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인체에서 carvedilol의 심혈관계 작용에 대한 PK/PD modeling
백인환,윤민혁,윤휘열,남진경,권광일 충남대학교 약학대학 의약품개발연구소 2007 藥學論文集 Vol.22 No.-
The objective of the present study was to determine and characterize the relationship between the cardiovascular effect and plasma concentration of carvedilol by PK/PD modeling in human. A group of 32 healthy males received oral doses of 25 mg carvedilol, and blood samples were collected thirteen times for up to 30 hours after the drug administration. The effect of carvedilol on blood pressure was measured during the same period. This experiment was analyzed using the liquid-liquid extractions of carvedilol by HPLC with fluorescence detection. Pharmacokinetics parameters of carvedilol were calculated using the two-compartment model with first-order absorption. The average value of C_(max), T_(max), CL/F (apparent clearance), V/F (apparent volume of distribution) and half-life of carvedilol were 62.74 ± 20.12 ng/ml, 1.26 ± 0.86 hrs, 94.64 ± 46.01 L/hr, 1561.78 ± 941.94 L, 12.47 hr, respectively. To explain the relationship between the cardiovascular effect and plasma concentration of carvedilol, plasma drug concentrations were linked to the observed SBP and DBP via a effect compartment with a sigmoid Emax model. The model parameters were estimated by using ADAPT Ⅱ program. This PK/PD model could describe the relationship between plasma concentrations of carvedilol and cardiovascular effect such as the aspects of decreasing blood pressure and the time delay between plasma concentration and pharmaco-dynamic data.
( Yu Kyung Jang ),( Mee Youn Lee ),( Hyang Yeon Kim ),( Sarah Lee ),( Soo Hwan Yeo ),( Seong Yeol Baek ),( Choong Hwan Lee ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.2
Metabolite profiles of seven commercial vinegars and two traditional vinegars were performed by gas chromatography time-of-flight mass spectrometry with multivariate statistical analysis. During alcohol fermentation, yeast, nuruk, and koji were used as sugars for nutrients and as fermentation substrates. Commercial and traditional vinegars were significantly separated in the principal component analysis and orthogonal partial least square discriminant analysis. Six sugars and sugar alcohols, three organic acids, and two other components were selected as different metabolites. Target analysis by ultra-performance liquid chromatography quadruple-time-of-flight mass spectrometry and liquid chromatographyion trap-mass spectrometry/mass spectrometry were used to detect several metabolites having antioxidant activity, such as cyanidin-3-xylosylrutinoside, cyanidin-3-rutinoside, and quercetin, which were mainly detected in Rural Korean Black raspberry vinegar (RKB). These metabolites contributed to the highest antioxidant activity measured in RKB among the nine vinegars. This study revealed that MS-based metabolite profiling was useful in helping to understand the metabolite differences between commercial and traditional vinegars and to evaluate the association between active compounds of vinegar and antioxidant activity.
족관절 만성 불안정성을 갖는 축구선수에 적용된 변형 Brostrom 수술식
이경태,김현철,양기원,송백용,김장열,박성률 대한스포츠의학회 2001 대한스포츠의학회지 Vol.19 No.2
To evaluate the surgical results of anatomical procedure(Modified Brostrom) for symptomatic ankle instability, 29 patients(29 feet) with chronic ankle instability evaluated retrospectively from August 1994 to September 1998 after failing non-operative method for 6 months. The consecutive series of patient compromised 29 male football players with the average age 21 years. 12 ;layers were high level professional ;layer and the 17 players were amateur student players. All patients had grade 3 symptomatic instability by anterior drawer test. To evaluated associated injury and exact pathology of the ligament, all patients took the MRI and/or bone scan. For the evaluation of clinical outcome, relief of pain & instability and anterior drawer test were used. A subjective grading scale modified from Hamilton was used. Of the 29 operation performed, there were 21 excellent results, 5 good results and fair results as a whole. The reason for the all fair results were delayed return to the sport activity, and associated with osteochondral lesions. As associated injuries, we found 5 anterior impingement syndromes of ankle, 5 peroneal tendon problems, ossicle under malleolus and others. Those who didn't have any associated injury had all excellent result. There were 3 minor complications. To conclude, modified Brostrom procedure is available operative procedure for football players with chronic symptomatic ankle instability.
Aggressive 비호즈킨 림프종의 예후인자 분석과 고위험군 환자 선별을 위한 International Prognostic Index Model
김경태(Kyung Tae Kim),김태유(Tae You Kim),임영혁(Young Hyuck Im),강윤구(Yoon Koo Kang),이창희(Chang Hee Lee),곽영임(Young Im Kwak),류백렬(Baek Yeol Ryoo),성주병(Ju Byeung Sung),이영우(Young Wo Lee),장은정(Eun Jung Jang),김재학(Jae Ha 대한내과학회 1997 대한내과학회지 Vol.53 No.3
Objective: Although the therapeutic outcome of aggressive non-Hodgkin's lymphoma (NHL) has been considerably improved by the introduction of combination chemotherapy, many patients still fail to achieve complete response(CR) and/or long-term survival. Because the outcome appears to depend on certain prognostic factors, long term prognosis can be predicted by identification of risk group. And also, the patients in high risk group may benefit from new therapeutic modality. In 1993, the international prognostic index model for aggressive NHL as developed far the purpose of predicting outcome and designing of therapeutic trial. Thus, analysis of prognostic factors was performed to identify independent factors for the end points of CR, overall survival, and disease-free survival. Methods : From 1989 to 1994, total 340 patients were treated with combination chemotherapy and/or radiotherapy for NHL in Korea Cancer Center Hospital. Among 340, informations on eleven prognostic factors(sex, age, performance status, Ann Arbor stage, serum LDH level, tumor size, number of extranodal disease sites, bone marrow involvement, presence of B symptom, sex, time to CR, and histologic grade) were avaliable for 273 patients. Among these, 221 patients with aggressive NHL(NCI clinical schema) were eligible for the prognostic factor analysis for the response and survival. Also, 186 patients were eligible to determine whether International Prognostic Index Model could be applicable for Korean NHL. Results: One hundred fifty patients(68%, 95% CI 62-74%) achieved a complete remission, 43 patients (20%) a partial remission. With a median follow-up of 3,5 years, overall 3 year survival rate was 6396, and 3 year DFS for the 150 CRs was 72%. In a univariate analysis for the CR and survival, Ann Arbor stage, number of extranadal disease, performance status, presence of B symptoms, presence of BM involvement, serum LDH level and histologic grade were found to be statistically significant prognostic factors. Among them, by multivariate analysis, number of extranodal disease(RR 0.2, 95% CI 0.1-0.7), B Symptoms (RR 0.4, 95% CI 0.2-0.9), and histologic grade(RR 0.2, 95% CI 0.08-0.7) showed to be independent adverse prognostic factors for CR. For disease-free survival, Ann Arbor stage(RR 2.6, 95% CI 1.1-6.4) was independent risk factor. For overall survival, number of extranodal involvement(RR 2, 95% CI 1.3-4) and histologic grade(RR 2, 95% CI 1.2-3.7) were independently significant prognostic factors. With these 2 independent prognostic factors for survival, we could establish a prognastic index model which could separate the high risk patients. However, the usefulness of this model should be confirmed in a larger patient population. The dose intensity of cyclophosphamide, during initial 3 months of treatment, was significantly associated with CR rate and overall survival(p=0.01 & 0.03, respectively). When International Prognostic Index Model was applied to our patients, patients in the lower risk groups had significantly better outcome than patients in the higher risk groups(3 year survival and RR: 77% & 1 for low risk group, 61% & 1.9 for low-intermediate risk group, 50% & 2.2 for high-intermediate risk group, and 25% & 6 for high risk group). Conclusion: In this study, we confirmed that features other than the Ann Arbor stage were independently associated with CR and survival, and the International Prognostic Index Model would be an useful tool for the selection of high-risk patients who could be benefited from more aggressive chemotherapy.
Persistent Java에서의 동시성제어 (pp.72-74)
백경원(Kyung-Won Baek),이정태(Jung-tae Lee),류기열(Ki-Yeol Ryu) 한국정보과학회 1999 한국정보과학회 학술발표논문집 Vol.26 No.1A
본 논문에서는 Java에 Persistent 프로그래밍 언어로서의 기능을 추가한 Orthogonally Persistent Java(PJama)의 동시성 제어문제를 다룬다. Orthogonally Persistent Java를 비롯한 Persistent 프로그래밍 언어에서는 프로그래밍 언어와 데이터베이스 각각의 영역에서 다르게 정의된 동의성 제어에 대한 통합된 개념과 메커니즘을 필요로 한다. PJama에서는 지속성 자료에 대한 동시성 제어를 위하여 트랜잭션 모형을 제공하고 있지만 현재까지 제공되는 트랜잭션 모형을 적용하는 경우 Orthogonally Persistent Principle 중, 자료의 지속성 유무에 관계없이 프로그램의 형태는 같아야 한다는 Persistent Independence Principle을 유지할 수 없다. 본 논문에서는 PJama의 프로그램 소스 코드에 대한 제어 흐름과 자료 흐름을 분석하여 트랜잭션으로 처리 되어야 될 부분을 감지하고, 컴파일러가 자동으로 트랜잭션을 설정하게 함으로써 Persistent Independence Principle이 유지 될 수 있는 방안을 제안하고자 한다.