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A Study of the Effects of Transmedia Storytelling on Active Participation and Language Learning
Lee Yun Joon Jason(Yun Joon Jason Lee) 영상영어교육학회 2022 영상영어교육 (STEM journal) Vol.23 No.2
This study observed the following two purposes: (1) to investigate whether transmedia storytelling (TS) encourages beginner-level college students to actively participate in classwork, and (2) to determine whether TS is positively related to second language (L2) learning. The transmedia approach will help the students to gain more knowledge and information about the target language. Two beginners were invited to act as case studies to these ends. An American television series, The Good Place (Holland, 2018), was chosen. This study was conducted in three stages: (1) participant presentations on selected topics via TS, (2) first recall test (one week later, with notice), and (3) second recall test (two weeks later, without notice). On the first test, Participant A scored well on his selected topic, but his score dropped somewhat on Participant B’s topic. Participant B had a better score than Participant A on both topics. The second test was an error analysis. Participant A had minor errors on the TS-based topic but significant ones on the not-TS-based topic. Participant B had fewer errors than Participant A on both topics, and all his errors were minor. Both participants were involved in active participation. Pedagogical implications are discussed in the conclusion.
Lee Yun Joon Jason(Yun Joon Jason Lee) 영상영어교육학회 2022 영상영어교육 (STEM journal) Vol.23 No.4
This study had two objectives: (1) to observe how the participants used a TV series to learn English and (2) to investigate to what extent they changed the way they used the TV series to learn English based on three activities or guidelines that a teacher gave for better learning. They were, first, that the centrality of the meaning (of the lexicon and of the pattern) is core in using TV series for L2 learning; second, how to learn conventional expressions; and third, that in using a language, language knowledge and world knowledge should be combined. For the analysis, the participants’ reports were used. For the first guideline, it was found that the participants primarily paid attention to understanding the utterances in the script. They performed poorly. In the second activity, the participants performed relatively well. In the third activity, when the participants were assisted, they were able to focus on patterns. After the activities, they realized that they could learn the importance of context and culture as well as conventional expressions. A pedagogical implication of these findings is that although TV series are expected to make learning enjoyable, language matters should take precedence.
EZH2 Generates a Methyl Degron that Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex
Lee, J.,Lee, Jason S.,Kim, H.,Kim, K.,Park, H.,Kim, J.Y.,Lee, S.,Kim, I.,Kim, J.,Lee, M.,Chung, C.,Seo, S.B.,Yoon, J.B.,Ko, E.,Noh, D.Y.,Kim, K.,Kim, K.,Baek, S. Cell Press 2012 Molecular cell Vol.48 No.4
Ubiquitination plays a major role in protein degradation. Although phosphorylation-dependent ubiquitination is well known for the regulation of protein stability, methylation-dependent ubiquitination machinery has not been characterized. Here, we provide evidence that methylation-dependent ubiquitination is carried out by damage-specific DNA binding protein 1 (DDB1)/cullin4 (CUL4) E3 ubiquitin ligase complex and a DDB1-CUL4-associated factor 1 (DCAF1) adaptor, which recognizes monomethylated substrates. Molecular modeling and binding affinity studies reveal that the putative chromo domain of DCAF1 directly recognizes monomethylated substrates, whereas critical binding pocket mutations of the DCAF1 chromo domain ablated the binding from the monomethylated substrates. Further, we discovered that enhancer of zeste homolog 2 (EZH2) methyltransferase has distinct substrate specificities for histone H3K27 and nonhistones exemplified by an orphan nuclear receptor, RORα. We propose that EZH2-DCAF1/DDB1/CUL4 represents a previously unrecognized methylation-dependent ubiquitination machinery specifically recognizing ''methyl degron''; through this, nonhistone protein stability can be dynamically regulated in a methylation-dependent manner.
Negative Regulation of Hypoxic Responses via Induced Reptin Methylation
Lee, Jason S.,Kim, Yunho,Kim, Ik Soo,Kim, Bogyou,Choi, Hee June,Lee, Ji Min,Shin, Hi-Jai R.,Kim, Jung Hwa,Kim, Ji-Young,Seo, Sang-Beom,Lee, Ho,Binda, Olivier,Gozani, Or,Semenza, Gregg L.,Kim, Minhyung Elsevier 2010 Molecular cell Vol.39 No.1
<P><B>Summary</B></P><P>Lysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to nonhistone proteins, underlying molecular mechanisms such as the upstream signaling cascade that induces lysine methylation and downstream target genes modulated by this modification have not been elucidated. Here, we show that Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a. Methylated Reptin binds to the promoters of a subset of hypoxia-responsive genes and negatively regulates transcription of these genes to modulate cellular responses to hypoxia.</P> <P><B>Highlights</B></P><P>► Reptin is a target of G9a methyltransferase ► Reptin K67 methylation is induced by hypoxia ► Genome-wide identification of hypoxia target genes negatively regulated by Reptin ► Hypoxia-driven Reptin methylation negatively regulates tumorigenic behavior in vivo</P>
Lee, Kyuho Jason,Bong, Kyeongryeol,Kim, Changhyeon,Jang, Jaeeun,Lee, Kyoung-Rog,Lee, Jihee,Kim, Gyeonghoon,Yoo, Hoi-Jun IEEE 2017 IEEE journal of solid-state circuits Vol.52 No.1
<P>The advanced driver assistance system (ADAS) for adaptive cruise control and collision avoidance is strongly dependent upon the robust image recognition technology such as lane detection, vehicle/pedestrian detection, and traffic sign recognition. However, the conventional ADAS cannot realize more advanced collision evasion in real environments due to the absence of intelligent vehicle/pedestrian behavior analysis. Moreover, accurate distance estimation is essential in ADAS applications and semiglobal matching (SGM) is most widely adopted for high accuracy, but its system-on-chip (SoC) implementation is difficult due to the massive external memory bandwidth. In this paper, an ADAS SoC with behavior analysis with Artificial Intelligence functions and hardware implementation of SGM is proposed. The proposed SoC has dual-mode operations of highperformance operation for intelligent ADAS with real-time SGM in D-Mode (d-mode) and ultralow-power operation for black box system in parking-mode. It features: 1) task-level pipelined SGM processor to reduce external memory bandwidth by 85.8%; 2) region-of-interest generation processor to reduce 86.2% of computation; 3) mixed-mode intention prediction engine for dualmode intelligence; and 4) dynamic voltage and frequency scaling control to save 36.2% of power in d-mode. The proposed ADAS processor achieves 862 GOPS/W energy efficiency and 31.4GOPS/ mm(2) area efficiency, which are 1.53x and 1.75x improvements than the state of the art, with 30 frames/s throughput under 720p stereo inputs.</P>
Anti-SEMA3A Antibody: A Novel Therapeutic Agent to Suppress Glioblastoma Tumor Growth
Lee, Jaehyun,Shin, Yong Jae,Lee, Kyoungmin,Cho, Hee Jin,Sa, Jason K.,Lee, Sang-Yun,Kim, Seok-Hyung,Lee, Jeongwu,Yoon, Yeup,Nam, Do-Hyun 대한암학회 2018 Cancer Research and Treatment Vol.50 No.3
<P><B>Purpose</B></P><P>Glioblastoma (GBM) is classified as one of the most aggressive and lethal brain tumor. Great strides have been made in understanding the genomic and molecular underpinnings of GBM, which translated into development of new therapeutic approaches to combat such deadly disease. However, there are only few therapeutic agents that can effectively inhibit GBM invasion in a clinical framework. In an effort to address such challenges, we have generated anti-SEMA3A monoclonal antibody as a potential therapeutic antibody against GBM progression.</P><P><B>Materials and Methods</B></P><P>We employed public glioma datasets, Repository of Molecular Brain Neoplasia Data and The Cancer Genome Atlas, to analyze <I>SEMA3A</I> mRNA expression in human GBM specimens. We also evaluated for protein expression level of SEMA3A via tissue microarray (TMA) analysis. Cell migration and proliferation kinetics were assessed in various GBM patient-derived cells (PDCs) and U87-MG cell-line for SEMA3A antibody efficacy. GBM patient-derived xenograft (PDX) models were generated to evaluate tumor inhibitory effect of anti-SEMA3A antibody <I>in vivo</I>.</P><P><B>Results</B></P><P>By combining bioinformatics and TMA analysis, we discovered that SEMA3A is highly expressed in human GBM specimens compared to non-neoplastic tissues. We developed three different anti-SEMA3A antibodies, in fully human IgG form, through screening phage-displayed synthetic antibody library using a classical panning method. Neutralization of SEMA3A significantly reduced migration and proliferation capabilities of PDCs and U87-MG cell line <I>in vitro</I>. In PDX models, treatment with anti-SEMA3A antibody exhibited notable tumor inhibitory effect through down-regulation of cellular proliferative kinetics and tumor-associated macrophages recruitment.</P><P><B>Conclusion</B></P><P>In present study, we demonstrated tumor inhibitory effect of SEMA3A antibody in GBM progression and present its potential relevance as a therapeutic agent in a clinical framework.</P>
Kim, Minseo,Jang, Jaeeun,Kim, Hyunki,Lee, Jihee,Lee, Jaehyuck,Lee, Jiwon,Lee, Kyoung-Rog,Kim, Kwantae,Lee, Yongsu,Lee, Kyuho Jason,Yoo, Hoi-Jun IEEE 2017 IEEE journal of solid-state circuits Vol.52 No.11
<P>A wearable electrical impedance tomography (EIT) system is proposed for the portable real-time 3-D lung ventilation monitoring. It consists of two types of SoCs, active electrode (AE)-SoC and Hub-SoC, mounted on wearable belts. The 48-channel AE-SoCs are integrated on flexible printed circuit board belt, and Hub-SoC is integrated in the hub module which performs data gathering and wireless communication between an external imaging device. To get high accuracy under the variation of conductivity, the dual-mode current stimulator provides the optimal frequency for time difference-EIT and frequency difference-EIT with simultaneous 4 k-128 kHz impedance sensing. A wide dynamic range instruments amplifier is proposed to provide 94 dB of wide dynamic range impedance sensing. In addition, the 48-channel AE system with the dedicated communication and calibration is implemented to achieve 1.4-m Omega sensitivity of impedance difference in the in vivo environment. The AE-/Hub-SoCs occupy 3.2 and 1.3 mm2in 65-nm CMOS technology and consume 124 mu W and 1.1 mW with 1.2 V supply, respectively. As a result, EIT images are reconstructed with 90% of accuracy, and up to 10 frames/s real-time 3-D lung images are successfully displayed.</P>
Jason Y Lee,Phillip Mucksavage 대한비뇨의학회 2012 Investigative and Clinical Urology Vol.53 No.12
The introduction of robot-assisted laparoscopic surgery has facilitated the application of minimally invasive surgical techniques to many complex reconstructive and extirpative procedures. Even early on in their learning experience, robotic surgeons have been able to complete procedures using a minimally invasive approach, but would not have been able to do so using a purely laparoscopic technique. Although the open surgical approach remains the standard of care in the management of large renal tumors presenting with a thrombus within the vena cava, robot-assisted surgery may provide the precision and dexterity necessary to allow for the safe application of minimally invasive techniques to such complex clinical scenarios, perhaps even by relatively novice robotic surgeons. We describe the management of a large renal mass with vena caval thrombus (cT3b), which required complete cross-clamping of the vena cava, with the use of a purely robot-assisted laparoscopic approach.