체성분이 폐경 전후 여성의 골밀도에 미치는 여향

배성욱,남철현,신두만,차경미,서인선 慶山大學校 保健福祉硏究所 2002 保健福祉硏究 Vol.7 No.-

Objectives : To evaluate the degree of bone mineral density and prevalence rate of osteoporosis according to age and to search the preventive strategy for osteoporosis, the factors that affect on bone density were studied in Physical Characteristics of pre- and postmenopausal women in korea. Methods : The subjects were 961 premenopausal and 1,167 postmenopausal women who have examined in health promotion center of Yeungnam University Hospital in Daegu city from January, 1999 to January, 2001. The test for bone mineral density, biochemical factors, and body composition were done. Results : 1) The prevalence rates of reduced bone mineral density and osteoporosis in premenopausal women were 23.8% and 1.6%, respectively. However, these values were increased to 46.1% and 28.1% in postmenopausal women. 2) The body weight and height were important predictive factors for bone mineral density. The effects of age, body weight, and height on bone mineral density were 39%. The body weight was correlated statistically significantly with bone mineral density in pre- and postmenopausal women. The higher body mass index (BMI), the greater value of bone mineral density was revealed in pre- and postmenopausal women. 3) The correlation between body composition adjusted for body weight and bone mineral density revealed similar pattern between pre- and postmenopausal women. The height, lean body mass, muscle mass, mineral content, and mineral fraction were positively correlated with bone mineral density, however, body fat mass, percent body fat, waist/hip ratio, and BMI were correlated negatively with bone mineral density. 4) There was no direct correlation between cardiovascular risk factor and bone mineral density in this study, however, further study is needed because cardiovascular disease and osteoporosis have common risk factor and the prevention of osteoporosis can help to prevent cardiovascular disease. 5) In multiple regression analysis among bone mineral density as a dependent variable and independent variables (age, body weight, height, Ca/creatinine ratio, and alkaline phosphatase (ALP)), ALP revealed statistically significant inverse correlation with bone mineral density. Conclusions : These results suggested that to prevent osteoporosis, the systemized program including physical condition for promoting anti-osteoporotic factor have to be developed and apply from the thirties whom have maximal bone mineral density.

Arthrobacter simplex의 Steroid △^1-dehydrogenase의 유도와 유도성 스테로이드의 성질

배무,오영주,민태경,이미경 이화여자대학교 생명과학연구소 1991 생명과학연구논문집 Vol.2 No.-

Arthrobacter simplex IAM 1660의 스테로이드 Δ^1-dehydrogenase에 대한 각종 steroid의 유도조건과 효과를 검토하였다. 그 결과 시험한 스테로이드 중 hydrocortisone이 가장 큰 효과를 나타냈고 progesterone, prednisolone, prednisone, androstendione의 순으로 유도효과를 보였고, 스테롤에 의해서는 유도효과가 낮았다. 유도 스테로이드의 특성으로는 스테로이드 모핵 C-3위가 수산기인 것보다 캐톤기이며 C-4위에 이중결합이 존재하고 스테로이드 D고리의 측쇄가 짧은 것이 유도효과가 높았다. 유도물질의 첨가시기는 대수증식기 초기가 최적이었으며 농도는 hydrocortisone의 경우 0.1%가 좋았으며 효소의 유도시간은 15시간이 최저이었다. 효소유도시 배양온도는 30℃가 가장 좋았고 초기 배양액의 pH는 6.5에서 8.0까지 큰 차이가 없었지만 pH6.5일 때 비교적 높은효과를 나타내었다. Hydrocortisone에 의해 유도된 균체효소의 Δ^1-dehydrogenase 수소반응의 기질특이성을 검토한 결과 progesterone, testosterone,cholestenone이 Δ^1-탈수소 반응산물로 전환되었다. Since steroid Δ^1-dehydrogenase synthesis has been known to be inducible, the mechanism of the enzyme induction of Arthrobacter simplex IAM 1660 was investigated. Among various steroids tested for inducers, hydrocortisone was the most effective inducer when hydrocortisone was used as a substrate for steroid Δ^1-dehydrogenase. Steroid Δ^1-dehydrogenase sysnthesis was effectively induced by progesterone, prednisolone and androstenedione, while the enzyme was less induced by cholesterol and not by phytosterols. The results suggest that the presence of 3-keto group and short side chain of sterodids are the favorable factors for the induction of the Δ^1-dehydrogenase synthesis. The enzyme was induced at the highest level when hydrocortisone was added at early log phase to the concentration of 0.01% of the culture and the culture was grown for 15 hours.

Silicon Carbide 형성에 관한 연구

裵長淳,李慶美 단국대학교 1993 論文集 Vol.27 No.-

The method of synthesis for silicon carbide by means of clay and industrial waste sawdust involves process of turning clay and sawdust by utilizing ferrous powder or ferric sulpate then baked within electric furnacd(700℃) produced coke. And then to the sample which fturned into coke NH_3, N_2 and H_2 gas were supplied and melted it (1500℃) and synthesized silicon carbide of β-SiC and by comparing the ferrous powder and ferric sulfate being employed at this time the rate of yield in the course of reaction was observed.

가소제에 따른 탈지강 단백질 필름의 물리적 특성

배동호,김경미 建國大學校附設農業資源開發硏究所 2002 農資源開發論集 Vol.24 No.-

Biodegradable firms were prepared from rice bran protein with 1%, 1.5%, 2% and 2.5% glycerol and 1%, 1.5%, 2% and 2.5% sorbitol. The effects of glycerol and sorbitol contents on tensile strength, % elongation and water vapour permeability of the films were studied. Films prepared with sorbitol had higher tensile strengh, lower % elongation and lower water vapour permeability than the films prepared with glycerol.

슬관절 등속성 운동시 근골격 모델의 검증:실험 및 모의실험 연구 : 실험 및 모의실험 연구 An Experimental and Simulatio study

배태수,강성재,최경주,김신기,유재욱,진미령,문무성 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

Helicobacter pylori 항원을 이용한 면역우유 생산 및 항체특성에 관한 연구

배만종,김수정,예은주,김병기,박창호,김미경 경산대학교 생명자원개발연구소 2003 생명자원과 산업 Vol.7 No.-

본 연구는 위염, 위궤양, 위림프종 및 위암과 같은 소화기 질환의 원인균으로 알려진 Helicobacter pylori균을 항원으로 하여 젖소에 면역시킨 후 생산된 우유의 anti-H. pylorigkdcp의 생성능을 검토하고, 백신투여량과 항체 생성과의 관계, 항원 항체의 특이성, H. Pylori균 응집력, 항체의 산과 열에 대한 안정성, 그리고 백신투여가 젖소에 미치는 영향을 알아보았다. 1. 백신 투여량에 따른 혈청과 유청내의 anti-H. pylori항체의 함량은 10㎖, 20㎖, 30㎖ 백신투여 모든 군에서 대조구에 비해서 높은 양의 항체 생성을 확인하였다. 유의적인 차이는 없었으나 20㎖투여가 항체 생성이 가장 많은 것으로 조사되었다. 백신 투여량에 따른 유청내의 anti-H. pylori항체 생성량은 혈청에서 나타난 결과와 유사한 양상으로 형성되었다. 2. Anti-H. pylori항체의 SDS-PAGE에 의한 분자량측정 결과 heavy chain은 50kDa정도, light chain은 24kDa정도로 확인 되었다. 3. H. pylori항원 단백질의 분자량측정 결과 12개의 band가 형성되었다. Anti-H. pylori의 항원 특이성을 알아보기 위해 western bloting을 한 결과 혈청, 혈청정제, 유청, 유청 정제 모두 7개의 항원성 물질을 확인할 수 있었고, 주 항 원성 물질은 분자량이 97, 66, 34kDa 이었다. 4. 응집반응결과 유청속의 anti-H. pylori항체가 H. pylori균에 대해 1/10의 응집가를 나타내었다. 5. Anti-H. pylori항체의 산·알칼리에 대한 안정성 실험에서는 pH 5 ∼ pH 10 범위에서 안정한 상태로 100%의 활성을 나타내었다. 6. Anti-H. pylori항체의 열에 대한 안정성 실험에서는 60℃에서 60분간 안정한 상태를 보였고, 70℃에서도 비교적 안정한 상태였으나 60분 경과후 40%정도 활성이 감소하였다. 80℃에서는 4분간 처리했을 때 77%의 활성을 유지하였고, 100℃에서도 1분간은 비교적 안정한 상태였다. 7. 백신투요로 인하여 유량이 12% 감소하는 경향을 나타냈고, 최장 1주일 정도 지나면서 회복되었다. 8. 백신투여 후 젖소의 체온을 측정한 결과 대조구에 비해 정상적인 범위 내에서 체온이 상승하는 경향을 나타내었다. This study has been to examine bio-function of anti-H. pylori antibodies of milk produced from cows immune with antigen germ of Helicobacter pylori and search the relation between vaccine dosage volume and antibody formation, peculiarity of antigen antibody, cohesion of H. pylori germ, stability about add and heat of antibody, and impact of vaccine dosage on cows. The content of serum and Anti-H. pylori antibody within whey in accordance with vaccine dosage volume has confirmed the formation of high-quantified antibody compared to the controlled conditions in all groups vaccine dosages of 10㎖, 20㎖, and 30㎖. It has been turned out that the antibody was farmed most in 20㎖ dosage on while there was no attention difference. The molecular weight of Anti-H. pylori antibody measured by SDS-PAGE were turned out as about 50kDa in the heavy chain and about 24kDa in the light chain. 12 bands were formed as the result of measured molecular weight of antibody protein. The western blotting was performed in order to examine the antigen peculiarity of Anti-H. pylori that all 7 antigen substances including serum, serum refining, whey and whey refining could be confirmed and the main antigen substances were 97, 66, 34kDa of molecular weight. As a result of cohesive response Anti-H. pylori antibody in whey showed 1/10 cohesive rate about H. pylori germ. In stability test about acid and alkali of antibody there was 100% activated in the range of pH 5-pH 10. In stability test about heat it showed stable condition in 60℃: for 60 minutes and comparatively stable condition in 70℃, but reduced activation to 40% after 60 minutes. It maintained 77% activation in 80℃ for 4 minutes and comparatively stable in 100℃ for I minute. It was inclined to reduce to 12% of flow caused by vaccine injection, but recovered after about maximum 1 week. In measurement of body temperature of cows after vaccine injected, it was inclined to rise with the normal scope in comparison with the controlled conditions.

중년후기 여성의 폐경관리와 삶의 질에 영향을 미치는 요인 분석

차경미,남철현,배성욱,서인선,김기열 慶山大學校 保健福祉硏究所 2002 保健福祉硏究 Vol.7 No.-

This study was conducted to identify influencing factors to management of menopause and quality of life and also to develope the developing education program of HRT(hormone replacement therapy) for healthy aging women. The hypothetical model explaining health promoting behavior and quality of life was constructed on the basis of Pender's health promotion model, Nho's quality of life model. The empirical data for testing the hypothetical model consisted of 356 late-middle aged(45~64) women who visited from 5th september to 20th september, 1999, in Pohang city. The reliabilities of instruments were adequate(Cronbach's alpha=0.7941, -0.9098). SPSS PC+ program were utilized for descriptive statistics and covariance structure analysis. The summary of research results was as follows: 1) The influential factors to management of menopause showed: The directed factors were the influences of family(β=.29), economical status(β=-.12), experienced symptoms of menopause(β=.24), multidimensional health locus of control(β=.15), subjective health status of compared with to another person(β=-.18). The indirected factors were the influences of family(β=.04), age(β=.05), experience of HRT's information(β=.02), belonging to occupation(β=-.03), stop of menstruation(β=-.02). 2) The influential factors to quality of life showed: The directed factors were the influences of family(β=.39), self efficiency(β=.15), subjective health status(β=-.31). The indirected factors were the influences of family(β=.37), age(β=-.97), belonging to occupation(β=.01), educational status(β=.21), a monthly income(β=.26). In conclusion, the purpose for "Healthy aging" in late-middle aged women is increasing of the quality of life after menopause. All the health providers have to efforts and harder study for developing health maintenances and health aging in late-middle aged women. Consequently, we need many kinds of public health education programs. And farther more, the developing HRT's educational program is very important in late middle-aged women's healthy aging.

편평세포암종이 동반된 비강의 도립유두종 - 2예 보고 -

구미진,김동석,배영경,김용대 대한병리학회 2001 Journal of Pathology and Translational Medicine Vol.35 No.3

환기정도에 따른 수술실용 신발 종류가 수술실 오염에 미치는 영향 : How to Choose Suitable Shoes?

남경동,정혜선,박영신,원진희,주미자,성화신,이지혜,이병희,조경숙,배재춘 한국의료QA학회 2000 한국의료질향상학회지 Vol.7 No.1

Background : Various types of protective footwear have been used to minimize bacterial contamination in operating rooms. In recent years, debate has arisen concerning the need for use of such protective footwear. This study was designed to provide useful data about choosing shoes most suitable for the surgical environment. Methods : Between November, 1999 and January, 2000, we performed this experimental study by comparing effect of three types of shoes (i.e., disposable shoescover, operating room-restricted shoes, and ordinary shoes) on bacterial contamination of operating rooms equipped with two different ventilation systems (i.e., high air-change, low air-change) respectively. Data were collected during two-hour sham operations in which subjects and their activities were strictly standardized. Bacterial flora were sampled from the study area floor and air colony-counts were measured. Results : In experiments involving high air-change ventilation system, there was a significant difference of floor contamination between three types of shoes, but no difference of air contamination. Under low air-change system, there was a significant difference of both floor and air contamination between three types of shoes. Conclusion : The results show that protective footwear would be unnecessary in the operating room with high air-change ventilation system, but it is important to choose suitable shoes carefully under low air-change system. Therefore, the use of outdoor shoes can be considered under high air-change system, but it would seem sensible to apply their first use in less bloody operations at the day surgery center or out-patient department to prevent transfer of body fluid into the outside environment.

NIHSS 활용을 통한 뇌졸중 환자 간호의 질향상 전략

박경현,송경애,공혜성,나화주,유수경,박소영,김상희,최혜림,배희준,한문구,양미화 한국의료QA학회 2009 한국의료질향상학회지 Vol.15 No.2

문제: 뇌졸중 환자를 돌보는 간호현장에서는 급성기 뇌졸중 환자의 증상악화에 대한 조기사정과 적절한 대처가 매우 중요한 문제이다. 그러나 임상현장에서는 이를 객관화하고 수치화하여 모든 의료진이 의사소통할 수 있는 유용한 도구를 사용하고 있지는 못하는 실정이다. 이러한 문제를 해결하기위해 NIHSS(National Institute of Health Stroke Scale)를 신경과 진료의사를 중심으로활용하고 있지만 아직 간호현장에서는보편적으로사용하지 않고있다. 이에 뇌졸중환자간호에 NIHSS를 활용하여 뇌졸중 증상악화의 조기사정과 빠른 대처로 궁극적으로는 뇌졸중환자 간호의 질을보다 향상시키기 위하여 본활동이 시도되었다. 목적: 첫째, 간호사의 NIHSS 측정 신뢰도의 현수준을 점검하고 이를향상시키기 위한 프로그램을 개발·적용한다. 둘째, 간호사가급성기 뇌졸중환자에게 NIHSS 측정을 통하여 뇌졸중악화를 얼마나 예측할 수 있는지 분석하고 이를 향상시킬수있는 방법을 모색한다. 셋째, 궁극적으로 급성기 뇌졸중 환자의 증상악화의 조기 발견과치료를위한의료진의 올바른 대처지침을 마련하여 이를 적용한다. 의료기관: 경기도에 소재한 대학병원의 뇌졸중 집중치료실 질 향상 활동: 첫째, 간호사의 NIHSS 측정 신뢰도 향상을 위해 「NIHSS 간호사 교육 프로그램」을 마련하였다.