition of type II collagen (CII) and its immunodominant epitope CII (255-274) in patients with rheumatoid arthritis(RA). Methods : T cell proliferative responses to bovine CII and synthetic peptide encompassing CII (255-274), by peripheral blood mononuclear cells (PBMC) and synovial fluid mononuclear cells (SFMC) from RA patients, and PBMC from osteoarthritis (OA) patients and healthy controls were assayed by mixed lymphocyte culture. Results : Stimulation index (SI) and the number of positive T cell responses (SI≥2) to CII were higher in RA patients (n=106) than in OA patients(n=26) and healthy controls (n=34). T cell responses to CII (255-274) were also enhanced in RA and correlated well with those to CII. In SFMC, positive responses to CII using SFMC were stronger and more prevalent than peripheral responses. SI and positive responses to CII were higher in early RA than in late RA. IgG antibodies to CㆍII in SF inversely correlated with T cell responses to CII. Conclusion : T cell responses to CII or CII(255-274) were enhanced in RA, especially in early disease. Synthetic peptide CII (255-274) as well as CII could be recognized as immunogenic antigens by T cells, particularly those in SF. These observations suggest that CII reactive T cells play an important role in the pathogenesis of RA. Peripheral tolerance induction using CII(255-274) might be useful in the treatment of RA. (Arthritis and Rheumatism 42(10):2085-2093, 1999)