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안치영,이경종,박재범,장재연,김문종 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.1
목 적 : 조선소에서 만성적 유기용제 노출과 간기능과의 관련성을 규명하고자 하였다. 방 법 : 한 대형 조선소에서 도장작업 부서의 근로자 461명과 유기용제 노출이 없는 대조군 125명, 총586명의 남성 근로자를 대상으로 유기용제 생체누적노출량과 간기능검사 지표와의 관련성을 단면적 연구를 통하여 수행하였다. 일반적 특성, 직업적 특성, 간기능 검사와 작업환경 평가 및 생물학적 모니터링을 이용하여 자료와 변수들을 수집하여 이변량 분석과 로지스틱 회귀분석을 시행하였다. 간 기능을 정상과 비정상으로 구분하여 종속변수로 삼고 생물학적 모니터링을 근간으로 하여 생체 누적 노출량(CE)을 독립변수로 하여 로지스틱 회귀 분석을 시행하였다. 결 과 : 다중 로지스틱 회귀분석을 한 결과SGOT(>351ua), SGPT(>401U/L), γ-GTP(>631U/L)에 대해 유기용제 생체누적노출량(CE)은 각각 1.10(95 %Cl, 1.02~l.20), 1.10(95 %Cl,1.Ol~l.19), 1.10(95% Cl; 1.Ol~l.19)의 비차비를 보였다. 결 론 : 그러므로 혼합 유기용제에의 누적폭로는B형 간염 항원이 음성인 남성근로자들에 있어 SGOT, SGPT, γ-GTP 등의 간기능검사의 비정상결과(검사치의 증가)에 유의한 관련성이 있는 것으로 판단된다. Objectives : This study was conducted to evaluate the association of cumulative exposure to organic solvent with liver function. Methods : We conducted a cross sectional study. 461 male workers who Perform painting job at a shipyard and use organic solvents routinely and 125 workers of the same shipyard who never have been exposed to organic solvents were studied. All subjects who were confirmed not having HBsAg surveyed their age, BMI (body mass index), alcohol drinking and smoking history, and examined liver function test (SGOT, SGPT, γ-GTP, Total protein, albumin, total bilirubin, direct bilirubin) . The amount of cumulative exposure (CE) to mixed organic solvents were measured by biological monitoring method using their metabolites in urine. Results : The CE was observed as a significant variable with logistic regression analysis on abnormality of SGOT(>35IU/L) , SGPT(>40IU/L) and γ-GTP(>63IU/L), their odds ratio were 1.10 (95 %CI, 1.02-1.20), 1.10 (95 %CI, 1.01-1.19), and 1.10 (95 %CI, 1.01-1.19) each. Conclusions : Therefore we suggest that the cumulative exposure to mixed organic solvents might be a significant variable on abnormal liver function indices (SGOT, SGPT, γ-GTP) in male shipyard workers.
도계처리과정에 사용되는 물에서 분리한 세균군과 각 세균종에 대한 살균제의 효능에 대하여
김성일,오경록,안동수,안태근,고경원,이민웅 동국대학교 대학원 1987 大學院硏究論集-東國大學校 大學院 Vol.17 No.-
The highest number of bacterial cell was observed in chicken washed water compared with the natural and chilled water. Fifteen bacterial strains were islated from the chicken processing water. When they were identified by the Bergey's Mannual of determinative bacteriology, they were all identified as the family Enterobacteriaceae; one genus of Citrobacter, three genera of Enterobacter, and four genera of Klebsiella except one isolate unknown. The concentration of Na₂HCIO₄to inhibit all the bacterial strains 30ppm, on the other hand the concentration of CIO₂to retard bacterial growth was 70ppm. The effective concentration of CIO₂was various according to bacterial species.
Kyung-Ann Lee,Bo Young Kim,Sung Soo Kim,Yun Hong Cheon,Sang-Il Lee,Sang-Hyon Kim,Jae Hyun Jung,Geun-Tae Kim,Jin-Wuk Hur,Myeung-Su Lee,Yun Sung Kim,Seung-Jae Hong,Suyeon Park,Hyun-Sook Kim 대한내과학회 2024 The Korean Journal of Internal Medicine Vol.39 No.5
Background/Aims: To compare the effects of abatacept and conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs) on the progression and development of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Methods: This multi-center retrospective study included RA patients receiving abatacept or csDMARDs who underwent at least two pulmonary function tests and/or chest high-resolution computed tomography (HRCT). We compared the following outcomes between the groups: progression of RA-ILD, development of new ILD in RA patients without ILD at baseline, 28-joint Disease Activity Score with the erythrocyte sedimentation rate (DAS28-ESR), and safety. Longitudinal changes were compared between the groups by using a generalized estimating equation. Results: The study included 123 patients who were treated with abatacept (n = 59) or csDMARDs (n = 64). Nineteen (32.2%) and 38 (59.4%) patients treated with abatacept and csDMARDs, respectively, presented with RA-ILD at baseline. Newly developed ILD occurred in one patient receiving triple csDMARDs for 32 months. Among patients with RA-ILD at baseline, ILD progressed in 21.1% of cases treated with abatacept and 34.2% of cases treated with csDMARDs during a median 21-month follow-up. Longitudinal changes in forced vital capacity and diffusing capacity for carbon monoxide were comparable between the two groups. However, the abatacept group showed a more significant decrease in DAS28-ESR and glucocorticoid doses than csDMARDs group during the follow-up. The safety of both regimens was comparable. Conclusions: Abatacept and csDMARDs showed comparable effects on the development and stabilization of RA-ILD. Nevertheless, compared to csDMARDs, abatacept demonstrated a significant improvement in disease activity and led to reduced glucocorticoid use.
Bilateral Ovarian Metastases from ALK Rearranged Non-Small Cell Lung Cancer
Lee, Kyung Ann,Lee, Jong Sik,Min, Jae Ki,Kim, Hee Joung,Kim, Wan Seop,Lee, Kye Young The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.77 No.6
Anaplastic lymphoma kinase (ALK) rearrangement, is a kind of driver mutation, accounts for 3%-5% of non-small cell lung cancer (NSCLC). NSCLC patients harboring ALK fusion genes have distinct clinical features and good response to ALK inhibitors. Metastasis from lung cancer to the ovary has rarely been known. We report a case of a 54-year-old woman with bilateral ovarian metastases from ALK rearranged NSCLC. She underwent bilateral salpingo-oophorectomy for ovary masses, which were progressed after cytotoxic chemotherapy although primary lung mass was decreased. Histopathological examination of the ovary tumor showed characteristic adenocarcinoma patterns of the lung and ALK rearrangement.
CASE REPORT : Bilateral Ovarian Metastases from ALK Rearranged Non-Small Cell Lung Cancer
( Kyung Ann Lee ),( Jong Sik Lee ),( Jae Ki Min ),( Hee Joung Kim ),( Wan Seop Kim ),( Kye Young Lee ) 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.77 No.6
Anaplastic lymphoma kinase (ALK) rearrangement, is a kind of driver mutation, accounts for 3%-5% of non-small celllung cancer (NSCLC). NSCLC patients harboring ALK fusion genes have distinct clinical features and good responseto ALK inhibitors. Metastasis from lung cancer to the ovary has rarely been known. We report a case of a 54-year-oldwoman with bilateral ovarian metastases from ALK rearranged NSCLC. She underwent bilateral salpingo-oophorectomyfor ovary masses, which were progressed after cytotoxic chemotherapy although primary lung mass was decreased. Histopathological examination of the ovary tumor showed characteristic adenocarcinoma patterns of the lung and ALKrearrangement.
Lee, Jong Sik,Lee, Kyung Ann,Lee, Kang Hoon,Moon, Sun Young,Kim, In Ae,Jeon, Sung Jin,Min, Jae Ki,Kim, Hee Joung,Lee, Kye Young Yeungnam University College of Medicine 2016 Yeungnam University Journal of Medicine Vol.33 No.1
We report on a 64-year-old man with leptomeningeal metastasis (LM) from an epidermal growth factor receptor (EGFR)-mutated adenocarcinoma of the lung. He was treated with paclitaxel, cisplatin. After completion of chemotherapy, he complained of headache, nausea, and vomiting. EGFR-mutated tumor cells were identified from the cerebrospinal fluid (CSF). Second-line therapy with gefitinib, methotrexate was started. After receiving gefitinib for 4 weeks, he had no more headaches or vomiting. Eleven months after initiation of gefitinib, he developed headache and nausea. Chest computed tomography showed aggravation of bone metastasis. Third-line therapy was started with gemcitabine and carboplatin. Two weeks later, he experienced disorientation. After a fourth relapse within the central nervous system, the therapy was switched to erlotinib and significant improvement of LM was achieved. This case shows that LM can be diagnosed by detecting EGFR mutation in CSF and EGFR tyrosine kinase inhibitors are effective for LM from EGFR mutant non-small cell lung cancer.
( Kyung-ann Lee ),( Hyun-woo Chung ),( Sang-heon Lee ),( Hae-rim Kim ) 대한내과학회 2016 대한내과학회 추계학술발표논문집 Vol.2016 No.1
Objective:?This study aimed to analyze the hand perfusion scintigraphic features in hand-arm vibration syndrome (HAVS) and to compare with primary Raynaud’s phenomenon (RP) and secondary RP associated with connective tissue disease (CTD).?Methods: The hand perfusion scingitraphy were performed in 57 patients with primary RP, 71 patients with HAVS-related RP and 36 patients with CTD-related RP, and clinical features were collected by a retrospective review of medical records. We calculated 6 ratios by using the time-activity curve and static blood pool images; the chilled to ambient hand and wrist ratios of the first peak height, the initial slope, and blood pool uptake. We analyzed 4 morphologic characteristics: an initial spike curve, a slow progress pattern, paradoxically increased uptake pattern in the time-activity curve and the inhomogeneous radioactivity uptake in the blood pool image.?Results:?All 71 patients with HAVS-related RP were mine workers. The onset duration of RP after exposure to vibration was 21.7±7.3 years with 26.3±7.0 years of vibration exposure time. The chilled to ambient hand ratios of the first peak height and the initial slope were significantly lower in patients with HAVS-related occupational RP, compared to patients with primary RP. The presence of paradoxically increased uptake pattern of hand was significantly lower in HAVS compared to primary RP.?Conclusions:?There were significant differences of both quantitative and morphologic characteristics of hand perfusion scintigraphy between primary RP and HAVS. The results suggest that each disease might have quite different pathophysiology and thus different criteria should be applied to evaluation of each RP.
( Jong Sik Lee ),( Kyung Ann Lee ),( Kang Hoon Lee ),( Sun Young Moon ),( In Ae Kim ),( Sung Jin Jeon ),( Jae Ki Min ),( Hee Joung Kim ),( Kye Young Lee ) 영남대학교 의과대학 2016 Yeungnam University Journal of Medicine Vol.33 No.1
We report on a 64-year-old man with leptomeningeal metastasis (LM) from an epidermal growth factor receptor (EGFR)-mutated adenocarcinoma of the lung. He was treated with paclitaxel, cisplatin. After completion of chemotherapy, he complained of headache, nausea, and vomiting. EGFR-mutated tumor cells were identified from the cerebrospinal fluid (CSF). Second-line therapy with gefitinib, methotrexate was started. After receiving gefitinib for 4 weeks, he had no more headaches or vomiting. Eleven months after initiation of gefitinib, he developed headache and nausea. Chest computed tomography showed aggravation of bone metastasis. Third-line therapy was started with gemcitabine and carboplatin. Two weeks later, he experienced disorientation. After a fourth relapse within the central nervous system, the therapy was switched to erlotinib and significant improvement of LM was achieved. This case shows that LM can be diagnosed by detecting EGFR mutation in CSF and EGFR tyrosine kinase inhibitors are effective for LM from EGFR mutant non-small cell lung cancer.
( Tae Hee Lee ),( Joon Seong Lee ),( Suyeon Park ),( Kyung-ann Lee ),( Hyun-sook Kim ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.6
Background/Aims: Systemic sclerosis (SSc) is associated with a wide range of gastrointestinal (GI) changes. The University of California-Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract (UCLA SCTC GIT 2.0) instrument is a self-administered GI assessment instrument for patients with SSc. We developed a Korean version of the UCLA SCTC GIT 2.0 instrument and evaluated its reliability and internal consistency. Methods: The participants were 37 Korean patients with SSc. Translation and cross-cultural adaptation of the UCLA SCTC GIT 2.0 were performed according to international standardized guidelines. We evaluated reproducibility by calculating the intraclass correlation coefficients and assessed the internal consistency of the Korean version of the UCLA SCTC GIT 2.0. We assessed its construct validity by evaluating its correlations with the Short Form Health Survey version 2 and EQ-5D scores by means of Spearman correlation analyses. Results: Patients with SSc were mostly women (89.19%) with a mean age of 52.2 years, median disease duration of 24 months, and median modified Rodnan total skin score of 4. The median total GIT score on the UCLA SCTC GIT 2.0 was 0.3. The UCLA SCTC GIT 2.0 Korean version showed excellent internal consistency (Cronbach’s α of total GIT score = 0.863). Most domains of the ULCA SCTC GIT 2.0 were correlated with those of the EuroQol (EQ)-5D score. Conclusions: The Korean version of the UCLA SCTC GIT 2.0 has acceptable internal consistency, reliability, and validity. Therefore, it can be used to assess GIT involvement in Korean patients with SSc.